ketoconazole and isoniazid

ketoconazole has been researched along with isoniazid in 37 studies

Research

Studies (37)

Timeframe	Studies, this research(%)	All Research%
pre-1990	5 (13.51)	18.7374
1990's	2 (5.41)	18.2507
2000's	10 (27.03)	29.6817
2010's	18 (48.65)	24.3611
2020's	2 (5.41)	2.80

Authors

Authors	Studies
Jones, LH; Nadanaciva, S; Rana, P; Will, Y	1
Brodsky, JL; Chiang, A; Chung, WJ; Denny, RA; Goeckeler-Fried, JL; Havasi, V; Hong, JS; Keeton, AB; Mazur, M; Piazza, GA; Plyler, ZE; Rasmussen, L; Rowe, SM; Sorscher, EJ; Weissman, AM; White, EL	1
Bernardino, AMR; Boechat, N; Dos Santos, MS; Faria, JV; Miguita, AGC; Vegi, PF	1
Bloomer, WD; Papadopoulou, MV; Rosenzweig, HS	1
Fu, L; Huang, H; Li, G; Li, Y; Liu, Y; Lu, H; Lu, Y; Ma, C; Sheng, L; Wang, B; Zhang, B; Zhang, D; Zhao, H	1
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL	1
Hashizume, H; Kawasaki, M; Komatsu, M; Matsumoto, M; Sasaki, H; Shimokawa, Y; Tomishige, T; Tsubouchi, H	1
Cho, SH; Franzblau, SG; Hwang, CH; Pauli, GF; Wan, B; Warit, S	1
Artursson, P; Bergström, CA; Hoogstraate, J; Matsson, P; Norinder, U; Pedersen, JM	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Choi, SS; Contrera, JF; Hastings, KL; Kruhlak, NL; Sancilio, LF; Weaver, JL; Willard, JM	1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ	1
Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ	1
Ekins, S; Williams, AJ; Xu, JJ	1
Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V	1
Barber, J; Dawson, S; Kenna, JG; Paul, N; Stahl, S	1
Chikhalia, KH; Kumari, P; Patel, PK; Patel, RV; Rajani, DP	1
Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR	1
Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY	1
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ	1
Bao, L; Cai, L; Chen, JL; Huang, P; Liu, HW; Liu, MM; Qi, QY; Wang, QX; Yang, JL; Yang, XL; Zhang, LX	1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ	1
Cai, G; Cho, S; Franzblau, SG; Jaki, BU; Lee, IA; McAlpine, JB; Napolitano, JG; Pauli, GF; Suh, JW; Wang, Y; Yang, SH	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Bhatt, KM; Okelo, GB; Sang, D	1
Acevedo, C; De Salvo, MC; Galati, MR; García Fernández, JC; Masana, M; Mingolla, L; Negroni, R; Pilheu, JA; Rubio, MC; Yunis, AS	1
Abadie-Kemmerly, S; Dalovisio, JR; Dalvisio, JR; Pankey, GA	1
Craven, PC	1
Engelhard, D; Marks, MI; Stutman, HR	1
Berman, JD; Lee, LS	1
Hurh, E; Kim, S; Kim, Y; Lee, A; Lee, E; Lee, M	1
Abraham, AM; Barr, S; Coetsee, C; Walubo, A	1
Bell, NH; Gupta, RP; Halpert, JR; He, YA; Patrick, KS	1
Byrne, ST; Denkin, SM; Gu, P; Nuermberger, E; Zhang, Y	1
Brilhante, RS; Cordeiro, Rde A; de Camargo, ZP; de Lima, RA; Medrano, DJ; Monteiro, AJ; Rocha, MF; Sidrim, JJ; Tavares, JL	1
Fasbender, F; Hengstler, JG; Metzler, S; Obholzer, M; Stöber, R; Watzl, C	1

Reviews

2 review(s) available for ketoconazole and isoniazid

Article	Year
Recently reported biological activities of pyrazole compounds. Bioorganic & medicinal chemistry, 2017, 11-01, Volume: 25, Issue:21 Topics: Analgesics; Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Antifungal Agents; Antineoplastic Agents; Antiviral Agents; Humans; Pyrazoles	2017
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016

