ketoconazole has been researched along with lanosterol in 29 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 13 (44.83) | 18.7374 |
| 1990's | 9 (31.03) | 18.2507 |
| 2000's | 4 (13.79) | 29.6817 |
| 2010's | 2 (6.90) | 24.3611 |
| 2020's | 1 (3.45) | 2.80 |
| Authors | Studies |
|---|---|
| Guengerich, FP; Hargrove, TY; Lepesheva, GI; Nes, WD; Rachakonda, G; Villalta, F; Wawrzak, Z | 1 |
| Ekins, S; Harwood, HJ; Hoover, DJ; Lawton, MP; Mankowski, DC; Treadway, JL | 1 |
| Delate, TA; Panini, SR; Sinensky, M | 1 |
| Gylling, H; Miettinen, TA; Vanhanen, H | 1 |
| Panini, SR; Schnitzer-Polokoff, R; Sinensky, M; Spencer, TA | 1 |
| Gibbons, GF; Iglesias, J | 1 |
| Rippon, JW | 1 |
| Gibbons, GF; Hwang, W; Marco de la Calle, C; Pullinger, CR | 1 |
| Beach, DH; Goad, LJ; Holz, GG | 2 |
| Aoyama, Y; Sato, Y; Sonoda, Y; Yoshida, Y | 1 |
| Chitrakorn, S; Gupta, AK; Panini, SR; Parish, EJ; Rudney, H; Sexton, RC | 1 |
| Chen, HW; Favata, MF; Fischer, RT; Greenberg, RS; Trzaskos, JM | 1 |
| Kraemer, FB; Spilman, SD | 1 |
| Favata, MF; Fischer, RT; Trzaskos, JM | 1 |
| Cools, W; Cornelissen, F; Lauwers, WF; van Cutsem, JM; Van den Bossche, H; Willemsens, G | 1 |
| Feingold, DS; Sud, IJ | 1 |
| Berry, PW; Burton, PM; Kertesz, DJ; Shelton, EJ; So, OY; Swinney, DC; Walker, KA; Watson, DM; Webb, AS | 1 |
| Bonaly, R; Coulon, J; Harmouch, N | 1 |
| Contreras, LM; Urbina, JA; Vivas, J | 1 |
| Barbuch, R; Bard, M; Gachotte, D; Koegel, C; Lees, ND; Pierson, CA | 1 |
| Casali, AK; Hamdan, JS | 1 |
| Lewis, DF; Tarbit, MH; Wiseman, A | 1 |
| Liendo, A; Piras, MM; Piras, R; Urbina, JA; Visbal, G | 1 |
| Downs, SM; Ruan, B; Schroepfer, GJ | 1 |
| Archakov, AI; Bulko, TV; Karuzina, II; Kuznetsova, GP; Lisitsa, AV; Rudakov, YO; Samenkova, NF; Shumyantseva, VV | 1 |
| Archakov, AI; Bulko, TV; Karuzina, II; Kuznetsova, GP; Lisitsa, AV; Ponomarenko, EA; Shumyantseva, VV | 1 |
| Kelly, DE; Kelly, SL; Parker, JE; Warrilow, AG | 1 |
| Garvey, EP; Hoekstra, WJ; Kelly, DE; Kelly, SL; Nes, WD; Parker, JE; Price, CL; Schotzinger, RJ; Warrilow, AG | 1 |
29 other study(ies) available for ketoconazole and lanosterol
| Article | Year |
|---|---|
Relaxed Substrate Requirements of Sterol 14α-Demethylase from
Topics: 14-alpha Demethylase Inhibitors; Ligands; Naegleria fowleri; Sterol 14-Demethylase; Substrate Specificity | 2021 |
Three-dimensional quantitative structure-activity relationship analysis of human CYP51 inhibitors.
Topics: Amides; Cytochrome P-450 Enzyme Inhibitors; Enzyme Inhibitors; Humans; Indoles; Models, Molecular; Oxidoreductases; Quantitative Structure-Activity Relationship; Sterol 14-Demethylase | 2007 |
Post-transcriptional regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase by 24(S),25-oxidolanosterol.
Topics: Animals; Cells, Cultured; CHO Cells; Cholesterol; Cricetinae; Dimethylallyltranstransferase; Gene Expression Regulation, Enzymologic; Hydroxymethylglutaryl CoA Reductases; Ketoconazole; Kinetics; Lanosterol; Liver; Male; Rats; Rats, Inbred Strains; RNA Processing, Post-Transcriptional; RNA, Messenger; Transcription, Genetic; Transfection | 1992 |
Hypolipidemic effect and mechanism of ketoconazole without and with cholestyramine in familial hypercholesterolemia.
Topics: Adult; Cholesterol; Cholestyramine Resin; Desmosterol; Drug Therapy, Combination; Feces; Female; Humans; Hyperlipoproteinemia Type II; Intestinal Absorption; Ketoconazole; Lanosterol; Lipids; Lipoproteins; Middle Aged; Squalene | 1991 |
Sterol-independent regulation of 3-hydroxy-3-methylglutaryl-CoA reductase by mevalonate in Chinese hamster ovary cells. Magnitude and specificity.
