ketoconazole and omeprazole

ketoconazole has been researched along with omeprazole in 48 studies

Research

Studies (48)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	11 (22.92)	18.2507
2000's	15 (31.25)	29.6817
2010's	17 (35.42)	24.3611
2020's	5 (10.42)	2.80

Authors

Authors	Studies
Brodsky, JL; Chiang, A; Chung, WJ; Denny, RA; Goeckeler-Fried, JL; Havasi, V; Hong, JS; Keeton, AB; Mazur, M; Piazza, GA; Plyler, ZE; Rasmussen, L; Rowe, SM; Sorscher, EJ; Weissman, AM; White, EL	1
Chen, LZ; Huang, X; Liu, MM; Liu, XH; Ma, D; Shi, JB; Shu, HY; Wu, J; Yu, YL	1
Ding, Q; Fan, G; Gao, D; Jiang, Y; Li, Q; Li, W; Ma, C; Mao, L; Xu, G; Yang, S; Zhang, D; Zhang, S; Zhao, J; Zhao, M; Zhu, L	1
Delabio, LC; Dutra, JP; Hembecker, M; Kita, DH; Moure, VR; Pereira, GDS; Scheiffer, G; Valdameri, G; Zattoni, IF	1
Pajeva, IK; Wiese, M	1
Doman, TN; McGovern, SL; Seidler, J; Shoichet, BK	1
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL	1
Artursson, P; Bergström, CA; Draheim, R; Holmén, AG; Wassvik, CM	1
Artursson, P; Bergström, CA; Hoogstraate, J; Matsson, P; Norinder, U; Pedersen, JM	1
Pratim Roy, P; Roy, K	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Choi, SS; Contrera, JF; Hastings, KL; Kruhlak, NL; Sancilio, LF; Weaver, JL; Willard, JM	1
García-Mera, X; González-Díaz, H; Prado-Prado, FJ	1
Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ	1
Freiwald, S; Jiang, Y; Jones, JP; Kaspera, R; Katayama, J; Lee, CA; Smith, E; Totah, RA; Walker, GS	1
Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR	1
Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY	1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ	1
Kheylik, Y; Kondratov, I; Krasavin, M; Naumchyk, V; Platonov, M; Zahanich, I; Zozulya, S	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Kovalenko, A; Krasavin, M; Lukin, A; Moore, D; Tikhonova, IG; Zahanich, I; Zhurilo, N; Zozulya, S	1
Chen, F; Chen, W; Lan, L; Li, B; Li, J; Liu, Y; Mao, F; Ni, S; Wei, H; Zhu, J	1
Chin, TW; Fong, IW; Loeb, M	1
Ando, T; Fort, FL; Hamashima, T; Hodgen, GD; Kitazaki, T; Mahony, MC; Miyajima, H; Sato, S; Suzuki, T; Yamamoto, M	1
Chawla, LS; Jain, NP; Kumar, R; Sharma, M; Sood, A	1
Houston, JB; Zomorodi, K	2
Checovich, WJ; Guengerich, FP; Inoue, K; Shaw, PM; Shimada, T; Yamazaki, H	1
Bertilsson, L; Böttiger, Y; Götharson, E; Tybring, G	1
Ishizaki, T; Zhao, XJ	1
Greenblatt, DJ; Harmatz, JS; Schmider, J; Shader, RI; Venkatakrishnan, K; von Moltke, LL	1
Duan, SX; Fleishaker, JC; Greenblatt, DJ; Shader, RI; Venkatakrishnan, K; von Moltke, LL	1
Butters, CJ; McKillop, D; Wild, MJ	1
Abbas, R; Bramer, SL; Browder, NJ; Chow, CP; Flockhart, DA; Forbes, W; Fu, CJ; Odomi, M; Thacker, D	1
Greenblatt, DJ; Hesse, LM; Shader, RI; Venkatakrishnan, K; von Moltke, LL	1
Kagayama, A; Naritomi, Y; Terashita, S	1
Fuhr, U; Kober, S; Mutschler, E; Spahn-Langguth, H; Zaigler, M	1
Marks, B; Raucy, J; Trubetskoy, O; Yueh, MF; Zielinski, T	1
Aman, AM; Kukanich, B; Lascelles, BD; Mealey, KL; Papich, MG	1
Chiron, C; Giraud, C; Pons, G; Rey, E; Tran, A; Treluyer, JM; Vincent, J	1
Böttiger, Y	1
Farid, NA; Hagihara, K; Ikeda, T; Ishizuka, T; Kazui, M; Kurihara, A; Nishiya, Y; Okazaki, O	1
Alava, MA; Cadenas, E; Casanova, A; Iñarrea, P; Iturralde, M	1
Buchbjerg, JK; Chen, G; Højer, AM; Lee, R; Serenko, M; Zhao, Z	1
Namiki, N; Tanaka, S; Uchida, S	1
Burmistrova, OA; Poloznikov, AA; Sakharov, DA; Shkurnikov, MY; Zakhariants, AA	1
Ahemad, N; Dong, AN; Ong, CE; Palanisamy, UD; Pan, Y; Yiap, BC	1
Hu, Z; Peng, Y; Shi, J; Su, M; Sun, C; Zhao, Y; Zheng, J	1

