ketoconazole and digoxin

ketoconazole has been researched along with digoxin in 38 studies

Research

Studies (38)

Timeframe	Studies, this research(%)	All Research%
pre-1990	2 (5.26)	18.7374
1990's	6 (15.79)	18.2507
2000's	12 (31.58)	29.6817
2010's	18 (47.37)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Jones, LH; Nadanaciva, S; Rana, P; Will, Y	1
Brodsky, JL; Chiang, A; Chung, WJ; Denny, RA; Goeckeler-Fried, JL; Havasi, V; Hong, JS; Keeton, AB; Mazur, M; Piazza, GA; Plyler, ZE; Rasmussen, L; Rowe, SM; Sorscher, EJ; Weissman, AM; White, EL	1
Fischer, H; Huwyler, J; Poli, S; Schwab, D; Tabatabaei, A	1
Artursson, P; Bergström, CA; Hoogstraate, J; Matsson, P; Norinder, U; Pedersen, JM	1
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM	1
Anderson, KS; Atreya, C; Babatunde, O; Jorgensen, WL; Martucci, WE; Udier-Blagovic, M; Vargo, MA	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Choi, SS; Contrera, JF; Hastings, KL; Kruhlak, NL; Sancilio, LF; Weaver, JL; Willard, JM	1
García-Mera, X; González-Díaz, H; Prado-Prado, FJ	1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ	1
Ekins, S; Williams, AJ; Xu, JJ	1
Chen, X; Lin, X; Skolnik, S; Wang, J	1
Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V	1
Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR	1
Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY	1
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Rex, J	1
Bagnasco, FA; Kauffman, CA	1
Lazor, JA; McNulty, RM; Sketch, M	1
Baciewicz, AM; Bekemeyer, WB; Self, TH	1
Blanchard, LM; Green, PJ; Sachs, MK	1
Benet, LZ; Salphati, L	2
Artursson, P; Hidalgo, IJ; Raeissi, SD; Segura-Aguilar, J	1
Baron, JM; Friedberg, T; Goh, LB; Wolf, CR; Yao, D	1
Keogh, JP; Kunta, JR	1
Fox, L; Harnett, M; Lasseter, K; Profy, A; Sabounjian, L; Sandage, B; Shipley, J	1
Andersen, V; Autrup, H; Eriksen, J; Guldborg Nyvold, C; Hyldahl Olesen, L; Jakobsen, P; Larsen, UL; Østergaard, M	1
Fan, Y; Rodriguez-Proteau, R	1
Hellum, BH; Nilsen, OG	1
Bizot, MN; Camenisch, G; Dieterich, HA; Dole, WP; Howard, D; Reynolds, C; Schuetz, H; Vaidyanathan, S; Yeh, CM	1
Georg Nilsen, O; Hellum, BH; Hoybakk, K; Rohloff, J; Thomsen, M; Tosse, A	1
Al-Bataineh, MM; Gehring, R; Schultz, BD; van der Merwe, D	1
Balimane, PV; Frost, CE; Gan, J; Han, YH; He, K; Herbst, JJ; Humphreys, WG; Kolb, J; Shou, W; Wang, L; Zhang, D	1
Ahmed, Z; Bentz, J; Ellens, H; Hidalgo, IJ; Li, J; Li, L; Lumen, AA; Meng, Z; Owen, A	1
Aspeslet, LJ; Foster, RT; Freitag, DG; Huizinga, RB; Larouche, R; Ling, SY; Mayo, PR	1
Fraczkiewicz, G; Shi, JG; Williams, WV; Yeleswaram, S	1

