ketoconazole and diltiazem

ketoconazole has been researched along with diltiazem in 38 studies

Research

Studies (38)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	6 (15.79)	18.2507
2000's	16 (42.11)	29.6817
2010's	15 (39.47)	24.3611
2020's	1 (2.63)	2.80

Authors

Authors	Studies
Huang, L; Humphreys, JE; Morgan, JB; Polli, JW; Serabjit-Singh, CS; Webster, LO; Wring, SA	1
Keserü, GM	1
Nagashima, R; Nishikawa, T; Tobita, M	1
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL	1
Jia, L; Sun, H	1
Artursson, P; Bergström, CA; Hoogstraate, J; Matsson, P; Norinder, U; Pedersen, JM	1
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM	1
Pratim Roy, P; Roy, K	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
García-Mera, X; González-Díaz, H; Prado-Prado, FJ	1
Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ	1
Chen, X; Lin, X; Skolnik, S; Wang, J	1
Aidasani, DK; Chen, X; Henne, KR; Johnson, MG; Mason, AK; Rock, DA; Stresser, DM; Subramanian, R; Teffera, Y; Tonn, GR; Tran, TB; VandenBrink, BM; Wong, BK; Wong, SG	1
Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR	1
Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY	1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Budriesi, R; Carosati, E; Chiarini, A; Chiu, FC; Cosimelli, B; Frosini, M; Fusi, F; Ioan, P; Katneni, K; Matucci, R; Micucci, M; Saponara, S; Severi, E; Spinelli, D	1
Aravoglou, M; Henricsson, S; Lindholm, A	1
Brunson, ME; Howard, RJ; Karlix, JL; Patton, PR; Peterson, JC; Pfaff, WW; Ramos, EL	1
Jones, TE	2
McLachlan, AJ; Tett, SE	1
Elberg, A; Foradori, A; Mezzano, S; Pefaur, J; Videla, C	1
Akhlaghi, F; Kaan, A; Keogh, AM; McLachlan, AJ	1
Akhlaghi, F; Keogh, AM; McLachlan, AJ; Ray, JE	1
AL-Shurbaji, A; Alván, G; Annas, A; Carlström, K	1
Kohno, Y; Suzuki, A; Yamamoto, T	1
Baba, T; Kanazu, T; Koike, M; Okamura, N; Yamaguchi, Y	1
Abdallah, H; Chu, N; Huan, BL; Hussein, Z; Jerling, M; Leung, K	1
Keogh, AM; McLachlan, AJ; Ray, JE	1
Kunze, KL; Lee, CA; Zhao, P	1
Bergman, AJ; Chodakewitz, J; Fraser, IP; Friedman, EJ; Larson, PJ; Li, CC; Stoch, SA; Wagner, JA; Wang, YH	1
Cruz, HG; Dingemanse, J; Gehin, M; Hoever, P	1
Chiu, YY; Ereshefsky, L; Loebel, A; Poola, N; Preskorn, SH	1
Boyd, RA; Byon, W; Dias, C; Frost, CE; LaCreta, F; Schuster, AE; Shenker, A; Song, Y; Wang, J; Yu, Z; Zhang, D	1
Chakravarthy, M; Kraft, WK; Liu, W; Mangin, E; Martinez-Cantarin, MP; McCrea, JB; Panebianco, D; Wrishko, RE; Yee, KL	1
Dickinson, GL; Hall, SD; Kulanthaivel, P; Morse, BL; Posada, MM; Turner, PK	1

Reviews

3 review(s) available for ketoconazole and diltiazem

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016
The use of other drugs to allow a lower dosage of cyclosporin to be used. Therapeutic and pharmacoeconomic considerations. Clinical pharmacokinetics, 1997, Volume: 32, Issue:5 Topics: Aryl Hydrocarbon Hydroxylases; Australia; Cyclosporine; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Diltiazem; Drug Synergism; Enzyme Inhibitors; Graft Rejection; Humans; Immunosuppressive Agents; Ketoconazole; New Zealand; Organ Transplantation; Oxidoreductases, N-Demethylating	1997
Lurasidone drug-drug interaction studies: a comprehensive review. Drug metabolism and drug interactions, 2014, Volume: 29, Issue:3 Topics: Antipsychotic Agents; Area Under Curve; Clinical Trials, Phase I as Topic; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inducers; Cytochrome P-450 CYP3A Inhibitors; Diltiazem; Drug Interactions; Drug Therapy, Combination; Humans; Isoindoles; Ketoconazole; Lithium Compounds; Lurasidone Hydrochloride; Rifampin; Thiazoles	2014

