ketoconazole and cyclosporine

ketoconazole has been researched along with cyclosporine in 139 studies

Research

Studies (139)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	52 (37.41)	18.2507
2000's	50 (35.97)	29.6817
2010's	31 (22.30)	24.3611
2020's	6 (4.32)	2.80

Authors

Authors	Studies
Jones, LH; Nadanaciva, S; Rana, P; Will, Y	1
Norman, BH	1
Delabio, LC; Dutra, JP; Hembecker, M; Kita, DH; Moure, VR; Pereira, GDS; Scheiffer, G; Valdameri, G; Zattoni, IF	1
Bae, S; Cho, Y; Choi, J; Kang, JA; Kim, YC; Lee, D; Lim, C; Park, M; Park, SG; Seo, J	1
Cvetkovic, M; Kim, RB; Leake, B; Nadeau, J; Roden, MM; Walubo, A; Wilkinson, GR	1
Choo, EF; Imamura, H; Kim, RB; Leake, B; Wandel, C; Wilkinson, GR; Wood, AJ	1
Huang, L; Humphreys, JE; Morgan, JB; Polli, JW; Serabjit-Singh, CS; Webster, LO; Wring, SA	1
Casciano, CN; Clement, RP; Johnson, WW; Wang, EJ	2
Dantzig, AH; Ekins, S; Kim, RB; Lan, LB; Leake, BF; Schuetz, EG; Schuetz, JD; Shepard, RL; Wikel, JH; Winter, MA; Wrighton, SA; Yasuda, K	1
Furuya, K; Lan, LB; Sanglard, D; Schuetz, EG; Schuetz, JD; Yasuda, K	1
Fischer, H; Huwyler, J; Poli, S; Schwab, D; Tabatabaei, A	1
Bacsó, Z; Cianfriglia, M; Fenyvesi, F; Goda, K; Kappelmayer, J; Lustyik, G; Nagy, H; Szabó, G; Szilasi, M	1
Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J	1
Artursson, P; Bergström, CA; Hoogstraate, J; Matsson, P; Norinder, U; Pedersen, JM	1
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM	1
Austin, CP; Fidock, DA; Hayton, K; Huang, R; Inglese, J; Jiang, H; Johnson, RL; Su, XZ; Wellems, TE; Wichterman, J; Yuan, J	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ	1
Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ	1
Ekins, S; Williams, AJ; Xu, JJ	1
Chen, X; Lin, X; Skolnik, S; Wang, J	1
Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V	1
Barber, J; Dawson, S; Kenna, JG; Paul, N; Stahl, S	1
Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR	1
Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY	1
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ	1
Avery, VM; Sykes, ML	1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ	1
Aleo, MD; Bonin, PD; Luo, Y; Potter, DM; Swiss, R; Will, Y	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Abel, SM; Back, DJ; Tjia, JF	1
McLelland, J; Shuster, S	1
Adibzadeh, M; Friccius, H; Pawelec, G; Pohla, H; Schenk, A; Siegels-Hübenthal, P	1
Hammer, C; Modic, PK; Mraz, W	1
Alano, F; Baniga, U; Gueco, IP; Tan-Torres, T	1
Bhowmik, DM; Gandhi, BV; Jain, AK; Kale, S	1
Chia, LG; Gau, JP; Hwang, WL; Young, JH	1
Albengres, E; Tillement, JP	1
Andrés, A; Calleja, J; Farias, J; Gomez, M; Hernandez, G; Morales, JM; Moreno, E; Rodicio, JL	1
Austin, HA; de Smet, MD; Lopez, JS; Nussenblatt, RB; Rubin, BI; Whitcup, SM	1
Back, DJ; Tjia, JF	1
First, MR; Grund, VR; Myre, SA; Nicely, PG; Pesce, AJ; Schoeder, TJ; Wandstrat, TL	1
García, R; Henríquez La Roche, C; Herrera, J; Marín, C; Rodríguez-Iturbe, B; Rubio, L	1
Aninat, M; Aranguiz, E; Becerra, E; Chadid, P; De Prada, MT; González, R; Merello, L; Orfali, C; Pedemonte, O; Torres, H	1
Benet, LZ; Gomez, DY; Gupta, SK; Hebert, MF; Rowland, M; Wacher, VJ; Wu, CY	1
Benet, LZ; Gomez, DY; Hebert, MF; Tomlanovich, SJ; Wacher, VJ	1
Kaan, A; Keogh, A; Macdonald, P; McCosker, C; Mundy, J; Spratt, P	1
Almond, PS; Barber, D; Canafax, DM; Granger, DK; Hewitt, JM; Lovdahl, M; Matas, AJ; Russlie, HQ; Sorenson, AL	1
Grevel, J; Kahan, BD; Napoli, KL; Serino, F; Strobel, HW	2
Balfe, JW; Berkovitch, M; Bitzan, M; Finkelstein, H; Koren, G; Matsui, D	1
Amsellem, C; De Doncker, P; Haftek, M; Schmitt, D; Thivolet, J	1
Bakr, MA; el-Sherif, AK; Foda, MA; Ghoneim, MA; Sally, S; Sobh, MA	1
Brunson, ME; Howard, RJ; Karlix, JL; Patton, PR; Peterson, JC; Pfaff, WW; Ramos, EL	1
Brunson, ME; Cheng, MA; Howard, RJ; Karlix, JL; Patton, PR; Peterson, JC; Pfaff, WW; Ramos, EL	1
Alexander, JW; First, MR; Hariharan, S; Michael, A; Schroeder, TJ; Weiskittel, P	2
Ballantyne, CM	1
Greenblatt, DJ; von Moltke, LL	1
Acchiardo, SR; Alloway, RR; Gaber, AO; Moore, LW; Shokouh-Amiri, M; Vera, SR	1
Callender, CO; Kelly, B; Murigande, C; Odocha, O; Toussaint, RM; Trimble, S	1
Manning, LS; O'Donoghue, HL; Penhale, WJ; Reynoldson, JA; Turner, JH	1
García, R; Henríquez-La Roche, C; Herrera, J; Rodríguez-Iturbe, B; Rubio, L; Salgado, O	1
Jones, TE	2
de Smet, MD; Nussenblatt, RB; Ramadan, AM	1
Chapman, SA; Kamps, MA; Lake, KD; Marshall, PS; Milfred, SK; Solbrack, DF	1
Burke, MD; Hawksworth, GM; Humphrey, MJ; Omar, G; Whiting, PH	1
Burdick, JF; Gao, ZH; Kuo, A; Schulick, RD; Shinozuka, N; Watanabe, T	1
Silverstein, BE; Wong, IG	1
Cripps, MC; Dahrouge, S; Davies, RA; Goel, R; Huan, S; Prosser, A; Soltys, K; Stewart, DJ; Tomiak, E; Yau, J	1
Aldunate, T; Borja, H; Clavero, R; Gatica, A; Vega, J; Videla, C	1
Ankova, EV; Shoĭkhet, IN; Treĭvish, VS	1
Kitada, M; Kiuchi, M; Nakamura, H; Nakasa, H; Ohmori, S; Ono, S; Tsutsui, M	1
McLachlan, AJ; Tett, SE	1
Elberg, A; Foradori, A; Mezzano, S; Pefaur, J; Videla, C	1
Arcos, O; Ayala, A; Espinoza, M; Espinoza, O; Galaz, G; González, F; Herrera, S; Muñoz, R; Reynolds, E; Roessler, E; Undurraga, A	1
Nussenblatt, RB	1
Christophersen, P; Jensen, BS; Jorgensen, NK; Odum, N; Olesen, SP	1
Baner, K; Benet, LZ; Christians, U; Deters, M; Hackbarth, I; Hallensleben, K; Jacobsen, W; Kirchner, G; Mancinelli, L; Sewing, KF	1
Fujita, KI; Itoh, S; Kamataki, T; Munakata, H; Nakamura, K; Satoh, T; Yoshizawa, I	1
Bakr, MA; El Agroudy, AE; El Sayed, K; El-Diasty, T; Ghoneim, MA; Hamdy, AF; Sobh, MA	1
Akhlaghi, F; Kaan, A; Keogh, AM; McLachlan, AJ	1
Bigler, L; Follath, F; Ha, HR; Kozlik, P; Stieger, B	1
Cullen, LK; Glancy, RJ; Hackett, LP; Ilett, KF; Manning, LS; O'Donoghue, HL; Penhale, WJ; Rose, AH; Turner, JH	1
Wacher, VJ; Wong, HT; Wong, S	2
Mouatt, JG	1
Hardie, RJ; McAnulty, JE; Patricelli, AJ	1
Abraham, MA; Jacob, CK; Job, V; John, GT; Shankar, V; Thomas, PP	1
Chanchairujira, T; Jeng, S; Jusko, W; Steiner, R	1
Akhlaghi, F; Keogh, AM; McLachlan, AJ; Ray, JE	1
Krynicka, A; Szewczyk, M; Wojarski, J; Zakliczynski, M; Zembala, M	1
Dominguez, J; Foradori, A; Kompatzki, A; Norambuena, R	1
Ackerley, C; De Rosa, MF; Lingwood, C; Sillence, D	1
Haehner, T; Müller-Enoch, D; Refaie, MO	1
Botha, JF; Gerntholtz, T; Halkett, J; Kahn, D; Pascoe, MD	1
Carbajal, H; Rodríguez-Montalvo, C; Soltero, L; Valdés, A	1
Edwards, GA; Holloway, S; O'Neill, T	1
Blackwood, L; German, AJ; O'Neill, T; Stell, AJ	1
el-Agroudy, AE; Ghoneim, MA; Hamdy, AF; Sobh, MA	1
Donia, A; El-Basuony, F; El-Husseini, A; Hassan, N; Mahmoud, I; Sayed-Ahmad, N; Sobh, M	2
Fukushima, H; Ito, Y; Kageyama, M; Namiki, H; Shibata, N; Takada, K	1
Donia, A; El-Basuony, F; El-Husseini, A; Hassan, N; Mahmoud, I; Sabry, A; Sayed-Ahmad, N; Sheashaa, H; Sobh, M	2
Borja, H; Vega, J; Videla, C	1
Dubielzig, R; McAnulty, J; Penzo, C; Schmiedt, C; Schwab, M	1
Keogh, AM; McLachlan, AJ; Ray, JE	1
Deneuche, A; Desbois, C; Fayolle, P; Hidalgo, A; Klein, A; Moissonnier, P; Scotti, S; Tessier, D; Viateau, V; Zylberstein, L	1
Akhlaghi, F; Gohh, RY; Harmon, M; Patel, CG	1
Adamo, PF; Adams, WM; Rylander, H	1
Iwasaki, K	1
Griffin, BT; O'Driscoll, CM	1
Fan, Y; Rodriguez-Proteau, R	1
Ikemura, K; Iwamoto, T; Matsuda, H; Mizutani, H; Okuda, M; Urano, K	1
de Greef-van der Sandt, IC; Freidig, AP; Nijmeijer, S; Treijtel, N; van Eijkeren, JC	1
El-Dahshan, K; El-Husseini, A; Sabry, A; Sobh, M	1
Mansfield, CS; Paul, AE; Thompson, M	1
Maares, J; Meyer, I; Roos, B; Sauer, J; Schmitt-Hoffmann, AH; Schoetzau, A; Spickermann, J	1
Cole, LK; Gray, LL; Hillier, A; Rajala-Schultz, PJ	1
Balimane, PV; Frost, CE; Gan, J; Han, YH; He, K; Herbst, JJ; Humphreys, WG; Kolb, J; Shou, W; Wang, L; Zhang, D	1
Ahmed, Z; Bentz, J; Ellens, H; Hidalgo, IJ; Li, J; Li, L; Lumen, AA; Meng, Z; Owen, A	1
Chen, F; Lu, YN; Shi, F; Zhai, XJ	1
Aspeslet, LJ; Foster, RT; Freitag, DG; Huizinga, RB; Larouche, R; Ling, SY; Mayo, PR	1
Banovic, F; Linder, KE; Olivry, T	1
Alexander, N; Barve, A; Einolf, H; Gu, H; Hanna, I; He, H; Heimbach, T; Ke, J; Mangold, JB; Sunkara, G; Wang, L; Xia, B; Zhang, T	1
Jivrajani, M; Nivsarkar, M; Shaikh, MV; Shrivastava, N	1
de Graaf, IA; de Jager, MH; Groothuis, GM; Li, M	1
Buchmann, S; de Kanter, R; Delahaye, S; Gnerre, C; Kohl, C; Segrestaa, J; Sidharta, PN; Treiber, A	1