Reviews

2 review(s) available for ketoconazole and omeprazole

Article	Year
Targeting breast cancer resistance protein (BCRP/ABCG2): Functional inhibitors and expression modulators. European journal of medicinal chemistry, 2022, Jul-05, Volume: 237 Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily G, Member 2; Breast Neoplasms; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Female; Humans; Neoplasm Proteins; Neoplastic Stem Cells	2022
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016

Trials

3 trial(s) available for ketoconazole and omeprazole

Article	Year
Effects of an acidic beverage (Coca-Cola) on absorption of ketoconazole. Antimicrobial agents and chemotherapy, 1995, Volume: 39, Issue:8 Topics: Achlorhydria; Adult; Carbonated Beverages; Female; Gastric Acid; Humans; Hydrogen-Ion Concentration; Intestinal Absorption; Ketoconazole; Male; Omeprazole; Prospective Studies	1995
Use of omeprazole sulfone in a single plasma sample as a probe for CYP3A4. European journal of clinical pharmacology, 2006, Volume: 62, Issue:8 Topics: Adult; Aged; Aryl Hydrocarbon Hydroxylases; Carbamazepine; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Drug Interactions; Enzyme Activators; Enzyme Inhibitors; Female; Humans; Ketoconazole; Male; Middle Aged; Mixed Function Oxygenases; Omeprazole; Pharmacogenetics	2006
Pharmacokinetic drug interactions involving vortioxetine (Lu AA21004), a multimodal antidepressant. Clinical drug investigation, 2013, Volume: 33, Issue:10 Topics: Adolescent; Adult; Antidepressive Agents; Antifungal Agents; Bupropion; Cohort Studies; Contraceptives, Oral, Hormonal; Cross-Over Studies; Drug Interactions; Enzyme Induction; Enzyme Inhibitors; Female; Fluconazole; Humans; Ketoconazole; Male; Middle Aged; Omeprazole; Piperazines; Rifampin; Single-Blind Method; Sulfides; Vortioxetine; Young Adult	2013