Trials

1 trial(s) available for ketoconazole and isoniazid

Article	Year
[Pharmacokinetic interaction of ketoconazole, isoniazid and rifampicin]. Medicina, 1989, Volume: 49, Issue:1 Topics: Adult; Clinical Trials as Topic; Drug Interactions; Drug Therapy, Combination; Humans; Isoniazid; Ketoconazole; Male; Middle Aged; Rifampin; Tuberculosis	1989

Other Studies

34 other study(ies) available for ketoconazole and isoniazid

Article	Year
Development of a cell viability assay to assess drug metabolite structure-toxicity relationships. Bioorganic & medicinal chemistry letters, 2016, 08-15, Volume: 26, Issue:16 Topics: Adenosine Triphosphate; Benzbromarone; Cell Line; Cell Survival; Chromans; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Humans; Pharmaceutical Preparations; Thiazolidinediones; Troglitazone	2016
Increasing the Endoplasmic Reticulum Pool of the F508del Allele of the Cystic Fibrosis Transmembrane Conductance Regulator Leads to Greater Folding Correction by Small Molecule Therapeutics. PloS one, 2016, Volume: 11, Issue:10 Topics: Alleles; Benzoates; Cells, Cultured; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Endoplasmic Reticulum; Furans; Gene Deletion; HEK293 Cells; HeLa Cells; High-Throughput Screening Assays; Humans; Hydroxamic Acids; Microscopy, Fluorescence; Protein Folding; Protein Structure, Tertiary; Pyrazoles; RNA, Messenger; Small Molecule Libraries; Ubiquitination; Vorinostat	2016
The antitubercular activity of various nitro(triazole/imidazole)-based compounds. Bioorganic & medicinal chemistry, 2017, 11-01, Volume: 25, Issue:21 Topics: Animals; Antitubercular Agents; Cell Line; Chlorocebus aethiops; Dose-Response Relationship, Drug; Humans; Imidazoles; Macrophages; Mice; Microbial Sensitivity Tests; Molecular Structure; Mycobacterium tuberculosis; Nitro Compounds; Structure-Activity Relationship; Triazoles	2017
Discovery of a Conformationally Constrained Oxazolidinone with Improved Safety and Efficacy Profiles for the Treatment of Multidrug-Resistant Tuberculosis. Journal of medicinal chemistry, 2020, 09-10, Volume: 63, Issue:17 Topics: Animals; Chlorocebus aethiops; Drug Design; Female; Hep G2 Cells; Humans; Mice; Microbial Sensitivity Tests; Molecular Conformation; Mycobacterium tuberculosis; Oxazolidinones; Safety; Tuberculosis, Multidrug-Resistant; Vero Cells	2020
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling. Current drug discovery technologies, 2004, Volume: 1, Issue:4 Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration	2004
OPC-67683, a nitro-dihydro-imidazooxazole derivative with promising action against tuberculosis in vitro and in mice. PLoS medicine, 2006, Volume: 3, Issue:11 Topics: Animals; Antitubercular Agents; Blood; Cell Line; Humans; In Vitro Techniques; Intracellular Membranes; Macrophages; Mammals; Mice; Microbial Sensitivity Tests; Microsomes, Liver; Mycobacterium; Mycobacterium bovis; Mycolic Acids; Nitroimidazoles; Oxazoles; Treatment Outcome; Tuberculosis	2006
Low-oxygen-recovery assay for high-throughput screening of compounds against nonreplicating Mycobacterium tuberculosis. Antimicrobial agents and chemotherapy, 2007, Volume: 51, Issue:4 Topics: Anti-Bacterial Agents; Antitubercular Agents; DNA, Bacterial; Drug Evaluation, Preclinical; Mycobacterium tuberculosis; Oxygen	2007
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2). Journal of medicinal chemistry, 2008, Jun-12, Volume: 51, Issue:11 Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Computer Simulation; Cytochrome P-450 Enzyme System; Drug-Related Side Effects and Adverse Reactions; Estradiol; Humans; Insecta; Liver; Models, Molecular; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Pharmaceutical Preparations; Pharmacology; Structure-Activity Relationship	2008
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models. Toxicology mechanisms and methods, 2008, Volume: 18, Issue:2-3 Topics:	2008
Developing structure-activity relationships for the prediction of hepatotoxicity. Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes	2010