Barve, A; Crabbe, R; Dabovic, K; Dole, K; Grosgurin, P; Ke, J; Kovacs, SJ; Menetrey, A; Nicolas-Métral, V; Praestgaard, J; Stein, D; Sunkara, G; Zhang, J	1
Matsushima, N; Mendell, J; Parasrampuria, DA; Shi, M; Truitt, K; Zahir, H	1
Affolter, VK; Outerbridge, CA; White, SD	1
Honda, H; Ito, Y; Kawamoto, T; Morita, O	1
Chen, C; Cui, Y; Li, M; Ma, L; Wu, S; Xue, T; Yang, T; Zhou, Y	1
Kang, BT; Kang, JH; Kim, H; Kim, S; Koo, Y; Yang, MP; Yun, T	1
Amini, A; Mesbah, G; Safdari, Y; Tash Shamsabadi, F; Zeyghami, MA	1

Reviews

9 review(s) available for ketoconazole and cyclosporine

Article	Year
Drug Induced Liver Injury (DILI). Mechanisms and Medicinal Chemistry Avoidance/Mitigation Strategies. Journal of medicinal chemistry, 2020, 10-22, Volume: 63, Issue:20 Topics: Animals; Cell Line; Cell Survival; Chemical and Drug Induced Liver Injury; Drug Discovery; Drug Evaluation, Preclinical; Hepatocytes; Humans; Liver; Mitochondria, Liver; Pharmaceutical Preparations; Risk Assessment; Tissue Distribution	2020
Targeting breast cancer resistance protein (BCRP/ABCG2): Functional inhibitors and expression modulators. European journal of medicinal chemistry, 2022, Jul-05, Volume: 237 Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily G, Member 2; Breast Neoplasms; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Female; Humans; Neoplasm Proteins; Neoplastic Stem Cells	2022
Approaches to protozoan drug discovery: phenotypic screening. Journal of medicinal chemistry, 2013, Oct-24, Volume: 56, Issue:20 Topics: Drug Discovery; Humans; Molecular Structure; Neglected Diseases; Phenotype; Plasmodium falciparum; Protozoan Infections; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosoma cruzi	2013
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016
Cyclosporin and ketoconazole, drug interaction or therapeutic association? International journal of clinical pharmacology, therapy, and toxicology, 1992, Volume: 30, Issue:12 Topics: Animals; Cyclosporine; Drug Combinations; Drug Interactions; Graft Rejection; Humans; Ketoconazole; Risk Factors	1992
The use of other drugs to allow a lower dosage of cyclosporin to be used. Therapeutic and pharmacoeconomic considerations. Clinical pharmacokinetics, 1997, Volume: 32, Issue:5 Topics: Aryl Hydrocarbon Hydroxylases; Australia; Cyclosporine; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Diltiazem; Drug Synergism; Enzyme Inhibitors; Graft Rejection; Humans; Immunosuppressive Agents; Ketoconazole; New Zealand; Organ Transplantation; Oxidoreductases, N-Demethylating	1997
Considerations for using ketoconazole in solid organ transplant recipients receiving cyclosporine immunosuppression. Journal of transplant coordination : official publication of the North American Transplant Coordinators Organization (NATCO), 1996, Volume: 6, Issue:3 Topics: Antifungal Agents; Cyclosporine; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Drug Interactions; Drug Monitoring; Humans; Immunosuppressive Agents; Ketoconazole; Mixed Function Oxygenases; Organ Transplantation	1996
Metabolism of tacrolimus (FK506) and recent topics in clinical pharmacokinetics. Drug metabolism and pharmacokinetics, 2007, Volume: 22, Issue:5 Topics: Biotransformation; Cyclosporine; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Cytochrome P-450 Enzyme System; Drug Interactions; Drug Monitoring; Enzyme Inhibitors; Humans; Immunoenzyme Techniques; Immunosuppressive Agents; Ketoconazole; Molecular Structure; Nifedipine; Polymorphism, Single Nucleotide; Tacrolimus	2007
Efficacy and safety of ketoconazole combined with calmodulin inhibitor in solid organ transplantation: A systematic review and meta-analysis. Journal of clinical pharmacy and therapeutics, 2020, Volume: 45, Issue:1 Topics: Calcineurin Inhibitors; Cyclosporine; Cytochrome P-450 Enzyme Inhibitors; Dose-Response Relationship, Drug; Drug Therapy, Combination; Humans; Ketoconazole; Organ Transplantation; Randomized Controlled Trials as Topic; Tacrolimus	2020

Trials

28 trial(s) available for ketoconazole and cyclosporine

Article	Year
Ketoconazole in posttransplant triple therapy: comparison of costs and outcomes. Transplantation proceedings, 1992, Volume: 24, Issue:5 Topics: Adult; Costs and Cost Analysis; Cyclosporine; Female; Humans; Ketoconazole; Kidney Transplantation; Male; Philippines; Prospective Studies; Retrospective Studies; Treatment Outcome	1992
Concomitant administration of cyclosporine and ketoconazole in renal transplant patients. Transplantation proceedings, 1992, Volume: 24, Issue:5 Topics: Azathioprine; Cyclosporine; Drug Therapy, Combination; Female; Humans; Ketoconazole; Kidney Transplantation; Male; Prednisolone	1992
Combined use of cyclosporine and ketoconazole in the treatment of endogenous uveitis. American journal of ophthalmology, 1992, Jun-15, Volume: 113, Issue:6 Topics: Autoimmune Diseases; Cyclosporine; Double-Blind Method; Drug Therapy, Combination; Follow-Up Studies; Glomerular Filtration Rate; Humans; Ketoconazole; Uveitis	1992
The effects of ketoconazole on the intestinal metabolism and bioavailability of cyclosporine. Clinical pharmacology and therapeutics, 1995, Volume: 58, Issue:1 Topics: Administration, Oral; Biological Availability; Cyclosporine; Drug Administration Schedule; Drug Interactions; Female; Humans; Infusions, Intravenous; Intestinal Absorption; Ketoconazole; Liver; Male	1995
Ketoconazole to reduce the need for cyclosporine after cardiac transplantation. The New England journal of medicine, 1995, Sep-07, Volume: 333, Issue:10 Topics: Actuarial Analysis; Adult; Cost Savings; Cyclosporine; Drug Interactions; Drug Therapy, Combination; Female; Graft Rejection; Heart Transplantation; Humans; Incidence; Ketoconazole; Liver; Male; Middle Aged; Mycoses; Prospective Studies; Survival Analysis	1995
Effects of ketoconazole on cyclosporine metabolism in renal allograft recipients. Transplantation proceedings, 1994, Volume: 26, Issue:5 Topics: Adult; Cyclosporine; Drug Interactions; Female; Half-Life; Humans; Ketoconazole; Kidney Transplantation; Male; Metabolic Clearance Rate; Middle Aged; Transplantation, Homologous	1994
Different trends in immunosuppression: 10 years' experience with cyclosporine after living related donor renal transplantation. Transplantation proceedings, 1994, Volume: 26, Issue:6 Topics: Adult; Azathioprine; Cause of Death; Cyclosporine; Drug Therapy, Combination; Family; Female; Follow-Up Studies; Graft Rejection; Graft Survival; Humans; Immunosuppression Therapy; Ketoconazole; Kidney Transplantation; Male; Prednisolone; Retrospective Studies; Survival Rate; Time Factors; Tissue Donors; Transplantation, Homologous	1994
A preliminary report of diltiazem and ketoconazole. Their cyclosporine-sparing effect and impact on transplant outcome. Transplantation, 1994, Mar-27, Volume: 57, Issue:6 Topics: Adult; Blood Pressure; Costs and Cost Analysis; Creatinine; Cyclosporine; Diltiazem; Dose-Response Relationship, Drug; Female; Graft Rejection; Humans; Ketoconazole; Kidney; Kidney Transplantation; Male; Middle Aged; Treatment Outcome	1994
Safety and efficacy of long-term cyclosporine-ketoconazole administration and preliminary results of a randomized trial. Transplantation proceedings, 1993, Volume: 25, Issue:1 Pt 1 Topics: Azathioprine; Blood Urea Nitrogen; Cholesterol; Creatinine; Cyclosporine; Drug Therapy, Combination; Follow-Up Studies; Graft Survival; Humans; Ketoconazole; Kidney Transplantation; Prednisone; Survival Analysis; Time Factors	1993
Cyclosporine-ketoconazole interaction. Long-term follow-up and preliminary results of a randomized trial. Transplantation, 1993, Volume: 55, Issue:5 Topics: Adult; Cyclosporine; Drug Interactions; Drug Therapy, Combination; Female; Graft Survival; Humans; Ketoconazole; Kidney Transplantation; Male; Middle Aged; Time Factors	1993
Clinical observations of metabolic changes occurring in renal transplant recipients receiving ketoconazole. Transplantation, 1996, Feb-27, Volume: 61, Issue:4 Topics: Adolescent; Adult; Bone and Bones; Child; Cholesterol; Cyclosporine; Cytochrome P-450 Enzyme System; Drug Interactions; Drug Therapy, Combination; Enzyme Inhibitors; Female; Humans; Immunosuppressive Agents; Ketoconazole; Kidney Transplantation; Lipids; Male; Middle Aged; Prednisone	1996