Other Studies

43 other study(ies) available for ketoconazole and omeprazole

Article	Year
Increasing the Endoplasmic Reticulum Pool of the F508del Allele of the Cystic Fibrosis Transmembrane Conductance Regulator Leads to Greater Folding Correction by Small Molecule Therapeutics. PloS one, 2016, Volume: 11, Issue:10 Topics: Alleles; Benzoates; Cells, Cultured; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Endoplasmic Reticulum; Furans; Gene Deletion; HEK293 Cells; HeLa Cells; High-Throughput Screening Assays; Humans; Hydroxamic Acids; Microscopy, Fluorescence; Protein Folding; Protein Structure, Tertiary; Pyrazoles; RNA, Messenger; Small Molecule Libraries; Ubiquitination; Vorinostat	2016
Discovery and development of novel pyrimidine and pyrazolo/thieno-fused pyrimidine derivatives as potent and orally active inducible nitric oxide synthase dimerization inhibitor with efficacy for arthritis. European journal of medicinal chemistry, 2021, Mar-05, Volume: 213 Topics: Administration, Oral; Animals; Arthritis; Cells, Cultured; Dimerization; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Development; Enzyme Inhibitors; Freund's Adjuvant; Humans; Lipopolysaccharides; Male; Mice; Molecular Structure; Nitric Oxide; Nitric Oxide Synthase Type II; Pyrazoles; Pyrimidines; Rats; Rats, Sprague-Dawley; RAW 264.7 Cells; Structure-Activity Relationship	2021
Discovery of 1-Amino-1 Journal of medicinal chemistry, 2021, 11-11, Volume: 64, Issue:21 Topics: Agammaglobulinaemia Tyrosine Kinase; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cytochrome P-450 Enzyme Inhibitors; Drug Discovery; Humans; Imidazoles; Molecular Docking Simulation; Protein Kinase Inhibitors; Signal Transduction; Structure-Activity Relationship	2021
Pharmacophore model of drugs involved in P-glycoprotein multidrug resistance: explanation of structural variety (hypothesis). Journal of medicinal chemistry, 2002, Dec-19, Volume: 45, Issue:26 Topics: Adenosine Triphosphatases; Algorithms; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Binding Sites; Binding, Competitive; Caco-2 Cells; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Fluoresceins; Humans; Ligands; Models, Molecular; Molecular Structure; Quantitative Structure-Activity Relationship; Radioligand Assay; Rhodamine 123; Stereoisomerism; Verapamil; Vinblastine	2002
Identification and prediction of promiscuous aggregating inhibitors among known drugs. Journal of medicinal chemistry, 2003, Oct-09, Volume: 46, Issue:21 Topics: Antifungal Agents; beta-Lactamase Inhibitors; Chemical Phenomena; Chemistry, Physical; Chymotrypsin; Enzyme Inhibitors; Kinetics; Light; Malate Dehydrogenase; Models, Molecular; Molecular Conformation; Scattering, Radiation; Structure-Activity Relationship	2003
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling. Current drug discovery technologies, 2004, Volume: 1, Issue:4 Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration	2004
Molecular characteristics for solid-state limited solubility. Journal of medicinal chemistry, 2008, May-22, Volume: 51, Issue:10 Topics: Chemical Phenomena; Chemistry, Physical; Molecular Structure; Multivariate Analysis; Pharmaceutical Preparations; Regression Analysis; Solubility	2008
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2). Journal of medicinal chemistry, 2008, Jun-12, Volume: 51, Issue:11 Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Computer Simulation; Cytochrome P-450 Enzyme System; Drug-Related Side Effects and Adverse Reactions; Estradiol; Humans; Insecta; Liver; Models, Molecular; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Pharmaceutical Preparations; Pharmacology; Structure-Activity Relationship	2008
Comparative chemometric modeling of cytochrome 3A4 inhibitory activity of structurally diverse compounds using stepwise MLR, FA-MLR, PLS, GFA, G/PLS and ANN techniques. European journal of medicinal chemistry, 2009, Volume: 44, Issue:7 Topics: Algorithms; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Enzyme Inhibitors; Factor Analysis, Statistical; Least-Squares Analysis; Linear Models; Models, Molecular; Neural Networks, Computer; Quantitative Structure-Activity Relationship; Reproducibility of Results	2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models. Toxicology mechanisms and methods, 2008, Volume: 18, Issue:2-3 Topics:	2008
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species. Bioorganic & medicinal chemistry, 2010, Mar-15, Volume: 18, Issue:6 Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics	2010
