ketoconazole and hki 272

ketoconazole has been researched along with hki 272 in 3 studies

Research

Studies (3)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	3 (100.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ	1
Abbas, R; Burns, J; Hug, B; Leister, C; Sonnichsen, D	1
Abbas, R; Burns, J; Hug, BA; Leister, C; Sonnichsen, D	1

Trials

2 trial(s) available for ketoconazole and hki 272

Article	Year
A single-dose, crossover, placebo- and moxifloxacin-controlled study to assess the effects of neratinib (HKI-272) on cardiac repolarization in healthy adult subjects. Clinical cancer research : an official journal of the American Association for Cancer Research, 2010, Aug-01, Volume: 16, Issue:15 Topics: Adolescent; Adult; Anti-Infective Agents; Antineoplastic Agents; Aza Compounds; Cross-Over Studies; Electrocardiography; Female; Fluoroquinolones; Heart; Humans; Ketoconazole; Male; Middle Aged; Moxifloxacin; Placebos; Quinolines; Young Adult	2010
Pharmacokinetics of oral neratinib during co-administration of ketoconazole in healthy subjects. British journal of clinical pharmacology, 2011, Volume: 71, Issue:4 Topics: Adolescent; Adult; Antifungal Agents; Area Under Curve; Cross-Over Studies; Cytochrome P-450 CYP3A Inhibitors; Dose-Response Relationship, Drug; Drug Interactions; Drug Therapy, Combination; Humans; Ketoconazole; Male; Middle Aged; Quinolines; Young Adult	2011

Article

Year

A single-dose, crossover, placebo- and moxifloxacin-controlled study to assess the effects of neratinib (HKI-272) on cardiac repolarization in healthy adult subjects.

Clinical cancer research : an official journal of the American Association for Cancer Research, 2010, Aug-01, Volume: 16, Issue:15

Topics: Adolescent; Adult; Anti-Infective Agents; Antineoplastic Agents; Aza Compounds; Cross-Over Studies; Electrocardiography; Female; Fluoroquinolones; Heart; Humans; Ketoconazole; Male; Middle Aged; Moxifloxacin; Placebos; Quinolines; Young Adult

2010

Pharmacokinetics of oral neratinib during co-administration of ketoconazole in healthy subjects.

British journal of clinical pharmacology, 2011, Volume: 71, Issue:4

Topics: Adolescent; Adult; Antifungal Agents; Area Under Curve; Cross-Over Studies; Cytochrome P-450 CYP3A Inhibitors; Dose-Response Relationship, Drug; Drug Interactions; Drug Therapy, Combination; Humans; Ketoconazole; Male; Middle Aged; Quinolines; Young Adult

2011

Other Studies

1 other study(ies) available for ketoconazole and hki 272

Article	Year
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests	2013

Article

Year

A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.

Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1

Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests

2013