Compounds > ketoconazole

ketoconazole and furafylline

ketoconazole has been researched along with furafylline in 42 studies

Research

Studies (42)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's7 (16.67)18.2507
2000's17 (40.48)29.6817
2010's18 (42.86)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Huan, Y; Liu, Z; Pan, X; Shen, Z; Sun, Z; Xiao, Z; Yang, Y; Zhou, T1
Battista, MR; Brun, R; Calvet, CM; Cirilli, R; Costi, R; De Leo, A; De Vita, D; Di Marco, A; Di Santo, R; Faggi, C; Jennings, GK; Kaiser, M; Madia, VN; Mäser, P; Messore, A; Pepe, G; Pescatori, L; Podust, LM; Saccoliti, F; Scipione, L; Summa, V; Tudino, V1
Caligari, S; Callegari, E; De Toma, C; Dilernia, R; Frigerio, F; Graziani, D; Longhi, M; Menegon, S; Pinzi, L; Pirona, L; Rastelli, G; Riva, C; Tazzari, V; Valsecchi, AE; Vistoli, G1
Adebesin, AM; Falck, JR; Fischer, R; Konkel, A; Lossie, J; Paudyal, MP; Puli, N; Schunck, WH; Vijaykumar, J; Wesser, T; Westphal, C; Zhu, C1
Hashizume, H; Kawasaki, M; Komatsu, M; Matsumoto, M; Sasaki, H; Shimokawa, Y; Tomishige, T; Tsubouchi, H1
Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J1
Fetzer, L; Frotscher, M; Hartmann, RW; Kruchten, P; Marchais-Oberwinkler, S; Messinger, J; Müller-Vieira, U; Neugebauer, A; Scherer, C; Thole, H; Ziegler, E1
Birk, B; Grombein, CM; Hartmann, RW; Heim, R; Lucas, S; Müller-Vieira, U; Negri, M; Ries, C; Schewe, KE1
Antes, I; Bisi, A; Gobbi, S; Hartmann, RW; Heim, R; Lucas, S; Negri, M; Ries, C; Schewe, KE1
Birk, B; Hartmann, RW; Heim, R; Lucas, S; Ries, C; Schewe, KE1
Barreiro, EJ; da Silva, LL; Fraga, AG; Fraga, CA1
Frotscher, M; Hartmann, RW; Henn, C; Kruchten, P; Marchais-Oberwinkler, S; Werth, R; Wetzel, M; Ziegler, E1
Hartmann, RW; Heim, R; Lucas, S; Negri, M; Zimmer, C1
Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR1
Calvet, CM; Cameron, MD; Choi, JY; Gunatilleke, SS; McKerrow, JH; Podust, LM; Roush, WR; Ruiz, C1
Andréola, ML; Bailly, F; Calmels, C; Christ, F; Cotelle, P; Debyser, Z; Lion, C; Suchaud, V1
Ahn, YG; Bang, HJ; Hong, DJ; Jung, SH; Kim, D; Kim, EY; Kim, J; Kim, M; Kim, YJ; Lee, K; Min, KH; Park, EJ; Suh, KH1
Bracke, ME; De Ryck, T; Katritzky, AR; Patronov, A; Roman, BI; Slavov, SH; Stevens, CV; Vanhoecke, BW1
Cho, H; Elkamhawy, A; Heo, JC; Kim, HY; Kim, KH; Lee, CO; Nam, DH; Pae, AN; Park, WK; Roh, EJ; Seol, HJ; Viswanath, AN; Yang, H1
Budriesi, R; Carosati, E; Chiarini, A; Chiu, FC; Cosimelli, B; Frosini, M; Fusi, F; Ioan, P; Katneni, K; Matucci, R; Micucci, M; Saponara, S; Severi, E; Spinelli, D1
Andréola, ML; Bailly, F; Billamboz, M; Christ, F; Cotelle, P; Debyser, Z; Lion, C; Suchaud, V1
Aljayyoussi, G; Amewu, RK; Angulo-Barturén, I; Bazaga, SF; Belén, M; Biagini, GA; Campo, B; Charman, SA; Chen, G; Davies, J; Martínez, MS; Nixon, GL; O' Neill, PM; Roberts, NL; Ryan, E; Sabbani, S; Shackleford, DM; Sharma, R; Shore, ER; Stocks, PA; Ward, SA1
Bayliss, MK; Eddershaw, PJ; Herriott, D; Manchee, GR; Park, GR; Ranshaw, LE; Tarbit, MH1
Feierman, DE; Lasker, JM1
Jones, BC; Smith, DA; Tyman, CA1
Back, DJ; Eagling, VA; Tjia, JF1
Benet, LZ; Salphati, L1
Hata, T; Iwasaki, K; Kaneko, H; Shiraga, T; Suzuki, A; Tozuka, Z1
Butters, CJ; McKillop, D; Wild, MJ1
de Groene, EM; Horbach, GJ; Kappers, WA; van Och, FM1
Horsmans, Y; Spatzenegger, M; Verbeeck, RK1
Anttila, M; Karnani, H; Nyman, L; Pelkonen, O; Salonen, JS; Taavitsainen, P1
Boobis, AR; Edwards, RJ; Kappers, WA; Murray, S1
Beckurts, KT; Brachtendorf, L; Fuhr, U; Hölscher, AH; Jetter, A1
Hyland, R; Jones, BC; Smith, DA1
Chiba, K; Kobayashi, K; Shimada, N; Urashima, K1
Fouda, HG; Khojasteh-Bakht, SC; Prakash, C; Rossulek, MI1
Honda, K; Inomata, S; Misawa, S; Nagashima, A; Tanaka, E1
Gottesdiener, KM; Kari, PP; Marbury, T; Miller, JL; Mistry, GC; Rodrigues, AD; Simpson, RC; Wagner, JA; Winchell, GA1
Fuhr, U; Kober, S; Mutschler, E; Spahn-Langguth, H; Zaigler, M1
Farid, NA; Hagihara, K; Ikeda, T; Ishizuka, T; Kazui, M; Kurihara, A; Nishiya, Y; Okazaki, O1
Camenisch, G; Chibale, K; Huth, F; Njuguna, NM; Schiller, H; Umehara, KI1

