ketoconazole has been researched along with metyrapone in 83 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (6.02) | 18.7374 |
| 1990's | 16 (19.28) | 18.2507 |
| 2000's | 16 (19.28) | 29.6817 |
| 2010's | 37 (44.58) | 24.3611 |
| 2020's | 9 (10.84) | 2.80 |
| Authors | Studies |
|---|---|
| Berger, ML; Hahner, S; Hammerschmidt, F; Peric-Simov, B; Schirbel, A; Zolle, IM | 1 |
| Pratim Roy, P; Roy, K | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Choi, SS; Contrera, JF; Hastings, KL; Kruhlak, NL; Sancilio, LF; Weaver, JL; Willard, JM | 1 |
| Hartmann, RW; Haupenthal, J; Hille, UE; Hu, Q; Jagusch, C | 1 |
| Ammann, D; Hafner, M; Hartmann, RW; Vock, CA; Zender, M; Zimmer, C | 1 |
| Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V | 1 |
| Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ | 1 |
| Hartmann, RW; Hu, Q; Yin, L | 1 |
| Hartmann, RW; Hille, UE; Vock, CA; Zimmer, C | 1 |
| Hartmann, RW; Haupenthal, J; Hille, UE; Zimmer, C | 1 |
| Carotti, A; Catto, M; Cellamare, S; Hanke, N; Hartmann, RW; Leonetti, F; Nicolotti, O; Pisani, L; Stefanachi, A | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Rothschild, AJ; Schatzberg, AF | 1 |
| Coceani, F; De Marte, J; Perreault, T | 1 |
| Chouinard, G; Dhar, V; Ghadirian, AM; Keller, R; Murphy, BE | 1 |
| Aupetit-Faisant, B | 1 |
| Havinga, R; Huijsmans, CM; Kuipers, F; Princen, HM; Vonk, RJ | 1 |
| Bons, EG; Bruining, HA; de Jong, FH; Lamberts, SW | 1 |
| Takeda, R | 1 |
| Napoli, JL; Williams, JB | 1 |
| Gregg, CR; Island, DP; Snell, BB; Tucker, WS | 1 |
| Dushkin, MI; Menshikova, EB; Pivovarova, EN; Volsky, NN; Zenkov, NK | 1 |
| Bernhardt, R; Denner, K; Doehmer, J; Schmalix, W; Vogel, R | 1 |
| Crapo, L; Miller, JW | 1 |
| Chouinard, G; Dhar, V; Engelsmann, F; Filipini, D; Ghadirian, AM; Keller, R; Murphy, BE | 1 |
| Bruyette, DS; Myers, NC | 1 |
| Engelhardt, D | 1 |
| Engelhardt, D; Weber, MM | 1 |
| Nishikawa, T; Saito, J | 1 |
| Khalil, MW; Killinger, DW; Strutt, B; Vachon, D | 1 |
| Almazan, G; Chemtob, S; Peri, KG; Varma, DR | 1 |
| Dhar, V; Ghadirian, AM; Murphy, BE | 1 |
| Alvarez Barreiro, JA; Calvo Romero, JM; Diaz Pérez de Madrid, J; Morales Pérez, F | 1 |
| Ito, N; Morishita, K; Okumura, H; Takahashi, N | 1 |
| Iio, R; Inoue, K; Katano, N; Yamamoto, H | 1 |
| Johansson, MK; Lund, BO; Sanderson, JT | 1 |
| Brain, CE; Greening, JE; Grossman, AB; Mushtaq, I; Perry, LA; Sales Marques, J; Savage, MO | 1 |
| Ishihara, Y; Shiba, D; Shimamoto, N | 1 |
| Giesy, JP; Gracia, T; Hecker, M; Higley, EB; Hilscherova, K; Jones, PD; Newsted, JL; Sanderson, JT; Wu, RS; Yu, RM; Zhang, X | 1 |
| Nishikawa, T; Omura, M; Saito, J | 1 |
| Dang, CN; Trainer, P | 1 |
| Iranmanesh, A; Veldhuis, JD | 1 |
| Coleman, VH; Kling, MA; Schulkin, J | 1 |
| Hori, H; Kawaguchi, Y; Masubuchi, Y; Ohkura, K; Shinohara, Y; Watanabe, Y | 1 |
| Forest, M; Nicolino, M; Vong, CH | 1 |
| Schteingart, DE | 1 |
| Alexandraki, KI; Grossman, AB | 2 |
| Grace, CE; Gudelsky, GA; Schaefer, TL; Vorhees, CV; Williams, MT | 1 |
| Munir, A; Newell-Price, J | 1 |
| de Herder, WW; Feelders, RA; Hofland, LJ | 1 |
| Bronstein, MD; Jallad, RS; Paraiba, DB | 1 |
| Baudin, E; Blanchard, A; Brailly-Tabard, S; Chanson, P; Droumaguet, C; Gautier, JF; Jublanc, C; Kamenický, P; Leboulleux, S; Salenave, S; Schlumberger, M; Young, J | 1 |
| Biller, BM; Tritos, NA | 1 |