Long-term follow-up of patients with chronic uveitis affecting the posterior pole treated with combination cyclosporine and ketoconazole. Ophthalmology, 1997, Volume: 104, Issue:4 Topics: Adult; Anti-Inflammatory Agents; Chronic Disease; Cyclosporine; Double-Blind Method; Drug Therapy, Combination; Follow-Up Studies; Humans; Immunosuppressive Agents; Ketoconazole; Longitudinal Studies; Middle Aged; Pilot Projects; Prednisone; Prospective Studies; Uveitis	1997
Modification of the pharmacokinetics of cyclosporine A and metabolites by the concomitant use of Neoral and diltiazem or ketoconazol in stable adult kidney transplants. Transplantation proceedings, 1998, Volume: 30, Issue:5 Topics: Administration, Oral; Adult; Antifungal Agents; Calcium Channel Blockers; Cyclosporine; Diltiazem; Drug Interactions; Drug Monitoring; Drug Therapy, Combination; Half-Life; Humans; Immunosuppressive Agents; Ketoconazole; Kidney Transplantation; Regression Analysis	1998
Conversion from Sandimmune to Neoral in renal transplant: functional histopathological, and pharmacokinetic changes. Transplantation proceedings, 1998, Volume: 30, Issue:5 Topics: Antifungal Agents; Creatinine; Cyclosporine; Drug Interactions; Graft Survival; Humans; Immunosuppressive Agents; Ketoconazole; Kidney Transplantation; Metabolic Clearance Rate; Potassium; Sodium	1998
Coadministration of ketoconazole and cyclosporine for kidney transplant recipients: long-term follow-up and study of metabolic consequences. American journal of kidney diseases : the official journal of the National Kidney Foundation, 2001, Volume: 37, Issue:3 Topics: Adult; Antifungal Agents; Bone Density; Cyclosporine; Drug Therapy, Combination; Female; Follow-Up Studies; Graft Rejection; Humans; Immunosuppressive Agents; Ketoconazole; Kidney Transplantation; Lipids; Male; Treatment Outcome; Vitamin D	2001
Cyclosporin and ketoconazole interaction for treatment of perianal fistulas in the dog. Australian veterinary journal, 2002, Volume: 80, Issue:4 Topics: Administration, Oral; Animals; Cyclosporine; Dog Diseases; Dogs; Drug Synergism; Drug Therapy, Combination; Female; Immunosuppressive Agents; Ketoconazole; Male; Perianal Glands; Prospective Studies; Rectal Fistula; Treatment Outcome	2002
Cyclosporine and ketoconazole for the treatment of perianal fistulas in dogs. Journal of the American Veterinary Medical Association, 2002, Apr-01, Volume: 220, Issue:7 Topics: Administration, Oral; Animals; Cyclosporine; Dog Diseases; Dogs; Drug Interactions; Drug Therapy, Combination; Female; Immunosuppressive Agents; Ketoconazole; Male; Perianal Glands; Rectal Fistula; Recurrence; Treatment Outcome	2002
Efficacy and safety of low-dose ketoconazole (50 mg) to reduce the cost of cyclosporine in renal allograft recipients. Transplantation proceedings, 2003, Volume: 35, Issue:1 Topics: Adult; Area Under Curve; Costs and Cost Analysis; Cyclosporine; Female; Humans; Immunosuppressive Agents; Ketoconazole; Kidney Transplantation; Male; Survival Rate; Time Factors; Transplantation, Homologous	2003
Prednisone metabolism in recipients of kidney or liver transplants and in lung recipients receiving ketoconazole. Transplantation, 2003, Mar-27, Volume: 75, Issue:6 Topics: Adult; Anti-Inflammatory Agents; Antifungal Agents; Area Under Curve; Cyclosporine; Humans; Immunosuppressive Agents; Ketoconazole; Kidney Transplantation; Liver Transplantation; Lung Transplantation; Middle Aged; Organ Transplantation; Prednisone	2003
Limited utility of cyclosporine C2 monitoring in heart transplant recipients receiving ketoconazole. Transplantation proceedings, 2003, Volume: 35, Issue:6 Topics: Adult; Antifungal Agents; Area Under Curve; Cyclosporine; Drug Monitoring; Follow-Up Studies; Heart Transplantation; Humans; Immunosuppressive Agents; Ketoconazole; Middle Aged; Time Factors	2003
A prospective, randomized study of coadministration of ketoconazole and cyclosporine a in kidney transplant recipients: ten-year follow-up. Transplantation, 2004, May-15, Volume: 77, Issue:9 Topics: Adult; Antifungal Agents; Cyclosporine; Drug Therapy, Combination; Female; Follow-Up Studies; Graft Rejection; Humans; Immunosuppressive Agents; Ketoconazole; Kidney Transplantation; Male; Mycoses; Prospective Studies; Survival Analysis; Treatment Outcome	2004
Preoperative immunosuppressive therapy and surgery as a treatment for anal furunculosis. Veterinary surgery : VS, 2006, Volume: 35, Issue:8 Topics: Anal Sacs; Animals; Anus Diseases; Combined Modality Therapy; Cyclosporine; Dog Diseases; Dogs; Female; Furunculosis; Immunosuppressive Agents; Ketoconazole; Male; Preoperative Care; Recurrence; Treatment Outcome	2006
Concentrations of mycophenolic acid and glucuronide metabolites under concomitant therapy with cyclosporine or tacrolimus. Therapeutic drug monitoring, 2007, Volume: 29, Issue:1 Topics: Administration, Oral; Aged; Animals; Antibiotics, Antineoplastic; Area Under Curve; Cyclosporine; Diabetes Mellitus; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Glucuronides; Humans; Immunosuppressive Agents; Ketoconazole; Kidney Transplantation; Male; Middle Aged; Mycophenolic Acid; Prednisone; Rats; Rats, Sprague-Dawley; Tacrolimus	2007
Pharmacokinetic interactions between alitretinoin and ketoconazole or simvastatin or ciclosporin A. Clinical and experimental dermatology, 2011, Volume: 36 Suppl 2 Topics: Adolescent; Adult; Alitretinoin; Antifungal Agents; Cross-Over Studies; Cyclosporine; Dermatologic Agents; Drug Administration Schedule; Drug Interactions; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Immunosuppressive Agents; Ketoconazole; Male; Middle Aged; Simvastatin; Tretinoin; Young Adult	2011
The effect of ketoconazole on whole blood and skin ciclosporin concentrations in dogs. Veterinary dermatology, 2013, Volume: 24, Issue:1 Topics: Animals; Antifungal Agents; Cross-Over Studies; Cyclosporine; Dogs; Drug Interactions; Immunosuppressive Agents; Ketoconazole; Pilot Projects; Skin	2013
Cytochrome P450 3A and P-glycoprotein drug-drug interactions with voclosporin. British journal of clinical pharmacology, 2014, Volume: 77, Issue:6 Topics: Adolescent; Adult; ATP Binding Cassette Transporter, Subfamily B, Member 1; Calcineurin Inhibitors; Cyclosporine; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Digoxin; Drug Interactions; Female; Humans; Ketoconazole; Male; Midazolam; Middle Aged; Verapamil	2014
The effects of CYP3A4 induction and inhibition on the pharmacokinetics of alisporivir in humans. Clinical pharmacology in drug development, 2015, Volume: 4, Issue:1 Topics: Area Under Curve; Azithromycin; Belgium; Biotransformation; Cross-Over Studies; Cyclosporine; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inducers; Cytochrome P-450 CYP3A Inhibitors; Drug Interactions; Female; Florida; Half-Life; Humans; Immunosuppressive Agents; Ketoconazole; Male; Metabolic Clearance Rate; Models, Biological; New York; Rifampin; Substrate Specificity	2015
Edoxaban drug-drug interactions with ketoconazole, erythromycin, and cyclosporine. British journal of clinical pharmacology, 2016, Volume: 82, Issue:6 Topics: Administration, Oral; Adolescent; Adult; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cross-Over Studies; Cyclosporine; Cytochrome P-450 CYP3A; Drug Administration Schedule; Drug Interactions; Erythromycin; Factor Xa Inhibitors; Healthy Volunteers; Humans; Ketoconazole; Metabolic Clearance Rate; Middle Aged; Pyridines; Substrate Specificity; Thiazoles; Young Adult	2016

Other Studies

102 other study(ies) available for ketoconazole and cyclosporine

Article	Year
Development of a cell viability assay to assess drug metabolite structure-toxicity relationships. Bioorganic & medicinal chemistry letters, 2016, 08-15, Volume: 26, Issue:16 Topics: Adenosine Triphosphate; Benzbromarone; Cell Line; Cell Survival; Chromans; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Humans; Pharmaceutical Preparations; Thiazolidinediones; Troglitazone	2016
