ketoconazole and cimetidine

ketoconazole has been researched along with cimetidine in 68 studies

Research

Studies (68)

Timeframe	Studies, this research(%)	All Research%
pre-1990	9 (13.24)	18.7374
1990's	14 (20.59)	18.2507
2000's	23 (33.82)	29.6817
2010's	21 (30.88)	24.3611
2020's	1 (1.47)	2.80

Authors

Authors	Studies
Brodsky, JL; Chiang, A; Chung, WJ; Denny, RA; Goeckeler-Fried, JL; Havasi, V; Hong, JS; Keeton, AB; Mazur, M; Piazza, GA; Plyler, ZE; Rasmussen, L; Rowe, SM; Sorscher, EJ; Weissman, AM; White, EL	1
Guo, HF; Jin, J; Li, ZR; Liu, ZY; Xie, ZS; Xue, ST; Yi, H; Zhang, L	1
Huang, L; Humphreys, JE; Morgan, JB; Polli, JW; Serabjit-Singh, CS; Webster, LO; Wring, SA	1
Alvarez-Pedraglio, A; Colmenarejo, G; Lavandera, JL	1
Fischer, H; Huwyler, J; Poli, S; Schwab, D; Tabatabaei, A	1
Casciano, CN; Clement, RP; Johnson, WW; Wang, EJ	1
Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J	1
Artursson, P; Bergström, CA; Hoogstraate, J; Matsson, P; Norinder, U; Pedersen, JM	1
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM	1
Pratim Roy, P; Roy, K	1
Austin, CP; Fidock, DA; Hayton, K; Huang, R; Inglese, J; Jiang, H; Johnson, RL; Su, XZ; Wellems, TE; Wichterman, J; Yuan, J	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Choi, SS; Contrera, JF; Hastings, KL; Kruhlak, NL; Sancilio, LF; Weaver, JL; Willard, JM	1
García-Mera, X; González-Díaz, H; Prado-Prado, FJ	1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ	1
Glen, RC; Lowe, R; Mitchell, JB	1
Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ	1
Ekins, S; Williams, AJ; Xu, JJ	1
Chen, X; Lin, X; Skolnik, S; Wang, J	1
Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V	1
Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR	1
Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY	1
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ	1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ	1
Artursson, P; Mateus, A; Matsson, P	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Chen, EC; Chien, HC; Giacomini, KM; Huang, Y; Khuri, N; Liang, X; Sali, A; Stecula, A; Yee, SW	1
Hsieh, CY; Huang, JD	1
Gibaldi, M	1
Hansten, PD	1
Blum, RA; D'Andrea, DT; Florentino, BM; Gardner, MJ; Goldstein, H; Henry, EB; Hilligoss, DM; Schentag, JJ; Wilton, JH	1
Morita, K; Ono, T; Shimakawa, H	2
Coleman, MD; Park, BK; Tingle, MD	1
Diekmann, HW; Overbosch, D; Schneidereit, M	1
de Moragas, JM; García, MP; Pérez, M; Puig, L	1
Advenier, C; Naline, E; Pays, M; Sanceaume, M	1
Kolts, BE; Langfitt, M	1
Darvey, DL; Sorkin, EM	1
Sedman, AJ	1
Beeley, L	1
Brugmans, J; Heykants, J; Keuning, JJ; Scheijgrond, HW; Van Cutsem, J; Van Der Meer, JW	1
Collins, JM; Jamis-Dow, CA; Katki, AG; Klecker, RW	1
Ring, BJ; Wrighton, SA	1
Csikó, G; Nijmeijer, SM; van Miert, AS; Witkamp, RF	1
Kalhorn, TF; Kharasch, ED; Mitra, AK; Slattery, JT; Thummel, KE; Unadkat, JD	1
Shaw, JC	1
Altschuler, SM; Athreya, B; Mascarenhas, MR; McGowan, KL; Ruchelli, E	1
Haaz, MC; Riché, C; Rivory, LP; Robert, J	1
Butters, CJ; McKillop, D; Wild, MJ	1
Rojas-Fernandez, C	1
Abbas, R; Bramer, SL; Browder, NJ; Chow, CP; Flockhart, DA; Forbes, W; Fu, CJ; Odomi, M; Thacker, D	1
Douya, R; Mushiroda, T; Nagata, O; Takahara, E	1
Fujita, KI; Itoh, S; Kamataki, T; Munakata, H; Nakamura, K; Satoh, T; Yoshizawa, I	1
Affrime, MB; Batra, VK; Cayen, MN; Kosoglou, T; Lim, JM; Salfi, M	1
Bigler, L; Follath, F; Ha, HR; Kozlik, P; Stieger, B	1
Green, CE; Hirota, N; Ito, K; Iwatsubo, T; Shimada, N; Sugiyama, Y; Suzuki, H; Tyson, CA	1
Haehner, T; Müller-Enoch, D; Refaie, MO	1
Honda, K; Inomata, S; Misawa, S; Nagashima, A; Tanaka, E	1
Huang, Q; Jia, YW; Wang, GJ; Xie, HT; Xu, MJ	1
Boralli, VB; Coelho, EB; Lanchote, VL	1
Hayashi, Y; Helmi, AR; Khalil, WF; Motoyama, S; Sasaki, K; Shah, SS; Shimoda, M	1
Ishihara, Y; Ishii, S; Onishi, Y; Sakai, Y; Shimamoto, N; Yamamura, N	1
Di Nardo, G; Ferrero, S; Gilardi, G; Sadeghi, SJ	1
Baldwin, HS; Brown, N; Cotton, RB; Ehinger, NJ; Paria, BC; Poole, SD; Reese, J; Shah, LP; Shelton, EL; Slaughter, JC	1
KuKanich, B; KuKanich, K	1
Black, J; KuKanich, B; KuKanich, K	1