| Crespo, I; Gich, I; Rodríguez, J; Valassi, E; Webb, SM | 1 |
| Barahona Constanzo, MJ; del Pozo Picó, C | 1 |
| Jeffries, WS; Lim, WH; Torpy, DJ | 1 |
| Kubickova, B; Martinkova, M; Stiborova, M | 1 |
| Stades, AM; van den Bosch, OF; Zelissen, PM | 1 |
| Gadelha, MR; Vieira Neto, L | 1 |
| Baudin, E; Chanson, P; Corcuff, JB; Masquefa-Giraud, P; Tabarin, A; Young, J | 1 |
| Daniel, E; Newell-Price, JD | 1 |
| Stigliano, A; Toscano, V | 1 |
| Cerquetti, L; Stigliano, A; Toscano, V | 1 |
| Michalak, R; Zieleniewski, W | 1 |
| Ayala, A; Biller, BMK; Bonert, V; Broder, MS; Carmichael, JD; Cherepanov, D; Eagan, M; Geer, EB; Gordon, MB; Hannoush, Z; Katznelson, L; Lalazar, Y; Lee, J; Manuylova, E; Neary, MP; Pulaski-Liebert, KJ; Said, Q; Shafiq, I; Surampudi, V; Swerdloff, RS | 1 |
| Aulinas, A; Glad, CA; Johannsson, G; Ragnarsson, O; Valassi, E; Webb, SM | 1 |
| Bolanowski, M; Brue, T; Chabre, O; Chanson, P; Droste, M; Fajardo, C; Feelders, RA; Franz, H; Kastelan, D; Komerdus, I; Krsek, M; Maiter, D; Netea-Maier, R; Pfeifer, M; Reincke, M; Santos, A; Strasburger, CJ; Tabarin, A; Tóth, M; Trainer, PJ; Tsagarakis, S; Valassi, E; Wass, JAH; Webb, SM; Yaneva, M | 1 |
| Ferriere, A; Haissaguerre, M; Ollivier, M; Tabarin, A | 1 |
| Creemers, SG; de Jong, FH; de Rijke, YB; Feelders, RA; Franssen, GJH; Hofland, LJ; van Koetsveld, PM | 1 |
| Athimulam, S; Bancos, I; Delivanis, DA | 1 |
| Biller, BMK; Tritos, NA | 1 |
| Fujii, Y; Kouchi, M; Matsumoto, I; Miyawaki, I; Tochitani, T; Yamada, T; Yamashita, A | 1 |
| Braun, LT; Reincke, M | 1 |
| Newell-Price, J; Nieman, LK; Reincke, M; Tabarin, A | 1 |
| Tritos, NA | 1 |
| Boguszewski, CL; Marques, JVO | 1 |
| Castinetti, F; Newell-Price, J; Nieman, LK; Reincke, M | 1 |
| Fleseriu, M; Han, AJ; Varlamov, EV | 1 |
| Boswell, L; Casals, G; Díaz-Catalán, D; Halperin, I; Hanzu, FA; Laguna-Moreno, J; Mora, M; Vega-Beyhart, A | 1 |
| Colao, A; Di Paola, N; Pivonello, R; Simeoli, C | 1 |
| Hull, B; Wedrychowicz, A | 1 |
28 review(s) available for ketoconazole and metyrapone
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
Plasma levels of aldosterone precursors (including the 18-hydroxylated compounds in this synthesis pathway)--a tool for the analysis of adrenal disorders?
Topics: 18-Hydroxycorticosterone; 18-Hydroxydesoxycorticosterone; Adrenal Gland Diseases; Adrenal Glands; Adrenocorticotropic Hormone; Aldosterone; Angiotensin II; Circadian Rhythm; Dopamine; Humans; Ketoconazole; Metyrapone; Mixed Function Oxygenases; Posture; Sodium | 1990 |
[Clinical studies on a disorder of mineralocorticoid metabolism].
Topics: Aldosterone; Humans; Hyperaldosteronism; Kanamycin; Ketoconazole; Metyrapone; Mineralocorticoids; Mitotane; Mixed Function Oxygenases | 1986 |
The medical treatment of Cushing's syndrome.
Topics: Adrenal Cortex Neoplasms; Adrenal Glands; Aminoglutethimide; Animals; Bromocriptine; Cushing Syndrome; Cyproheptadine; Dogs; Horses; Humans; Ketoconazole; Metyrapone; Mifepristone; Mitotane; Octreotide; Palliative Care; Pituitary Gland; Radiography; Valproic Acid | 1993 |
Feline adrenocortical diseases: Part I--Hyperadrenocorticism.
Topics: Adrenocorticotropic Hormone; Animals; Cat Diseases; Cats; Cushing Syndrome; Dexamethasone; Diagnosis, Differential; Dogs; Humans; Ketoconazole; Metyrapone; Mitotane; Tomography, X-Ray Computed | 1994 |
Steroid biosynthesis inhibitors in Cushing's syndrome.