Trials

1 trial(s) available for ketoconazole and furafylline

ArticleYear
The effect of ketoconazole on the pharmacokinetics of a selective alpha 1A-adrenoceptor antagonist.
    Journal of clinical pharmacology, 2005, Volume: 45, Issue:6

    Topics: Administration, Oral; Adrenergic alpha-1 Receptor Antagonists; Adult; Area Under Curve; Carbon Radioisotopes; Coumarins; Cross-Over Studies; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Double-Blind Method; Drug Administration Schedule; Drug Therapy, Combination; Fomepizole; Half-Life; Humans; Ketoconazole; Male; Microsomes, Liver; Pyrazoles; Pyrimidinones; Quinidine; Receptors, Adrenergic, alpha-1; Sulfaphenazole; Theophylline

2005

Other Studies

41 other study(ies) available for ketoconazole and furafylline

ArticleYear
Design, synthesis and biological evaluation of a series of novel GPR40 agonists containing nitrogen heterocyclic rings.
    Bioorganic & medicinal chemistry letters, 2018, 10-01, Volume: 28, Issue:18

    Topics: Animals; Dose-Response Relationship, Drug; Drug Design; Isoindoles; Mice; Mice, Inbred ICR; Molecular Structure; Receptors, G-Protein-Coupled; Structure-Activity Relationship; Tetrahydroisoquinolines

2018
Design, Synthesis, and Biological Evaluation of New 1-(Aryl-1 H-pyrrolyl)(phenyl)methyl-1 H-imidazole Derivatives as Antiprotozoal Agents.
    Journal of medicinal chemistry, 2019, 02-14, Volume: 62, Issue:3

    Topics: Animals; Antiprotozoal Agents; Cytochrome P-450 Enzyme Inhibitors; Drug Design; Drug Evaluation, Preclinical; Humans; Imidazoles; Parasitic Sensitivity Tests; Trypanosoma

2019
Evaluation of Amides, Carbamates, Sulfonamides, and Ureas of 4-Prop-2-ynylidenecycloalkylamine as Potent, Selective, and Bioavailable Negative Allosteric Modulators of Metabotropic Glutamate Receptor 5.
    Journal of medicinal chemistry, 2019, 02-14, Volume: 62, Issue:3

