ketoconazole has been researched along with deacylketoconazole in 9 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (22.22) | 18.7374 |
| 1990's | 4 (44.44) | 18.2507 |
| 2000's | 1 (11.11) | 29.6817 |
| 2010's | 2 (22.22) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Dawson, B; Menzies, A; Sy, WW; Whitehouse, LW; Zamecnik, J | 1 |
| Krogstad, DJ; Pfaller, MA; Segal, JJ | 1 |
| Brasseur, R; Ruysschaert, JM; Van den Bossche, H; Vandenbosch, C | 1 |
| Acosta, D; Rodriguez, RJ | 2 |
| Buckholz, CJ; Hetherington, CL; Marquez, BL; O'Connell, KL; Proteau, PJ; Rodriguez, RJ | 1 |
| Miranda, CL; Rodriguez, RJ | 1 |
| Blüher, M; Gebauer, S; Gebhardt, R; Jouy, F; Kalkhof, S; Luch, A; Pirow, R; von Bergen, M; Wewering, F; Wissenbach, DK; Zellmer, S | 1 |
| Fukami, T; Iida, A; Konishi, K; Nakajima, M | 1 |
9 other study(ies) available for ketoconazole and deacylketoconazole
| Article | Year |
|---|---|
Deacetylated ketoconazole: a major ketoconazole metabolite isolated from mouse liver.
Topics: Animals; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Ketoconazole; Liver; Male; Mice | 1990 |
Activity of ketoconazole and its deacyl derivative against Plasmodium falciparum and Candida isolates.
Topics: Animals; Antifungal Agents; Candida; Imidazoles; Ketoconazole; Piperazines; Plasmodium falciparum | 1982 |
Mode of insertion of miconazole, ketoconazole and deacylated ketoconazole in lipid layers. A conformational analysis.
Topics: Antifungal Agents; Calorimetry; Chemical Phenomena; Chemistry; Imidazoles; Ketoconazole; Membrane Lipids; Miconazole; Models, Theoretical; Molecular Conformation; Piperazines; Pulmonary Surfactants | 1983 |
N-deacetyl ketoconazole-induced hepatotoxicity in a primary culture system of rat hepatocytes.
Topics: Animals; Antifungal Agents; Cell Membrane; Cells, Cultured; Coloring Agents; Female; Ketoconazole; L-Lactate Dehydrogenase; Liver; Male; Mitochondria; Oxidation-Reduction; Oxygenases; Rats; Rats, Sprague-Dawley; Tetrazolium Salts; Thiazoles | 1997 |
Metabolism of ketoconazole and deacetylated ketoconazole by rat hepatic microsomes and flavin-containing monooxygenases.
Topics: Animals; Antifungal Agents; Ketoconazole; Microsomes, Liver; Oxygenases; Rats; Rats, Sprague-Dawley; Swine | 1997 |
Flavin-containing monooxygenase-mediated metabolism of N-deacetyl ketoconazole by rat hepatic microsomes.
Topics: Animals; Chromatography, High Pressure Liquid; Female; Flavins; In Vitro Techniques; Ketoconazole; Magnetic Resonance Spectroscopy; Male; Mass Spectrometry; Mice; Microsomes, Liver; Mixed Function Oxygenases; Oxidation-Reduction; Piperazines; Rats; Rats, Sprague-Dawley | 1999 |
Isoform specificity of N-deacetyl ketoconazole by human and rabbit flavin-containing monooxygenases.
Topics: Animals; Chromatography, High Pressure Liquid; Humans; Hydrogen-Ion Concentration; Isoenzymes; Ketoconazole; Oxygenases; Rabbits; Substrate Specificity; Time Factors | 2000 |
Characterization of chemical-induced sterile inflammation in vitro: application of the model compound ketoconazole in a human hepatic co-culture system.
Topics: Chemical and Drug Induced Liver Injury; Coculture Techniques; Hep G2 Cells; Humans; Interleukin-8; Ketoconazole; Membrane Potential, Mitochondrial; NF-kappa B; Proteins; Reactive Oxygen Species; Toxicity Tests; Tumor Necrosis Factor-alpha | 2017 |
Human arylacetamide deacetylase hydrolyzes ketoconazole to trigger hepatocellular toxicity.
Topics: Activation, Metabolic; Antifungal Agents; Biocatalysis; Carboxylic Ester Hydrolases; Cell Line, Tumor; Cells, Cultured; Chemical and Drug Induced Liver Injury; Cytochrome P-450 CYP3A Inhibitors; Enzyme Inhibitors; Female; Hepatocytes; Humans; Hydrolysis; Hydroxylation; Isoflurophate; Ketoconazole; Male; Microsomes, Liver; Middle Aged; Oxygenases; Recombinant Proteins | 2016 |