ketoconazole has been researched along with fadrozole in 23 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (4.35) | 18.7374 |
| 1990's | 4 (17.39) | 18.2507 |
| 2000's | 10 (43.48) | 29.6817 |
| 2010's | 8 (34.78) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Antes, I; Hartmann, RW; Klein, CD; Lengauer, T; Müller-Vieira, U; Ulmschneider, S | 1 |
| Antes, I; Biemel, K; Hartmann, RW; Marchais-Oberwinkler, S; Müller-Vieira, U; Scherer, C; Voets, M | 1 |
| Cole, PA; Robinson, CH | 1 |
| Belluti, F; Bisi, A; Cavalli, A; Gobbi, S; Hartmann, RW; Palusczak, A; Palzer, M; Rampa, A; Recanatini, M; Valenti, P | 1 |
| Antes, I; Bernhardt, R; Bureik, M; Hartmann, RW; Klein, CD; Lengauer, T; Mitrenga, M; Müller-Vieira, U; Oberwinkler-Marchais, S; Ulmschneider, S | 1 |
| Antes, I; Barassin, C; Biemel, K; Hartmann, RW; Marchais-Oberwinkler, S; Müller-Vieira, U; Scherer, C; Voets, M | 1 |
| Birk, B; Grombein, CM; Hartmann, RW; Heim, R; Lucas, S; Müller-Vieira, U; Negri, M; Ries, C; Schewe, KE | 1 |
| Antes, I; Bisi, A; Gobbi, S; Hartmann, RW; Heim, R; Lucas, S; Negri, M; Ries, C; Schewe, KE | 1 |
| Birk, B; Hartmann, RW; Heim, R; Lucas, S; Ries, C; Schewe, KE | 1 |
| Muftuoglu, Y; Mustata, G | 1 |
| Belluti, F; Bisi, A; Gobbi, S; Hartmann, RW; Rampa, A; Recanatini, M; Zimmer, C | 1 |
| Ammann, D; Hafner, M; Hartmann, RW; Vock, CA; Zender, M; Zimmer, C | 1 |
| Carotti, A; Catto, M; Favia, AD; Hartmann, RW; Leonetti, F; Nicolotti, O; Pisani, L; Stefanachi, A; Zimmer, C | 1 |
| Hartmann, RW; Heim, R; Lucas, S; Negri, M; Zimmer, C | 1 |
| Hartmann, RW; Hu, Q; Yin, L | 1 |
| Grombein, CM; Hartmann, RW; Hu, Q; Rau, S; Zimmer, C | 1 |
| Nicholls, PJ; Shaw, MA; Smith, HJ | 1 |
| Bhatnagar, AS; King, EJ; Purba, HS; Richert, P | 1 |
| Moslemi, S; Seralini, GE | 1 |
| Carney, EW; Crissman, JW; Marty, MS | 2 |
| Giesy, JP; Hecker, M; Higley, EB; Jones, PD; Murphy, MB; Newsted, JL; Wu, R | 1 |
| Ankley, GT; Jensen, KM; Mayo, M; Perkins, EJ; Villeneuve, DL; Watanabe, KH | 1 |
2 review(s) available for ketoconazole and fadrozole
| Article | Year |
|---|---|
Mechanism and inhibition of cytochrome P-450 aromatase.
Topics: Affinity Labels; Aromatase; Aromatase Inhibitors; Binding, Competitive; Humans; Molecular Structure; Photochemistry | 1990 |
Aminoglutethimide and ketoconazole: historical perspectives and future prospects.
Topics: Adrenal Gland Neoplasms; Aminoglutethimide; Aromatase Inhibitors; Breast Neoplasms; Fadrozole; Female; Humans; Imidazoles; Ketoconazole; Male; Nitriles; Prostatic Neoplasms | 1988 |
21 other study(ies) available for ketoconazole and fadrozole
| Article | Year |
|---|---|
Synthesis and evaluation of (pyridylmethylene)tetrahydronaphthalenes/-indanes and structurally modified derivatives: potent and selective inhibitors of aldosterone synthase.
Topics: Adrenal Cortex Hormones; Aromatase; Cell Line; Cytochrome P-450 CYP11B2; Escherichia coli; Humans; In Vitro Techniques; Indans; Microsomes; Models, Molecular; Molecular Conformation; Placenta; Pyridines; Schizosaccharomyces; Stereoisomerism; Steroid 11-beta-Hydroxylase; Steroid 17-alpha-Hydroxylase; Structure-Activity Relationship; Tetrahydronaphthalenes | 2005 |
Synthesis and evaluation of heteroaryl-substituted dihydronaphthalenes and indenes: potent and selective inhibitors of aldosterone synthase (CYP11B2) for the treatment of congestive heart failure and myocardial fibrosis.
