ketoconazole and moxifloxacin

ketoconazole has been researched along with moxifloxacin in 16 studies

Research

Studies (16)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's7 (43.75)29.6817
2010's9 (56.25)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Keserü, GM1
Nagashima, R; Nishikawa, T; Tobita, M1
Cho, SH; Franzblau, SG; Hwang, CH; Pauli, GF; Wan, B; Warit, S1
Jia, L; Sun, H1
Chlipala, G; Krunic, A; Mo, S; Orjala, J1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Sen, S; Sinha, N1
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Agin, M; Darpo, B; Gray, P; Jorkasky, DK; Kazierad, DJ; Layton, G; Muirhead, G1
Amantea, MA; Nickens, DJ; Raber, SR; Reynolds, RR; Sarapa, N1
Abbas, R; Burns, J; Hug, B; Leister, C; Sonnichsen, D1
Abbas, R; Hug, BA; Leister, C; Sonnichsen, D1
Darpo, B; Ferber, G; Sager, P; Sumeray, M; Zhou, M1
Darpo, B; Ferber, G; Zhou, M1
Farahat, HG; Mandour, SS; Marey, HM1

Reviews

1 review(s) available for ketoconazole and moxifloxacin

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016

Trials

5 trial(s) available for ketoconazole and moxifloxacin

ArticleYear
Man versus machine: is there an optimal method for QT measurements in thorough QT studies?
    Journal of clinical pharmacology, 2006, Volume: 46, Issue:6

    Topics: Adolescent; Adult; Aza Compounds; Control Groups; Cross-Over Studies; Electrocardiography; Female; Fluoroquinolones; Humans; Ketoconazole; Long QT Syndrome; Male; Middle Aged; Moxifloxacin; Quinolines; Reproducibility of Results; Research Design; Signal Processing, Computer-Assisted

2006
Ritonavir 100 mg does not cause QTc prolongation in healthy subjects: a possible role as CYP3A inhibitor in thorough QTc studies.
    Clinical pharmacology and therapeutics, 2008, Volume: 83, Issue:1

    Topics: Adult; Aza Compounds; Cross-Over Studies; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Evaluation, Preclinical; Drug Therapy, Combination; Electrocardiography; Female; Fluoroquinolones; Heart Rate; HIV Protease Inhibitors; Humans; Imidazoles; Ketoconazole; Liver; Long QT Syndrome; Male; Middle Aged; Moxifloxacin; Quinolines; Reference Values; Reproducibility of Results; Research Design; Reverse Transcriptase Inhibitors; Ritonavir; Sulfur Compounds; Treatment Outcome

2008
A single-dose, crossover, placebo- and moxifloxacin-controlled study to assess the effects of neratinib (HKI-272) on cardiac repolarization in healthy adult subjects.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2010, Aug-01, Volume: 16, Issue:15

    Topics: Adolescent; Adult; Anti-Infective Agents; Antineoplastic Agents; Aza Compounds; Cross-Over Studies; Electrocardiography; Female; Fluoroquinolones; Heart; Humans; Ketoconazole; Male; Middle Aged; Moxifloxacin; Placebos; Quinolines; Young Adult

2010
A randomized, crossover, placebo- and moxifloxacin-controlled study to evaluate the effects of bosutinib (SKI-606), a dual Src/Abl tyrosine kinase inhibitor, on cardiac repolarization in healthy adult subjects.
    International journal of cancer, 2012, Aug-01, Volume: 131, Issue:3

    Topics: Adolescent; Adult; Aniline Compounds; Aza Compounds; Cross-Over Studies; Double-Blind Method; Electrocardiography; Female; Fluoroquinolones; Heart; Humans; Ketoconazole; Male; Middle Aged; Moxifloxacin; Nitriles; Quinolines; Young Adult

2012
Lomitapide at supratherapeutic plasma levels does not prolong the Qtc interval--results from a TQT study with moxifloxacin and ketoconazole.
    Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc, 2013, Volume: 18, Issue:6