Entry inhibition of hepatitis B virus using cyclosporin O derivatives with peptoid side chain incorporation. Bioorganic & medicinal chemistry, 2022, 08-15, Volume: 68 Topics: Antiviral Agents; Cyclosporins; Hepatitis B; Hepatitis B virus; Humans; Imidazoles; Liver Neoplasms; Organic Anion Transporters, Sodium-Dependent; Peptoids; Sulfonamides; Symporters; Thiophenes; Virus Internalization	2022
Modulation by drugs of human hepatic sodium-dependent bile acid transporter (sodium taurocholate cotransporting polypeptide) activity. The Journal of pharmacology and experimental therapeutics, 1999, Volume: 291, Issue:3 Topics: Bile Acids and Salts; Biological Transport, Active; Carrier Proteins; Cells, Cultured; HeLa Cells; Humans; Kinetics; Liver; Nicotine; Organic Anion Transporters, Sodium-Dependent; Plasmids; RNA, Messenger; Salicylates; Symporters; Vaccinia virus; Valproic Acid	1999
Pharmacological inhibition of P-glycoprotein transport enhances the distribution of HIV-1 protease inhibitors into brain and testes. Drug metabolism and disposition: the biological fate of chemicals, 2000, Volume: 28, Issue:6 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Brain; Caco-2 Cells; Dibenzocycloheptenes; HIV Protease Inhibitors; Humans; Inhibitory Concentration 50; Male; Mice; Quinolines; Testis	2000
Rational use of in vitro P-glycoprotein assays in drug discovery. The Journal of pharmacology and experimental therapeutics, 2001, Volume: 299, Issue:2 Topics: Adenosine Triphosphatases; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cells, Cultured; Chromatography, Liquid; Enzyme Inhibitors; Fluoresceins; Fluorescent Dyes; Humans; Mass Spectrometry; Pharmacology; Spodoptera	2001
Active transport of fluorescent P-glycoprotein substrates: evaluation as markers and interaction with inhibitors. Biochemical and biophysical research communications, 2001, Nov-30, Volume: 289, Issue:2 Topics: 3T3 Cells; Adrenergic Uptake Inhibitors; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Binding Sites; Biological Transport, Active; Cell Line; Cell Separation; Cell Survival; Flow Cytometry; Fluorescent Dyes; Humans; Inhibitory Concentration 50; Mice; Protein Binding; Reserpine; Spectrometry, Fluorescence; Substrate Specificity; Time Factors	2001
Three-dimensional quantitative structure-activity relationships of inhibitors of P-glycoprotein. Molecular pharmacology, 2002, Volume: 61, Issue:5 Topics: Animals; Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Caco-2 Cells; Ergonovine; Fluoxetine; Humans; Models, Molecular; Oxytocics; Protein Conformation; Selective Serotonin Reuptake Inhibitors; Structure-Activity Relationship; Swine; Transfection; Vinblastine	2002
Interaction of cytochrome P450 3A inhibitors with P-glycoprotein. The Journal of pharmacology and experimental therapeutics, 2002, Volume: 303, Issue:1 Topics: Animals; Aryl Hydrocarbon Hydroxylases; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Cell Line; Cells, Cultured; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dihydroergocryptine; Drug Interactions; Enzyme Inhibitors; Fluconazole; Humans; Mice; Mice, Knockout; Microsomes, Liver; Oxidoreductases, N-Demethylating; Recombinant Proteins; Reserpine; Swine; Tissue Distribution; Transfection; Vinblastine	2002
Comparison of in vitro P-glycoprotein screening assays: recommendations for their use in drug discovery. Journal of medicinal chemistry, 2003, Apr-24, Volume: 46, Issue:9 Topics: Adenosine Triphosphatases; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Cells, Cultured; Drug Evaluation, Preclinical; Fluoresceins; Fluorescent Dyes; Humans; Indicators and Reagents; Mice; Models, Molecular; Rhodamines; Species Specificity; Swine	2003
Fluorescent substrates of sister-P-glycoprotein (BSEP) evaluated as markers of active transport and inhibition: evidence for contingent unequal binding sites. Pharmaceutical research, 2003, Volume: 20, Issue:4 Topics: ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Binding Sites; Biological Transport, Active; Biomarkers; Cells, Cultured; Drug Interactions; Fluorescent Dyes; Humans	2003
Distinct groups of multidrug resistance modulating agents are distinguished by competition of P-glycoprotein-specific antibodies. Biochemical and biophysical research communications, 2004, Mar-19, Volume: 315, Issue:4 Topics: Adenosine Triphosphatases; Animals; Anti-Bacterial Agents; Antibodies, Monoclonal; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Binding, Competitive; Calcium Channel Blockers; Cyclosporine; Detergents; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Flow Cytometry; Fluoresceins; Humans; Ivermectin; Mice; NIH 3T3 Cells; Substrate Specificity	2004
Chemical genetics reveals a complex functional ground state of neural stem cells. Nature chemical biology, 2007, Volume: 3, Issue:5 Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells	2007
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2). Journal of medicinal chemistry, 2008, Jun-12, Volume: 51, Issue:11 Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Computer Simulation; Cytochrome P-450 Enzyme System; Drug-Related Side Effects and Adverse Reactions; Estradiol; Humans; Insecta; Liver; Models, Molecular; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Pharmaceutical Preparations; Pharmacology; Structure-Activity Relationship	2008
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1. Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19 Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship	2008
Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum. Nature chemical biology, 2009, Volume: 5, Issue:10 Topics: Animals; Antimalarials; ATP Binding Cassette Transporter, Subfamily B, Member 1; Chromosome Mapping; Crosses, Genetic; Dihydroergotamine; Drug Design; Drug Resistance; Humans; Inhibitory Concentration 50; Mutation; Plasmodium falciparum; Quantitative Trait Loci; Transfection	2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Developing structure-activity relationships for the prediction of hepatotoxicity. Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes	2010
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development. Toxicological sciences : an official journal of the Society of Toxicology, 2010, Volume: 118, Issue:2 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics	2010
A predictive ligand-based Bayesian model for human drug-induced liver injury. Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12 Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands	2010
Attenuation of intestinal absorption by major efflux transporters: quantitative tools and strategies using a Caco-2 model. Drug metabolism and disposition: the biological fate of chemicals, 2011, Volume: 39, Issue:2 Topics: Adenosine; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Sub-Family B Member 4; ATP-Binding Cassette Transporters; Biological Transport; Caco-2 Cells; Chromatography, Liquid; Dibenzocycloheptenes; Diketopiperazines; Drug Discovery; Heterocyclic Compounds, 4 or More Rings; Humans; Intestinal Absorption; Mass Spectrometry; Models, Biological; Neoplasm Proteins; Pharmaceutical Preparations; Predictive Value of Tests; Propionates; Quinolines; Substrate Specificity	2011
FDA-approved drug labeling for the study of drug-induced liver injury. Drug discovery today, 2011, Volume: 16, Issue:15-16 Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Design; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmaceutical Preparations; Reproducibility of Results; United States; United States Food and Drug Administration	2011
In vitro inhibition of the bile salt export pump correlates with risk of cholestatic drug-induced liver injury in humans. Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:1 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Cholestasis; Drug-Related Side Effects and Adverse Reactions; Humans; Insecta; Rats; Risk Factors	2012
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions. Journal of medicinal chemistry, 2012, May-24, Volume: 55, Issue:10 Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection	2012
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds. Chemical research in toxicology, 2012, Oct-15, Volume: 25, Issue:10 Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding	2012
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification. Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship	2012
