ketoconazole has been researched along with morphine in 14 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (7.14) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 6 (42.86) | 29.6817 |
| 2010's | 7 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Fischer, H; Huwyler, J; Poli, S; Schwab, D; Tabatabaei, A | 1 |
| Nagashima, R; Nishikawa, T; Tobita, M | 1 |
| Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| García-Mera, X; González-Díaz, H; Prado-Prado, FJ | 1 |
| Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ | 1 |
| Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Sedman, AJ | 1 |
| Ishii, Y; Kitajima, Y; Mackenzie, PI; Nishimura, Y; Oguri, K; Takeda, S; Yamada, H | 1 |
| Achterberg, E; Althoff, H; Bohm, B; Eggers, V; Hegenscheid, K; Kaisers, U; Klein, M; Lau, A; Marks, C; Miller, P; Paschen, C; Pfeiffer, S; Sander, M; Schoenfeld, H; Schroeder, T; Spies, C; Szabo, G; Volk, HD; von Dossow, V; Wernecke, KD; Ziemer, S | 1 |
| Borum, SL; Kukanich, B | 1 |
| Croubels, S; Gadeyne, C; Gasthuys, F; Polis, I; Schauvliege, S; Van der Heyden, S | 1 |
| Budda, B; Kwatra, D; Mitra, AK; Pal, D; Vadlapatla, RK; Vadlapudi, AD | 1 |
2 review(s) available for ketoconazole and morphine
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
Cimetidine-drug interactions.
Topics: Adrenergic beta-Antagonists; Anticonvulsants; Benzodiazepines; Chlormethiazole; Cimetidine; Drug Interactions; Humans; Ketoconazole; Kidney; Lidocaine; Morphine; Penicillins; Theophylline | 1984 |
2 trial(s) available for ketoconazole and morphine
| Article | Year |
|---|---|
Intervention at the level of the neuroendocrine-immune axis and postoperative pneumonia rate in long-term alcoholics.
Topics: Aged; Alcoholism; Antifungal Agents; APACHE; Comorbidity; Cushing Syndrome; Digestive System Neoplasms; Double-Blind Method; Ethanol; Female; Humans; Hydrocortisone; Hypothalamo-Hypophyseal System; Interferon-gamma; Interleukin-10; Ketoconazole; Length of Stay; Male; Middle Aged; Morphine; Pituitary-Adrenal System; Pneumonia; Postoperative Complications; ROC Curve; Stress, Physiological; Th1 Cells; Th2 Cells | 2006 |
The influence of modulation of P-glycoprotein and /or cytochrome P450 3A on the pharmacokinetics and pharmacodynamics of orally administered morphine in dogs.
Topics: Absorption; Acridines; Administration, Oral; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cross-Over Studies; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Dogs; Enzyme Inhibitors; Female; Ketoconazole; Male; Morphine; Rifampin; Tetrahydroisoquinolines | 2011 |
10 other study(ies) available for ketoconazole and morphine
| Article | Year |
|---|---|
Comparison of in vitro P-glycoprotein screening assays: recommendations for their use in drug discovery.
Topics: Adenosine Triphosphatases; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Cells, Cultured; Drug Evaluation, Preclinical; Fluoresceins; Fluorescent Dyes; Humans; Indicators and Reagents; Mice; Models, Molecular; Rhodamines; Species Specificity; Swine | 2003 |
A discriminant model constructed by the support vector machine method for HERG potassium channel inhibitors.
Topics: Animals; CHO Cells; Cricetinae; Discriminant Analysis; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Potassium Channel Blockers; Potassium Channels, Voltage-Gated | 2005 |
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.
Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship | 2008 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species.
Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics | 2010 |
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics | 2010 |
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds.
Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding | 2012 |
Inhibition of UDP-glucuronosyltransferase 2b7-catalyzed morphine glucuronidation by ketoconazole: dual mechanisms involving a novel noncompetitive mode.
Topics: Analgesics, Opioid; Cytochrome P-450 Enzyme Inhibitors; Enzyme Inhibitors; Glucuronosyltransferase; Humans; In Vitro Techniques; Ketoconazole; Microsomes, Liver; Morphine; Morphine Derivatives | 2006 |
Effects of ketoconazole on the pharmacokinetics and pharmacodynamics of morphine in healthy Greyhounds.
Topics: Analgesics, Opioid; Animals; Area Under Curve; Dogs; Drug Interactions; Enzyme Inhibitors; Female; Half-Life; Ketoconazole; Male; Morphine | 2008 |
Transfected MDCK cell line with enhanced expression of CYP3A4 and P-glycoprotein as a model to study their role in drug transport and metabolism.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Caco-2 Cells; Cell Line; Cell Line, Tumor; Cytochrome P-450 CYP3A; Dogs; Drug Interactions; Flavanones; Hep G2 Cells; Humans; Hydrocortisone; Ketoconazole; Madin Darby Canine Kidney Cells; Morphine; Permeability; Transfection | 2012 |