Compounds > ketoconazole

ketoconazole and clozapine n-oxide

ketoconazole has been researched along with clozapine n-oxide in 3 studies

Research

Studies (3)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (66.67)29.6817
2010's1 (33.33)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Giordanetto, F; Leach, AG; Zachariae, U1
D'Esposito, F; Edwards, RJ; Murray, M; Ramzan, I; Zhang, WV1
Edwards, RJ; Murray, M; Zhang, WV1

Other Studies

3 other study(ies) available for ketoconazole and clozapine n-oxide

ArticleYear
Side chain flexibilities in the human ether-a-go-go related gene potassium channel (hERG) together with matched-pair binding studies suggest a new binding mode for channel blockers.
    Journal of medicinal chemistry, 2009, Jul-23, Volume: 52, Issue:14

    Topics: Binding Sites; Ether-A-Go-Go Potassium Channels; Humans; Hydrophobic and Hydrophilic Interactions; Ligands; Models, Molecular; Potassium Channel Blockers; Protein Binding; Protein Conformation

2009
Interindividual variation in relative CYP1A2/3A4 phenotype influences susceptibility of clozapine oxidation to cytochrome P450-specific inhibition in human hepatic microsomes.
    Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:12

    Topics: Alleles; Aryl Hydrocarbon Hydroxylases; Biotransformation; Catalysis; Clozapine; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP1A2 Inhibitors; Cytochrome P-450 CYP2B6; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dextromethorphan; Enzyme Inhibitors; Fluvoxamine; Humans; Isoenzymes; Ketoconazole; Kinetics; Microsomes, Liver; Oxidation-Reduction; Oxidoreductases, N-Demethylating; Oxygenases; Recombinant Proteins; Testosterone; Tolbutamide

2008
Variation in the Response of Clozapine Biotransformation Pathways in Human Hepatic Microsomes to CYP1A2- and CYP3A4-selective Inhibitors.
    Basic & clinical pharmacology & toxicology, 2018, Volume: 122, Issue:4

    Topics: Antipsychotic Agents; Biotransformation; Clozapine; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP1A2 Inhibitors; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Drug Interactions; Fluvoxamine; Humans; Hydroxylation; Ketoconazole; Liver; Microsomes, Liver; Oxidation-Reduction

2018