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development. Toxicological sciences : an official journal of the Society of Toxicology, 2010, Volume: 118, Issue:2 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics	2010
A predictive ligand-based Bayesian model for human drug-induced liver injury. Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12 Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands	2010
FDA-approved drug labeling for the study of drug-induced liver injury. Drug discovery today, 2011, Volume: 16, Issue:15-16 Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Design; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmaceutical Preparations; Reproducibility of Results; United States; United States Food and Drug Administration	2011
In vitro inhibition of the bile salt export pump correlates with risk of cholestatic drug-induced liver injury in humans. Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:1 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Cholestasis; Drug-Related Side Effects and Adverse Reactions; Humans; Insecta; Rats; Risk Factors	2012
Synthesis of benzimidazolyl-1,3,4-oxadiazol-2ylthio-N-phenyl (benzothiazolyl) acetamides as antibacterial, antifungal and antituberculosis agents. European journal of medicinal chemistry, 2012, Volume: 53 Topics: Antifungal Agents; Antitubercular Agents; Bacteria; Benzothiazoles; Chemistry Techniques, Synthetic; Fungi; Microbial Sensitivity Tests; Mycobacterium tuberculosis	2012
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions. Journal of medicinal chemistry, 2012, May-24, Volume: 55, Issue:10 Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection	2012
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds. Chemical research in toxicology, 2012, Oct-15, Volume: 25, Issue:10 Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding	2012
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification. Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship	2012
3-Anhydro-6-hydroxy-ophiobolin A, a new sesterterpene inhibiting the growth of methicillin-resistant Staphylococcus aureus and inducing the cell death by apoptosis on K562, from the phytopathogenic fungus Bipolaris oryzae. Bioorganic & medicinal chemistry letters, 2013, Jun-15, Volume: 23, Issue:12 Topics: Apoptosis; Cell Death; Drug Screening Assays, Antitumor; Flow Cytometry; Hep G2 Cells; Humans; K562 Cells; Methicillin-Resistant Staphylococcus aureus; Oryza; Sesterterpenes; Structure-Activity Relationship	2013
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests	2013
Hytramycins V and I, anti-Mycobacterium tuberculosis hexapeptides from a Streptomyces hygroscopicus strain. Journal of natural products, 2013, Nov-22, Volume: 76, Issue:11 Topics: Animals; Antitubercular Agents; Chlorocebus aethiops; Chromatography, High Pressure Liquid; Inhibitory Concentration 50; Microbial Sensitivity Tests; Molecular Structure; Mycobacterium tuberculosis; Nuclear Magnetic Resonance, Biomolecular; Peptides, Cyclic; Streptomyces; Vero Cells	2013
The treatment of diffuse cutaneous leishmaniasis: a report of two cases. East African medical journal, 1991, Volume: 68, Issue:1 Topics: Adolescent; Adult; Antimony Sodium Gluconate; Biopsy; Female; Humans; Isoniazid; Ketoconazole; Leishmaniasis; Levamisole; Male; Rifampin; Ultraviolet Therapy	1991
Failure of ketoconazole treatment of Blastomyces dermatitidis [corrected] due to interaction of isoniazid and rifampin. Annals of internal medicine, 1988, Nov-15, Volume: 109, Issue:10 Topics: Blastomycosis; Drug Interactions; Female; Humans; Isoniazid; Ketoconazole; Middle Aged; Rifampin	1988
Interaction of ketoconazole with rifampin and isoniazid. The New England journal of medicine, 1985, Apr-18, Volume: 312, Issue:16 Topics: Child, Preschool; Drug Interactions; Humans; Isoniazid; Ketoconazole; Male; Rifampin	1985
Interaction of ketoconazole with rifampin and isoniazid. The New England journal of medicine, 1984, Dec-27, Volume: 311, Issue:26 Topics: Drug Interactions; Drug Therapy, Combination; Humans; Infant; Isoniazid; Ketoconazole; Kinetics; Rifampin; Tinea Capitis; Tuberculosis, Lymph Node	1984