    Topics: Allosteric Regulation; Amides; Animals; Biological Availability; Carbamates; CHO Cells; Cricetulus; Dogs; Excitatory Amino Acid Agents; Humans; Ligands; Rats; Receptor, Metabotropic Glutamate 5; Structure-Activity Relationship; Sulfonamides; Urea

2019
Development of Robust 17(
    Journal of medicinal chemistry, 2019, 11-27, Volume: 62, Issue:22

    Topics: Administration, Oral; Animals; Anti-Arrhythmia Agents; Arachidonic Acids; Dose-Response Relationship, Drug; Drug Stability; Epoxide Hydrolases; Esterification; Hepatocytes; Humans; Male; Mice; Microsomes, Liver; Myocardial Infarction; Myocytes, Cardiac; Rats, Sprague-Dawley; Rats, Wistar

2019
OPC-67683, a nitro-dihydro-imidazooxazole derivative with promising action against tuberculosis in vitro and in mice.
    PLoS medicine, 2006, Volume: 3, Issue:11

    Topics: Animals; Antitubercular Agents; Blood; Cell Line; Humans; In Vitro Techniques; Intracellular Membranes; Macrophages; Mammals; Mice; Microbial Sensitivity Tests; Microsomes, Liver; Mycobacterium; Mycobacterium bovis; Mycolic Acids; Nitroimidazoles; Oxazoles; Treatment Outcome; Tuberculosis

2006
Chemical genetics reveals a complex functional ground state of neural stem cells.
    Nature chemical biology, 2007, Volume: 3, Issue:5

    Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells

2007
Design, synthesis, and biological evaluation of (hydroxyphenyl)naphthalene and -quinoline derivatives: potent and selective nonsteroidal inhibitors of 17beta-hydroxysteroid dehydrogenase type 1 (17beta-HSD1) for the treatment of estrogen-dependent disease
    Journal of medicinal chemistry, 2008, Apr-10, Volume: 51, Issue:7

    Topics: 17-Hydroxysteroid Dehydrogenases; Animals; Aryl Hydrocarbon Hydroxylases; Binding Sites; Caco-2 Cells; Computer Simulation; Drug Design; Enzyme Inhibitors; Estrogens; Humans; Hydrogen Bonding; Liver; Male; Microsomes, Liver; Models, Molecular; Molecular Structure; Naphthalenes; Neoplasms, Hormone-Dependent; Quinolines; Rats; Rats, Sprague-Dawley; Stereoisomerism; Structure-Activity Relationship

2008
Overcoming undesirable CYP1A2 inhibition of pyridylnaphthalene-type aldosterone synthase inhibitors: influence of heteroaryl derivatization on potency and selectivity.
    Journal of medicinal chemistry, 2008, Aug-28, Volume: 51, Issue:16

    Topics: Animals; Cytochrome P-450 CYP11B2; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP1A2 Inhibitors; Fibrosis; Heart Failure; Humans; Male; Myocardium; Naphthalenes; Rats; Rats, Wistar; Structure-Activity Relationship

2008
Novel aldosterone synthase inhibitors with extended carbocyclic skeleton by a combined ligand-based and structure-based drug design approach.
    Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19

    Topics: Acids, Carbocyclic; Binding Sites; Computer Simulation; Crystallography, X-Ray; Cytochrome P-450 CYP11B2; Dose-Response Relationship, Drug; Drug Design; Humans; Ligands; Models, Chemical; Models, Molecular; Molecular Structure; Naphthalenes; Stereoisomerism; Structure-Activity Relationship

2008
In vivo active aldosterone synthase inhibitors with improved selectivity: lead optimization providing a series of pyridine substituted 3,4-dihydro-1H-quinolin-2-one derivatives.
    Journal of medicinal chemistry, 2008, Dec-25, Volume: 51, Issue:24

    Topics: Animals; Carbon; Chemistry, Pharmaceutical; Cytochrome P-450 CYP11B2; Cytochrome P-450 CYP1A2; Drug Design; Enzyme Inhibitors; Humans; Inhibitory Concentration 50; Liver; Pyridines; Quinolones; Rats; Temperature; U937 Cells

2008
CYP1A2-mediated biotransformation of cardioactive 2-thienylidene-3,4-methylenedioxybenzoylhydrazine (LASSBio-294) by rat liver microsomes and human recombinant CYP enzymes.
    European journal of medicinal chemistry, 2011, Volume: 46, Issue:1