Topics: Adrenal Cortex Hormones; Aminoglutethimide; Cushing Syndrome; Dihydrotestosterone; Etomidate; Humans; Ketoconazole; Metyrapone; Mitotane | 1994 |
Therapy of Cushing's syndrome with steroid biosynthesis inhibitors.
Topics: 3-Hydroxysteroid Dehydrogenases; Aminoglutethimide; Cushing Syndrome; Dihydrotestosterone; Etomidate; Humans; Ketoconazole; Metyrapone; Steroids | 1994 |
[Clinical usefulness of pharmacological treatment of Cushing's syndrome].
Topics: Administration, Oral; Aminoglutethimide; Cushing Syndrome; Dihydrotestosterone; Humans; Ketoconazole; Metyrapone; Mitotane | 1994 |
[Medical treatment for Cushing's syndrome].
Topics: Aminoglutethimide; Aromatase Inhibitors; Cushing Syndrome; Humans; Ketoconazole; Metyrapone; Steroid 11-beta-Hydroxylase | 2008 |
Glucocorticoid inhibition in the treatment of depression: can we think outside the endocrine hypothalamus?
Topics: Adrenal Glands; Aminoglutethimide; Anti-Inflammatory Agents; Corticotropin-Releasing Hormone; Depressive Disorder, Major; Double-Blind Method; Glucocorticoids; Humans; Hydrocortisone; Hypothalamus; Ketoconazole; Metyrapone; Mifepristone; Severity of Illness Index | 2009 |
Drugs in the medical treatment of Cushing's syndrome.
Topics: Adrenal Cortex Neoplasms; Adrenocorticotropic Hormone; Antiparkinson Agents; Cabergoline; Cushing Syndrome; Ergolines; Human Growth Hormone; Humans; Hydrocortisone; Ketoconazole; Metyrapone; Pituitary Hormones; Pituitary Neoplasms | 2009 |
Medical therapy of Cushing's disease: where are we now?
Topics: Dopamine Agonists; Humans; Hydrocortisone; Ketoconazole; Metyrapone; Mifepristone; Mitotane; Pituitary ACTH Hypersecretion; Somatostatin | 2010 |
Management of diabetes mellitus in Cushing's syndrome.
Topics: Cushing Syndrome; Diabetes Mellitus; Enzyme Inhibitors; Humans; Hypoglycemic Agents; Insulin Resistance; Ketoconazole; Metformin; Metyrapone | 2010 |
Medical treatment of Cushing's syndrome: adrenal-blocking drugs and ketaconazole.
Topics: Cushing Syndrome; Enzyme Inhibitors; Etomidate; Humans; Ketoconazole; Metyrapone; Mitotane | 2010 |
Management of pituitary tumors in pregnancy.
Topics: Dopamine Agonists; Female; Humans; Ketoconazole; Metyrapone; Pituitary Neoplasms; Pregnancy; Pregnancy Complications, Neoplastic | 2011 |
Advances in medical therapies for Cushing's syndrome.
Topics: Animals; Bexarotene; Cushing Syndrome; Etomidate; Humans; Ketoconazole; Lapatinib; Metyrapone; Mifepristone; Mitotane; Quinazolines; Somatostatin; Tetrahydronaphthalenes | 2012 |
New prospects for drug treatment in Cushing disease.
Topics: Adenoma; Adrenocorticotropic Hormone; Animals; Cabergoline; Clinical Trials as Topic; Clinical Trials, Phase III as Topic; Drug Evaluation, Preclinical; Ergolines; Etomidate; Humans; Hydrocortisone; Imidazoles; Ketoconazole; Metyrapone; Mice; Mifepristone; Mitotane; Multicenter Studies as Topic; Pituitary ACTH Hypersecretion; Pituitary Neoplasms; PPAR gamma; Pyridines; Rats; Somatostatin; Therapies, Investigational; Tretinoin | 2012 |
The medical management of Cushing's syndrome during pregnancy.
Topics: Adrenalectomy; Cushing Syndrome; Female; Humans; Hydrocortisone; Ketoconazole; Metyrapone; Pre-Eclampsia; Pregnancy; Pregnancy Complications; Pregnancy Outcome | 2013 |
Efficacy of medical treatment in Cushing's disease: a systematic review.
Topics: Cabergoline; Ergolines; Female; Humans; Ketoconazole; Male; Metyrapone; Mitotane; Pituitary ACTH Hypersecretion; Somatostatin | 2014 |
Therapy of endocrine disease: steroidogenesis enzyme inhibitors in Cushing's syndrome.
Topics: Cushing Syndrome; Etomidate; Humans; Imidazoles; Ketoconazole; Metyrapone; Mitotane; Pyridines; Steroid Synthesis Inhibitors | 2015 |
Therapeutic Strategies for the Treatment of Severe Cushing's Syndrome.
Topics: Animals; Cushing Syndrome; Etomidate; Humans; Hydrocortisone; Ketoconazole; Metyrapone | 2016 |
Medical Management of Cushing Disease.
