ketoconazole has been researched along with nadp in 30 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (6.67) | 18.7374 |
| 1990's | 14 (46.67) | 18.2507 |
| 2000's | 9 (30.00) | 29.6817 |
| 2010's | 5 (16.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Aiyar, J; De Flora, S; Wetterhahn, KE | 1 |
| Brosz, CS; Fischer, RT; Ko, SS; Larsen, B; Magolda, RL; Trzaskos, JM | 1 |
| Boerman, MH; Burns, RD; Napoli, JL; Posch, KC | 1 |
| Jacobs, JM; Lambrecht, RW; Sinclair, JF; Sinclair, PR | 1 |
| Higashi, Y; Oshima, H; Yoshida, K | 1 |
| Coleman, MD; Park, BK; Tingle, MD | 1 |
| Hollis, BW | 1 |
| Capdevila, J; Falck, JR; Gil, L; Marnett, LJ; Mason, JI; Orellana, M; Yadagiri, P | 1 |
| Bickers, DR; Das, M; Kaufmann, I; Merk, HF; Mukhtar, H | 1 |
| Grevel, J; Kahan, BD; Napoli, KL; Serino, F; Strobel, HW | 1 |
| Coon, MJ; Ding, X | 1 |
| Lennard, MS; Martin, IJ; Tucker, GT; Williams, ML | 1 |
| Ahmed, F; Kelly, SL; Smith, KE; Williams, RA | 1 |
| Estabrook, RW; Mason, JI; Swart, AC; Swart, P; Waterman, MR | 1 |
| Dräger, UC; McCaffery, P; Yamamoto, M | 1 |
| Arai, N; Fujimaki, Y; Inaba, T | 1 |
| Baillie, TA; Dean, D; Doss, G; Elmore, C; Kassahun, K; Leung, K; McIntosh, I; Pearson, PG; Tang, W; Wang, R | 1 |
| Iio, R; Inoue, K; Katano, N; Yamamoto, H | 1 |
| Tschirret-Guth, RA; Wood, HB | 1 |
| Blanchard, AP; Broudy, MI; Cargill, CE; Crespi, CL; Dandeneau, AA; Dehal, SS; Erve, JC; Goodwin, JJ; Ho, T; Patten, CJ; Sharma, R; Stresser, DM; Turner, SD | 1 |
| Fouda, HG; Khojasteh-Bakht, SC; Prakash, C; Rossulek, MI | 1 |
| Kalgutkar, AS; Nguyen, HT | 1 |
| Awano, K; Dean, D; Hop, CE; Karanam, BV; Komuro, M; Liu, DQ; Satoh, H; Vincent, SH; Wallace, M | 1 |
| Ishihara, Y; Shiba, D; Shimamoto, N | 1 |
| Chu, FM; Gong, AS; Guo, ZR; Sun, YM; Xu, HY; Zhang, P; Zhong, DF | 1 |
| Farid, NA; Hagihara, K; Ikeda, T; Ishizuka, T; Kazui, M; Kurihara, A; Nishiya, Y; Okazaki, O | 1 |
| Alvarez, LI; Brennan, GP; Devine, C; Fairweather, I; Hoey, E; Lanusse, CE; Trudgett, A | 1 |
| Kelly, DE; Kelly, SL; Parker, JE; Warrilow, AG | 1 |
| Baj, F; Baravalle, R; Ciaramella, A; Di Nardo, G; Gilardi, G | 1 |
| Chen, Y; Guo, X; Li, Q; Li, W; Peng, Y; Zhao, G; Zheng, J | 1 |
30 other study(ies) available for ketoconazole and nadp
| Article | Year |
|---|---|
Reduction of chromium(VI) to chromium(V) by rat liver cytosolic and microsomal fractions: is DT-diaphorase involved?
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Biotransformation; Chromium; Cytochrome P-450 Enzyme System; Cytosol; Dicumarol; Electron Spin Resonance Spectroscopy; Glutathione; Ketoconazole; Liver; Male; Microsomes, Liver; Mutagenicity Tests; NAD; NAD(P)H Dehydrogenase (Quinone); NADP; Oxidation-Reduction; Rats; Rats, Inbred Strains; Salmonella typhimurium | 1992 |
Lanosterol 14 alpha-methyl demethylase. Isolation and characterization of the third metabolically generated oxidative demethylation intermediate.
Topics: Animals; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Gas Chromatography-Mass Spectrometry; Ketoconazole; Kinetics; Magnetic Resonance Spectroscopy; Microsomes, Liver; NADP; Oxidation-Reduction; Oxidoreductases; Rats; Spectrophotometry, Infrared; Sterol 14-Demethylase | 1991 |
Holocellular retinol binding protein as a substrate for microsomal retinal synthesis.