Reviews

6 review(s) available for ketoconazole and cimetidine

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016
Drug interactions: Part I. The Annals of pharmacotherapy, 1992, Volume: 26, Issue:5 Topics: Antidepressive Agents, Tricyclic; Caffeine; Cimetidine; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Interactions; Enzyme Induction; Fluconazole; Fluoxetine; Hexobarbital; Humans; Ketoconazole; Nimodipine; Oxidoreductases; Pharmaceutical Preparations; Rifampin; Stereoisomerism; Warfarin; Zidovudine	1992
Review of cimetidine drug interactions. Drug intelligence & clinical pharmacy, 1983, Volume: 17, Issue:2 Topics: Adrenergic beta-Antagonists; Animals; Anti-Anxiety Agents; Anti-Bacterial Agents; Benzodiazepines; Cimetidine; Diet; Drug Interactions; Glucose; Guanidines; Histamine H1 Antagonists; Humans; Imidazoles; Insulin; Ketoconazole; Metoclopramide; Microsomes, Liver; Mixed Function Oxygenases; Phenobarbital; Phenytoin; Piperazines; Propantheline	1983
Cimetidine-drug interactions. The American journal of medicine, 1984, Volume: 76, Issue:1 Topics: Adrenergic beta-Antagonists; Anticonvulsants; Benzodiazepines; Chlormethiazole; Cimetidine; Drug Interactions; Humans; Ketoconazole; Kidney; Lidocaine; Morphine; Penicillins; Theophylline	1984
Drug-induced sexual dysfunction and infertility. Adverse drug reactions and acute poisoning reviews, 1984,Spring, Volume: 3, Issue:1 Topics: Adult; Antidepressive Agents, Tricyclic; Antipsychotic Agents; Benzothiadiazines; Child; Cimetidine; Clonidine; Cytotoxins; Diuretics; Ejaculation; Erectile Dysfunction; Ethanol; Female; Humans; Infertility; Infertility, Female; Infertility, Male; Ketoconazole; Libido; Male; Methyldopa; Middle Aged; Narcotics; Orgasm; Parasympatholytics; Penis; Phenothiazines; Propranolol; Sexual Dysfunction, Physiological; Sodium Chloride Symporter Inhibitors; Sulfasalazine	1984
Antiandrogen therapy in dermatology. International journal of dermatology, 1996, Volume: 35, Issue:11 Topics: Adrenal Cortex Hormones; Androgen Antagonists; Cimetidine; Contraceptives, Oral; Cyproterone Acetate; Finasteride; Flutamide; Humans; Ketoconazole; Skin Diseases; Spironolactone	1996