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development. Toxicological sciences : an official journal of the Society of Toxicology, 2010, Volume: 118, Issue:2 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics	2010
Identifying a selective substrate and inhibitor pair for the evaluation of CYP2J2 activity. Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:5 Topics: Amiodarone; Astemizole; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2J2; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Danazol; Drug Discovery; Drug Interactions; Enzyme Inhibitors; Humans; Hydroxylation; In Vitro Techniques; Methylation; Microsomes, Liver; Models, Biological; Molecular Structure; Substrate Specificity; Tandem Mass Spectrometry; Terfenadine	2012
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions. Journal of medicinal chemistry, 2012, May-24, Volume: 55, Issue:10 Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection	2012
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds. Chemical research in toxicology, 2012, Oct-15, Volume: 25, Issue:10 Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding	2012
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests	2013
Phenoxymethyl 1,3-oxazoles and 1,2,4-oxadiazoles as potent and selective agonists of free fatty acid receptor 1 (GPR40). Bioorganic & medicinal chemistry letters, 2015, Aug-15, Volume: 25, Issue:16 Topics: Animals; Binding Sites; Caco-2 Cells; Cytochrome P-450 Enzyme System; Half-Life; Humans; Methylamines; Mice; Molecular Docking Simulation; Oxadiazoles; Oxazoles; Propionates; Protein Binding; Protein Isoforms; Protein Structure, Tertiary; Receptors, G-Protein-Coupled; Structure-Activity Relationship	2015
Novel free fatty acid receptor 1 (GPR40) agonists based on 1,3,4-thiadiazole-2-carboxamide scaffold. Bioorganic & medicinal chemistry, 2016, 07-01, Volume: 24, Issue:13 Topics: Amides; Animals; Drug Delivery Systems; Humans; Hypoglycemic Agents; Mice; Microsomes, Liver; Molecular Docking Simulation; Protein Binding; Receptors, G-Protein-Coupled; Thiadiazoles	2016
Novel Terminal Bipheny-Based Diapophytoene Desaturases (CrtN) Inhibitors as Anti-MRSA/VISR/LRSA Agents with Reduced hERG Activity. Journal of medicinal chemistry, 2018, 01-11, Volume: 61, Issue:1 Topics: Animals; Drug Design; Enzyme Inhibitors; ERG1 Potassium Channel; HEK293 Cells; Hep G2 Cells; Humans; Inhibitory Concentration 50; Methicillin-Resistant Staphylococcus aureus; Mice; Oxidoreductases; Rats; Safety; Solubility; Structure-Activity Relationship; Water	2018
Mechanism for species-specific induction of Leydig cell tumors in rats by lansoprazole. Fundamental and applied toxicology : official journal of the Society of Toxicology, 1995, Volume: 26, Issue:2 Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Animals; Carcinogens; Chorionic Gonadotropin; Dose-Response Relationship, Drug; Haplorhini; Ketoconazole; Lansoprazole; Leydig Cell Tumor; Male; Mice; Omeprazole; Rats; Rats, Inbred F344; Rats, Sprague-Dawley; Species Specificity; Testicular Neoplasms; Testosterone	1995
Esophageal candidiasis following omeprazole therapy: a report of two cases. Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology, 1995, Volume: 14, Issue:2 Topics: Abdominal Pain; Adolescent; Adult; Candidiasis; Esophageal Diseases; Female; Gastritis; Humans; Ketoconazole; Male; Omeprazole	1995
Diazepam-omeprazole inhibition interaction: an in vitro investigation using human liver microsomes. British journal of clinical pharmacology, 1996, Volume: 42, Issue:2 Topics: Adult; Anti-Anxiety Agents; Anti-Ulcer Agents; Diazepam; Drug Interactions; Female; Humans; Ketoconazole; Male; Microsomes, Liver; Middle Aged; Omeprazole	1996
Selectivity of omeprazole inhibition towards rat liver cytochromes P450. Xenobiotica; the fate of foreign compounds in biological systems, 1997, Volume: 27, Issue:1 Topics: 7-Alkoxycoumarin O-Dealkylase; Animals; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Diazepam; Ethylmorphine-N-Demethylase; Ketoconazole; Male; Microsomes, Liver; Omeprazole; Rats; Rats, Sprague-Dawley; Substrate Specificity	1997
Different contributions of cytochrome P450 2C19 and 3A4 in the oxidation of omeprazole by human liver microsomes: effects of contents of these two forms in individual human samples. The Journal of pharmacology and experimental therapeutics, 1997, Volume: 283, Issue:2 Topics: Animals; Anti-Ulcer Agents; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Fluvoxamine; Humans; Hydroxylation; Ketoconazole; Microsomes, Liver; Mixed Function Oxygenases; Omeprazole; Rabbits; Recombinant Proteins; Sulfaphenazole	1997