Topics: Cabergoline; Etomidate; Humans; Ketoconazole; Metyrapone; Mitotane; Pituitary ACTH Hypersecretion; Somatostatin; Temozolomide; Treatment Outcome | 2019 |
What is the role of medical therapy in adrenal-dependent Cushing's syndrome?
Topics: Adrenal Gland Diseases; Cushing Syndrome; Humans; Ketoconazole; Metyrapone; Mitotane; Pituitary ACTH Hypersecretion; Prospective Studies; Treatment Outcome | 2020 |
Adrenally Directed Medical Therapies for Cushing Syndrome.
Topics: Adrenal Glands; Cushing Syndrome; Etomidate; Humans; Imidazoles; Ketoconazole; Metyrapone; Mitotane; Molecular Targeted Therapy; Pyridines | 2021 |
Medical therapy in severe hypercortisolism.
Topics: Cabergoline; Cushing Syndrome; Humans; Ketoconazole; Metyrapone; Mitotane | 2021 |
Updates in adrenal steroidogenesis inhibitors for Cushing's syndrome - A practical guide.
Topics: Cushing Syndrome; Cytochrome P-450 CYP11B2; Enzyme Inhibitors; Etomidate; Humans; Hydrocortisone; Imidazoles; Ketoconazole; Metyrapone; Pituitary ACTH Hypersecretion; Practice Patterns, Physicians'; Pyridines; Steroids | 2021 |
Cushing's disease: adrenal steroidogenesis inhibitors.
Topics: Adrenocorticotropic Hormone; Cushing Syndrome; Female; Humans; Hypokalemia; Ketoconazole; Male; Metyrapone; Pituitary ACTH Hypersecretion; Pituitary Neoplasms; Steroid Synthesis Inhibitors | 2022 |
The function of adrenal glands in children and adolescents during and after oncological treatment.
Topics: Adolescent; Adrenal Glands; Child; Etomidate; Fluconazole; Humans; Hypothalamo-Hypophyseal System; Immune Checkpoint Inhibitors; Ketoconazole; Metyrapone; Mitotane; Pituitary-Adrenal System; Quality of Life | 2022 |
3 trial(s) available for ketoconazole and metyrapone
| Article | Year |
|---|---|
Response to steroid suppression in major depression resistant to antidepressant therapy.
Topics: Adult; Aminoglutethimide; Antidepressive Agents; Dehydroepiandrosterone; Depressive Disorder; Dexamethasone; Dose-Response Relationship, Drug; Female; Hospitalization; Humans; Hydrocortisone; Ketoconazole; Male; Metyrapone; Middle Aged; Psychiatric Status Rating Scales | 1991 |
Neuroendocrine responses to inhibitors of steroid biosynthesis in patients with major depression resistant to antidepressant therapy.
Topics: Adult; Aminoglutethimide; Analysis of Variance; Androgen Antagonists; Antidepressive Agents; Dehydroepiandrosterone Sulfate; Depressive Disorder; Dexamethasone; Drug Resistance; Enzyme Inhibitors; Female; Hormone Antagonists; Humans; Hydrocortisone; Ketoconazole; Male; Metyrapone; Middle Aged; Steroids; Treatment Outcome | 1998 |
Hypocortisolemic clamp unmasks jointly feedforward- and feedback-dependent control of overnight ACTH secretion.
Topics: Adrenocorticotropic Hormone; Adult; Circadian Rhythm; Entropy; Enzyme Inhibitors; Feedback, Physiological; Glucocorticoids; Humans; Hydrocortisone; Hypothalamus; Ketoconazole; Male; Metyrapone; Middle Aged; Placebos | 2008 |
52 other study(ies) available for ketoconazole and metyrapone
| Article | Year |
|---|---|
New selective inhibitors of steroid 11beta-hydroxylation in the adrenal cortex. Synthesis and structure-activity relationship of potent etomidate analogues.
Topics: Adrenal Cortex; Animals; Binding Sites; Etomidate; Humans; Hydroxylation; Iodine Radioisotopes; Kinetics; Male; Molecular Structure; Rats; Rats, Wistar; Stereoisomerism; Steroid 11-beta-Hydroxylase; Structure-Activity Relationship | 2008 |
Comparative chemometric modeling of cytochrome 3A4 inhibitory activity of structurally diverse compounds using stepwise MLR, FA-MLR, PLS, GFA, G/PLS and ANN techniques.
Topics: Algorithms; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Enzyme Inhibitors; Factor Analysis, Statistical; Least-Squares Analysis; Linear Models; Models, Molecular; Neural Networks, Computer; Quantitative Structure-Activity Relationship; Reproducibility of Results | 2009 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models.
Topics: | 2008 |
Replacement of imidazolyl by pyridyl in biphenylmethylenes results in selective CYP17 and dual CYP17/CYP11B1 inhibitors for the treatment of prostate cancer.
Topics: Androgen Antagonists; Animals; Biphenyl Compounds; Cell Line; Cricetinae; Cricetulus; Humans; Imidazoles; In Vitro Techniques; Male; Microsomes; Prostatic Neoplasms; Pyridines; Steroid 11-beta-Hydroxylase; Steroid 17-alpha-Hydroxylase; Structure-Activity Relationship; Testis | 2010 |
N-(Pyridin-3-yl)benzamides as selective inhibitors of human aldosterone synthase (CYP11B2).