Trials

3 trial(s) available for ketoconazole and cimetidine

Article	Year
Increased gastric pH and the bioavailability of fluconazole and ketoconazole. Annals of internal medicine, 1991, May-01, Volume: 114, Issue:9 Topics: Adult; Biological Availability; Cimetidine; Drug Interactions; Fluconazole; Gastric Acidity Determination; Humans; Ketoconazole; Male; Random Allocation; Statistics as Topic	1991
Inhibition of sulfamethoxazole hydroxylamine formation by fluconazole in human liver microsomes and healthy volunteers. Clinical pharmacology and therapeutics, 1996, Volume: 59, Issue:3 Topics: Adult; Antifungal Agents; Cimetidine; Fluconazole; Histamine H2 Antagonists; Humans; Ketoconazole; Male; Microsomes, Liver; Reference Values; Sulfamethoxazole	1996
Evaluation of the pharmacokinetics and electrocardiographic pharmacodynamics of loratadine with concomitant administration of ketoconazole or cimetidine. British journal of clinical pharmacology, 2000, Volume: 50, Issue:6 Topics: Adult; Antifungal Agents; Cimetidine; Consumer Product Safety; Cross-Over Studies; Drug Interactions; Electrocardiography; Histamine H1 Antagonists; Histamine H2 Antagonists; Humans; Ketoconazole; Loratadine; Male; Single-Blind Method	2000