Topics: Animals; Binding Sites; Cell Line; Cell Membrane Permeability; Cricetinae; Cricetulus; Cytochrome P-450 CYP11B2; Fibrosis; Heart Failure; Humans; Indenes; Models, Molecular; Myocardium; Naphthalenes; Schizosaccharomyces; Structure-Activity Relationship | 2006 |
A new class of nonsteroidal aromatase inhibitors: design and synthesis of chromone and xanthone derivatives and inhibition of the P450 enzymes aromatase and 17 alpha-hydroxylase/C17,20-lyase.
Topics: Aromatase Inhibitors; Chromones; Drug Design; Enzyme Inhibitors; Humans; In Vitro Techniques; Male; Microsomes; Models, Molecular; Placenta; Steroid 17-alpha-Hydroxylase; Structure-Activity Relationship; Testis; Xanthenes; Xanthones | 2001 |
Synthesis and evaluation of imidazolylmethylenetetrahydronaphthalenes and imidazolylmethyleneindanes: potent inhibitors of aldosterone synthase.
Topics: Animals; Aromatase; Aromatase Inhibitors; Aryl Hydrocarbon Hydroxylases; Cattle; Cell Line; Cytochrome P-450 CYP11B2; Cytochrome P-450 CYP2C9; Humans; Imidazoles; Indans; Indenes; Models, Molecular; Schizosaccharomyces; Stereoisomerism; Steroid 11-beta-Hydroxylase; Steroid 17-alpha-Hydroxylase; Structure-Activity Relationship; Tetrahydronaphthalenes | 2005 |
Heteroaryl-substituted naphthalenes and structurally modified derivatives: selective inhibitors of CYP11B2 for the treatment of congestive heart failure and myocardial fibrosis.
Topics: Aromatase; Aromatase Inhibitors; Caco-2 Cells; Cell Membrane Permeability; Cytochrome P-450 CYP11B2; Fibrosis; Heart Failure; Humans; In Vitro Techniques; Liver; Microsomes, Liver; Models, Molecular; Myocardium; Naphthalenes; Schizosaccharomyces; Steroid 11-beta-Hydroxylase; Steroid 17-alpha-Hydroxylase; Structure-Activity Relationship | 2005 |
Overcoming undesirable CYP1A2 inhibition of pyridylnaphthalene-type aldosterone synthase inhibitors: influence of heteroaryl derivatization on potency and selectivity.
Topics: Animals; Cytochrome P-450 CYP11B2; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP1A2 Inhibitors; Fibrosis; Heart Failure; Humans; Male; Myocardium; Naphthalenes; Rats; Rats, Wistar; Structure-Activity Relationship | 2008 |
Novel aldosterone synthase inhibitors with extended carbocyclic skeleton by a combined ligand-based and structure-based drug design approach.
Topics: Acids, Carbocyclic; Binding Sites; Computer Simulation; Crystallography, X-Ray; Cytochrome P-450 CYP11B2; Dose-Response Relationship, Drug; Drug Design; Humans; Ligands; Models, Chemical; Models, Molecular; Molecular Structure; Naphthalenes; Stereoisomerism; Structure-Activity Relationship | 2008 |
In vivo active aldosterone synthase inhibitors with improved selectivity: lead optimization providing a series of pyridine substituted 3,4-dihydro-1H-quinolin-2-one derivatives.
Topics: Animals; Carbon; Chemistry, Pharmaceutical; Cytochrome P-450 CYP11B2; Cytochrome P-450 CYP1A2; Drug Design; Enzyme Inhibitors; Humans; Inhibitory Concentration 50; Liver; Pyridines; Quinolones; Rats; Temperature; U937 Cells | 2008 |
Pharmacophore modeling strategies for the development of novel nonsteroidal inhibitors of human aromatase (CYP19).
Topics: Antineoplastic Agents; Aromatase; Aromatase Inhibitors; Binding Sites; Breast Neoplasms; Computer Simulation; Drug Design; Female; Humans; Models, Chemical; Models, Molecular; Structure-Activity Relationship | 2010 |
Novel highly potent and selective nonsteroidal aromatase inhibitors: synthesis, biological evaluation and structure-activity relationships investigation.
Topics: Aromatase Inhibitors; Female; Humans; Imidazoles; In Vitro Techniques; Microsomes; Molecular Conformation; Placenta; Pregnancy; Steroid 17-alpha-Hydroxylase; Structure-Activity Relationship; Thioxanthenes; Xanthones | 2010 |
N-(Pyridin-3-yl)benzamides as selective inhibitors of human aldosterone synthase (CYP11B2).
Topics: Aromatase; Benzamides; Cytochrome P-450 CYP11B2; Enzyme Inhibitors; Humans; Steroid 11-beta-Hydroxylase; Steroid 17-alpha-Hydroxylase; Structure-Activity Relationship | 2011 |
Design, synthesis, and biological evaluation of imidazolyl derivatives of 4,7-disubstituted coumarins as aromatase inhibitors selective over 17-α-hydroxylase/C17-20 lyase.
