Compounds > ketoconazole

ketoconazole and isomethyleugenol

ketoconazole has been researched along with isomethyleugenol in 10 studies

Research

Studies (10)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's3 (30.00)18.2507
2000's5 (50.00)29.6817
2010's2 (20.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Bonaly, R; Coulon, J; Harmouch, N1
Jones, BC; Smith, DA; Tyman, CA1
Linnet, K; Olesen, OV1
Ekins, S; Mankowski, DC; Margolis, JM; O'Donnell, JP; Obach, RS1
Greenblatt, DJ; Hesse, LM; Shader, RI; Venkatakrishnan, K; von Moltke, LL1
Howald, W; Lalovic, B; Phillips, B; Risler, LL; Shen, DD1
Kunze, KL; Lee, CA; Zhao, P1
Derks, M; Fowler, S; Kuhlmann, O1
Kwan, HY; Thormann, W1
Chen, Y; Guo, X; Li, Q; Peng, Y; Yang, X; Zhao, G; Zheng, J1

Trials

1 trial(s) available for ketoconazole and isomethyleugenol

ArticleYear
A single-center, open-label, one-sequence study of dalcetrapib coadministered with ketoconazole, and an in vitro study of the S-methyl metabolite of dalcetrapib.
    Clinical therapeutics, 2009, Volume: 31, Issue:3

    Topics: Administration, Oral; Adolescent; Adult; Aged; Amides; Anticholesteremic Agents; Antifungal Agents; Biotransformation; Cohort Studies; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Drug Administration Schedule; Drug Interactions; Esters; Humans; In Vitro Techniques; Ketoconazole; Male; Methylation; Microsomes, Liver; Middle Aged; Recombinant Proteins; Sulfhydryl Compounds; Young Adult

2009

Other Studies

9 other study(ies) available for ketoconazole and isomethyleugenol

ArticleYear
Identification of 24-methylene-24,25-dihydrolanosterol as a precursor of ergosterol in the yeasts Schizosaccharomyces pombe and Schizosaccharomyces octosporus.
    FEMS microbiology letters, 1995, Dec-15, Volume: 134, Issue:2-3

    Topics: Binding Sites; Cell Membrane; Ergosterol; Ketoconazole; Lanosterol; Methylation; Schizosaccharomyces; Species Specificity; Sterols

1995
Identification of the cytochrome P450 isoforms involved in the O-demethylation of 4-nitroanisole in human liver microsomes.
    Xenobiotica; the fate of foreign compounds in biological systems, 1997, Volume: 27, Issue:10

    Topics: Adult; Aged; Anisoles; Anti-Infective Agents; Anticoagulants; Antifungal Agents; Antimalarials; Binding, Competitive; Coumarins; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Inhibitors; Female; Humans; Isoenzymes; Ketoconazole; Kinetics; Male; Methylation; Microsomes, Liver; Middle Aged; Quinidine; Substrate Specificity; Sulfaphenazole; Theophylline

1997
Studies on the stereoselective metabolism of citalopram by human liver microsomes and cDNA-expressed cytochrome P450 enzymes.
    Pharmacology, 1999, Volume: 59, Issue:6

    Topics: Citalopram; Cytochrome P-450 Enzyme System; DNA, Complementary; Fluvoxamine; Gene Expression; Humans; Ketoconazole; Kinetics; Methylation; Microsomes, Liver; Oxidation-Reduction; Quinidine; Recombinant Proteins; Stereoisomerism

1999
(R)-, (S)-, and racemic fluoxetine N-demethylation by human cytochrome P450 enzymes.
    Drug metabolism and disposition: the biological fate of chemicals, 2000, Volume: 28, Issue:10

    Topics: Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Fluoxetine; Humans; Isoenzymes; Ketoconazole; Kinetics; Methylation; Microsomes, Liver; Quinidine; Recombinant Proteins; Selective Serotonin Reuptake Inhibitors; Stereoisomerism; Sulfaphenazole

2000
CYP3A4 is the major CYP isoform mediating the in vitro hydroxylation and demethylation of flunitrazepam.
    Drug metabolism and disposition: the biological fate of chemicals, 2001, Volume: 29, Issue:2

    Topics: Anti-Anxiety Agents; Benzoflavones; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Inhibitors; Flunitrazepam; Humans; Hydroxylation; Isoenzymes; Ketoconazole; Kinetics; Methylation; Microsomes, Liver; Mixed Function Oxygenases; Omeprazole; Quinidine; Ritonavir; Sulfaphenazole; Transfection

2001
Quantitative contribution of CYP2D6 and CYP3A to oxycodone metabolism in human liver and intestinal microsomes.
    Drug metabolism and disposition: the biological fate of chemicals, 2004, Volume: 32, Issue:4

    Topics: Aryl Hydrocarbon Hydroxylases; Biotransformation; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; DNA, Complementary; Humans; Intestinal Mucosa; Intestines; Ketoconazole; Kinetics; Metabolic Clearance Rate; Methylation; Microsomes; Microsomes, Liver; Molecular Structure; Morphinans; Oxidoreductases, N-Demethylating; Oxycodone; Oxymorphone; Protein Binding; Quinidine

2004
Sequential metabolism is responsible for diltiazem-induced time-dependent loss of CYP3A.
    Drug metabolism and disposition: the biological fate of chemicals, 2007, Volume: 35, Issue:5

    Topics: Antifungal Agents; Calcium Channel Blockers; Cells, Cultured; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Diltiazem; Dose-Response Relationship, Drug; Enzyme Inhibitors; Hepatocytes; Humans; Ketoconazole; Kinetics; Methylation; Microsomes, Liver; Molecular Structure; Time Factors

2007
Enantioselective capillary electrophoresis for the assessment of CYP3A4-mediated ketamine demethylation and inhibition in vitro.
    Electrophoresis, 2011, Volume: 32, Issue:19

    Topics: beta-Cyclodextrins; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Electrophoresis, Capillary; gamma-Cyclodextrins; Humans; Ketamine; Ketoconazole; Kinetics; Methylation; Nonlinear Dynamics; Recombinant Proteins; Stereoisomerism

2011
Studies on hepatotoxicity and toxicokinetics of colchicine.
    Journal of biochemical and molecular toxicology, 2019, Volume: 33, Issue:9

    Topics: Animals; Colchicine; Cytochrome P-450 CYP3A; Ketoconazole; Liver; Male; Methylation; Mice

2019