    Topics: 14-alpha Demethylase Inhibitors; Adolescent; Adult; Aza Compounds; Benzimidazoles; Cross-Over Studies; Dose-Response Relationship, Drug; Drug Administration Schedule; Electrocardiography; Female; Fluoroquinolones; Heart Rate; Humans; Ketoconazole; Male; Middle Aged; Moxifloxacin; Quinolines; Reference Values; Time Factors; Topoisomerase II Inhibitors; Young Adult

2013

Other Studies

10 other study(ies) available for ketoconazole and moxifloxacin

ArticleYear
Prediction of hERG potassium channel affinity by traditional and hologram qSAR methods.
    Bioorganic & medicinal chemistry letters, 2003, Aug-18, Volume: 13, Issue:16

    Topics: Cation Transport Proteins; Databases, Factual; Discriminant Analysis; Ether-A-Go-Go Potassium Channels; Holography; Linear Models; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Quantitative Structure-Activity Relationship

2003
A discriminant model constructed by the support vector machine method for HERG potassium channel inhibitors.
    Bioorganic & medicinal chemistry letters, 2005, Jun-02, Volume: 15, Issue:11

    Topics: Animals; CHO Cells; Cricetinae; Discriminant Analysis; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Potassium Channel Blockers; Potassium Channels, Voltage-Gated

2005
Low-oxygen-recovery assay for high-throughput screening of compounds against nonreplicating Mycobacterium tuberculosis.
    Antimicrobial agents and chemotherapy, 2007, Volume: 51, Issue:4

    Topics: Anti-Bacterial Agents; Antitubercular Agents; DNA, Bacterial; Drug Evaluation, Preclinical; Mycobacterium tuberculosis; Oxygen

2007
Support vector machines classification of hERG liabilities based on atom types.
    Bioorganic & medicinal chemistry, 2008, Jun-01, Volume: 16, Issue:11

    Topics: Animals; Arrhythmias, Cardiac; CHO Cells; Computer Simulation; Cricetinae; Cricetulus; Discriminant Analysis; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Models, Chemical; Patch-Clamp Techniques; Potassium Channel Blockers; Potassium Channels, Voltage-Gated; Predictive Value of Tests; ROC Curve

2008
Antimicrobial ambiguine isonitriles from the cyanobacterium Fischerella ambigua.
    Journal of natural products, 2009, May-22, Volume: 72, Issue:5

    Topics: Anti-Bacterial Agents; Bacillus anthracis; Cyanobacteria; Indole Alkaloids; Microbial Sensitivity Tests; Molecular Structure; Mycobacterium tuberculosis; Nuclear Magnetic Resonance, Biomolecular

2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Predicting hERG activities of compounds from their 3D structures: development and evaluation of a global descriptors based QSAR model.
    European journal of medicinal chemistry, 2011, Volume: 46, Issue:2

    Topics: Computer Simulation; Ether-A-Go-Go Potassium Channels; Humans; Molecular Structure; Organic Chemicals; Quantitative Structure-Activity Relationship

2011
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
    Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship

2012
Detection of QTc effects in small studies--implications for replacing the thorough QT study.
    Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc, 2015, Volume: 20, Issue:4

    Topics: Cytochrome P-450 CYP3A Inhibitors; Dose-Response Relationship, Drug; Electrocardiography; Fluoroquinolones; Heart Rate; Humans; Ketoconazole; Moxifloxacin; Topoisomerase II Inhibitors

2015
Resistant Microbial Keratitis in South Nile Delta, Egypt: Influence of Regional Risk Factors.
    Seminars in ophthalmology, 2016, Volume: 31, Issue:5

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Bacteria; Child; Child, Preschool; Climate; Corneal Ulcer; Cross-Sectional Studies; Drug Resistance, Bacterial; Drug Resistance, Fungal; Drug Therapy, Combination; Egypt; Eye Infections, Bacterial; Eye Infections, Fungal; Female; Fluoroquinolones; Fungi; Geography; Humans; Incidence; Infant; Infant, Newborn; Ketoconazole; Male; Middle Aged; Moxifloxacin; Natamycin; Prospective Studies; Risk Factors; Social Class

2016