ketoconazole and panobinostat

ketoconazole has been researched along with panobinostat in 3 studies

Research

Studies (3)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	2 (66.67)	24.3611
2020's	1 (33.33)	2.80

Authors

Authors	Studies
Chen, SH; Duan, YC; Guan, YY; He, ZH; Jin, LF; Liu, YJ; Ren, HM; Song, Y; Xu, YT; Yuan, H; Zhang, SJ	1
Chen, LC; de Jonge, M; Hamberg, P; Hengelage, T; Li, W; Porro, MG; Sharma, S; van der Biessen, D; Verweij, J; Woo, MM; Zhao, L	1
Srinivas, NR	1

Reviews

1 review(s) available for ketoconazole and panobinostat

Article	Year
Clinical pharmacokinetics of panobinostat, a novel histone deacetylase (HDAC) inhibitor: review and perspectives. Xenobiotica; the fate of foreign compounds in biological systems, 2017, Volume: 47, Issue:4 Topics: Cytochrome P-450 CYP3A; Dexamethasone; Drug Interactions; Histone Deacetylase Inhibitors; Hydroxamic Acids; Indoles; Ketoconazole; Panobinostat	2017

Trials

1 trial(s) available for ketoconazole and panobinostat

Article	Year
Effect of ketoconazole-mediated CYP3A4 inhibition on clinical pharmacokinetics of panobinostat (LBH589), an orally active histone deacetylase inhibitor. Cancer chemotherapy and pharmacology, 2011, Volume: 68, Issue:3 Topics: Adult; Aged; Antifungal Agents; Area Under Curve; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Drug Interactions; Electrocardiography; Female; Half-Life; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Hypophosphatemia; Indoles; Ketoconazole; Male; Mass Spectrometry; Middle Aged; Neoplasms; Panobinostat; Pharmacogenetics; Sample Size	2011

Article

Year

Effect of ketoconazole-mediated CYP3A4 inhibition on clinical pharmacokinetics of panobinostat (LBH589), an orally active histone deacetylase inhibitor.

Cancer chemotherapy and pharmacology, 2011, Volume: 68, Issue:3

Topics: Adult; Aged; Antifungal Agents; Area Under Curve; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Drug Interactions; Electrocardiography; Female; Half-Life; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Hypophosphatemia; Indoles; Ketoconazole; Male; Mass Spectrometry; Middle Aged; Neoplasms; Panobinostat; Pharmacogenetics; Sample Size

2011

Other Studies

1 other study(ies) available for ketoconazole and panobinostat

Article	Year
Design, synthesis, and biological evaluation of novel dual inhibitors targeting lysine specific demethylase 1 (LSD1) and histone deacetylases (HDAC) for treatment of gastric cancer. European journal of medicinal chemistry, 2021, Aug-05, Volume: 220 Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Proliferation; Dose-Response Relationship, Drug; Drug Design; Drug Screening Assays, Antitumor; Enzyme Inhibitors; Histone Deacetylases; Histone Demethylases; Humans; Microsomes, Liver; Molecular Docking Simulation; Molecular Structure; Rats; Stomach Neoplasms; Structure-Activity Relationship; Tumor Cells, Cultured	2021

Article

Year

Design, synthesis, and biological evaluation of novel dual inhibitors targeting lysine specific demethylase 1 (LSD1) and histone deacetylases (HDAC) for treatment of gastric cancer.

European journal of medicinal chemistry, 2021, Aug-05, Volume: 220

Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Proliferation; Dose-Response Relationship, Drug; Drug Design; Drug Screening Assays, Antitumor; Enzyme Inhibitors; Histone Deacetylases; Histone Demethylases; Humans; Microsomes, Liver; Molecular Docking Simulation; Molecular Structure; Rats; Stomach Neoplasms; Structure-Activity Relationship; Tumor Cells, Cultured

2021