Topics: Animals; Ethanol; Ketoconazole; Kinetics; Male; Microsomes; Microsomes, Liver; NADP; Organ Specificity; Rats; Rats, Inbred Strains; Retinaldehyde; Retinol-Binding Proteins; Retinol-Binding Proteins, Cellular; Tretinoin | 1991 |
Inhibition of uroporphyrinogen decarboxylase activity. The role of cytochrome P-450-mediated uroporphyrinogen oxidation.
Topics: Animals; Carboxy-Lyases; Chick Embryo; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Ketoconazole; Kinetics; Liver; Male; Methylcholanthrene; Mice; Mice, Inbred C57BL; Microsomes, Liver; NADP; Oxidation-Reduction; Polychlorinated Biphenyls; Porphyrinogens; Uroporphyrinogen Decarboxylase; Uroporphyrinogens | 1990 |
In vitro inhibition by ketoconazole of human testicular steroid oxidoreductases.
Topics: 20-Hydroxysteroid Dehydrogenases; 3-Hydroxysteroid Dehydrogenases; Binding, Competitive; Humans; Hydroxysteroid Dehydrogenases; In Vitro Techniques; Ketoconazole; Male; NAD; NADP; Steroid Isomerases; Testis | 1990 |
An investigation of the role of metabolism in dapsone-induced methaemoglobinaemia using a two compartment in vitro test system.
Topics: Cimetidine; Dapsone; Enzyme Induction; Humans; Ketoconazole; Methemoglobin; Microsomes, Liver; NADP | 1990 |
25-Hydroxyvitamin D3-1 alpha-hydroxylase in porcine hepatic tissue: subcellular localization to both mitochondria and microsomes.
Topics: 25-Hydroxyvitamin D3 1-alpha-Hydroxylase; Animals; Cell Fractionation; Isocitrates; Ketoconazole; Kinetics; Male; Microsomes, Liver; Mitochondria, Liver; NADP; Oxidation-Reduction; Steroid Hydroxylases; Swine; Ultracentrifugation | 1990 |
Inhibitors of cytochrome P-450-dependent arachidonic acid metabolism.
Topics: 5,8,11,14-Eicosatetraynoic Acid; Animals; Arachidonate Lipoxygenases; Arachidonic Acid; Arachidonic Acids; Aspirin; Clotrimazole; Cyclooxygenase Inhibitors; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Indomethacin; Ketoconazole; Male; Masoprocol; Microsomes, Liver; NADP; Oxygenases; Rats; Rats, Inbred Strains | 1988 |
Human hair follicle benzo[a]pyrene and benzo[a]pyrene 7,8-diol metabolism: effect of exposure to a coal tar-containing shampoo.
Topics: Aryl Hydrocarbon Hydroxylases; Benzo(a)pyrene; Benzoflavones; Carbon Monoxide; Clotrimazole; Coal Tar; Dihydroxydihydrobenzopyrenes; DNA; Drug Interactions; Enzyme Induction; Hair; Hair Preparations; Humans; Ketoconazole; NADP | 1987 |
Oxygen radical formation by the cytochrome P450 system as a cellular mechanism for cyclosporine toxicity.
Topics: Aminopyrine; Animals; Chloramphenicol; Cyclosporine; Cytochrome P-450 Enzyme System; Enzyme Induction; Free Radical Scavengers; Ketoconazole; Kinetics; Lipid Peroxidation; Male; Microsomes, Liver; NADP; Phenobarbital; Proadifen; Rats; Rats, Sprague-Dawley | 1994 |
Steroid metabolism by rabbit olfactory-specific P450 2G1.
Topics: Androstenedione; Animals; Benzoflavones; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Cytochromes b5; Dihydrotestosterone; Estradiol; Female; Ketoconazole; Kinetics; Male; NADP; Olfactory Mucosa; Progesterone; Rabbits; Steroids; Substrate Specificity; Testosterone | 1994 |
Interindividual variation in the isomerization of 4-hydroxytamoxifen by human liver microsomes: involvement of cytochromes P450.
Topics: Adult; Biotransformation; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Resistance; Female; Genetic Variation; Humans; Isomerism; Ketoconazole; Male; Microsomes, Liver; Middle Aged; NADP; Proadifen; Tamoxifen | 1994 |
Microbial transformations of steroids--VIII. Transformation of progesterone by whole cells and microsomes of Aspergillus fumigatus.