Topics: Aromatase; Benzamides; Cytochrome P-450 CYP11B2; Enzyme Inhibitors; Humans; Steroid 11-beta-Hydroxylase; Steroid 17-alpha-Hydroxylase; Structure-Activity Relationship | 2011 |
FDA-approved drug labeling for the study of drug-induced liver injury.
Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Design; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmaceutical Preparations; Reproducibility of Results; United States; United States Food and Drug Administration | 2011 |
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship | 2012 |
Aldosterone synthase inhibitors as promising treatments for mineralocorticoid dependent cardiovascular and renal diseases.
Topics: Aldosterone; Animals; Benzimidazoles; Cardiovascular Diseases; Cytochrome P-450 CYP11B2; Fadrozole; Humans; Indans; Indoles; Kidney Diseases; Mineralocorticoids; Naphthalenes; Quinolines; Receptors, Mineralocorticoid | 2014 |
First Selective CYP11B1 Inhibitors for the Treatment of Cortisol-Dependent Diseases.
Topics: | 2011 |
Optimization of the First Selective Steroid-11β-hydroxylase (CYP11B1) Inhibitors for the Treatment of Cortisol Dependent Diseases.
Topics: | 2011 |
Discovery of new 7-substituted-4-imidazolylmethyl coumarins and 4'-substituted-2-imidazolyl acetophenones open analogues as potent and selective inhibitors of steroid-11β-hydroxylase.
Topics: Acetophenones; Coumarins; Cytochrome P-450 CYP11B2; Dose-Response Relationship, Drug; Drug Discovery; Enzyme Inhibitors; Humans; Molecular Structure; Steroid 11-beta-Hydroxylase; Structure-Activity Relationship | 2015 |
Theoretical basis for response to steroid suppression in major depression.
Topics: Aminoglutethimide; Depressive Disorder; Dopamine; Humans; Hydrocortisone; Ketoconazole; Metyrapone | 1992 |
Evidence against the involvement of a cytochrome P-450 mechanism in pulmonary hemodynamics in the newborn pig.
Topics: Animals; Animals, Newborn; Cyclooxygenase Inhibitors; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Indomethacin; Isoenzymes; Ketoconazole; Lipoxygenase Inhibitors; Metyrapone; Perfusion; Pulmonary Circulation; Swine | 1991 |
Inhibition and induction of bile acid synthesis by ketoconazole. Effects on bile formation in the rat.
Topics: Animals; Bile; Bile Acids and Salts; Cholesterol 7-alpha-Hydroxylase; Ketoconazole; Male; Metyrapone; Microsomes, Liver; Rats; Rats, Inbred Strains; Time Factors | 1989 |
Differential effects of the imidazole derivatives etomidate, ketoconazole and miconazole and of metyrapone on the secretion of cortisol and its precursors by human adrenocortical cells.
Topics: 17-alpha-Hydroxyprogesterone; Adrenal Cortex; Adrenocorticotropic Hormone; Cortodoxone; Cushing Syndrome; Etomidate; Humans; Hydrocortisone; Hydroxyprogesterones; In Vitro Techniques; Ketoconazole; Metyrapone; Miconazole; Progesterone | 1987 |
Inhibition of retinoic acid metabolism by imidazole antimycotics in F9 embryonal carcinoma cells.
Topics: Cell Line; Clotrimazole; Embryonal Carcinoma Stem Cells; Imidazoles; Ketoconazole; Metyrapone; Miconazole; Neoplastic Stem Cells; Tretinoin | 1987 |
Reversible adrenal insufficiency induced by ketoconazole.
Topics: 17-Hydroxycorticosteroids; Adrenal Insufficiency; Cortodoxone; Cosyntropin; Humans; Hydrocortisone; Ketoconazole; Male; Metyrapone; Middle Aged | 1985 |
Ketoconazole inhibits oxidative modification of low density lipoprotein.
Topics: Animals; Benzoflavones; Benzopyrene Hydroxylase; Cells, Cultured; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Drug Interactions; Humans; Ketoconazole; Lipoproteins, LDL; Luminescent Measurements; Macrophages, Peritoneal; Methoxsalen; Metyrapone; Mice; Mice, Inbred Strains; Oxidation-Reduction | 1995 |
Cloning and stable expression of the human mitochondrial cytochrome P45011B1 cDNA in V79 Chinese hamster cells and their application for testing of potential inhibitors.
Topics: Adrenal Glands; Animals; Base Sequence; Cell Line; Cloning, Molecular; Clotrimazole; Cricetinae; Cricetulus; DNA Primers; DNA, Complementary; Fluconazole; Gene Expression; Hydrocortisone; Hydroxylation; Ketoconazole; Kinetics; Metyrapone; Miconazole; Mitochondria; Molecular Sequence Data; Polymerase Chain Reaction; Recombinant Proteins; Restriction Mapping; Spironolactone; Steroid 11-beta-Hydroxylase; Transfection | 1995 |
The psychotropic effects of inhibitors of steroid biosynthesis in depressed patients refractory to treatment.