Other Studies

59 other study(ies) available for ketoconazole and cimetidine

Article	Year
Increasing the Endoplasmic Reticulum Pool of the F508del Allele of the Cystic Fibrosis Transmembrane Conductance Regulator Leads to Greater Folding Correction by Small Molecule Therapeutics. PloS one, 2016, Volume: 11, Issue:10 Topics: Alleles; Benzoates; Cells, Cultured; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Endoplasmic Reticulum; Furans; Gene Deletion; HEK293 Cells; HeLa Cells; High-Throughput Screening Assays; Humans; Hydroxamic Acids; Microscopy, Fluorescence; Protein Folding; Protein Structure, Tertiary; Pyrazoles; RNA, Messenger; Small Molecule Libraries; Ubiquitination; Vorinostat	2016
Substituted benzothiophene and benzofuran derivatives as a novel class of bone morphogenetic Protein-2 upregulators: Synthesis, anti-osteoporosis efficacies in ovariectomized rats and a zebrafish model, and ADME properties. European journal of medicinal chemistry, 2020, Aug-15, Volume: 200 Topics: Animals; Benzofurans; Bone Morphogenetic Protein 2; Caco-2 Cells; Disease Models, Animal; Dose-Response Relationship, Drug; Humans; Mice; Mice, Inbred BALB C; Molecular Structure; Osteoporosis; Ovariectomy; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship; Thiophenes; Zebrafish	2020
Rational use of in vitro P-glycoprotein assays in drug discovery. The Journal of pharmacology and experimental therapeutics, 2001, Volume: 299, Issue:2 Topics: Adenosine Triphosphatases; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cells, Cultured; Chromatography, Liquid; Enzyme Inhibitors; Fluoresceins; Fluorescent Dyes; Humans; Mass Spectrometry; Pharmacology; Spodoptera	2001
Cheminformatic models to predict binding affinities to human serum albumin. Journal of medicinal chemistry, 2001, Dec-06, Volume: 44, Issue:25 Topics: Adrenergic beta-Antagonists; Antidepressive Agents, Tricyclic; Chromatography, Affinity; Cyclooxygenase Inhibitors; Databases, Factual; Humans; Hydrophobic and Hydrophilic Interactions; Penicillins; Pharmaceutical Preparations; Protein Binding; Quantitative Structure-Activity Relationship; Reproducibility of Results; Serum Albumin; Steroids	2001
Comparison of in vitro P-glycoprotein screening assays: recommendations for their use in drug discovery. Journal of medicinal chemistry, 2003, Apr-24, Volume: 46, Issue:9 Topics: Adenosine Triphosphatases; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Cells, Cultured; Drug Evaluation, Preclinical; Fluoresceins; Fluorescent Dyes; Humans; Indicators and Reagents; Mice; Models, Molecular; Rhodamines; Species Specificity; Swine	2003
Fluorescent substrates of sister-P-glycoprotein (BSEP) evaluated as markers of active transport and inhibition: evidence for contingent unequal binding sites. Pharmaceutical research, 2003, Volume: 20, Issue:4 Topics: ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Binding Sites; Biological Transport, Active; Biomarkers; Cells, Cultured; Drug Interactions; Fluorescent Dyes; Humans	2003
Chemical genetics reveals a complex functional ground state of neural stem cells. Nature chemical biology, 2007, Volume: 3, Issue:5 Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells	2007
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2). Journal of medicinal chemistry, 2008, Jun-12, Volume: 51, Issue:11 Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Computer Simulation; Cytochrome P-450 Enzyme System; Drug-Related Side Effects and Adverse Reactions; Estradiol; Humans; Insecta; Liver; Models, Molecular; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Pharmaceutical Preparations; Pharmacology; Structure-Activity Relationship	2008
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1. Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19 Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship	2008
Comparative chemometric modeling of cytochrome 3A4 inhibitory activity of structurally diverse compounds using stepwise MLR, FA-MLR, PLS, GFA, G/PLS and ANN techniques. European journal of medicinal chemistry, 2009, Volume: 44, Issue:7 Topics: Algorithms; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Enzyme Inhibitors; Factor Analysis, Statistical; Least-Squares Analysis; Linear Models; Models, Molecular; Neural Networks, Computer; Quantitative Structure-Activity Relationship; Reproducibility of Results	2009
Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum. Nature chemical biology, 2009, Volume: 5, Issue:10 Topics: Animals; Antimalarials; ATP Binding Cassette Transporter, Subfamily B, Member 1; Chromosome Mapping; Crosses, Genetic; Dihydroergotamine; Drug Design; Drug Resistance; Humans; Inhibitory Concentration 50; Mutation; Plasmodium falciparum; Quantitative Trait Loci; Transfection	2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models. Toxicology mechanisms and methods, 2008, Volume: 18, Issue:2-3 Topics:	2008
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species. Bioorganic & medicinal chemistry, 2010, Mar-15, Volume: 18, Issue:6 Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics	2010
Developing structure-activity relationships for the prediction of hepatotoxicity. Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes	2010
Predicting phospholipidosis using machine learning. Molecular pharmaceutics, 2010, Oct-04, Volume: 7, Issue:5 Topics: Animals; Artificial Intelligence; Databases, Factual; Drug Discovery; Humans; Lipidoses; Models, Biological; Phospholipids; Support Vector Machine	2010
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development. Toxicological sciences : an official journal of the Society of Toxicology, 2010, Volume: 118, Issue:2 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics	2010
A predictive ligand-based Bayesian model for human drug-induced liver injury. Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12 Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands	2010
Attenuation of intestinal absorption by major efflux transporters: quantitative tools and strategies using a Caco-2 model. Drug metabolism and disposition: the biological fate of chemicals, 2011, Volume: 39, Issue:2 Topics: Adenosine; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Sub-Family B Member 4; ATP-Binding Cassette Transporters; Biological Transport; Caco-2 Cells; Chromatography, Liquid; Dibenzocycloheptenes; Diketopiperazines; Drug Discovery; Heterocyclic Compounds, 4 or More Rings; Humans; Intestinal Absorption; Mass Spectrometry; Models, Biological; Neoplasm Proteins; Pharmaceutical Preparations; Predictive Value of Tests; Propionates; Quinolines; Substrate Specificity	2011
FDA-approved drug labeling for the study of drug-induced liver injury. Drug discovery today, 2011, Volume: 16, Issue:15-16 Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Design; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmaceutical Preparations; Reproducibility of Results; United States; United States Food and Drug Administration	2011
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions. Journal of medicinal chemistry, 2012, May-24, Volume: 55, Issue:10 Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection	2012
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds. Chemical research in toxicology, 2012, Oct-15, Volume: 25, Issue:10 Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding	2012
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification. Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship	2012
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests	2013
A high-throughput cell-based method to predict the unbound drug fraction in the brain. Journal of medicinal chemistry, 2014, Apr-10, Volume: 57, Issue:7 Topics: Animals; Brain; Dialysis; HEK293 Cells; High-Throughput Screening Assays; Humans; Pharmaceutical Preparations; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization	2014
Discovery of Competitive and Noncompetitive Ligands of the Organic Cation Transporter 1 (OCT1; SLC22A1). Journal of medicinal chemistry, 2017, 04-13, Volume: 60, Issue:7 Topics: Drug Discovery; HEK293 Cells; Humans; Ligands; Molecular Docking Simulation; Organic Cation Transporter 1; Small Molecule Libraries	2017
Two-dimensional high-performance liquid chromatographic method to assay p-hydroxyphenylphenylhydantoin enantiomers in biological fluids and stereoselectivity of enzyme induction in phenytoin metabolism. Journal of chromatography, 1992, Mar-13, Volume: 575, Issue:1 Topics: Acetone; Animals; Aroclors; Chlorodiphenyl (54% Chlorine); Chromatography, High Pressure Liquid; Cimetidine; Dexamethasone; Diazepam; Enzyme Induction; Female; Ketoconazole; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Phenytoin; Rats; Safrole; Sex Characteristics; Stereoisomerism; Sulfaphenazole	1992
Overview of the safety profile of the H2-receptor antagonists. DICP : the annals of pharmacotherapy, 1990, Volume: 24, Issue:11 Suppl Topics: Cimetidine; Critical Care; Drug Interactions; Gastric Acid; Histamine H2 Antagonists; Humans; Hydrogen-Ion Concentration; Ketoconazole; Liver; Ranitidine	1990