Topics: Aspergillus fumigatus; Biotransformation; Carbon Monoxide; Cycloheximide; Cytochrome P-450 Enzyme System; Hydroxyprogesterones; Iodates; Ketoconazole; Microsomes; NADP; Progesterone | 1994 |
Progesterone 16 alpha-hydroxylase activity is catalyzed by human cytochrome P450 17 alpha-hydroxylase.
Topics: 17-alpha-Hydroxyprogesterone; Adrenal Glands; Animals; Aryl Hydrocarbon Hydroxylases; Cell Line, Transformed; Chlorocebus aethiops; Cytochrome P-450 CYP2C8; Cytochrome P-450 CYP2C9; DNA; Humans; Hydroxyprogesterones; Ketoconazole; Kidney; Kinetics; Male; Microsomes; NADP; Pregnenolone; Progesterone; Steroid 16-alpha-Hydroxylase; Steroid 17-alpha-Hydroxylase; Steroid Hydroxylases; Testis; Transfection | 1993 |
A novel assay for retinoic acid catabolic enzymes shows high expression in the developing hindbrain.
Topics: Aging; Animals; Animals, Newborn; Embryo, Mammalian; Embryonic and Fetal Development; Enzymes; Ketoconazole; Methods; Mice; NADP; Receptors, Retinoic Acid; Recombinant Proteins; Rhombencephalon; Tretinoin | 1998 |
Identification of cytochromes P450 involved in human liver microsomal metabolism of ecabapide, a prokinetic agent.
Topics: Anti-Ulcer Agents; Benzamides; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP1A1; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Interactions; Enzyme Inhibitors; Humans; Inactivation, Metabolic; Isoenzymes; Ketoconazole; Miconazole; Microsomes, Liver; NADP; Substrate Specificity; Troleandomycin | 1999 |
Studies on the metabolism of troglitazone to reactive intermediates in vitro and in vivo. Evidence for novel biotransformation pathways involving quinone methide formation and thiazolidinedione ring scission.
Topics: Animals; Bile; Biotransformation; Catalysis; Chromans; Chromatography, Liquid; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Glutathione; Humans; Hypoglycemic Agents; Isoenzymes; Ketoconazole; Kinetics; Mass Spectrometry; Microsomes, Liver; NADP; Rats; Steroid Hydroxylases; Thiazoles; Thiazolidinediones; Troglitazone | 2001 |
7-Deoxyloganin 7-hydroxylase in Lonicera japonica cell cultures.
Topics: Carbon Monoxide; Cells, Cultured; Cytochrome P-450 Enzyme Inhibitors; Enzyme Inhibitors; Glucosides; Iridoids; Ketoconazole; Magnoliopsida; Metyrapone; Miconazole; Microsomes; Mixed Function Oxygenases; NADP; Oxygen; Oxygen Consumption; Pyrans | 2001 |
Substituent effect on the reductive N-dearylation of 3-(indol-1-yl)-1,2-benzisoxazoles by rat liver microsomes.
Topics: Air; Amidines; Animals; Carbon Monoxide; Chemistry Techniques, Analytical; Cytochrome P-450 Enzyme System; Electrons; Indoles; Isoxazoles; Ketoconazole; Microsomes, Liver; Molecular Structure; NADP; Oxazoles; Oxidation-Reduction; Rats; Structure-Activity Relationship | 2003 |
Highly selective inhibition of human CYP3Aa in vitro by azamulin and evidence that inhibition is irreversible.
Topics: Anti-Infective Agents; Bridged-Ring Compounds; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Inhibitors; Fluorometry; Humans; In Vitro Techniques; Ketoconazole; Microsomes, Liver; NADP; Pleurotus; Solubility; Steroid Hydroxylases; Substrate Specificity; Triazoles; Xenobiotics | 2004 |
Identification of the human cytochrome P450s responsible for the in vitro metabolism of a leukotriene B4 receptor antagonist, CP-195,543.