Trials

7 trial(s) available for ketoconazole and diltiazem

Article	Year
A preliminary report of diltiazem and ketoconazole. Their cyclosporine-sparing effect and impact on transplant outcome. Transplantation, 1994, Mar-27, Volume: 57, Issue:6 Topics: Adult; Blood Pressure; Costs and Cost Analysis; Creatinine; Cyclosporine; Diltiazem; Dose-Response Relationship, Drug; Female; Graft Rejection; Humans; Ketoconazole; Kidney; Kidney Transplantation; Male; Middle Aged; Treatment Outcome	1994
Modification of the pharmacokinetics of cyclosporine A and metabolites by the concomitant use of Neoral and diltiazem or ketoconazol in stable adult kidney transplants. Transplantation proceedings, 1998, Volume: 30, Issue:5 Topics: Administration, Oral; Adult; Antifungal Agents; Calcium Channel Blockers; Cyclosporine; Diltiazem; Drug Interactions; Drug Monitoring; Drug Therapy, Combination; Half-Life; Humans; Immunosuppressive Agents; Ketoconazole; Kidney Transplantation; Regression Analysis	1998
Studies to investigate the pharmacokinetic interactions between ranolazine and ketoconazole, diltiazem, or simvastatin during combined administration in healthy subjects. Journal of clinical pharmacology, 2005, Volume: 45, Issue:4 Topics: Acetanilides; Adolescent; Adult; Diltiazem; Double-Blind Method; Drug Combinations; Drug Interactions; Female; Humans; Ketoconazole; Male; Middle Aged; Piperazines; Ranolazine; Simvastatin	2005
Effect of different durations and formulations of diltiazem on the single-dose pharmacokinetics of midazolam: how long do we go? Journal of clinical pharmacology, 2011, Volume: 51, Issue:11 Topics: Adult; Area Under Curve; Chemistry, Pharmaceutical; Cross-Over Studies; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Diltiazem; Drug Interactions; Female; Humans; Ketoconazole; Male; Midazolam; Middle Aged; Sensitivity and Specificity; Young Adult	2011
Pharmacokinetic interactions between the orexin receptor antagonist almorexant and the CYP3A4 inhibitors ketoconazole and diltiazem. Journal of pharmaceutical sciences, 2014, Volume: 103, Issue:5 Topics: Acetamides; Adult; Area Under Curve; Cross-Over Studies; Cytochrome P-450 CYP3A; Diltiazem; Drug Interactions; Enzyme Inhibitors; Humans; Isoquinolines; Ketoconazole; Male; Orexin Receptor Antagonists; Young Adult	2014
Effect of ketoconazole and diltiazem on the pharmacokinetics of apixaban, an oral direct factor Xa inhibitor. British journal of clinical pharmacology, 2015, Volume: 79, Issue:5 Topics: Adolescent; Adult; Cross-Over Studies; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Diltiazem; Dose-Response Relationship, Drug; Drug Interactions; Factor Xa Inhibitors; Female; Healthy Volunteers; Humans; Ketoconazole; Male; Middle Aged; Pyrazoles; Pyridones; Young Adult	2015
Effect of CYP3A Inhibition and Induction on the Pharmacokinetics of Suvorexant: Two Phase I, Open-Label, Fixed-Sequence Trials in Healthy Subjects. Clinical drug investigation, 2019, Volume: 39, Issue:5 Topics: Administration, Oral; Adult; Azepines; Cytochrome P-450 CYP3A Inducers; Cytochrome P-450 CYP3A Inhibitors; Diltiazem; Drug Interactions; Healthy Volunteers; Humans; Ketoconazole; Male; Middle Aged; Orexin Receptor Antagonists; Rifampin; Triazoles; Young Adult	2019