Inhibition of testosterone biosynthesis in testicular microsomes by various imidazole drugs. Comparative study with ketoconazole. Journal of pharmacobio-dynamics, 1990, Volume: 13, Issue:6 Topics: Animals; Cimetidine; Cytochrome P-450 Enzyme System; Humans; Imidazoles; Ketoconazole; Male; Methacrylates; Miconazole; Microsomes; Middle Aged; Rats; Rats, Inbred Strains; Spectrophotometry; Testis; Testosterone; Thromboxane-A Synthase	1990
An investigation of the role of metabolism in dapsone-induced methaemoglobinaemia using a two compartment in vitro test system. British journal of clinical pharmacology, 1990, Volume: 30, Issue:6 Topics: Cimetidine; Dapsone; Enzyme Induction; Humans; Ketoconazole; Methemoglobin; Microsomes, Liver; NADP	1990
Inhibitory effects of cimetidine ketoconazole and miconazole on the metabolism of praziquantel. Acta Leidensia, 1989, Volume: 57, Issue:2 Topics: Animals; Biological Availability; Cimetidine; Cytochrome P-450 Enzyme Inhibitors; In Vitro Techniques; Ketoconazole; Miconazole; Praziquantel; Rats; Rats, Inbred Strains	1989
[Chronic mucocutaneous candidiasis]. Medicina cutanea ibero-latino-americana, 1988, Volume: 16, Issue:6 Topics: Adult; Candidiasis; Candidiasis, Chronic Mucocutaneous; Child; Cimetidine; Drug Therapy, Combination; Humans; Ketoconazole; Male	1988
Application of theophylline metabolite assays to the exploration of liver microsome oxidative function in man. Fundamental & clinical pharmacology, 1988, Volume: 2, Issue:4 Topics: Adult; Biotransformation; Cimetidine; Humans; Ketoconazole; Male; Microsomes, Liver; Oxidation-Reduction; Spectrophotometry, Ultraviolet; Theophylline; Troleandomycin	1988
Inhibitory effects of ketoconazole and miconazole on cytochrome P-450-mediated oxidative metabolism of testosterone and xenobiotics in mouse hepatic microsomes--comparative study with cimetidine. Journal of pharmacobio-dynamics, 1988, Volume: 11, Issue:2 Topics: Aminopyrine N-Demethylase; Aniline Hydroxylase; Animals; Cimetidine; Ketoconazole; Mice; Miconazole; Microsomes, Liver; NADPH-Ferrihemoprotein Reductase; Oxidation-Reduction; Oxidoreductases; Pharmaceutical Preparations; Sleep; Steroid Hydroxylases; Testosterone	1988
Drugs and the liver. Comprehensive therapy, 1984, Volume: 10, Issue:12 Topics: Acetaminophen; Adult; Aspirin; Chemical and Drug Induced Liver Injury; Chemical and Drug Induced Liver Injury, Chronic; Cholestasis; Cimetidine; Fatty Liver; Female; Hepatic Artery; Hepatic Veins; Humans; Ketoconazole; Liver; Liver Diseases; Liver Neoplasms; Methyldopa; Necrosis; Nitrofurantoin; Peliosis Hepatis; Portal Vein; Valproic Acid; Verapamil	1984
The influence of gastric acidity on the bio-availability of ketoconazole. The Journal of antimicrobial chemotherapy, 1980, Volume: 6, Issue:4 Topics: Adult; Antifungal Agents; Biological Availability; Cimetidine; Cryptococcosis; Female; Gastric Acid; Humans; Imidazoles; Ketoconazole; Piperazines	1980
Metabolism of taxol by human and rat liver in vitro: a screen for drug interactions and interspecies differences. Cancer chemotherapy and pharmacology, 1995, Volume: 36, Issue:2 Topics: Animals; Biotransformation; Cimetidine; Cytochrome P-450 Enzyme System; Dexamethasone; Diphenhydramine; Drug Evaluation, Preclinical; Drug Interactions; Glycerol; Humans; In Vitro Techniques; Ketoconazole; Kinetics; Liver; Microsomes, Liver; Paclitaxel; Quinidine; Rats; Species Specificity; Surface-Active Agents; Taxoids; Tritium	1995
Inhibition of human CYP3A catalyzed 1'-hydroxy midazolam formation by ketoconazole, nifedipine, erythromycin, cimetidine, and nizatidine. Pharmaceutical research, 1994, Volume: 11, Issue:6 Topics: Chromatography, High Pressure Liquid; Cimetidine; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Erythromycin; Humans; In Vitro Techniques; Ketoconazole; Microsomes, Liver; Midazolam; Nifedipine; Nizatidine	1994
Tiamulin selectively inhibits oxidative hepatic steroid and drug metabolism in vitro in the pig. Journal of veterinary pharmacology and therapeutics, 1994, Volume: 17, Issue:4 Topics: Animals; Anti-Bacterial Agents; Cimetidine; Cytochrome P-450 CYP1A1; Cytochrome P-450 Enzyme System; Diterpenes; Erythromycin; Ethylmorphine; Hydroxylation; Ketoconazole; Male; Microsomes, Liver; Oxidoreductases; Oxidoreductases, N-Demethylating; Swine; Testosterone	1994