Topics: Adolescent; Adult; Aged; Chromans; Coumarins; Cytochrome P-450 CYP1A2 Inhibitors; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Inhibitors; Female; Humans; Ketoconazole; Kinetics; Male; Mephenytoin; Microsomes, Liver; Middle Aged; NADP; Oxidation-Reduction; Quinidine; Receptors, Leukotriene B4; Recombinant Proteins; Sulfaphenazole; Theophylline | 2003 |
Identification of an N-methyl-4-phenylpyridinium-like metabolite of the antidiarrheal agent loperamide in human liver microsomes: underlying reason(s) for the lack of neurotoxicity despite the bioactivation event.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Animals; Antidiarrheals; Bupropion; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Dealkylation; Haloperidol; Humans; Hydroxylation; Ketoconazole; Loperamide; Male; Microsomes, Liver; NADP; Neurons; Pyridinium Compounds; Rats; Rats, Sprague-Dawley; Time Factors | 2004 |
In vitro metabolism of MK-0767 [(+/-)-5-[(2,4-dioxothiazolidin-5-yl)methyl]-2-methoxy-N-[[(4-trifluoromethyl) phenyl]methyl]benzamide], a peroxisome proliferator-activated receptor alpha/gamma agonist. I. Role of cytochrome P450, methyltransferases, flavi
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Benzylamines; Carbon Radioisotopes; Cytosol; Dogs; Drug Evaluation, Preclinical; Esterases; Hepatocytes; Humans; Ketoconazole; Macaca mulatta; Methyltransferases; Microsomes, Liver; Mixed Function Oxygenases; NADP; PPAR alpha; PPAR gamma; Rats; S-Adenosylmethionine; Sulfhydryl Compounds; Sulfoxides; Temperature; Thiazoles; Thiazolidinediones | 2004 |
Enhancement of DMNQ-induced hepatocyte toxicity by cytochrome P450 inhibition.
Topics: Animals; Antioxidants; Benzoquinones; Catecholamines; Cell Survival; Cytochrome P-450 Enzyme Inhibitors; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Inhibitors; Glutathione Disulfide; Hepatocytes; Imidazolines; Iron Chelating Agents; Ketoconazole; L-Lactate Dehydrogenase; Lipid Peroxidation; Male; Metyrapone; Molecular Structure; NADP; Naphthoquinones; Oxidative Stress; Proadifen; Rats; Rats, Wistar; Superoxides; Thiobarbituric Acid Reactive Substances | 2006 |
Formation of 4'-carboxyl acid metabolite of imrecoxib by rat liver microsomes.
Topics: Animals; Biotransformation; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Dexamethasone; Ketoconazole; Male; Microsomes, Liver; NADP; Pyrroles; Rats; Rats, Wistar; Sulfides | 2006 |
Identification of the human cytochrome P450 enzymes involved in the two oxidative steps in the bioactivation of clopidogrel to its pharmacologically active metabolite.
Topics: Antibodies; Aryl Hydrocarbon Hydroxylases; Biocatalysis; Biotransformation; Cell Line; Cell Line, Tumor; Clopidogrel; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP1A2 Inhibitors; Cytochrome P-450 CYP2B6; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Inhibitors; Glutathione; Humans; Ketoconazole; Kinetics; Mephenytoin; Microsomes; Microsomes, Liver; NADP; Omeprazole; Oxidation-Reduction; Oxidoreductases, N-Demethylating; Platelet Aggregation Inhibitors; Sulfaphenazole; Theophylline; Ticlopidine | 2010 |
Inhibition of triclabendazole metabolism in vitro by ketoconazole increases disruption to the tegument of a triclabendazole-resistant isolate of Fasciola hepatica.
Topics: Animals; Anthelmintics; Benzimidazoles; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Resistance; Drug Synergism; Fasciola hepatica; Fascioliasis; Golgi Apparatus; Ketoconazole; Microscopy, Electron, Scanning; Microscopy, Electron, Transmission; Mitochondria; NADP; Rats; Rats, Sprague-Dawley; Sulfoxides; Triclabendazole | 2011 |
Azole affinity of sterol 14α-demethylase (CYP51) enzymes from Candida albicans and Homo sapiens.
Topics: Antifungal Agents; Candida albicans; Clotrimazole; Escherichia coli; Fluconazole; Fungal Proteins; Humans; Itraconazole; Ketoconazole; Kinetics; Lanosterol; NADP; Protein Binding; Pyrimidines; Recombinant Proteins; Species Specificity; Sterol 14-Demethylase; Triazoles; Voriconazole | 2013 |
Identification of endocrine disrupting chemicals acting on human aromatase.
Topics: Anastrozole; Aromatase; Aromatase Inhibitors; Benzhydryl Compounds; Biological Assay; Endocrine Disruptors; Enzyme-Linked Immunosorbent Assay; Estrone; Gene Expression; Humans; Ketoconazole; Ligands; NADP; Nicotine; Nitriles; Phenols; Protein Binding; Recombinant Proteins; Resveratrol; Sildenafil Citrate; Small Molecule Libraries; Stilbenes; Triazoles | 2018 |
Tofacitinib Is a Mechanism-Based Inactivator of Cytochrome P450 3A4.
Topics: Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Enzyme Assays; Humans; Ketoconazole; Male; Microsomes, Liver; NADP; Piperidines; Pyrimidines; Pyrroles | 2019 |