    Topics: Animals; Biotransformation; Catalytic Domain; Chromatography, High Pressure Liquid; Chromatography, Liquid; Cytochrome P-450 CYP1A2; Heart; Humans; Hydrazones; Male; Mass Spectrometry; Microsomes, Liver; Models, Molecular; Rats; Rats, Wistar; Recombinant Proteins; Thiophenes

2011
New drug-like hydroxyphenylnaphthol steroidomimetics as potent and selective 17β-hydroxysteroid dehydrogenase type 1 inhibitors for the treatment of estrogen-dependent diseases.
    Journal of medicinal chemistry, 2011, Jan-27, Volume: 54, Issue:2

    Topics: 17-Hydroxysteroid Dehydrogenases; Administration, Oral; Animals; Biological Availability; Cell Line, Tumor; Cell Membrane Permeability; Cell-Free System; Estrogen Receptor alpha; Estrogen Receptor beta; Estrogens; Female; Humans; Liver; Male; Microsomes; Molecular Mimicry; Naphthols; Phenols; Placenta; Pregnancy; Rats; Rats, Sprague-Dawley; Rats, Wistar; Recombinant Proteins; Steroids; Structure-Activity Relationship

2011
Fine-tuning the selectivity of aldosterone synthase inhibitors: structure-activity and structure-selectivity insights from studies of heteroaryl substituted 1,2,5,6-tetrahydropyrrolo[3,2,1-ij]quinolin-4-one derivatives.
    Journal of medicinal chemistry, 2011, Apr-14, Volume: 54, Issue:7

    Topics: Animals; Cytochrome P-450 CYP11B2; Drug Design; Enzyme Inhibitors; Humans; Male; Models, Molecular; Protein Conformation; Quinolines; Rats; Rats, Wistar; Structure-Activity Relationship; Substrate Specificity

2011
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.
    Journal of medicinal chemistry, 2012, May-24, Volume: 55, Issue:10

    Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection

2012
Rational development of 4-aminopyridyl-based inhibitors targeting Trypanosoma cruzi CYP51 as anti-chagas agents.
    Journal of medicinal chemistry, 2013, Oct-10, Volume: 56, Issue:19

    Topics: 14-alpha Demethylase Inhibitors; Aminopyridines; Animals; Crystallography, X-Ray; Humans; Indoles; Mice; Microsomes, Liver; Molecular Docking Simulation; Rats; Stereoisomerism; Sterol 14-Demethylase; Structure-Activity Relationship; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosoma cruzi

2013
Investigation of a novel series of 2-hydroxyisoquinoline-1,3(2H,4H)-diones as human immunodeficiency virus type 1 integrase inhibitors.
    Journal of medicinal chemistry, 2014, Jun-12, Volume: 57, Issue:11

    Topics: Aryl Hydrocarbon Hydroxylases; Cell Line, Tumor; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Drug Resistance, Viral; HIV Integrase Inhibitors; HIV-1; Humans; Isoquinolines; Molecular Docking Simulation; Mutation; Structure-Activity Relationship

2014
Discovery of novel pyrimidine and malonamide derivatives as TGR5 agonists.
    Bioorganic & medicinal chemistry letters, 2014, Sep-01, Volume: 24, Issue:17

    Topics: Animals; Biological Availability; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Drug Discovery; HEK293 Cells; Humans; Malonates; Mice; Mice, Inbred ICR; Microsomes, Liver; Molecular Structure; Pyrimidines; Receptors, G-Protein-Coupled; Structure-Activity Relationship

2014
4-Fluoro-3',4',5'-trimethoxychalcone as a new anti-invasive agent. From discovery to initial validation in an in vivo metastasis model.
    European journal of medicinal chemistry, 2015, Aug-28, Volume: 101

    Topics: Animals; Antineoplastic Agents, Phytogenic; Biological Products; Cell Line, Tumor; Cell Movement; Cell Survival; Chalcones; Chick Embryo; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Discovery; Female; Humans; Mice; Mice, Nude; Molecular Structure; Myocardium; Neoplasm Invasiveness; Neoplasm Metastasis; Quantitative Structure-Activity Relationship

2015
Discovery of potent and selective cytotoxic activity of new quinazoline-ureas against TMZ-resistant glioblastoma multiforme (GBM).
    European journal of medicinal chemistry, 2015, Oct-20, Volume: 103

    Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Dacarbazine; Dose-Response Relationship, Drug; Drug Discovery; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Glioblastoma; Humans; Models, Molecular; Molecular Conformation; Quinazolines; Structure-Activity Relationship; Temozolomide; Urea

2015
Understanding Oxadiazolothiazinone Biological Properties: Negative Inotropic Activity versus Cytochrome P450-Mediated Metabolism.
    Journal of medicinal chemistry, 2016, Apr-14, Volume: 59, Issue:7

    Topics: Animals; Cells, Cultured; Cytochrome P-450 Enzyme System; Enzyme Inhibitors; Guinea Pigs; Heart Atria; Humans; Male; Microsomes, Liver; Myocytes, Cardiac; Oxadiazoles; Oxidation-Reduction; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship; Thiazines; Vasodilator Agents

2016
2-hydroxyisoquinoline-1,3(2H,4H)-diones (HIDs) as human immunodeficiency virus type 1 integrase inhibitors: Influence of the alkylcarboxamide substitution of position 4.
    European journal of medicinal chemistry, 2016, Jul-19, Volume: 117

    Topics: Alkylation; Anti-HIV Agents; Cell Line; Drug Resistance, Viral; HIV Integrase Inhibitors; Humans; Isoquinolines; Structure-Activity Relationship

2016
Synthesis and profiling of benzylmorpholine 1,2,4,5-tetraoxane analogue N205: Towards tetraoxane scaffolds with potential for single dose cure of malaria.
    Bioorganic & medicinal chemistry, 2018, 07-15, Volume: 26, Issue:11

    Topics: Administration, Oral; Animals; Antimalarials; Disease Models, Animal; Drug Stability; Humans; Inhibitory Concentration 50; Malaria; Mice; Morpholines; Plasmodium falciparum; Rats; Tetraoxanes

2018
The aliphatic oxidation of salmeterol to alpha-hydroxysalmeterol in human liver microsomes is catalyzed by CYP3A.
    Drug metabolism and disposition: the biological fate of chemicals, 1996, Volume: 24, Issue:5

    Topics: Adrenergic beta-Agonists; Albuterol; Biomarkers; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Disulfiram; Humans; Isoenzymes; Ketoconazole; Microsomes, Liver; Midazolam; Molecular Structure; Oxidation-Reduction; Quinidine; Recombinant Proteins; Salmeterol Xinafoate; Sulfaphenazole; Theophylline

1996
Metabolism of fentanyl, a synthetic opioid analgesic, by human liver microsomes. Role of CYP3A4.
    Drug metabolism and disposition: the biological fate of chemicals, 1996, Volume: 24, Issue:9

    Topics: Analgesics, Opioid; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2C8; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Fentanyl; Gas Chromatography-Mass Spectrometry; Humans; Ketoconazole; Kinetics; Microsomes, Liver; Mixed Function Oxygenases; Steroid 16-alpha-Hydroxylase; Steroid Hydroxylases; Theophylline; Tolbutamide

1996
Identification of the cytochrome P450 isoforms involved in the O-demethylation of 4-nitroanisole in human liver microsomes.
    Xenobiotica; the fate of foreign compounds in biological systems, 1997, Volume: 27, Issue:10

    Topics: Adult; Aged; Anisoles; Anti-Infective Agents; Anticoagulants; Antifungal Agents; Antimalarials; Binding, Competitive; Coumarins; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Inhibitors; Female; Humans; Isoenzymes; Ketoconazole; Kinetics; Male; Methylation; Microsomes, Liver; Middle Aged; Quinidine; Substrate Specificity; Sulfaphenazole; Theophylline

1997
Differential selectivity of cytochrome P450 inhibitors against probe substrates in human and rat liver microsomes.
    British journal of clinical pharmacology, 1998, Volume: 45, Issue:2

    Topics: Animals; Chlorzoxazone; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Ditiocarb; Enzyme Inhibitors; Humans; Ketoconazole; Kinetics; Male; Microsomes, Liver; Phenacetin; Rats; Rats, Wistar; Substrate Specificity; Sulfaphenazole; Testosterone; Theophylline; Tolbutamide

1998
Metabolism of digoxin and digoxigenin digitoxosides in rat liver microsomes: involvement of cytochrome P4503A.
    Xenobiotica; the fate of foreign compounds in biological systems, 1999, Volume: 29, Issue:2