Topics: Adrenal Cortex Hormones; Adult; Aminoglutethimide; Bipolar Disorder; Depressive Disorder; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Female; Humans; Ketoconazole; Male; Metyrapone; Middle Aged; Personality Inventory; Psychotic Disorders | 1995 |
Effect of dexamethasone and cytochrome P450 inhibitors on the formation of 7 alpha-hydroxydehydroepiandrosterone by human adipose stromal cells.
Topics: Adipose Tissue; Aminoglutethimide; Cells, Cultured; Cytochrome P-450 Enzyme Inhibitors; Dehydroepiandrosterone; Dexamethasone; Humans; Ketoconazole; Metyrapone; Mifepristone; Stromal Cells | 1994 |
A role for protein kinase C alpha in stimulation of prostaglandin G/H synthase-2 transcription by 14,15-epoxyeicosatrienoic acid.
Topics: 16,16-Dimethylprostaglandin E2; 8,11,14-Eicosatrienoic Acid; Animals; Cell Line; Colforsin; Cyclooxygenase 2; Diclofenac; Epithelial Cells; Intestinal Mucosa; Isoenzymes; Ketoconazole; Metyrapone; Miconazole; Peroxidases; Prostaglandin-Endoperoxide Synthases; Prostaglandins F, Synthetic; Protein Kinase C; Protein Kinase C-alpha; Rats; RNA, Messenger; Signal Transduction; Tetradecanoylphorbol Acetate; Transcription, Genetic | 1998 |
[Cushing's syndrome: clinical study of fifteen cases].
Topics: Adult; Aged; Cushing Syndrome; Dexamethasone; Female; Humans; Hydrocortisone; Ketoconazole; Male; Metyrapone; Middle Aged | 1998 |
Primary culture system of adrenocortical cells from dogs to evaluate direct effects of chemicals on steroidogenesis.
Topics: Adrenal Cortex; Adrenal Cortex Hormones; Aminoglutethimide; Animals; Cell Survival; Cells, Cultured; Chromatography, High Pressure Liquid; Dogs; Female; Ketoconazole; Metyrapone; Miconazole; Mitotane; Toxicity Tests | 2001 |
7-Deoxyloganin 7-hydroxylase in Lonicera japonica cell cultures.
Topics: Carbon Monoxide; Cells, Cultured; Cytochrome P-450 Enzyme Inhibitors; Enzyme Inhibitors; Glucosides; Iridoids; Ketoconazole; Magnoliopsida; Metyrapone; Miconazole; Microsomes; Mixed Function Oxygenases; NADP; Oxygen; Oxygen Consumption; Pyrans | 2001 |
Effects of 3-MeSO2-DDE and some CYP inhibitors on glucocorticoid steroidogenesis in the H295R human adrenocortical carcinoma cell line.
Topics: Adrenal Cortex Neoplasms; Aminoglutethimide; Carcinoma; Chromatography, High Pressure Liquid; Colforsin; Cytochrome P-450 Enzyme Inhibitors; Dichlorodiphenyl Dichloroethylene; Dose-Response Relationship, Drug; Drug Combinations; Environmental Pollutants; Enzyme Inhibitors; Hydrocortisone; Ketoconazole; Metyrapone; Tumor Cells, Cultured | 2002 |
Efficient short-term control of hypercortisolaemia by low-dose etomidate in severe paediatric Cushing's disease.
Topics: Adrenalectomy; Child; Contraindications; Cushing Syndrome; Etomidate; Humans; Hydrocortisone; Ketoconazole; Male; Metyrapone | 2005 |
Enhancement of DMNQ-induced hepatocyte toxicity by cytochrome P450 inhibition.
Topics: Animals; Antioxidants; Benzoquinones; Catecholamines; Cell Survival; Cytochrome P-450 Enzyme Inhibitors; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Inhibitors; Glutathione Disulfide; Hepatocytes; Imidazolines; Iron Chelating Agents; Ketoconazole; L-Lactate Dehydrogenase; Lipid Peroxidation; Male; Metyrapone; Molecular Structure; NADP; Naphthoquinones; Oxidative Stress; Proadifen; Rats; Rats, Wistar; Superoxides; Thiobarbituric Acid Reactive Substances | 2006 |
The H295R system for evaluation of endocrine-disrupting effects.
Topics: Aminoglutethimide; Biological Assay; Cell Line, Tumor; Colforsin; Drug Interactions; Endocrine Disruptors; Estradiol; Gene Expression Profiling; Gene Expression Regulation; Humans; Ketoconazole; Metyrapone; Progesterone; Testosterone | 2006 |
Pharmacological management of Cushing's syndrome: an update.