Acremonium infection of the esophagus. Journal of pediatric gastroenterology and nutrition, 1997, Volume: 24, Issue:3 Topics: Acremonium; Barrett Esophagus; Child, Preschool; Cimetidine; Connective Tissue Diseases; Esophageal Stenosis; Esophagitis; Female; Fundoplication; Humans; Ketoconazole; Metoclopramide; Mycoses; Prednisone	1997
Biosynthesis of an aminopiperidino metabolite of irinotecan [7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecine] by human hepatic microsomes. Drug metabolism and disposition: the biological fate of chemicals, 1998, Volume: 26, Issue:8 Topics: Anti-Bacterial Agents; Antifungal Agents; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Biotransformation; Camptothecin; Cimetidine; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Interactions; Enzyme Inhibitors; Humans; Irinotecan; Isoenzymes; Ketoconazole; Kinetics; Microsomes, Liver; Troleandomycin	1998
Determination of the human cytochrome P450 isoforms involved in the metabolism of zolmitriptan. Xenobiotica; the fate of foreign compounds in biological systems, 1999, Volume: 29, Issue:8 Topics: Cimetidine; Clorgyline; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Inhibitors; Female; Humans; Isoenzymes; Ketoconazole; Liver; Male; Microsomes, Liver; Omeprazole; Oxazoles; Oxazolidinones; Recombinant Proteins; Serotonin Receptor Agonists; Theophylline; Tryptamines	1999
Drug interactions and donepezil. Journal of the American Geriatrics Society, 2000, Volume: 48, Issue:5 Topics: Antidepressive Agents, Second-Generation; Antifungal Agents; Cholinesterase Inhibitors; Cimetidine; Cytochrome P-450 Enzyme Inhibitors; Donepezil; Drug Interactions; Enzyme Inhibitors; Humans; Indans; Ketoconazole; Paroxetine; Piperidines	2000
Dofetilide for atrial fibrillation. The Medical letter on drugs and therapeutics, 2000, May-15, Volume: 42, Issue:1078 Topics: Anti-Arrhythmia Agents; Anti-Infective Agents; Anti-Infective Agents, Urinary; Anti-Ulcer Agents; Antifungal Agents; Atrial Fibrillation; Cimetidine; Clinical Trials as Topic; Dose-Response Relationship, Drug; Drug Interactions; Humans; Ketoconazole; Phenethylamines; Potassium Channel Blockers; Sulfamethoxazole; Sulfonamides; Torsades de Pointes; Trimethoprim	2000
In vitro metabolism and interaction of cilostazol with human hepatic cytochrome P450 isoforms. Human & experimental toxicology, 2000, Volume: 19, Issue:3 Topics: Chromatography, High Pressure Liquid; Cilostazol; Cimetidine; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Interactions; Enzyme Inhibitors; Felodipine; Humans; In Vitro Techniques; Isoenzymes; Ketoconazole; Microsomes, Liver; Omeprazole; Platelet Aggregation Inhibitors; Tetrazoles	2000
The involvement of flavin-containing monooxygenase but not CYP3A4 in metabolism of itopride hydrochloride, a gastroprokinetic agent: comparison with cisapride and mosapride citrate. Drug metabolism and disposition: the biological fate of chemicals, 2000, Volume: 28, Issue:10 Topics: Administration, Oral; Animals; Antiemetics; Area Under Curve; Benzamides; Benzyl Compounds; Cimetidine; Cisapride; Clarithromycin; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dealkylation; Enzyme Stability; Erythromycin; Hot Temperature; Isoenzymes; Ketoconazole; Male; Microsomes, Liver; Mixed Function Oxygenases; Morpholines; Oxygen; Oxygenases; Rats; Rats, Sprague-Dawley	2000
Studies on the interactions between drugs and estrogen: analytical method for prediction system of gynecomastia induced by drugs on the inhibitory metabolism of estradiol using Escherichia coli coexpressing human CYP3A4 with human NADPH-cytochrome P450 re Analytical biochemistry, 2000, Nov-15, Volume: 286, Issue:2 Topics: Catechols; Cimetidine; Cyclosporine; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Inhibitors; Escherichia coli; Estradiol; Female; Gynecomastia; Humans; Hydroxylation; In Vitro Techniques; Ketoconazole; Kinetics; Male; Mixed Function Oxygenases; NADPH-Ferrihemoprotein Reductase; Recombinant Proteins	2000
Metabolism of amiodarone (Part III): identification of rabbit cytochrome P450 isoforms involved in the hydroxylation of mono-N-desethylamiodarone. Xenobiotica; the fate of foreign compounds in biological systems, 2001, Volume: 31, Issue:5 Topics: Amiodarone; Animals; Anti-Anxiety Agents; Anti-Arrhythmia Agents; Aryl Hydrocarbon Hydroxylases; Benzoflavones; Chromatography, High Pressure Liquid; Cimetidine; Cyclosporine; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Enzyme Inhibitors; Ketoconazole; Kinetics; Microsomes, Liver; Midazolam; Models, Chemical; Oxidoreductases, N-Demethylating; Protein Isoforms; Quinidine; Rabbits; Rifampin; Time Factors	2001