    Topics: Animals; Aryl Hydrocarbon Hydroxylases; Cells, Cultured; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Digoxigenin; Digoxin; Enzyme Inhibitors; Female; Humans; Ketoconazole; Kinetics; Male; Microsomes, Liver; Models, Chemical; Oxidoreductases, N-Demethylating; Rats; Rats, Sprague-Dawley; Theophylline

1999
Identification of cytochrome P450 enzymes involved in the metabolism of zotepine, an antipsychotic drug, in human liver microsomes.
    Xenobiotica; the fate of foreign compounds in biological systems, 1999, Volume: 29, Issue:3

    Topics: Antipsychotic Agents; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dibenzothiepins; Enzyme Inhibitors; Humans; Immune Sera; Isoenzymes; Ketoconazole; Microsomes, Liver; Oxidation-Reduction; Quinidine; Recombinant Proteins; Theophylline

1999
Determination of the human cytochrome P450 isoforms involved in the metabolism of zolmitriptan.
    Xenobiotica; the fate of foreign compounds in biological systems, 1999, Volume: 29, Issue:8

    Topics: Cimetidine; Clorgyline; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Inhibitors; Female; Humans; Isoenzymes; Ketoconazole; Liver; Male; Microsomes, Liver; Omeprazole; Oxazoles; Oxazolidinones; Recombinant Proteins; Serotonin Receptor Agonists; Theophylline; Tryptamines

1999
Comparison of three different in vitro mutation assays used for the investigation of cytochrome P450-mediated mutagenicity of nitro-polycyclic aromatic hydrocarbons.
    Mutation research, 2000, Mar-23, Volume: 466, Issue:2

    Topics: 3T3 Cells; Animals; Cell Line; Cell Survival; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Enzyme Inhibitors; Ethyl Methanesulfonate; Fluorenes; Humans; Hypoxanthine Phosphoribosyltransferase; Ketoconazole; Lac Operon; Mice; Microsomes, Liver; Mutagenicity Tests; Mutagens; Mutation; Polycyclic Aromatic Hydrocarbons; Pyrenes; Rats; Recombinant Fusion Proteins; Salmonella typhimurium; Theophylline

2000
Differential activities of CYP1A isozymes in hepatic and intestinal microsomes of control and 3-methylcholanthrene-induced rats.
    Pharmacology & toxicology, 2000, Volume: 86, Issue:2

    Topics: Animals; Caffeine; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP1A2 Inhibitors; Enzyme Induction; Enzyme Inhibitors; Injections, Intraperitoneal; Intestine, Small; Ketoconazole; Liver; Male; Methylcholanthrene; Microsomes, Liver; Rats; Rats, Wistar; Theobromine; Theophylline

2000
Selegiline metabolism and cytochrome P450 enzymes: in vitro study in human liver microsomes.
    Pharmacology & toxicology, 2000, Volume: 86, Issue:5

    Topics: Amphetamines; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP2C19; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Fluvoxamine; Humans; Ketoconazole; Methamphetamine; Microsomes, Liver; Mixed Function Oxygenases; Monoamine Oxidase Inhibitors; Selegiline; Theophylline

2000
Diazinon is activated by CYP2C19 in human liver.
    Toxicology and applied pharmacology, 2001, Nov-15, Volume: 177, Issue:1

    Topics: Aryl Hydrocarbon Hydroxylases; Biotransformation; Cytochrome P-450 CYP2B6; Cytochrome P-450 CYP2C19; Cytochrome P-450 Enzyme System; Diazinon; Dose-Response Relationship, Drug; Humans; Insecticides; Ketoconazole; Liver; Microsomes, Liver; Mixed Function Oxygenases; Oxidoreductases, N-Demethylating; Recombinant Proteins; Theophylline; Troleandomycin

2001
Cytochrome P450 enzymes contributing to demethylation of maprotiline in man.
    Pharmacology & toxicology, 2002, Volume: 90, Issue:3

    Topics: Cells, Cultured; Chlorzoxazone; Coumarins; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzymes; Humans; Ketoconazole; Kinetics; Maprotiline; Mephenytoin; Microsomes, Liver; Models, Biological; Quinidine; Sulfaphenazole; Theophylline