Topics: Cushing Syndrome; Dopamine Antagonists; Hormone Antagonists; Humans; Hypothalamo-Hypophyseal System; Ketoconazole; Metyrapone; Mifepristone; Mitotane; Pituitary-Adrenal System; PPAR gamma; Somatostatin; Steroids | 2007 |
Flexible structure of cytochrome P450: promiscuity of ligand binding in the CYP3A4 heme pocket.
Topics: Amino Acid Sequence; Binding Sites; Crystallography, X-Ray; Cytochrome P-450 CYP3A; Erythromycin; Heme; Humans; Ketoconazole; Ligands; Metyrapone; Models, Molecular; Molecular Sequence Data; Progesterone; Protein Binding; Protein Conformation; Static Electricity; Substrate Specificity | 2009 |
Ketoconazole treatment for Cushing syndrome in McCune-Albright syndrome.
Topics: Adrenergic Agents; Adrenocorticotropic Hormone; Aminoglutethimide; Antifungal Agents; Chemical and Drug Induced Liver Injury; Cushing Syndrome; Enzyme Inhibitors; Female; Fibrous Dysplasia, Polyostotic; Humans; Hydrocortisone; Infant; Ketoconazole; Liver Function Tests; Metyrapone; Remission Induction | 2009 |
Effects on plasma corticosterone levels and brain serotonin from interference with methamphetamine-induced corticosterone release in neonatal rats.
Topics: Adrenal Glands; Adrenalectomy; Adrenocorticotropic Hormone; Animals; Animals, Newborn; Brain; Corticosterone; Dopamine; Female; Ketoconazole; Male; Methamphetamine; Metyrapone; Rats; Rats, Sprague-Dawley; Serotonin | 2010 |
Mitotane, metyrapone, and ketoconazole combination therapy as an alternative to rescue adrenalectomy for severe ACTH-dependent Cushing's syndrome.
Topics: Adolescent; Adult; Aged; Antimetabolites; Antineoplastic Agents; Cushing Syndrome; Drug Therapy, Combination; Female; Humans; Hydrocortisone; Ketoconazole; Male; Metyrapone; Middle Aged; Mitotane; Treatment Outcome | 2011 |
A reappraisal of the medical therapy with steroidogenesis inhibitors in Cushing's syndrome.
Topics: Adolescent; Adult; Aged; Antimetabolites; Child; Cushing Syndrome; Female; Humans; Ketoconazole; Male; Metyrapone; Middle Aged; Preoperative Period; Retrospective Studies; Young Adult | 2012 |
Effects of cytochrome P450 inhibitors on peroxidase activity.
Topics: Benzoflavones; Cytochrome P-450 Enzyme Inhibitors; Disulfiram; Ditiocarb; Ellipticines; Enzyme Activation; Enzyme Inhibitors; Horseradish Peroxidase; Humans; Ketoconazole; Metyrapone; Piperonyl Butoxide; Proadifen; Quinidine; Structure-Activity Relationship; Substrate Specificity; Sulfaphenazole; Triazoles; Troleandomycin | 2012 |
Increased long-term remission after adequate medical cortisol suppression therapy as presurgical treatment in Cushing's disease.
Topics: Adolescent; Adrenocorticotropic Hormone; Adult; Aged; Enzyme Inhibitors; Female; Humans; Hydrocortisone; Ketoconazole; Male; Metyrapone; Middle Aged; Pituitary ACTH Hypersecretion; Preoperative Period; Remission Induction; Retrospective Studies; Time Factors; Treatment Outcome; Young Adult | 2014 |
Rapid control of severe neoplastic hypercortisolism with metyrapone and ketoconazole.
Topics: ACTH Syndrome, Ectopic; Adrenal Gland Neoplasms; Adrenocortical Carcinoma; Adult; Aged; Cushing Syndrome; Drug Therapy, Combination; Female; Humans; Ketoconazole; Male; Metyrapone; Middle Aged; Retrospective Studies; Severity of Illness Index; Time Factors; Treatment Outcome; Young Adult | 2015 |
[Indications and future perspectives in the pharmacological treatment of hypercortisolism].
Topics: Adenoma; Cushing Syndrome; Humans; Hydrocortisone; Italy; Ketoconazole; Metyrapone; Pituitary Neoplasms; Somatostatin | 2016 |
[Pharmacological treatment in adrenal Cushing's syndrome.]
Topics: Cushing Syndrome; Humans; Ketoconazole; Metyrapone | 2016 |
A successful case of pregnancy in a woman with ACTH-independent Cushing's syndrome treated with ketoconazole and metyrapone.
Topics: Adult; Cushing Syndrome; Drug Therapy, Combination; Female; Humans; Ketoconazole; Metyrapone; Pregnancy; Pregnancy Complications; Treatment Outcome | 2017 |
BIOCHEMICAL CONTROL DURING LONG-TERM FOLLOW-UP OF 230 ADULT PATIENTS WITH CUSHING DISEASE: A MULTICENTER RETROSPECTIVE STUDY.