Activity of oral drugs against Leishmania tropica in human macrophages in vitro. The American journal of tropical medicine and hygiene, 1983, Volume: 32, Issue:5 Topics: Antiprotozoal Agents; Cells, Cultured; Drug Interactions; Humans; Isoniazid; Ketoconazole; Leishmania; Macrophages; Metronidazole; Nitrofurans; Phenothiazines; Quinacrine; Rifampin; Sulfamethoxazole; Trimethoprim	1983
Drugs for AIDS and associated infections. The Medical letter on drugs and therapeutics, 1995, Oct-13, Volume: 37, Issue:959 Topics: Acquired Immunodeficiency Syndrome; AIDS-Related Opportunistic Infections; Amphotericin B; Antifungal Agents; Antiprotozoal Agents; Antiviral Agents; Atovaquone; Candidiasis, Oral; Clindamycin; Clotrimazole; Cryptosporidiosis; Cytomegalovirus Infections; Dapsone; Didanosine; Drug Combinations; Drug Therapy, Combination; Fluconazole; Flucytosine; Folic Acid Antagonists; Foscarnet; Glucuronates; Herpes Simplex; Herpes Zoster; Humans; Isoniazid; Itraconazole; Ketoconazole; Lamivudine; Mycobacterium avium-intracellulare Infection; Naphthoquinones; Nystatin; Pentamidine; Pneumocystis Infections; Pneumonia, Pneumocystis; Prednisone; Primaquine; Reverse Transcriptase Inhibitors; Stavudine; Syphilis; Toxoplasmosis; Trimetrexate; Tuberculosis; Zalcitabine; Zidovudine	1995
Effects of enzyme inducers or inhibitors on the pharmacokinetics of intravenous parathion in rats. Biopharmaceutics & drug disposition, 2000, Volume: 21, Issue:5 Topics: Animals; Aryl Hydrocarbon Hydroxylases; Blotting, Western; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dexamethasone; Drug Interactions; Enzyme Induction; Enzyme Inhibitors; Insecticides; Isoenzymes; Isoniazid; Ketoconazole; Male; Methylcholanthrene; Microsomes, Liver; Paraoxon; Parathion; Phenobarbital; Proadifen; Rats; Rats, Sprague-Dawley; Tissue Distribution	2000
The role of cytochrome-P450 inhibitors in the prevention of hepatotoxicity after paracetamol overdose in rats. Human & experimental toxicology, 2004, Volume: 23, Issue:1 Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Drug Overdose; Enzyme Inhibitors; Isoniazid; Ketoconazole; Male; Rats; Rats, Sprague-Dawley	2004
CYP3A4 is a vitamin D-24- and 25-hydroxylase: analysis of structure function by site-directed mutagenesis. The Journal of clinical endocrinology and metabolism, 2005, Volume: 90, Issue:2 Topics: Animals; Baculoviridae; Cholestanetriol 26-Monooxygenase; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Humans; Insecta; Isoniazid; Ketoconazole; Kinetics; Microsomes, Liver; Mutagenesis, Site-Directed; Recombinant Proteins; Steroid Hydroxylases; Transfection; Troleandomycin; Vitamin D; Vitamin D3 24-Hydroxylase	2005
Activity of ketoconazole against Mycobacterium tuberculosis in vitro and in the mouse model. Journal of medical microbiology, 2007, Volume: 56, Issue:Pt 8 Topics: Administration, Oral; Animals; Antibiotics, Antitubercular; Antitubercular Agents; Drug Evaluation, Preclinical; Drug Synergism; Drug Therapy, Combination; Female; Isoniazid; Ketoconazole; Mice; Mice, Inbred BALB C; Microbial Sensitivity Tests; Mycobacterium tuberculosis; Pyrazinamide; Rifampin; Time Factors; Treatment Outcome; Tuberculosis, Pulmonary	2007
In vitro synergistic effects of antituberculous drugs plus antifungals against Coccidioides posadasii. International journal of antimicrobial agents, 2009, Volume: 34, Issue:3 Topics: Amphotericin B; Antifungal Agents; Antitubercular Agents; Caspofungin; Coccidioides; Coccidioidomycosis; Drug Synergism; Echinocandins; Ethambutol; Fluconazole; Humans; Isoniazid; Itraconazole; Ketoconazole; Lipopeptides; Microbial Sensitivity Tests; Pyrazinamide; Pyrimidines; Triazoles; Voriconazole	2009
Enhanced activation of human NK cells by drug-exposed hepatocytes. Archives of toxicology, 2020, Volume: 94, Issue:2 Topics: Antibodies, Neutralizing; Aspirin; Chemical and Drug Induced Liver Injury; Coculture Techniques; Cytotoxicity Tests, Immunologic; Gene Expression Regulation; Hepatocytes; Histocompatibility Antigens Class I; Humans; Interferon-gamma; Isoniazid; Ketoconazole; Killer Cells, Natural; Natural Cytotoxicity Triggering Receptor 3; NK Cell Lectin-Like Receptor Subfamily K; Valproic Acid	2020