Inhibition of the sulfoxidation of omeprazole by ketoconazole in poor and extensive metabolizers of S-mephenytoin. Clinical pharmacology and therapeutics, 1997, Volume: 62, Issue:4 Topics: Adult; Aged; Anti-Ulcer Agents; Anticonvulsants; Antifungal Agents; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Drug Interactions; Female; Humans; Ketoconazole; Male; Mephenytoin; Middle Aged; Mixed Function Oxygenases; Omeprazole; Oxidation-Reduction; Time Factors	1997
Metabolic interactions of selected antimalarial and non-antimalarial drugs with the major pathway (3-hydroxylation) of quinine in human liver microsomes. British journal of clinical pharmacology, 1997, Volume: 44, Issue:5 Topics: Anti-Infective Agents; Antimalarials; Chromatography; Cytochrome P-450 Enzyme System; Doxycycline; Drug Interactions; Erythromycin; Humans; Hydroxylation; Ketoconazole; Microsomes, Liver; Nifedipine; Omeprazole; Primaquine; Quinine; Tetracycline; Troleandomycin	1997
Five distinct human cytochromes mediate amitriptyline N-demethylation in vitro: dominance of CYP 2C19 and 3A4. Journal of clinical pharmacology, 1998, Volume: 38, Issue:2 Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Antifungal Agents; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Enzyme Inhibitors; Humans; Ketoconazole; Microsomes, Liver; Mixed Function Oxygenases; Omeprazole; Transfection; Tumor Cells, Cultured	1998
Kinetic characterization and identification of the enzymes responsible for the hepatic biotransformation of adinazolam and N-desmethyladinazolam in man. The Journal of pharmacy and pharmacology, 1998, Volume: 50, Issue:3 Topics: Anti-Anxiety Agents; Aryl Hydrocarbon Hydroxylases; Benzodiazepines; Biotransformation; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Inhibitors; Humans; In Vitro Techniques; Ketoconazole; Kinetics; Macrolides; Microsomes, Liver; Mixed Function Oxygenases; Omeprazole; Steroid 16-alpha-Hydroxylase; Steroid Hydroxylases	1998
Determination of the human cytochrome P450 isoforms involved in the metabolism of zolmitriptan. Xenobiotica; the fate of foreign compounds in biological systems, 1999, Volume: 29, Issue:8 Topics: Cimetidine; Clorgyline; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Inhibitors; Female; Humans; Isoenzymes; Ketoconazole; Liver; Male; Microsomes, Liver; Omeprazole; Oxazoles; Oxazolidinones; Recombinant Proteins; Serotonin Receptor Agonists; Theophylline; Tryptamines	1999
In vitro metabolism and interaction of cilostazol with human hepatic cytochrome P450 isoforms. Human & experimental toxicology, 2000, Volume: 19, Issue:3 Topics: Chromatography, High Pressure Liquid; Cilostazol; Cimetidine; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Interactions; Enzyme Inhibitors; Felodipine; Humans; In Vitro Techniques; Isoenzymes; Ketoconazole; Microsomes, Liver; Omeprazole; Platelet Aggregation Inhibitors; Tetrazoles	2000
CYP3A4 is the major CYP isoform mediating the in vitro hydroxylation and demethylation of flunitrazepam. Drug metabolism and disposition: the biological fate of chemicals, 2001, Volume: 29, Issue:2 Topics: Anti-Anxiety Agents; Benzoflavones; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Inhibitors; Flunitrazepam; Humans; Hydroxylation; Isoenzymes; Ketoconazole; Kinetics; Methylation; Microsomes, Liver; Mixed Function Oxygenases; Omeprazole; Quinidine; Ritonavir; Sulfaphenazole; Transfection	2001
Identification and relative contributions of human cytochrome P450 isoforms involved in the metabolism of glibenclamide and lansoprazole: evaluation of an approach based on the in vitro substrate disappearance rate. Xenobiotica; the fate of foreign compounds in biological systems, 2004, Volume: 34, Issue:5 Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Antibodies; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Inhibitors; Glyburide; Humans; In Vitro Techniques; Ketoconazole; Kinetics; Lansoprazole; Mephenytoin; Microsomes, Liver; Mixed Function Oxygenases; Omeprazole; Recombinant Proteins	2004
Rate-limiting biotransformation of triamterene is mediated by CYP1A2. International journal of clinical pharmacology and therapeutics, 2005, Volume: 43, Issue:7 Topics: Caffeine; Chromatography, High Pressure Liquid; Coumarins; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP1A2 Inhibitors; Dose-Response Relationship, Drug; Enzyme Inhibitors; Erythromycin; Humans; Hydroxylation; Ketoconazole; Kinetics; Microsomes, Liver; Omeprazole; Quinidine; Substrate Specificity; Sulfuric Acid Esters; Theophylline; Triamterene	2005