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests	2013
Human drug-induced liver injury severity is highly associated with dual inhibition of liver mitochondrial function and bile salt export pump. Hepatology (Baltimore, Md.), 2014, Volume: 60, Issue:3 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Chemical and Drug Induced Liver Injury; Humans; Male; Mitochondria, Liver; Rats; Rats, Sprague-Dawley; Severity of Illness Index	2014
Overcoming drug resistance: studies presented at ASCO. Oncology (Williston Park, N.Y.), 1992, Volume: 6, Issue:12 Topics: Antigens, CD; Antigens, CD34; Cyclosporine; Drug Resistance; Humans; Ketoconazole; Leukemia; Tretinoin	1992
Azoles, allylamines and drug metabolism. The British journal of dermatology, 1992, Volume: 126 Suppl 39 Topics: Antifungal Agents; Azoles; Cyclosporine; Dose-Response Relationship, Drug; Humans; Hydrocortisone; In Vitro Techniques; Itraconazole; Ketoconazole; Microsomes, Liver; Naphthalenes; Terbinafine	1992
Topical ketoconazole does not potentiate oral cyclosporin A in allergic contact dermatitis. Acta dermato-venereologica, 1992, Volume: 72, Issue:4 Topics: Administration, Cutaneous; Administration, Oral; Cyclosporine; Dermatitis, Allergic Contact; Drug Synergism; Humans; Ketoconazole	1992
The effects of the antifungal azoles itraconazole, fluconazole, ketoconazole and miconazole on cytokine gene expression in human lymphoid cells. International journal of immunopharmacology, 1992, Volume: 14, Issue:5 Topics: Antifungal Agents; Cells, Cultured; Cyclosporine; Cytokines; Fluconazole; Gene Expression; Humans; Itraconazole; Ketoconazole; Lymphocytes; Miconazole; Tacrolimus	1992
Impact of imipenem/cilastatin on cyclosporine metabolism and excretion. Transplantation proceedings, 1992, Volume: 24, Issue:5 Topics: Animals; Bile; Cilastatin; Cyclosporine; Cytosol; Imipenem; Ketoconazole; Liver; Male; Phenobarbital; Rats; Rats, Inbred Strains; Time Factors	1992
Ketoconazole and high-dose methylprednisolone predisposing to cyclosporine-induced seizures: report of 3 cases. Acta haematologica, 1992, Volume: 88, Issue:2-3 Topics: Adolescent; Adult; Anemia, Aplastic; Cyclosporine; Drug Therapy, Combination; Female; Humans; Immunosuppression Therapy; Ketoconazole; Male; Methylprednisolone; Seizures	1992
Acute renal failure after liver transplantation in patients treated with cyclosporine. Transplantation proceedings, 1992, Volume: 24, Issue:1 Topics: Acute Kidney Injury; Adult; Candidiasis; Cyclosporine; Female; Humans; Ketoconazole; Liver Cirrhosis; Liver Transplantation; Male; Prednisone; Retrospective Studies	1992
Comparative effects of the antimycotic drugs ketoconazole, fluconazole, itraconazole and terbinafine on the metabolism of cyclosporin by human liver microsomes. British journal of clinical pharmacology, 1991, Volume: 32, Issue:5 Topics: Adult; Antifungal Agents; Cyclosporine; Female; Fluconazole; Humans; Itraconazole; Ketoconazole; Male; Microsomes, Liver; Naphthalenes; Terbinafine	1991
Critical ketoconazole dosage range for ciclosporin clearance inhibition in the dog. Pharmacology, 1991, Volume: 43, Issue:5 Topics: Administration, Oral; Animals; Biological Availability; Chromatography, High Pressure Liquid; Cyclosporine; Dogs; Dose-Response Relationship, Drug; Drug Interactions; Fluorescence Polarization Immunoassay; Injections, Intravenous; Ketoconazole	1991
[Usefulness of ketoconazole combined with cyclosporin in renal transplantation]. Investigacion clinica, 1991, Volume: 32, Issue:3 Topics: Adolescent; Adult; Azathioprine; Biotransformation; Chemical and Drug Induced Liver Injury; Cyclosporine; Cytochrome P-450 Enzyme Inhibitors; Drug Therapy, Combination; Female; Humans; Immunosuppression Therapy; Ketoconazole; Kidney Diseases; Kidney Transplantation; Liver Function Tests; Male; Middle Aged; Prednisone	1991
[Cardiac transplantation: economizing cyclosporin A by including ketoconazole in the immunosuppressive schedule]. Revista medica de Chile, 1991, Volume: 119, Issue:9 Topics: Adult; Cyclosporine; Drug Administration Schedule; Drug Therapy, Combination; Heart Transplantation; Humans; Ketoconazole; Male	1991
Differentiation of absorption and first-pass gut and hepatic metabolism in humans: studies with cyclosporine. Clinical pharmacology and therapeutics, 1995, Volume: 58, Issue:5 Topics: Administration, Oral; Biological Availability; Cyclosporine; Drug Interactions; Erythromycin; Humans; Immunosuppressive Agents; Injections, Intravenous; Intestinal Absorption; Intestinal Mucosa; Ketoconazole; Kidney Transplantation; Liver; Protein Synthesis Inhibitors; Rifampin	1995
Oxygen radical formation by the cytochrome P450 system as a cellular mechanism for cyclosporine toxicity. Transplantation proceedings, 1994, Volume: 26, Issue:5 Topics: Aminopyrine; Animals; Chloramphenicol; Cyclosporine; Cytochrome P-450 Enzyme System; Enzyme Induction; Free Radical Scavengers; Ketoconazole; Kinetics; Lipid Peroxidation; Male; Microsomes, Liver; NADP; Phenobarbital; Proadifen; Rats; Rats, Sprague-Dawley	1994
Pediatric clinical use of the ketoconazole/cyclosporin interaction. Pediatric nephrology (Berlin, Germany), 1994, Volume: 8, Issue:4 Topics: Child; Cyclosporine; Drug Interactions; Drug Therapy, Combination; Graft Rejection; Humans; Ketoconazole; Kidney Transplantation; Male; Transplantation, Homologous	1994
Potentializing effect of ketoconazole on cyclosporin A-induced inhibition of keratinocyte DNA synthesis. Acta dermato-venereologica, 1994, Volume: 74, Issue:4 Topics: Animals; Bromodeoxyuridine; Cyclosporine; DNA; Dose-Response Relationship, Drug; Drug Synergism; Female; Humans; Keratinocytes; Ketoconazole; Mice; Mice, Nude; Skin Transplantation	1994
Generation of oxygen free radicals during the metabolism of cyclosporine A: a cause-effect relationship with metabolism inhibition. Molecular and cellular biochemistry, 1993, May-26, Volume: 122, Issue:2 Topics: Aminopyrine; Animals; Carbon Tetrachloride; Catalase; Chloramphenicol; Cyclosporine; Cytochrome P-450 Enzyme System; Erythromycin; Free Radicals; Ketoconazole; Lipid Peroxidation; Male; Proadifen; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Superoxide Dismutase	1993
Decreased cyclosporine concentrations with the addition of an H2-receptor antagonist in a patient on ketoconazole. Transplantation, 1993, Volume: 56, Issue:6 Topics: Adult; Cyclosporine; Drug Interactions; Famotidine; Female; Humans; Ketoconazole; Kidney Transplantation	1993
Drugs in cardiac transplantation. The New England journal of medicine, 1996, Feb-08, Volume: 334, Issue:6 Topics: Anticholesteremic Agents; Antifungal Agents; Cholesterol; Cyclosporine; Drug Interactions; Graft Rejection; Heart Transplantation; Humans; Immunosuppressive Agents; Ketoconazole; Pravastatin	1996
Drugs in cardiac transplantation. The New England journal of medicine, 1996, Feb-08, Volume: 334, Issue:6 Topics: Cyclosporine; Cytochrome P-450 Enzyme Inhibitors; Drug Interactions; Enzyme Inhibitors; Heart Transplantation; Humans; Immunosuppressive Agents; Ketoconazole	1996
Cost-containment strategies in transplantation: the utility of cyclosporine-ketoconazole combination therapy. Transplantation proceedings, 1996, Volume: 28, Issue:2 Topics: Adolescent; Adult; Alanine Transaminase; Cost Control; Creatinine; Cyclosporine; Drug Therapy, Combination; Female; Humans; Immunosuppressive Agents; Ketoconazole; Kidney Transplantation; Liver Function Tests; Liver Transplantation; Male; Middle Aged; Platelet Count	1996
Cyclosporine a immunosuppression in sheep with response enhancement by concomitant ketoconazole. Clinical and experimental pharmacology & physiology, 1996, Volume: 23, Issue:9 Topics: Animals; Antifungal Agents; Cyclosporine; Immunosuppressive Agents; Ketoconazole; Lymphocytes; Mitogens; Regression Analysis; Sheep	1996
Effects of low-dose ketoconazole on thyroid hormones in renal transplant recipients. Transplantation proceedings, 1996, Volume: 28, Issue:6 Topics: Adult; Antifungal Agents; Azathioprine; Cyclosporine; Female; Humans; Immunosuppressive Agents; Ketoconazole; Kidney Transplantation; Male; Prednisone; Thyrotropin; Thyroxine; Triiodothyronine	1996