Other Studies

28 other study(ies) available for ketoconazole and diltiazem

Article	Year
Rational use of in vitro P-glycoprotein assays in drug discovery. The Journal of pharmacology and experimental therapeutics, 2001, Volume: 299, Issue:2 Topics: Adenosine Triphosphatases; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cells, Cultured; Chromatography, Liquid; Enzyme Inhibitors; Fluoresceins; Fluorescent Dyes; Humans; Mass Spectrometry; Pharmacology; Spodoptera	2001
Prediction of hERG potassium channel affinity by traditional and hologram qSAR methods. Bioorganic & medicinal chemistry letters, 2003, Aug-18, Volume: 13, Issue:16 Topics: Cation Transport Proteins; Databases, Factual; Discriminant Analysis; Ether-A-Go-Go Potassium Channels; Holography; Linear Models; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Quantitative Structure-Activity Relationship	2003
A discriminant model constructed by the support vector machine method for HERG potassium channel inhibitors. Bioorganic & medicinal chemistry letters, 2005, Jun-02, Volume: 15, Issue:11 Topics: Animals; CHO Cells; Cricetinae; Discriminant Analysis; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Potassium Channel Blockers; Potassium Channels, Voltage-Gated	2005
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling. Current drug discovery technologies, 2004, Volume: 1, Issue:4 Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration	2004
Support vector machines classification of hERG liabilities based on atom types. Bioorganic & medicinal chemistry, 2008, Jun-01, Volume: 16, Issue:11 Topics: Animals; Arrhythmias, Cardiac; CHO Cells; Computer Simulation; Cricetinae; Cricetulus; Discriminant Analysis; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Models, Chemical; Patch-Clamp Techniques; Potassium Channel Blockers; Potassium Channels, Voltage-Gated; Predictive Value of Tests; ROC Curve	2008
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2). Journal of medicinal chemistry, 2008, Jun-12, Volume: 51, Issue:11 Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Computer Simulation; Cytochrome P-450 Enzyme System; Drug-Related Side Effects and Adverse Reactions; Estradiol; Humans; Insecta; Liver; Models, Molecular; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Pharmaceutical Preparations; Pharmacology; Structure-Activity Relationship	2008
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1. Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19 Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship	2008
Comparative chemometric modeling of cytochrome 3A4 inhibitory activity of structurally diverse compounds using stepwise MLR, FA-MLR, PLS, GFA, G/PLS and ANN techniques. European journal of medicinal chemistry, 2009, Volume: 44, Issue:7 Topics: Algorithms; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Enzyme Inhibitors; Factor Analysis, Statistical; Least-Squares Analysis; Linear Models; Models, Molecular; Neural Networks, Computer; Quantitative Structure-Activity Relationship; Reproducibility of Results	2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species. Bioorganic & medicinal chemistry, 2010, Mar-15, Volume: 18, Issue:6 Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics	2010
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development. Toxicological sciences : an official journal of the Society of Toxicology, 2010, Volume: 118, Issue:2 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics	2010
Attenuation of intestinal absorption by major efflux transporters: quantitative tools and strategies using a Caco-2 model. Drug metabolism and disposition: the biological fate of chemicals, 2011, Volume: 39, Issue:2 Topics: Adenosine; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Sub-Family B Member 4; ATP-Binding Cassette Transporters; Biological Transport; Caco-2 Cells; Chromatography, Liquid; Dibenzocycloheptenes; Diketopiperazines; Drug Discovery; Heterocyclic Compounds, 4 or More Rings; Humans; Intestinal Absorption; Mass Spectrometry; Models, Biological; Neoplasm Proteins; Pharmaceutical Preparations; Predictive Value of Tests; Propionates; Quinolines; Substrate Specificity	2011
Sequential metabolism of AMG 487, a novel CXCR3 antagonist, results in formation of quinone reactive metabolites that covalently modify CYP3A4 Cys239 and cause time-dependent inhibition of the enzyme. Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:7 Topics: Acetamides; Biotransformation; Cytochrome P-450 CYP3A; Humans; Metabolic Networks and Pathways; Microsomes, Liver; Midazolam; Oxygen; Proteolysis; Pyrimidinones; Quinones; Receptors, CXCR3; Testosterone	2012
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions. Journal of medicinal chemistry, 2012, May-24, Volume: 55, Issue:10 Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection	2012
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds. Chemical research in toxicology, 2012, Oct-15, Volume: 25, Issue:10 Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding	2012
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests	2013
Understanding Oxadiazolothiazinone Biological Properties: Negative Inotropic Activity versus Cytochrome P450-Mediated Metabolism. Journal of medicinal chemistry, 2016, Apr-14, Volume: 59, Issue:7 Topics: Animals; Cells, Cultured; Cytochrome P-450 Enzyme System; Enzyme Inhibitors; Guinea Pigs; Heart Atria; Humans; Male; Microsomes, Liver; Myocytes, Cardiac; Oxadiazoles; Oxidation-Reduction; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship; Thiazines; Vasodilator Agents	2016