2002
Identification of the cytochrome P450 enzymes involved in the N-oxidation of voriconazole.
    Drug metabolism and disposition: the biological fate of chemicals, 2003, Volume: 31, Issue:5

    Topics: Antifungal Agents; Chromatography, High Pressure Liquid; Cyclic N-Oxides; Cytochrome P-450 Enzyme System; Enzyme Inhibitors; Humans; In Vitro Techniques; Ketoconazole; Microsomes, Liver; Oxidation-Reduction; Pyrimidines; Quinidine; Sulfaphenazole; Theophylline; Triazoles; Voriconazole

2003
Selectivities of human cytochrome P450 inhibitors toward rat P450 isoforms: study with cDNA-expressed systems of the rat.
    Drug metabolism and disposition: the biological fate of chemicals, 2003, Volume: 31, Issue:7

    Topics: Aniline Compounds; Animals; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP1A2 Inhibitors; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP2E1 Inhibitors; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Cytochrome P450 Family 2; DNA, Complementary; Enzyme Inhibitors; Gene Expression; Humans; Isoenzymes; Ketoconazole; Methoxsalen; Microsomes, Liver; Quinidine; Rats; Steroid 16-alpha-Hydroxylase; Steroid 21-Hydroxylase; Steroid Hydroxylases; Substrate Specificity; Sulfaphenazole; Theophylline

2003
Identification of the human cytochrome P450s responsible for the in vitro metabolism of a leukotriene B4 receptor antagonist, CP-195,543.
    Xenobiotica; the fate of foreign compounds in biological systems, 2003, Volume: 33, Issue:12

    Topics: Adolescent; Adult; Aged; Chromans; Coumarins; Cytochrome P-450 CYP1A2 Inhibitors; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Inhibitors; Female; Humans; Ketoconazole; Kinetics; Male; Mephenytoin; Microsomes, Liver; Middle Aged; NADP; Oxidation-Reduction; Quinidine; Receptors, Leukotriene B4; Recombinant Proteins; Sulfaphenazole; Theophylline

2003
A study of the in vitro interaction between lidocaine and premedications using human liver microsomes.
    Journal of clinical pharmacy and therapeutics, 2005, Volume: 30, Issue:2

    Topics: Animals; Cimetidine; Clonidine; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP1A2 Inhibitors; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Drug Combinations; Drug Interactions; Enzyme Inhibitors; Humans; Inhibitory Concentration 50; Ketoconazole; Lidocaine; Microsomes, Liver; Midazolam; Neuromuscular Depolarizing Agents; Pentobarbital; Pharmacogenetics; Premedication; Rats; Theophylline; Thiamylal

2005
Rate-limiting biotransformation of triamterene is mediated by CYP1A2.
    International journal of clinical pharmacology and therapeutics, 2005, Volume: 43, Issue:7

    Topics: Caffeine; Chromatography, High Pressure Liquid; Coumarins; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP1A2 Inhibitors; Dose-Response Relationship, Drug; Enzyme Inhibitors; Erythromycin; Humans; Hydroxylation; Ketoconazole; Kinetics; Microsomes, Liver; Omeprazole; Quinidine; Substrate Specificity; Sulfuric Acid Esters; Theophylline; Triamterene

2005
Identification of the human cytochrome P450 enzymes involved in the two oxidative steps in the bioactivation of clopidogrel to its pharmacologically active metabolite.
    Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:1

    Topics: Antibodies; Aryl Hydrocarbon Hydroxylases; Biocatalysis; Biotransformation; Cell Line; Cell Line, Tumor; Clopidogrel; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP1A2 Inhibitors; Cytochrome P-450 CYP2B6; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Inhibitors; Glutathione; Humans; Ketoconazole; Kinetics; Mephenytoin; Microsomes; Microsomes, Liver; NADP; Omeprazole; Oxidation-Reduction; Oxidoreductases, N-Demethylating; Platelet Aggregation Inhibitors; Sulfaphenazole; Theophylline; Ticlopidine

2010
Improvement of the chemical inhibition phenotyping assay by cross-reactivity correction.
    Drug metabolism and personalized therapy, 2016, 12-01, Volume: 31, Issue:4

    Topics: Acetates; Cyclopropanes; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Humans; Ketoconazole; Phenotype; Quinidine; Quinolines; Sulfaphenazole; Sulfides; Theophylline; Ticlopidine

2016