Survey of cyclosporin-sparing agent use in Australasian transplant centres. Australian and New Zealand journal of medicine, 1996, Volume: 26, Issue:6 Topics: Australia; Cyclosporine; Diltiazem; Drug Therapy, Combination; Humans; Immunosuppressive Agents; Ketoconazole; New Zealand; Organ Transplantation; Surveys and Questionnaires	1996
Ketoconazole and fluconazole inhibition of the metabolism of cyclosporin A by human liver in vitro. Therapeutic drug monitoring, 1997, Volume: 19, Issue:4 Topics: Adult; Antifungal Agents; Antirheumatic Agents; Chromatography, High Pressure Liquid; Cyclosporine; Dose-Response Relationship, Drug; Drug Interactions; Female; Fluconazole; Humans; Ketoconazole; Liver; Male; Microsomes, Liver; Middle Aged	1997
Unexpectedly low immunocompetence in transplant patients on ketoconazole. Clinical transplantation, 1997, Volume: 11, Issue:6 Topics: Adult; Aged; Antimetabolites; Cyclosporine; Drug Interactions; Female; Humans; Immunocompetence; Immunosuppression Therapy; Immunosuppressive Agents; Ketoconazole; Kidney Transplantation; Lymphocyte Culture Test, Mixed; Male; Middle Aged; Transplantation, Homologous	1997
Reduction of cyclosporine dosage with ketoconazole in a patient with birdshot retinochoroidopathy. American journal of ophthalmology, 1998, Volume: 125, Issue:1 Topics: Chemotherapy, Adjuvant; Choroid Diseases; Cyclosporine; Drug Therapy, Combination; Female; Humans; Immunosuppressive Agents; Ketoconazole; Middle Aged; Retinal Diseases; Safety; Uveitis, Posterior	1998
Pilot study of multiple chemotherapy resistance modulators plus epirubicin in the treatment of resistant malignancies. Cancer chemotherapy and pharmacology, 1997, Volume: 41, Issue:1 Topics: Adjuvants, Pharmaceutic; Administration, Oral; Adult; Aged; Antibiotics, Antineoplastic; Antifungal Agents; Antineoplastic Agents, Hormonal; Antineoplastic Combined Chemotherapy Protocols; Antitrichomonal Agents; Cyclosporine; Dipyridamole; Drug Resistance, Neoplasm; Epirubicin; Female; Humans; Immunosuppressive Agents; Ketoconazole; Male; Metronidazole; Middle Aged; Neoplasms; Pilot Projects; Tamoxifen; Vasodilator Agents	1997
[Conversion from +Sandimmune to Neoral in kidney transplant recipients treated with cyclosporine and ketoconazole]. Revista medica de Chile, 1997, Volume: 125, Issue:4 Topics: Adolescent; Adult; Antifungal Agents; Blood Pressure; Creatinine; Cyclosporine; Emulsions; Female; Humans; Immunosuppressive Agents; Ketoconazole; Kidney Transplantation; Male; Middle Aged	1997
[Combination of cyclosporin and ketoconazole in immunosuppression schemes in patients with transplanted kidney]. Klinicheskaia meditsina, 1998, Volume: 76, Issue:1 Topics: Acute Disease; Antifungal Agents; Cyclosporine; Dose-Response Relationship, Drug; Drug Therapy, Combination; Follow-Up Studies; Graft Rejection; Graft Survival; Humans; Immunosuppression Therapy; Immunosuppressive Agents; Ketoconazole; Kidney Transplantation; Retrospective Studies; Treatment Outcome	1998
Prediction of drug-drug interactions of zonisamide metabolism in humans from in vitro data. European journal of clinical pharmacology, 1998, Volume: 54, Issue:2 Topics: Anticonvulsants; Cyclosporine; Cytochrome P-450 Enzyme System; Dihydroergotamine; Drug Interactions; Humans; In Vitro Techniques; Isoxazoles; Itraconazole; Ketoconazole; Metabolic Clearance Rate; Miconazole; Triazolam; Zonisamide	1998
Effect of metabolic inhibitors on cyclosporine pharmacokinetics using a population approach. Therapeutic drug monitoring, 1998, Volume: 20, Issue:4 Topics: Administration, Oral; Adolescent; Adult; Aged; Antifungal Agents; Calcium Channel Blockers; Child; Cyclosporine; Diltiazem; Drug Administration Schedule; Drug Interactions; Fluconazole; Heart-Lung Transplantation; Humans; Immunosuppressive Agents; Individuality; Itraconazole; Ketoconazole; Linear Models; Middle Aged	1998
Reduction of cyclosporine dosage with ketoconazole in a patient with birdshot retinochoroidopathy. American journal of ophthalmology, 1998, Volume: 126, Issue:5 Topics: Chorioretinitis; Cyclosporine; Drug Therapy, Combination; Humans; Immunosuppressive Agents; Ketoconazole; Randomized Controlled Trials as Topic; Uveitis, Posterior	1998
Inhibition of T cell proliferation by selective block of Ca(2+)-activated K(+) channels. Proceedings of the National Academy of Sciences of the United States of America, 1999, Sep-14, Volume: 96, Issue:19 Topics: Calcium; Calcium Channel Blockers; Cells, Cultured; Clotrimazole; Concanavalin A; Cyclosporine; Dose-Response Relationship, Drug; Electrochemistry; Enzyme Inhibitors; Growth Inhibitors; Humans; Interferon-gamma; Ketoconazole; Lymphocyte Activation; Nitrendipine; Patch-Clamp Techniques; Phytohemagglutinins; Potassium Channel Blockers; Potassium Channels; T-Lymphocytes; Tetanus Toxin; Time Factors	1999
Small intestinal metabolism of the 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitor lovastatin and comparison with pravastatin. The Journal of pharmacology and experimental therapeutics, 1999, Volume: 291, Issue:1 Topics: Animals; Aryl Hydrocarbon Hydroxylases; Cyclosporine; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Interactions; Enzyme Inhibitors; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Intestine, Small; Ketoconazole; Lovastatin; Male; Microsomes, Liver; Oxidoreductases, N-Demethylating; Pravastatin; Swine; Troleandomycin	1999
Studies on the interactions between drugs and estrogen: analytical method for prediction system of gynecomastia induced by drugs on the inhibitory metabolism of estradiol using Escherichia coli coexpressing human CYP3A4 with human NADPH-cytochrome P450 re Analytical biochemistry, 2000, Nov-15, Volume: 286, Issue:2 Topics: Catechols; Cimetidine; Cyclosporine; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Inhibitors; Escherichia coli; Estradiol; Female; Gynecomastia; Humans; Hydroxylation; In Vitro Techniques; Ketoconazole; Kinetics; Male; Mixed Function Oxygenases; NADPH-Ferrihemoprotein Reductase; Recombinant Proteins	2000
Pharmacokinetics of cyclosporine in heart transplant recipients receiving metabolic inhibitors. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation, 2001, Volume: 20, Issue:4 Topics: Calcium Channel Blockers; Cyclosporine; Diltiazem; Drug Interactions; Female; Heart Transplantation; Humans; Immunosuppressive Agents; Ketoconazole; Linear Models; Male; Middle Aged; Multivariate Analysis	2001
Metabolism of amiodarone (Part III): identification of rabbit cytochrome P450 isoforms involved in the hydroxylation of mono-N-desethylamiodarone. Xenobiotica; the fate of foreign compounds in biological systems, 2001, Volume: 31, Issue:5 Topics: Amiodarone; Animals; Anti-Anxiety Agents; Anti-Arrhythmia Agents; Aryl Hydrocarbon Hydroxylases; Benzoflavones; Chromatography, High Pressure Liquid; Cimetidine; Cyclosporine; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Enzyme Inhibitors; Ketoconazole; Kinetics; Microsomes, Liver; Midazolam; Models, Chemical; Oxidoreductases, N-Demethylating; Protein Isoforms; Quinidine; Rabbits; Rifampin; Time Factors	2001
Cyclosporin immunosuppression of sheep: pharmacokinetics and allograft survival. Veterinary immunology and immunopathology, 2001, Aug-30, Volume: 81, Issue:1-2 Topics: Animals; Chromatography, High Pressure Liquid; Cyclosporine; Female; Graft Survival; Immunosuppressive Agents; Ketoconazole; Sheep; Skin Transplantation; Transplantation, Homologous	2001
Peppermint oil enhances cyclosporine oral bioavailability in rats: comparison with D-alpha-tocopheryl poly(ethylene glycol 1000) succinate (TPGS) and ketoconazole. Journal of pharmaceutical sciences, 2002, Volume: 91, Issue:1 Topics: Administration, Oral; Animals; Antiemetics; Antifungal Agents; Biological Availability; Cyclosporine; Drug Synergism; Humans; Immunosuppressive Agents; Ketoconazole; Male; Mentha piperita; Microsomes, Liver; Plant Oils; Polyethylene Glycols; Rats; Rats, Sprague-Dawley; Vitamin E	2002
Minimal effect of ketoconazole on cyclosporine (SangCyA) oral absorption and first-pass metabolism in rats: evidence of a significant vehicle effect on SangCyA absorption. Biopharmaceutics & drug disposition, 2002, Volume: 23, Issue:2 Topics: Animals; Antifungal Agents; Area Under Curve; Biological Availability; Chromatography, High Pressure Liquid; Cyclosporine; Drug Interactions; Immunosuppressive Agents; Intestinal Absorption; Ketoconazole; Male; Pharmaceutical Vehicles; Rats; Spectrophotometry, Ultraviolet	2002
