ketoconazole and norfentanyl

ketoconazole has been researched along with norfentanyl in 3 studies

Research

Studies (3)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	2 (66.67)	18.2507
2000's	0 (0.00)	29.6817
2010's	1 (33.33)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Feierman, DE	1
Feierman, DE; Lasker, JM	1
Haefeli, WE; König, SK; Mahlke, NS; Mikus, G; Skopp, G; Ziesenitz, VC	1

Trials

1 trial(s) available for ketoconazole and norfentanyl

Article	Year
Pharmacokinetic interaction of intravenous fentanyl with ketoconazole. Journal of clinical pharmacology, 2015, Volume: 55, Issue:6 Topics: Administration, Intravenous; Adult; Analgesics, Opioid; Chromatography, Liquid; Cross-Over Studies; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Drug Interactions; Female; Fentanyl; Healthy Volunteers; Humans; Ketoconazole; Male; Midazolam; Middle Aged; Naloxone; Prospective Studies; Tandem Mass Spectrometry; Young Adult	2015

Article

Year

Pharmacokinetic interaction of intravenous fentanyl with ketoconazole.

Journal of clinical pharmacology, 2015, Volume: 55, Issue:6

Topics: Administration, Intravenous; Adult; Analgesics, Opioid; Chromatography, Liquid; Cross-Over Studies; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Drug Interactions; Female; Fentanyl; Healthy Volunteers; Humans; Ketoconazole; Male; Midazolam; Middle Aged; Naloxone; Prospective Studies; Tandem Mass Spectrometry; Young Adult

2015

Other Studies

2 other study(ies) available for ketoconazole and norfentanyl

Article	Year
Identification of cytochrome P450 3A1/2 as the major P450 isoform responsible for the metabolism of fentanyl by rat liver microsomes. Anesthesia and analgesia, 1996, Volume: 82, Issue:5 Topics: Anesthetics, Intravenous; Animals; Anti-Bacterial Agents; Antifungal Agents; Aryl Hydrocarbon Hydroxylases; Benzoflavones; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dealkylation; Enzyme Inhibitors; Erythromycin; Fentanyl; GABA Modulators; Gas Chromatography-Mass Spectrometry; Isoenzymes; Ketoconazole; Male; Microsomes, Liver; Mixed Function Oxygenases; Oxidation-Reduction; Phenobarbital; Rats; Rats, Sprague-Dawley; Sodium Chloride	1996
Metabolism of fentanyl, a synthetic opioid analgesic, by human liver microsomes. Role of CYP3A4. Drug metabolism and disposition: the biological fate of chemicals, 1996, Volume: 24, Issue:9 Topics: Analgesics, Opioid; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2C8; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Fentanyl; Gas Chromatography-Mass Spectrometry; Humans; Ketoconazole; Kinetics; Microsomes, Liver; Mixed Function Oxygenases; Steroid 16-alpha-Hydroxylase; Steroid Hydroxylases; Theophylline; Tolbutamide	1996

Article

Year

Identification of cytochrome P450 3A1/2 as the major P450 isoform responsible for the metabolism of fentanyl by rat liver microsomes.

Anesthesia and analgesia, 1996, Volume: 82, Issue:5

Topics: Anesthetics, Intravenous; Animals; Anti-Bacterial Agents; Antifungal Agents; Aryl Hydrocarbon Hydroxylases; Benzoflavones; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dealkylation; Enzyme Inhibitors; Erythromycin; Fentanyl; GABA Modulators; Gas Chromatography-Mass Spectrometry; Isoenzymes; Ketoconazole; Male; Microsomes, Liver; Mixed Function Oxygenases; Oxidation-Reduction; Phenobarbital; Rats; Rats, Sprague-Dawley; Sodium Chloride

1996

Metabolism of fentanyl, a synthetic opioid analgesic, by human liver microsomes. Role of CYP3A4.

Drug metabolism and disposition: the biological fate of chemicals, 1996, Volume: 24, Issue:9

Topics: Analgesics, Opioid; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2C8; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Fentanyl; Gas Chromatography-Mass Spectrometry; Humans; Ketoconazole; Kinetics; Microsomes, Liver; Mixed Function Oxygenases; Steroid 16-alpha-Hydroxylase; Steroid Hydroxylases; Theophylline; Tolbutamide

1996