Topics: 14-alpha Demethylase Inhibitors; ACTH-Secreting Pituitary Adenoma; Adenoma; Adolescent; Adrenalectomy; Adult; Aged; Antineoplastic Agents; Cabergoline; Comorbidity; Enzyme Inhibitors; Ergolines; Female; Follow-Up Studies; Hirsutism; Hormone Antagonists; Hormones; Humans; Hyperlipidemias; Hypertension; Hypoglycemic Agents; Ketoconazole; Male; Metyrapone; Middle Aged; Mifepristone; Muscle Weakness; Muscular Atrophy; Neurosurgical Procedures; Obesity, Abdominal; Pituitary ACTH Hypersecretion; Pituitary Irradiation; Polycystic Ovary Syndrome; Retrospective Studies; Rosiglitazone; Somatostatin; Striae Distensae; Thiazolidinediones; Treatment Outcome; Tumor Burden; Young Adult | 2017 |
A polymorphism in the CYP17A1 gene influences the therapeutic response to steroidogenesis inhibitors in Cushing's syndrome.
Topics: Adult; Cushing Syndrome; Female; Humans; Ketoconazole; Male; Metyrapone; Middle Aged; Pharmacogenetics; Polymorphism, Single Nucleotide; Steroid 17-alpha-Hydroxylase; Steroids | 2017 |
Preoperative medical treatment in Cushing's syndrome: frequency of use and its impact on postoperative assessment: data from ERCUSYN.
Topics: Adrenal Glands; Adult; Aged; Cushing Syndrome; Databases, Factual; Europe; Female; Humans; Ketoconazole; Male; Metyrapone; Middle Aged; Paraneoplastic Endocrine Syndromes; Pituitary Gland; Postoperative Care; Postoperative Period; Quality of Life; Treatment Outcome | 2018 |
Should we avoid using ketoconazole in patients with severe Cushing’s syndrome and increased levels of liver enzymes?
Topics: Adult; Cushing Syndrome; Drug Therapy, Combination; Enzyme Inhibitors; Female; Humans; Ketoconazole; Liver; Male; Metyrapone; Middle Aged; Treatment Outcome | 2018 |
Osilodrostat Is a Potential Novel Steroidogenesis Inhibitor for the Treatment of Cushing Syndrome: An In Vitro Study.
Topics: Aldosterone; Cell Culture Techniques; Cortodoxone; Cushing Syndrome; Cytochrome P-450 CYP11B2; Enzyme Inhibitors; Humans; Hydrocortisone; Imidazoles; Ketoconazole; Metyrapone; Pyridines; Steroid 11-beta-Hydroxylase | 2019 |
Modern Management of Mild Autonomous Cortisol Secretion.
Topics: 14-alpha Demethylase Inhibitors; Adrenal Cortex Neoplasms; Adrenal Insufficiency; Adrenalectomy; Adrenocortical Adenoma; Adrenocorticotropic Hormone; Dehydroepiandrosterone Sulfate; Diabetes Mellitus, Type 2; Disease Management; Dyslipidemias; Enzyme Inhibitors; Glucocorticoids; Hormone Antagonists; Humans; Hydrocortisone; Hypertension; Incidental Findings; Ketoconazole; Metyrapone; Mifepristone; Mortality; Obesity; Osteoporosis; Postoperative Hemorrhage; Risk; Saliva; Severity of Illness Index | 2019 |
Physiological and drug-induced changes in blood levels of adrenal steroids and their precursors in cynomolgus monkeys: An application of steroid profiling by LC-MS/MS for evaluation of the adrenal toxicity.
Topics: Adrenal Glands; Aldosterone; Androgens; Animals; Chromatography, Liquid; Circadian Rhythm; Desoxycorticosterone; Female; Humans; Hydrocortisone; Ketoconazole; Macaca fascicularis; Male; Metyrapone; Steroid 11-beta-Hydroxylase; Tandem Mass Spectrometry | 2019 |
ENDOCRINOLOGY IN THE TIME OF COVID-19: Management of Cushing's syndrome.
Topics: 14-alpha Demethylase Inhibitors; ACTH-Secreting Pituitary Adenoma; Adenoma; Coronavirus Infections; COVID-19; Cushing Syndrome; Disease Management; Enzyme Inhibitors; Glucocorticoids; Humans; Hydrocortisone; Immunocompromised Host; Infection Control; Ketoconazole; Metyrapone; Neurosurgical Procedures; Pandemics; Patient Education as Topic; Pneumonia, Viral; Practice Guidelines as Topic; Severity of Illness Index; Telemedicine; Time Factors | 2020 |
Approach to the Patient Treated with Steroidogenesis Inhibitors.
Topics: Adrenocorticotropic Hormone; Adult; Cushing Syndrome; Enzyme Inhibitors; Female; Humans; Imidazoles; Ketoconazole; Metyrapone; Pyridines | 2021 |
Ketoconazole- and Metyrapone-Induced Reductions on Urinary Steroid Metabolites Alter the Urinary Free Cortisol Immunoassay Reliability in Cushing Syndrome.
Topics: Cushing Syndrome; Humans; Hydrocortisone; Immunoassay; Ketoconazole; Metyrapone; Reproducibility of Results; Steroids | 2022 |