Cyclosporin C(2) and C(0) concentration monitoring in stable, long-term heart transplant recipients receiving metabolic inhibitors. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation, 2003, Volume: 22, Issue:7 Topics: Antifungal Agents; Area Under Curve; Biological Availability; Calcium Channel Blockers; Cyclosporine; Cyclosporins; Diltiazem; Dose-Response Relationship, Drug; Drug Monitoring; Enzyme Inhibitors; Female; Heart Transplantation; Humans; Ketoconazole; Male; Middle Aged; Predictive Value of Tests; Statistics as Topic; Time; Time Factors	2003
Ketoconazole alters cyclosporine pharmacokinetic profile and may predispose to acute rejection. Transplantation proceedings, 2003, Volume: 35, Issue:7 Topics: Antifungal Agents; Area Under Curve; Cyclosporine; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Graft Rejection; Humans; Immunosuppressive Agents; Ketoconazole; Kidney Transplantation; Male; Middle Aged	2003
Role of multiple drug resistance protein 1 in neutral but not acidic glycosphingolipid biosynthesis. The Journal of biological chemistry, 2004, Feb-27, Volume: 279, Issue:9 Topics: Acidic Glycosphingolipids; Animals; Astrocytoma; ATP Binding Cassette Transporter, Subfamily B, Member 1; Carrier Proteins; Cell Line; Cyclosporine; Dogs; Gene Expression; Glucosylceramides; HeLa Cells; Humans; Ketoconazole; Kidney; Lactosylceramides; Membrane Proteins; Meningioma; Mice; Mice, Knockout; Microscopy, Immunoelectron; Neutral Glycosphingolipids; Phospholipid Transfer Proteins; Recombinant Proteins; Transfection; Trihexosylceramides; Tumor Cells, Cultured	2004
Drug-drug interactions evaluated by a highly active reconstituted native human cytochrome P4503A4 and human NADPH-cytochrome P450 reductase system. Arzneimittel-Forschung, 2004, Volume: 54, Issue:1 Topics: Antifungal Agents; Antimalarials; Catalysis; Chromatography, High Pressure Liquid; Cimetidine; Cyclosporine; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Drug Interactions; Electrophoresis, Polyacrylamide Gel; Estrogen Antagonists; Ethinyl Estradiol; Flavanones; Hormone Antagonists; Humans; Immunosuppressive Agents; In Vitro Techniques; Ketoconazole; Microsomes, Liver; Mifepristone; NADPH-Ferrihemoprotein Reductase; Phospholipids; Quinidine; Quinine; Tacrolimus	2004
The use of a cyclosporin-ketoconazole combination: making renal transplantation affordable in developing countries. European journal of clinical pharmacology, 2004, Volume: 60, Issue:3 Topics: Adolescent; Adult; Cyclosporine; Developing Countries; Drug Administration Schedule; Drug Combinations; Female; Graft Survival; Humans; Ketoconazole; Kidney Transplantation; Liver; Male; Middle Aged; Retrospective Studies; Risk Factors; South Africa; Survival Analysis; Time Factors; Transaminases	2004
Cyclosporine and low-dose ketoconazole in renal transplant recipients: a single-center experience. Transplantation, 2004, Apr-15, Volume: 77, Issue:7 Topics: Adult; Antifungal Agents; Cyclosporine; Female; Humans; Immunosuppressive Agents; Ketoconazole; Kidney Transplantation; Male; Middle Aged	2004
Efficacy of combined cyclosporine A and ketoconazole treatment of anal furunculosis. The Journal of small animal practice, 2004, Volume: 45, Issue:5 Topics: Animals; Antifungal Agents; Anus Diseases; Cyclosporine; Dog Diseases; Dogs; Drug Therapy, Combination; Female; Furunculosis; Immunosuppressive Agents; Ketoconazole; Male; Severity of Illness Index; Treatment Outcome; Victoria	2004
Multicentric lymphoma in a dog after cyclosporine therapy. The Journal of small animal practice, 2004, Volume: 45, Issue:5 Topics: Animals; Antifungal Agents; Anus Diseases; Blood Cell Count; Blood Chemical Analysis; Cyclosporine; Diagnosis, Differential; Dog Diseases; Dogs; Furunculosis; Immunosuppressive Agents; Ketoconazole; Lymphoma; Male	2004
Concomitant administration of cyclosporine and ketoconazole in idiopathic nephrotic syndrome. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2004, Volume: 19, Issue:9 Topics: Adolescent; Adrenal Cortex Hormones; Adult; Antifungal Agents; Child; Cyclosporine; Drug Synergism; Drug Therapy, Combination; Female; Humans; Immunosuppressive Agents; Ketoconazole; Male; Nephrotic Syndrome; Retrospective Studies; Treatment Outcome	2004
Co-administration of cyclosporine and ketoconazole in idiopathic childhood nephrosis. Pediatric nephrology (Berlin, Germany), 2004, Volume: 19, Issue:9 Topics: Child; Child, Preschool; Cohort Studies; Costs and Cost Analysis; Cyclosporine; Drug Interactions; Drug Therapy, Combination; Female; Humans; Immunosuppressive Agents; Ketoconazole; Male; Nephrotic Syndrome; Retrospective Studies	2004
In vivo effects of cyclosporin A and ketoconazole on the pharmacokinetics of representative substrates for P-glycoprotein and cytochrome P450 (CYP) 3A in rats. Biological & pharmaceutical bulletin, 2005, Volume: 28, Issue:2 Topics: Animals; Aryl Hydrocarbon Hydroxylases; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cyclosporine; Cytochrome P-450 CYP3A; Dose-Response Relationship, Drug; Enzyme Inhibitors; Ketoconazole; Male; Oxidoreductases, N-Demethylating; Rats; Rats, Wistar; Substrate Specificity	2005
Co-administration of cyclosporine and ketoconazole in children with minimal change nephrotic syndrome. Nephron. Clinical practice, 2005, Volume: 100, Issue:2 Topics: Child; Child, Preschool; Cyclosporine; Drug Therapy, Combination; Female; Humans; Ketoconazole; Male; Nephrosis, Lipoid; Retrospective Studies	2005
Hepatotoxicity associated with cyclosporine monitoring using C2 recommendations in adults renal recipients receiving ketoconazole. Transplantation proceedings, 2005, Volume: 37, Issue:3 Topics: Adult; Antifungal Agents; Cyclosporine; Drug Monitoring; Drug Therapy, Combination; Female; Humans; Immunosuppressive Agents; Ketoconazole; Kidney Transplantation; Liver; Male; Middle Aged	2005
Impact of the cyclosporine-ketoconazole interaction in children with steroid-dependent idiopathic nephrotic syndrome. European journal of clinical pharmacology, 2006, Volume: 62, Issue:1 Topics: Adolescent; Angiotensin-Converting Enzyme Inhibitors; Captopril; Child; Child, Preschool; Cyclosporine; Drug Synergism; Drug Therapy, Combination; Female; Humans; Immunosuppressive Agents; Ketoconazole; Male; Nephrotic Syndrome; Retrospective Studies; Steroids	2006
Use of capecitabine after renal allograft transplantation in dog erythrocyte antigen-matched dogs. Veterinary surgery : VS, 2006, Volume: 35, Issue:2 Topics: Animals; Blood Chemical Analysis; Capecitabine; Cyclosporine; Deoxycytidine; Dogs; Dose-Response Relationship, Drug; Dose-Response Relationship, Immunologic; Drug Therapy, Combination; Female; Fluorouracil; Graft Rejection; Immunosuppressive Agents; Ketoconazole; Kidney Transplantation; Nephrectomy; Pilot Projects; Prednisolone; Prospective Studies; Transplantation Immunology; Transplantation, Homologous; Treatment Outcome	2006
Decision support tool to individualize cyclosporine dose in stable, long-term heart transplant recipients receiving metabolic inhibitors: overcoming limitations of cyclosporine C2 monitoring. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation, 2006, Volume: 25, Issue:10 Topics: Area Under Curve; Bayes Theorem; Cardiovascular Agents; Cyclosporine; Decision Support Techniques; Diltiazem; Dose-Response Relationship, Drug; Drug Monitoring; Drug Therapy, Combination; Feedback, Physiological; Heart Transplantation; Humans; Immunosuppressive Agents; Ketoconazole; Predictive Value of Tests; Time Factors	2006
Ciclosporin use in multi-drug therapy for meningoencephalomyelitis of unknown aetiology in dogs. The Journal of small animal practice, 2007, Volume: 48, Issue:9 Topics: Adrenal Cortex Hormones; Animals; Blood Cell Count; Blood Chemical Analysis; Cyclosporine; Dog Diseases; Dogs; Drug Therapy, Combination; Female; Immunosuppressive Agents; Ketoconazole; Meningoencephalitis; Prognosis; Safety; Survival Analysis; Time Factors; Treatment Outcome	2007