Cyclosporin metabolism in human liver microsomes and its inhibition by other drugs. Pharmacology & toxicology, 1990, Volume: 66, Issue:1 Topics: Cyclosporins; Diltiazem; Humans; Ketoconazole; Microsomes, Liver; Time Factors	1990
Survey of cyclosporin-sparing agent use in Australasian transplant centres. Australian and New Zealand journal of medicine, 1996, Volume: 26, Issue:6 Topics: Australia; Cyclosporine; Diltiazem; Drug Therapy, Combination; Humans; Immunosuppressive Agents; Ketoconazole; New Zealand; Organ Transplantation; Surveys and Questionnaires	1996
Effect of metabolic inhibitors on cyclosporine pharmacokinetics using a population approach. Therapeutic drug monitoring, 1998, Volume: 20, Issue:4 Topics: Administration, Oral; Adolescent; Adult; Aged; Antifungal Agents; Calcium Channel Blockers; Child; Cyclosporine; Diltiazem; Drug Administration Schedule; Drug Interactions; Fluconazole; Heart-Lung Transplantation; Humans; Immunosuppressive Agents; Individuality; Itraconazole; Ketoconazole; Linear Models; Middle Aged	1998
Pharmacokinetics of cyclosporine in heart transplant recipients receiving metabolic inhibitors. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation, 2001, Volume: 20, Issue:4 Topics: Calcium Channel Blockers; Cyclosporine; Diltiazem; Drug Interactions; Female; Heart Transplantation; Humans; Immunosuppressive Agents; Ketoconazole; Linear Models; Male; Middle Aged; Multivariate Analysis	2001
Cyclosporin C(2) and C(0) concentration monitoring in stable, long-term heart transplant recipients receiving metabolic inhibitors. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation, 2003, Volume: 22, Issue:7 Topics: Antifungal Agents; Area Under Curve; Biological Availability; Calcium Channel Blockers; Cyclosporine; Cyclosporins; Diltiazem; Dose-Response Relationship, Drug; Drug Monitoring; Enzyme Inhibitors; Female; Heart Transplantation; Humans; Ketoconazole; Male; Middle Aged; Predictive Value of Tests; Statistics as Topic; Time; Time Factors	2003
The effect of ketoconazole and diltiazem on oestrogen metabolism in postmenopausal women after single dose oestradiol treatment. British journal of clinical pharmacology, 2003, Volume: 56, Issue:3 Topics: Administration, Oral; Antifungal Agents; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Diltiazem; Estradiol; Estrogens; Female; Humans; Ketoconazole; Middle Aged; Postmenopause	2003
High-throughput screening for the assessment of time-dependent inhibitions of new drug candidates on recombinant CYP2D6 and CYP3A4 using a single concentration method. Xenobiotica; the fate of foreign compounds in biological systems, 2004, Volume: 34, Issue:1 Topics: Amiodarone; Animals; Baculoviridae; Binding, Competitive; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2D6 Inhibitors; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Diltiazem; Enzyme Inhibitors; Fluorescence; Humans; Inhibitory Concentration 50; Ketoconazole; Miconazole; Midazolam; Propafenone; Quinolines; Recombinant Proteins; Troleandomycin; Verapamil	2004
Model for the drug-drug interaction responsible for CYP3A enzyme inhibition. I: evaluation of cynomolgus monkeys as surrogates for humans. Xenobiotica; the fate of foreign compounds in biological systems, 2004, Volume: 34, Issue:5 Topics: Administration, Oral; Animals; Antibodies; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Diltiazem; Drug Interactions; Enzyme Inhibitors; Erythromycin; Female; Humans; In Vitro Techniques; Ketoconazole; Kinetics; Macaca fascicularis; Microsomes, Liver; Midazolam; Models, Animal; Oxidoreductases, N-Demethylating	2004
Decision support tool to individualize cyclosporine dose in stable, long-term heart transplant recipients receiving metabolic inhibitors: overcoming limitations of cyclosporine C2 monitoring. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation, 2006, Volume: 25, Issue:10 Topics: Area Under Curve; Bayes Theorem; Cardiovascular Agents; Cyclosporine; Decision Support Techniques; Diltiazem; Dose-Response Relationship, Drug; Drug Monitoring; Drug Therapy, Combination; Feedback, Physiological; Heart Transplantation; Humans; Immunosuppressive Agents; Ketoconazole; Predictive Value of Tests; Time Factors	2006
Sequential metabolism is responsible for diltiazem-induced time-dependent loss of CYP3A. Drug metabolism and disposition: the biological fate of chemicals, 2007, Volume: 35, Issue:5 Topics: Antifungal Agents; Calcium Channel Blockers; Cells, Cultured; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Diltiazem; Dose-Response Relationship, Drug; Enzyme Inhibitors; Hepatocytes; Humans; Ketoconazole; Kinetics; Methylation; Microsomes, Liver; Molecular Structure; Time Factors	2007
Predicting Clinical Effects of CYP3A4 Modulators on Abemaciclib and Active Metabolites Exposure Using Physiologically Based Pharmacokinetic Modeling. Journal of clinical pharmacology, 2020, Volume: 60, Issue:7 Topics: Administration, Oral; Adult; Aged; Alkynes; Aminopyridines; Area Under Curve; Benzimidazoles; Benzoxazines; Bosentan; Clarithromycin; Computer Simulation; Cyclin-Dependent Kinases; Cyclopropanes; Cytochrome P-450 CYP3A Inducers; Cytochrome P-450 CYP3A Inhibitors; Diltiazem; Drug Interactions; Female; Healthy Volunteers; Humans; Itraconazole; Ketoconazole; Male; Middle Aged; Modafinil; Models, Biological; Rifampin; Verapamil	2020