Reviews

1 review(s) available for ketoconazole and digoxin

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016

Trials

4 trial(s) available for ketoconazole and digoxin

Article	Year
Predictive power of an in vitro system to assess drug interactions of an antimuscarinic medication: a comparison of in vitro and in vivo drug-drug interaction studies of trospium chloride with digoxin. Journal of clinical pharmacology, 2006, Volume: 46, Issue:7 Topics: Adolescent; Adult; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Benzilates; Cardiotonic Agents; Cross-Over Studies; Digoxin; Drug Evaluation, Preclinical; Drug Interactions; Female; Humans; Ketoconazole; Kidney; LLC-PK1 Cells; Male; Middle Aged; Muscarinic Antagonists; Nortropanes; Predictive Value of Tests; Reference Values; Swine; Transfection	2006
Human intestinal P-glycoprotein activity estimated by the model substrate digoxin. Scandinavian journal of clinical and laboratory investigation, 2007, Volume: 67, Issue:2 Topics: Adult; Aged; Area Under Curve; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blotting, Western; Cardiotonic Agents; Digoxin; Drug Interactions; Duodenum; Female; Gene Expression; Homozygote; Humans; Ketoconazole; Male; Middle Aged; Polymorphism, Restriction Fragment Length; Reverse Transcriptase Polymerase Chain Reaction; Rifampin; RNA, Messenger	2007
Pharmacokinetics of the oral direct renin inhibitor aliskiren in combination with digoxin, atorvastatin, and ketoconazole in healthy subjects: the role of P-glycoprotein in the disposition of aliskiren. Journal of clinical pharmacology, 2008, Volume: 48, Issue:11 Topics: Adult; Amides; Animals; Antifungal Agents; Atorvastatin; ATP Binding Cassette Transporter, Subfamily B, Member 1; Caco-2 Cells; Cell Line; Cytochrome P-450 CYP3A; Digoxin; Drug Interactions; Female; Fumarates; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Ketoconazole; Male; Organic Anion Transporters; Pyrroles; Renin; Tissue Distribution; Young Adult	2008
Cytochrome P450 3A and P-glycoprotein drug-drug interactions with voclosporin. British journal of clinical pharmacology, 2014, Volume: 77, Issue:6 Topics: Adolescent; Adult; ATP Binding Cassette Transporter, Subfamily B, Member 1; Calcineurin Inhibitors; Cyclosporine; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Digoxin; Drug Interactions; Female; Humans; Ketoconazole; Male; Midazolam; Middle Aged; Verapamil	2014