An examination of the effect of intestinal first pass extraction on intestinal lymphatic transport of saquinavir in the rat. Pharmaceutical research, 2008, Volume: 25, Issue:5 Topics: Animals; Anti-HIV Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Availability; Biological Transport, Active; Cyclosporine; Cytochrome P-450 Enzyme System; Data Interpretation, Statistical; Intestinal Absorption; Ketoconazole; Lymphatic System; Male; Micelles; Rats; Rats, Wistar; Saquinavir; Triglycerides; Triolein; Verapamil	2008
Ketoconazole and the modulation of multidrug resistance-mediated transport in Caco-2 and MDCKII-MDR1 drug transport models. Xenobiotica; the fate of foreign compounds in biological systems, 2008, Volume: 38, Issue:2 Topics: Animals; Antifungal Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Caco-2 Cells; Cells, Cultured; Cyclosporine; Digoxin; Dogs; Drug Resistance, Multiple; Humans; Ketoconazole	2008
Decreased oral absorption of cyclosporine A after liver ischemia-reperfusion injury in rats: the contribution of CYP3A and P-glycoprotein to the first-pass metabolism in intestinal epithelial cells. The Journal of pharmacology and experimental therapeutics, 2009, Volume: 328, Issue:1 Topics: Animals; Area Under Curve; ATP Binding Cassette Transporter, Subfamily B, Member 1; Bile; Biological Availability; Cyclosporine; Cytochrome P-450 CYP3A; Hydroxylation; Immunosuppressive Agents; Intestinal Absorption; Intestinal Mucosa; Intestine, Small; Ketoconazole; Liver Circulation; Liver Transplantation; Male; Microsomes; Microsomes, Liver; Postoperative Complications; Rats; Rats, Wistar; Reperfusion Injury; Testosterone	2009
Clearance and clearance inhibition of the HIV-1 protease inhibitors ritonavir and saquinavir in sandwich-cultured rat hepatocytes and rat microsomes. Toxicology in vitro : an international journal published in association with BIBRA, 2009, Volume: 23, Issue:1 Topics: Animals; Biological Transport, Active; Cell Culture Techniques; Cell Survival; Cells, Cultured; Cyclosporine; Cyclosporins; Dose-Response Relationship, Drug; Hepatocytes; HIV Protease Inhibitors; Ketoconazole; Male; Metabolic Clearance Rate; Microsomes, Liver; Rats; Rats, Wistar; Ritonavir; Saquinavir	2009
Single-center experience with cyclosporine for treatment of idiopathic minimal change nephrotic syndrome in children. Iranian journal of kidney diseases, 2009, Volume: 3, Issue:3 Topics: Antifungal Agents; Child; Child, Preschool; Cyclophosphamide; Cyclosporine; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Immunosuppressive Agents; Ketoconazole; Male; Nephrosis, Lipoid; Remission Induction; Retrospective Studies; Secondary Prevention; Steroids	2009
Presumptive Nocardia spp. infection in a dog treated with cyclosporin and ketoconazole. New Zealand veterinary journal, 2010, Volume: 58, Issue:5 Topics: Animals; Antifungal Agents; Cyclosporine; Dermatitis, Atopic; Dogs; Female; Immunosuppression Therapy; Immunosuppressive Agents; Ketoconazole; Nocardia; Nocardia Infections; Opportunistic Infections	2010
Characterization of efflux transporters involved in distribution and disposition of apixaban. Drug metabolism and disposition: the biological fate of chemicals, 2013, Volume: 41, Issue:4 Topics: Adenosine; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Caco-2 Cells; Cell Line, Transformed; Cell Membrane Permeability; Cyclosporine; Digoxin; Diketopiperazines; Dose-Response Relationship, Drug; Drug Interactions; Fibrinolytic Agents; Heterocyclic Compounds, 4 or More Rings; Humans; Ketoconazole; Male; Naproxen; Neoplasm Proteins; Pyrazoles; Pyridones; Rats	2013
Transport inhibition of digoxin using several common P-gp expressing cell lines is not necessarily reporting only on inhibitor binding to P-gp. PloS one, 2013, Volume: 8, Issue:8 Topics: Acridines; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Caco-2 Cells; Carbamates; Cell Membrane Permeability; Cyclosporine; Digoxin; Dogs; Furans; Gene Expression; Humans; Ketoconazole; Kinetics; Loperamide; Madin Darby Canine Kidney Cells; Protein Binding; Quinidine; Sulfonamides; Tetrahydroisoquinolines; Vinblastine	2013
Capsaicin pretreatment increased the bioavailability of cyclosporin in rats: involvement of P-glycoprotein and CYP 3A inhibition. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2013, Volume: 62 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP-Binding Cassette Sub-Family B Member 4; Biological Availability; Capsaicin; Cyclosporine; Cytochrome P-450 CYP3A; Dexamethasone; Dietary Supplements; Dose-Response Relationship, Drug; Food-Drug Interactions; Ketoconazole; Male; Rats, Sprague-Dawley	2013
Ciclosporin therapy for canine generalized discoid lupus erythematosus refractory to doxycycline and niacinamide. Veterinary dermatology, 2014, Volume: 25, Issue:5 Topics: Animals; Anti-Bacterial Agents; Antifungal Agents; Cyclosporine; Dermatologic Agents; Dog Diseases; Dogs; Doxycycline; Drug Therapy, Combination; Ketoconazole; Lupus Erythematosus, Discoid; Male; Niacinamide; Treatment Failure; Treatment Outcome	2014
Physiologically based pharmacokinetic modeling for assessing the clinical drug-drug interaction of alisporivir. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 2014, Oct-15, Volume: 63 Topics: Administration, Oral; Caco-2 Cells; Cyclosporine; Cytochrome P-450 CYP3A; Dose-Response Relationship, Drug; Drug Interactions; Humans; Ketoconazole; Models, Biological; Rifampin	2014
An improved and versatile immunosuppression protocol for the development of tumor xenograft in mice. Anticancer research, 2014, Volume: 34, Issue:12 Topics: Adenocarcinoma; Animals; Cell Line, Tumor; Cyclophosphamide; Cyclosporine; Cytochrome P-450 CYP3A Inhibitors; Humans; Immunosuppression Therapy; Immunosuppressive Agents; Ketoconazole; Male; Mice; Mice, Inbred C57BL; Xenograft Model Antitumor Assays	2014
Rat precision-cut intestinal slices to study P-gp activity and the potency of its inhibitors ex vivo. Toxicology in vitro : an international journal published in association with BIBRA, 2015, Volume: 29, Issue:5 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cyclosporine; Cyclosporins; In Vitro Techniques; Intestinal Mucosa; Isoquinolines; Ketoconazole; Male; Quinazolines; Quinidine; Rats, Wistar; Rhodamine 123; Verapamil	2015
Physiologically-Based Pharmacokinetic Modeling of Macitentan: Prediction of Drug-Drug Interactions. Clinical pharmacokinetics, 2016, Volume: 55, Issue:3 Topics: Adult; Cyclosporine; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Drug Interactions; Endothelin A Receptor Antagonists; Endothelin B Receptor Antagonists; Humans; Ketoconazole; Male; Models, Biological; Pyrimidines; Rifampin; Sildenafil Citrate; Sulfonamides; Warfarin	2016
Alopecia universalis in a dog with testicular neoplasia. Veterinary dermatology, 2016, Volume: 27, Issue:6 Topics: 14-alpha Demethylase Inhibitors; Alopecia; Animals; Cyclosporine; Dermatologic Agents; Dog Diseases; Dogs; Ketoconazole; Male; Testicular Neoplasms	2016
Mechanism-based risk assessment strategy for drug-induced cholestasis using the transcriptional benchmark dose derived by toxicogenomics. The Journal of toxicological sciences, 2017, Volume: 42, Issue:4 Topics: Administration, Oral; Animals; Chlorpromazine; Cholestasis; Cholesterol; Cyclosporine; Diclofenac; Dose-Response Relationship, Drug; Flutamide; Gene Expression; Humans; Imipramine; Inflammation; Ketoconazole; Liver; Methyltestosterone; Oxidative Stress; Rats; Risk Assessment; Sulindac; Tamoxifen; Toxicogenetics	2017
Combination therapy with azathioprine, cyclosporine and ketoconazole in a dog with concurrent pemphigus foliaceus and hyperadrenocorticism - Case report. Acta veterinaria Hungarica, 2020, 09-30, Volume: 68, Issue:3 Topics: Adrenocortical Hyperfunction; Animals; Azathioprine; Cyclosporine; Dog Diseases; Dogs; Drug Combinations; Female; Immunosuppressive Agents; Ketoconazole; Pemphigus	2020
Tumour induction in BALB/c mice for imaging studies: An improved protocol. Journal of cellular and molecular medicine, 2023, Volume: 27, Issue:13 Topics: Animals; Cyclophosphamide; Cyclosporine; Humans; Ketoconazole; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasms	2023