A simultaneous assessment of CYP3A4 metabolism and induction in the DPX-2 cell line. The AAPS journal, 2005, Mar-04, Volume: 7, Issue:1 Topics: Carcinoma, Hepatocellular; Cell Line, Tumor; Chromans; Clotrimazole; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dexamethasone; Dimethyl Sulfoxide; Enhancer Elements, Genetic; Enzyme Induction; Genes, Reporter; Genes, Synthetic; Humans; Ketoconazole; Liver Neoplasms; Lovastatin; Luciferases; Mifepristone; Neoplasm Proteins; Nifedipine; Omeprazole; Paclitaxel; Phenytoin; Pregnane X Receptor; Receptors, Cytoplasmic and Nuclear; Receptors, Steroid; Recombinant Fusion Proteins; Rifampin; Thiazolidinediones; Transcription, Genetic; Troglitazone; Troleandomycin	2005
The effects of inhibiting cytochrome P450 3A, p-glycoprotein, and gastric acid secretion on the oral bioavailability of methadone in dogs. Journal of veterinary pharmacology and therapeutics, 2005, Volume: 28, Issue:5 Topics: Administration, Oral; Animals; Area Under Curve; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Availability; Cross-Over Studies; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Dogs; Enzyme Inhibitors; Female; Gastric Acid; Injections, Intravenous; Ketoconazole; Male; Methadone; Omeprazole; Proton Pump Inhibitors	2005
In vitro and in vivo inhibitory effect of stiripentol on clobazam metabolism. Drug metabolism and disposition: the biological fate of chemicals, 2006, Volume: 34, Issue:4 Topics: Anticonvulsants; Aryl Hydrocarbon Hydroxylases; Benzodiazepines; Clinical Trials as Topic; Clobazam; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dioxolanes; Drug Interactions; Enzyme Inhibitors; Humans; In Vitro Techniques; Ketoconazole; Mixed Function Oxygenases; Omeprazole; Recombinant Proteins	2006
Identification of the human cytochrome P450 enzymes involved in the two oxidative steps in the bioactivation of clopidogrel to its pharmacologically active metabolite. Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:1 Topics: Antibodies; Aryl Hydrocarbon Hydroxylases; Biocatalysis; Biotransformation; Cell Line; Cell Line, Tumor; Clopidogrel; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP1A2 Inhibitors; Cytochrome P-450 CYP2B6; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Inhibitors; Glutathione; Humans; Ketoconazole; Kinetics; Mephenytoin; Microsomes; Microsomes, Liver; NADP; Omeprazole; Oxidation-Reduction; Oxidoreductases, N-Demethylating; Platelet Aggregation Inhibitors; Sulfaphenazole; Theophylline; Ticlopidine	2010
Melatonin and steroid hormones activate intermembrane Cu,Zn-superoxide dismutase by means of mitochondrial cytochrome P450. Free radical biology & medicine, 2011, Jun-01, Volume: 50, Issue:11 Topics: Animals; Antioxidants; Cytochrome P-450 Enzyme System; Enzyme Activation; Free Radical Scavengers; Gonadal Steroid Hormones; Ketoconazole; Male; Melatonin; Membrane Potentials; Mitochondria, Liver; Omeprazole; Rats; Rats, Wistar; Superoxide Dismutase	2011
Simultaneous and comprehensive in vivo analysis of cytochrome P450 activity by using a cocktail approach in rats. Biopharmaceutics & drug disposition, 2014, Volume: 35, Issue:4 Topics: Animals; Caffeine; Cytochrome P-450 Enzyme Inducers; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dexamethasone; Dextromethorphan; Drug Interactions; Fluconazole; Fluvoxamine; Ketoconazole; Losartan; Male; Midazolam; Omeprazole; Rats, Sprague-Dawley	2014
Development of a Specific Substrate-Inhibitor Panel (Liver-on-a-Chip) for Evaluation of Cytochrome P450 Activity. Bulletin of experimental biology and medicine, 2016, Volume: 162, Issue:1 Topics: Bupropion; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2B6; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Humans; Ketoconazole; Lab-On-A-Chip Devices; Liver; Mass Spectrometry; Mephenytoin; Microsomes, Liver; Omeprazole; Phencyclidine; Substrate Specificity; Sulfaphenazole; Testosterone; Tolbutamide	2016
The Molecular and Enzyme Kinetic Basis for Altered Activity of Three Cytochrome P450 2C19 Variants Found in the Chinese Population. Current molecular pharmacology, 2020, Volume: 13, Issue:3 Topics: Alleles; Amino Acid Sequence; Asian People; Catalytic Domain; Coumarins; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C19 Inhibitors; Fluoxetine; Humans; Ketoconazole; Kinetics; Loratadine; Models, Molecular; Molecular Docking Simulation; Mutagenesis, Site-Directed; Nitriles; Omeprazole; Polymorphism, Genetic; Protein Conformation; Protein Isoforms; Recombinant Proteins; Sertraline; Substrate Specificity	2020
Evidence for Metabolic Activation of Omeprazole In Vitro and In Vivo. Chemical research in toxicology, 2022, 09-19, Volume: 35, Issue:9 Topics: Acetylcysteine; Activation, Metabolic; Animals; Benzoquinones; Cytochrome P-450 CYP3A; Glutathione; Humans; Imines; Ketoconazole; Microsomes, Liver; Omeprazole; Proton Pump Inhibitors; Rats	2022