Other Studies

33 other study(ies) available for ketoconazole and digoxin

Article	Year
Development of a cell viability assay to assess drug metabolite structure-toxicity relationships. Bioorganic & medicinal chemistry letters, 2016, 08-15, Volume: 26, Issue:16 Topics: Adenosine Triphosphate; Benzbromarone; Cell Line; Cell Survival; Chromans; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Humans; Pharmaceutical Preparations; Thiazolidinediones; Troglitazone	2016
Increasing the Endoplasmic Reticulum Pool of the F508del Allele of the Cystic Fibrosis Transmembrane Conductance Regulator Leads to Greater Folding Correction by Small Molecule Therapeutics. PloS one, 2016, Volume: 11, Issue:10 Topics: Alleles; Benzoates; Cells, Cultured; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Endoplasmic Reticulum; Furans; Gene Deletion; HEK293 Cells; HeLa Cells; High-Throughput Screening Assays; Humans; Hydroxamic Acids; Microscopy, Fluorescence; Protein Folding; Protein Structure, Tertiary; Pyrazoles; RNA, Messenger; Small Molecule Libraries; Ubiquitination; Vorinostat	2016
Comparison of in vitro P-glycoprotein screening assays: recommendations for their use in drug discovery. Journal of medicinal chemistry, 2003, Apr-24, Volume: 46, Issue:9 Topics: Adenosine Triphosphatases; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Cells, Cultured; Drug Evaluation, Preclinical; Fluoresceins; Fluorescent Dyes; Humans; Indicators and Reagents; Mice; Models, Molecular; Rhodamines; Species Specificity; Swine	2003
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2). Journal of medicinal chemistry, 2008, Jun-12, Volume: 51, Issue:11 Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Computer Simulation; Cytochrome P-450 Enzyme System; Drug-Related Side Effects and Adverse Reactions; Estradiol; Humans; Insecta; Liver; Models, Molecular; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Pharmaceutical Preparations; Pharmacology; Structure-Activity Relationship	2008
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1. Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19 Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship	2008
Novel non-active site inhibitor of Cryptosporidium hominis TS-DHFR identified by a virtual screen. Bioorganic & medicinal chemistry letters, 2009, Jan-15, Volume: 19, Issue:2 Topics: Allosteric Site; Animals; Catalytic Domain; Cryptosporidium; Enzyme Inhibitors; Folic Acid Antagonists; Models, Molecular; Tetrahydrofolate Dehydrogenase	2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models. Toxicology mechanisms and methods, 2008, Volume: 18, Issue:2-3 Topics:	2008
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species. Bioorganic & medicinal chemistry, 2010, Mar-15, Volume: 18, Issue:6 Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics	2010
Developing structure-activity relationships for the prediction of hepatotoxicity. Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes	2010
A predictive ligand-based Bayesian model for human drug-induced liver injury. Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12 Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands	2010
Attenuation of intestinal absorption by major efflux transporters: quantitative tools and strategies using a Caco-2 model. Drug metabolism and disposition: the biological fate of chemicals, 2011, Volume: 39, Issue:2 Topics: Adenosine; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Sub-Family B Member 4; ATP-Binding Cassette Transporters; Biological Transport; Caco-2 Cells; Chromatography, Liquid; Dibenzocycloheptenes; Diketopiperazines; Drug Discovery; Heterocyclic Compounds, 4 or More Rings; Humans; Intestinal Absorption; Mass Spectrometry; Models, Biological; Neoplasm Proteins; Pharmaceutical Preparations; Predictive Value of Tests; Propionates; Quinolines; Substrate Specificity	2011
FDA-approved drug labeling for the study of drug-induced liver injury. Drug discovery today, 2011, Volume: 16, Issue:15-16 Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Design; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmaceutical Preparations; Reproducibility of Results; United States; United States Food and Drug Administration	2011
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions. Journal of medicinal chemistry, 2012, May-24, Volume: 55, Issue:10 Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection	2012
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds. Chemical research in toxicology, 2012, Oct-15, Volume: 25, Issue:10 Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding	2012
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification. Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship	2012
Itraconazole-digoxin interaction. Annals of internal medicine, 1992, Mar-15, Volume: 116, Issue:6 Topics: Aged; Antifungal Agents; Digoxin; Drug Interactions; Humans; Itraconazole; Ketoconazole; Male	1992
Digoxin toxicity associated with itraconazole therapy. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 1992, Volume: 15, Issue:5 Topics: Aged; Antifungal Agents; Aspergillosis; Digoxin; Drug Interactions; Female; Humans; Itraconazole; Ketoconazole	1992
Transient increase in plasma quinidine concentrations during ketoconazole-quinidine therapy. Clinical pharmacy, 1989, Volume: 8, Issue:3 Topics: Aged; Candidiasis; Creatinine; Digoxin; Drug Interactions; Humans; Ketoconazole; Leukemia, Myeloid, Acute; Male; Quinidine; Time Factors	1989
Update on rifampin drug interactions. Archives of internal medicine, 1987, Volume: 147, Issue:3 Topics: Adrenergic beta-Antagonists; Cyclosporins; Digoxin; Drug Interactions; Humans; Ketoconazole; Phenytoin; Rifampin; Theophylline; Verapamil	1987
Interaction of itraconazole and digoxin. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 1993, Volume: 16, Issue:3 Topics: Aged; Antifungal Agents; Aspergillosis; Aspergillus fumigatus; Digoxin; Drug Interactions; Half-Life; Humans; Itraconazole; Ketoconazole; Least-Squares Analysis; Male; Osteomyelitis	1993