Topics: Acetyl-CoA C-Acetyltransferase; Animals; Cell Line; Chromatography, High Pressure Liquid; Cricetinae; Dose-Response Relationship, Drug; Hydroxycholesterols; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hydroxymethylglutaryl-CoA Synthase; Ketoconazole; Lanosterol; Mevalonic Acid; Naphthols; Squalene; Sterols | 1989 |
Regulation of hepatic cholesterol biosynthesis. Effects of a cytochrome P-450 inhibitor on the formation and metabolism of oxygenated sterol products of lanosterol.
Topics: Animals; Biotransformation; Cell-Free System; Cells, Cultured; Cholesterol; Cytochrome P-450 Enzyme Inhibitors; Hydroxymethylglutaryl CoA Reductases; Ketoconazole; Lanosterol; Liver; Male; Mevalonic Acid; Oxidoreductases; Rats; Rats, Inbred Strains; Sterol 14-Demethylase; Subcellular Fractions | 1989 |
A new era in antimycotic agents.
Topics: Animals; Antifungal Agents; Azoles; Candida albicans; Chitin; Cholesterol; Cytochrome P-450 Enzyme Inhibitors; Dogs; Ergosterol; Fungi; Humans; Itraconazole; Ketoconazole; Lanosterol; Liver; Rats; Sterols | 1986 |
A relationship between the activities of hepatic lanosterol 14 alpha-demethylase and 3-hydroxy-3-methylglutaryl-CoA reductase.
Topics: Animals; Cholesterol; Cytochrome P-450 Enzyme System; Enzyme Induction; Hydroxymethylglutaryl CoA Reductases; Intestine, Small; Ketoconazole; Lanosterol; Lipids; Liver; Male; Oxidoreductases; Rats; Rats, Inbred Strains; Sterol 14-Demethylase; Sterols | 1988 |
Effects of ketoconazole on sterol biosynthesis by Trypanosoma cruzi epimastigotes.
Topics: Animals; Chromatography, Thin Layer; Ketoconazole; Lanosterol; Sterols; Trypanosoma cruzi | 1986 |
Metabolism of 32-hydroxy-24,25-dihydrolanosterol by purified cytochrome P-45014DM from yeast. Evidence for contribution of the cytochrome to whole process of lanosterol 14 alpha-demethylation.
Topics: Chromatography, Gas; Cytochrome P-450 Enzyme System; Ketoconazole; Kinetics; Lanosterol; Oxidoreductases; Saccharomyces cerevisiae; Spectrophotometry; Sterol 14-Demethylase | 1987 |
Regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity and cholesterol biosynthesis by oxylanosterols.
Topics: Androstenes; Animals; Anticholesteremic Agents; Cell Line; Cholesterol; Hydroxymethylglutaryl CoA Reductases; Indicators and Reagents; Intestines; Ketoconazole; Kinetics; Lanosterol; Rats; Structure-Activity Relationship; Tritium | 1986 |
Modulation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase by azole antimycotics requires lanosterol demethylation, but not 24,25-epoxylanosterol formation.
Topics: Animals; Antifungal Agents; Cell Line; Chromatography, High Pressure Liquid; Cricetinae; Cricetulus; Female; Hydroxymethylglutaryl CoA Reductases; Ketoconazole; Lanosterol; Miconazole; Ovary | 1987 |
Effects of ketoconazole on cholesterol synthesis.
Topics: Cells, Cultured; Cholesterol; Dose-Response Relationship, Drug; Feedback; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Ketoconazole; Lanosterol | 1986 |
Mechanistic studies of lanosterol C-32 demethylation. Conditions which promote oxysterol intermediate accumulation during the demethylation process.
Topics: Animals; Cholesterol; Ketoconazole; Kinetics; Lanosterol; Miconazole; Microsomes, Liver; Multienzyme Complexes; Oxidoreductases | 1986 |
Sterols of ketoconazole-inhibited Leishmania mexicana mexicana promastigotes.
Topics: Animals; Cholesterol; Chromatography, Gas; Cytochrome P-450 Enzyme System; Ketoconazole; Lanosterol; Leishmania; Magnetic Resonance Spectroscopy; Mass Spectrometry; Mevalonic Acid; Sterols | 1985 |
In vitro and in vivo effects of the antimycotic drug ketoconazole on sterol synthesis.
Topics: Animals; Antifungal Agents; Candida albicans; Cell Membrane; Cholesterol; Culture Media; Dose-Response Relationship, Drug; Ergosterol; Female; Imidazoles; Ketoconazole; Lanosterol; Piperazines; Rats; Sterols; Time Factors | 1980 |
Heterogeneity of action of mechanisms among antimycotic imidazoles.
Topics: Aerobiosis; Anaerobiosis; Antifungal Agents; Clotrimazole; Ergosterol; Imidazoles; Ketoconazole; Lanosterol; Miconazole; Piperazines; Saccharomyces cerevisiae | 1981 |
Selective inhibition of mammalian lanosterol 14 alpha-demethylase by RS-21607 in vitro and in vivo.