Topics: Aromatase Inhibitors; Cell Line; Coumarins; Drug Design; Escherichia coli; Female; Humans; Imidazoles; In Vitro Techniques; Ligands; Microsomes; Models, Molecular; Placenta; Pregnancy; Protein Binding; Steroid 17-alpha-Hydroxylase; Structure-Activity Relationship | 2011 |
Fine-tuning the selectivity of aldosterone synthase inhibitors: structure-activity and structure-selectivity insights from studies of heteroaryl substituted 1,2,5,6-tetrahydropyrrolo[3,2,1-ij]quinolin-4-one derivatives.
Topics: Animals; Cytochrome P-450 CYP11B2; Drug Design; Enzyme Inhibitors; Humans; Male; Models, Molecular; Protein Conformation; Quinolines; Rats; Rats, Wistar; Structure-Activity Relationship; Substrate Specificity | 2011 |
Aldosterone synthase inhibitors as promising treatments for mineralocorticoid dependent cardiovascular and renal diseases.
Topics: Aldosterone; Animals; Benzimidazoles; Cardiovascular Diseases; Cytochrome P-450 CYP11B2; Fadrozole; Humans; Indans; Indoles; Kidney Diseases; Mineralocorticoids; Naphthalenes; Quinolines; Receptors, Mineralocorticoid | 2014 |
Heteroatom insertion into 3,4-dihydro-1H-quinolin-2-ones leads to potent and selective inhibitors of human and rat aldosterone synthase.
Topics: Animals; Cell Line; Cytochrome P-450 CYP11B2; Dose-Response Relationship, Drug; Enzyme Inhibitors; Humans; Molecular Structure; Quinolones; Rats; Steroid 11-beta-Hydroxylase; Structure-Activity Relationship | 2015 |
Effect of aromatase inhibitors on estrogen 2-hydroxylase in rat liver.
Topics: Aminoglutethimide; Androstenedione; Animals; Aromatase Inhibitors; Binding, Competitive; Cytochrome P-450 CYP1A1; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Estradiol; Estrone; Fadrozole; Female; Ketoconazole; Microsomes, Liver; Rats; Rats, Sprague-Dawley; Steroid Hydroxylases; Substrate Specificity | 1994 |
Inhibition and inactivation of equine aromatase by steroidal and non-steroidal compounds. A comparison with human aromatase inhibition.
Topics: Androstenedione; Animals; Aromatase Inhibitors; Enzyme Activation; Fadrozole; Horses; Humans; Imidazoles; Ketoconazole; Male; Miconazole; Substrate Specificity | 1997 |
Evaluation of the EDSTAC female pubertal assay in CD rats using 17beta-estradiol, steroid biosynthesis inhibitors, and a thyroid inhibitor.
Topics: 5-alpha Reductase Inhibitors; Animals; Antineoplastic Agents, Hormonal; Antithyroid Agents; Endocrine Glands; Enzyme Inhibitors; Estradiol; Evaluation Studies as Topic; Fadrozole; Female; Finasteride; Ketoconazole; Male; Organ Size; Propylthiouracil; Rats; Rats, Inbred Strains; Sexual Maturation; Steroids; Testolactone; Thyroid Hormones; Toxicology; Uterus; Weight Gain | 1999 |
Evaluation of the male pubertal onset assay to detect testosterone and steroid biosynthesis inhibitors in CD rats.
Topics: Animals; Body Weight; Dihydrotestosterone; Fadrozole; Finasteride; Genitalia, Male; Hormone Antagonists; Ketoconazole; Liver; Male; Organ Size; Rats; Rats, Sprague-Dawley; Sexual Maturation; Testolactone; Testosterone; Thyroid Gland; Toxicity Tests; Weaning | 2001 |
Human adrenocarcinoma (H295R) cells for rapid in vitro determination of effects on steroidogenesis: hormone production.
Topics: Adrenal Cortex; Adrenocortical Carcinoma; Aminoglutethimide; Antifungal Agents; Aromatase Inhibitors; Cell Line, Tumor; Cell Survival; Dose-Response Relationship, Drug; Endocrine Disruptors; Enzyme-Linked Immunosorbent Assay; Estradiol; Fadrozole; Fungicides, Industrial; Gonadal Steroid Hormones; Humans; Imidazoles; Ketoconazole; Oxazoles; Progesterone; Testosterone | 2006 |
Predicting Fecundity of Fathead Minnows (Pimephales promelas) Exposed to Endocrine-Disrupting Chemicals Using a MATLAB®-Based Model of Oocyte Growth Dynamics.
Topics: Animals; Cell Proliferation; Cyprinidae; Endocrine Disruptors; Environmental Exposure; Fadrozole; Fertility; Imidazoles; Ketoconazole; Models, Biological; Oocytes; Reproduction; Trenbolone Acetate; Triazoles; Vitellogenins | 2016 |