Effects of ketoconazole on digoxin absorption and disposition in rat. Pharmacology, 1998, Volume: 56, Issue:6 Topics: Animals; Antifungal Agents; Area Under Curve; Biological Availability; Cardiotonic Agents; Digoxin; Intestinal Absorption; Ketoconazole; Male; Rats	1998
Metabolism of digoxin and digoxigenin digitoxosides in rat liver microsomes: involvement of cytochrome P4503A. Xenobiotica; the fate of foreign compounds in biological systems, 1999, Volume: 29, Issue:2 Topics: Animals; Aryl Hydrocarbon Hydroxylases; Cells, Cultured; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Digoxigenin; Digoxin; Enzyme Inhibitors; Female; Humans; Ketoconazole; Kinetics; Male; Microsomes, Liver; Models, Chemical; Oxidoreductases, N-Demethylating; Rats; Rats, Sprague-Dawley; Theophylline	1999
Interplay between CYP3A-mediated metabolism and polarized efflux of terfenadine and its metabolites in intestinal epithelial Caco-2 (TC7) cell monolayers. Pharmaceutical research, 1999, Volume: 16, Issue:5 Topics: Anti-Anxiety Agents; Antifungal Agents; Aryl Hydrocarbon Hydroxylases; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Caco-2 Cells; Calcium Channel Blockers; Catalytic Domain; Cell Polarity; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Digoxin; Enzyme Inhibitors; Epithelial Cells; Gene Expression; Histamine H1 Antagonists; Humans; Hydroxylation; Intestinal Mucosa; Intestines; Ketoconazole; Kinetics; Oligonucleotide Probes; Oxidoreductases, N-Demethylating; Piperidines; RNA, Messenger; Terfenadine; Tritium; Verapamil	1999
Modulation of P450 CYP3A4-dependent metabolism by P-glycoprotein: implications for P450 phenotyping. The Journal of pharmacology and experimental therapeutics, 2001, Volume: 296, Issue:2 Topics: Antifungal Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cardiotonic Agents; Cell Line; Cells, Cultured; Cysteine Proteinase Inhibitors; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Digoxin; Humans; Hydroxylation; Ketoconazole; Mixed Function Oxygenases; NADPH-Ferrihemoprotein Reductase; Phenotype; Steroid Hydroxylases; Transfection	2001
Development, validation and utility of an in vitro technique for assessment of potential clinical drug-drug interactions involving P-glycoprotein. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 2006, Volume: 27, Issue:5 Topics: Animals; Astemizole; ATP Binding Cassette Transporter, Subfamily B, Member 1; Automation; Cell Line; Digoxin; Dogs; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Drug Interactions; Ketoconazole; Quinidine; Reproducibility of Results; Transfection; Tritium	2006
Ketoconazole and the modulation of multidrug resistance-mediated transport in Caco-2 and MDCKII-MDR1 drug transport models. Xenobiotica; the fate of foreign compounds in biological systems, 2008, Volume: 38, Issue:2 Topics: Animals; Antifungal Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Caco-2 Cells; Cells, Cultured; Cyclosporine; Digoxin; Dogs; Drug Resistance, Multiple; Humans; Ketoconazole	2008
In vitro inhibition of CYP3A4 metabolism and P-glycoprotein-mediated transport by trade herbal products. Basic & clinical pharmacology & toxicology, 2008, Volume: 102, Issue:5 Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Caco-2 Cells; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Digoxin; Herb-Drug Interactions; Humans; Ketoconazole; Plant Extracts; Plant Preparations; Testosterone; Verapamil	2008
Potent in vitro inhibition of CYP3A4 and P-glycoprotein by Rhodiola rosea. Planta medica, 2010, Volume: 76, Issue:4 Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Baculoviridae; Caco-2 Cells; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Digoxin; DNA, Complementary; Herb-Drug Interactions; Humans; Inhibitory Concentration 50; Ketoconazole; Plant Extracts; Rhodiola; Structure-Activity Relationship; Testosterone; Verapamil	2010
Tumor necrosis factor alpha increases P-glycoprotein expression in a BME-UV in vitro model of mammary epithelial cells. Biopharmaceutics & drug disposition, 2010, Volume: 31, Issue:8-9 Topics: 14-alpha Demethylase Inhibitors; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP-Binding Cassette Transporters; Biological Transport; Calcium Channel Blockers; Cattle; Cell Line, Transformed; Cell Membrane Permeability; Cytokines; Digoxin; Enzyme Inhibitors; Epithelial Cells; Female; Inflammation; Ketoconazole; Mammary Glands, Animal; RNA, Messenger; Tumor Necrosis Factor-alpha; Verapamil	2010
Characterization of efflux transporters involved in distribution and disposition of apixaban. Drug metabolism and disposition: the biological fate of chemicals, 2013, Volume: 41, Issue:4 Topics: Adenosine; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Caco-2 Cells; Cell Line, Transformed; Cell Membrane Permeability; Cyclosporine; Digoxin; Diketopiperazines; Dose-Response Relationship, Drug; Drug Interactions; Fibrinolytic Agents; Heterocyclic Compounds, 4 or More Rings; Humans; Ketoconazole; Male; Naproxen; Neoplasm Proteins; Pyrazoles; Pyridones; Rats	2013
Transport inhibition of digoxin using several common P-gp expressing cell lines is not necessarily reporting only on inhibitor binding to P-gp. PloS one, 2013, Volume: 8, Issue:8 Topics: Acridines; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Caco-2 Cells; Carbamates; Cell Membrane Permeability; Cyclosporine; Digoxin; Dogs; Furans; Gene Expression; Humans; Ketoconazole; Kinetics; Loperamide; Madin Darby Canine Kidney Cells; Protein Binding; Quinidine; Sulfonamides; Tetrahydroisoquinolines; Vinblastine	2013
Predicting drug-drug interactions involving multiple mechanisms using physiologically based pharmacokinetic modeling: a case study with ruxolitinib. Clinical pharmacology and therapeutics, 2015, Volume: 97, Issue:2 Topics: Cytochrome P-450 CYP3A Inducers; Cytochrome P-450 CYP3A Inhibitors; Digoxin; Drug Interactions; Erythromycin; Fasting; Fluconazole; Humans; Ketoconazole; Models, Biological; Nitriles; Prospective Studies; Pyrazoles; Pyrimidines; Retrospective Studies; Rifampin	2015