Topics: Adrenocorticotropic Hormone; Aniline Compounds; Animals; Binding, Competitive; Cattle; Cholesterol; Cricetinae; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Female; Gonadotropin-Releasing Hormone; Humans; Ketoconazole; Lanosterol; Male; Microsomes, Liver; Oxidoreductases; Rats; Species Specificity; Stereoisomerism; Sterol 14-Demethylase; Sulfides; Tritium | 1994 |
Identification of 24-methylene-24,25-dihydrolanosterol as a precursor of ergosterol in the yeasts Schizosaccharomyces pombe and Schizosaccharomyces octosporus.
Topics: Binding Sites; Cell Membrane; Ergosterol; Ketoconazole; Lanosterol; Methylation; Schizosaccharomyces; Species Specificity; Sterols | 1995 |
Altered lipid composition and enzyme activities of plasma membranes from Trypanosoma (Schizotrypanum) cruzi epimastigotes grown in the presence of sterol biosynthesis inhibitors.
Topics: Animals; Ca(2+) Mg(2+)-ATPase; Cholestanol; Ketoconazole; Lanosterol; Membrane Lipids; Phospholipids; Sterols; Trypanosoma cruzi | 1997 |
A yeast sterol auxotroph (erg25) is rescued by addition of azole antifungals and reduced levels of heme.
Topics: Antifungal Agents; Azoles; Clotrimazole; Genes, Fungal; Genotype; Heme; Itraconazole; Ketoconazole; Lanosterol; Mixed Function Oxygenases; Mutation; Saccharomyces cerevisiae; Sterols; Suppression, Genetic | 1997 |
Effects of three azole derivatives on the lipids of different strains of Sporothrix schenckii.
Topics: Antifungal Agents; Fluconazole; Itraconazole; Ketoconazole; Lanosterol; Lipids; Sporothrix | 1997 |
Molecular modelling of lanosterol 14 alpha-demethylase (CYP51) from Saccharomyces cerevisiae via homology with CYP102, a unique bacterial cytochrome P450 isoform: quantitative structure-activity relationships (QSARs) within two related series of antifunga
Topics: Amino Acid Sequence; Antifungal Agents; Azoles; Bacterial Proteins; Catalytic Domain; Computer Simulation; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Fungal Proteins; Ketoconazole; Lanosterol; Mixed Function Oxygenases; Models, Molecular; Molecular Sequence Data; NADPH-Ferrihemoprotein Reductase; Oxidoreductases; Saccharomyces cerevisiae; Sequence Homology, Amino Acid; Sterol 14-Demethylase; Structure-Activity Relationship | 1999 |
Sterol composition and biosynthesis in Trypanosoma cruzi amastigotes.
Topics: Animals; Chlorocebus aethiops; Cholestanol; Cytochrome P-450 Enzyme Inhibitors; Ketoconazole; Lanosterol; Methyltransferases; Oxidoreductases; Sterol 14-Demethylase; Sterols; Trypanosoma cruzi; Vero Cells | 1999 |
Meiosis-activating sterol and the maturation of isolated mouse oocytes.
Topics: Animals; Bucladesine; Cells, Cultured; Cholestenes; Cholesterol; Culture Media; Enzyme Inhibitors; Female; Follicle Stimulating Hormone; Hypoxanthine; Ketoconazole; Lanosterol; Meiosis; Mice; Mice, Inbred C57BL; Oocytes; Ovarian Follicle | 2001 |
Electrochemical properties of cytochroms P450 using nanostructured electrodes: direct electron transfer and electro catalysis.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Benzphetamine; Biosensing Techniques; Catalysis; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme System; Cytochrome P450 Family 2; Gold; Ketoconazole; Lanosterol; Metal Nanoparticles; Oxidation-Reduction; Oxidoreductases; Potentiometry; Quaternary Ammonium Compounds; Rabbits; Sterol 14-Demethylase | 2007 |
Electrochemical reduction of sterol-14alpha-demethylase from Mycobacterium tuberculosis (CYP51b1).
Topics: Bacterial Proteins; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Electrochemistry; Electrodes; Gold; Ketoconazole; Lanosterol; Metal Nanoparticles; Oxidation-Reduction | 2007 |
Azole affinity of sterol 14α-demethylase (CYP51) enzymes from Candida albicans and Homo sapiens.
Topics: Antifungal Agents; Candida albicans; Clotrimazole; Escherichia coli; Fluconazole; Fungal Proteins; Humans; Itraconazole; Ketoconazole; Kinetics; Lanosterol; NADP; Protein Binding; Pyrimidines; Recombinant Proteins; Species Specificity; Sterol 14-Demethylase; Triazoles; Voriconazole | 2013 |
The Investigational Drug VT-1129 Is a Highly Potent Inhibitor of Cryptococcus Species CYP51 but Only Weakly Inhibits the Human Enzyme.
Topics: Antifungal Agents; Clotrimazole; Cryptococcus; Enzyme Activation; Ergosterol; Fluconazole; Humans; Itraconazole; Ketoconazole; Lanosterol; Pyridines; Sterol 14-Demethylase; Tetrazoles; Voriconazole | 2016 |