In vitro/in vivo scaling of alprazolam metabolism by CYP3A4 and CYP3A5 in humans. Biopharmaceutics & drug disposition, 2001, Volume: 22, Issue:2 Topics: Adult; Alprazolam; Anti-Anxiety Agents; Area Under Curve; Cimetidine; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Cytochromes b5; Female; Humans; Intestinal Mucosa; Ketoconazole; Male; Microsomes, Liver; Middle Aged; Mixed Function Oxygenases; Recombinant Proteins	2001
Drug-drug interactions evaluated by a highly active reconstituted native human cytochrome P4503A4 and human NADPH-cytochrome P450 reductase system. Arzneimittel-Forschung, 2004, Volume: 54, Issue:1 Topics: Antifungal Agents; Antimalarials; Catalysis; Chromatography, High Pressure Liquid; Cimetidine; Cyclosporine; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Drug Interactions; Electrophoresis, Polyacrylamide Gel; Estrogen Antagonists; Ethinyl Estradiol; Flavanones; Hormone Antagonists; Humans; Immunosuppressive Agents; In Vitro Techniques; Ketoconazole; Microsomes, Liver; Mifepristone; NADPH-Ferrihemoprotein Reductase; Phospholipids; Quinidine; Quinine; Tacrolimus	2004
A study of the in vitro interaction between lidocaine and premedications using human liver microsomes. Journal of clinical pharmacy and therapeutics, 2005, Volume: 30, Issue:2 Topics: Animals; Cimetidine; Clonidine; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP1A2 Inhibitors; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Drug Combinations; Drug Interactions; Enzyme Inhibitors; Humans; Inhibitory Concentration 50; Ketoconazole; Lidocaine; Microsomes, Liver; Midazolam; Neuromuscular Depolarizing Agents; Pentobarbital; Pharmacogenetics; Premedication; Rats; Theophylline; Thiamylal	2005
[Enzyme kinetics of schizandrin metabolism and sex differences in rat liver microsomes]. Yao xue xue bao = Acta pharmaceutica Sinica, 2007, Volume: 42, Issue:7 Topics: Animals; Chromatography, High Pressure Liquid; Cimetidine; Cyclooctanes; Enzyme Inhibitors; Female; In Vitro Techniques; Ketoconazole; Lignans; Male; Microsomes, Liver; Orphenadrine; Plants, Medicinal; Polycyclic Compounds; Rats; Rats, Sprague-Dawley; Schisandra; Sex Factors; Spectrophotometry, Ultraviolet	2007
Influence of quinidine, cimetidine, and ketoconazole on the enantioselective pharmacokinetics and metabolism of metoprolol in rats. Chirality, 2009, Volume: 21, Issue:10 Topics: Adrenergic beta-Antagonists; Animals; Area Under Curve; Chromatography, High Pressure Liquid; Cimetidine; Cytochrome P-450 CYP3A Inhibitors; Drug Interactions; Enzyme Inhibitors; Fasting; Hydrogen-Ion Concentration; Ketoconazole; Male; Metabolic Clearance Rate; Metoprolol; Molecular Structure; Quinidine; Rats; Rats, Wistar; Spectrometry, Fluorescence; Stereoisomerism	2009
Inhibitory effects of ketoconazole, cimetidine and erythromycin on hepatic CYP3A activities in cats. The Journal of veterinary medical science, 2009, Volume: 71, Issue:9 Topics: Animals; Anti-Bacterial Agents; Antifungal Agents; Area Under Curve; Cats; Cimetidine; Cytochrome P-450 CYP3A Inhibitors; Dose-Response Relationship, Drug; Enzyme Inhibitors; Erythromycin; Female; Half-Life; Hypnotics and Sedatives; Ketoconazole; Microsomes, Liver; Midazolam	2009
Crucial role of cytochrome P450 in hepatotoxicity induced by 2,3-dimethoxy-1,4-naphthoquinone in rats. Journal of applied toxicology : JAT, 2011, Volume: 31, Issue:2 Topics: alpha-Tocopherol; Animals; Antioxidants; Chemical and Drug Induced Liver Injury; Cimetidine; Cytochrome P-450 Enzyme Inhibitors; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Glutathione; Ketoconazole; Lipid Peroxidation; Liver; Male; Naphthoquinones; Oxidation-Reduction; Oxidative Stress; Proadifen; Rats; Rats, Wistar; Substrate Cycling	2011
Drug-drug interactions and cooperative effects detected in electrochemically driven human cytochrome P450 3A4. Bioelectrochemistry (Amsterdam, Netherlands), 2012, Volume: 86 Topics: Cimetidine; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Diclofenac; Drug Interactions; Electrochemical Techniques; Electrodes; Enzyme Inhibitors; Enzymes, Immobilized; Erythromycin; Inhibitory Concentration 50; Ketoconazole; Polyethylenes; Quaternary Ammonium Compounds; Quinidine	2012
Cimetidine-associated patent ductus arteriosus is mediated via a cytochrome P450 mechanism independent of H2 receptor antagonism. Journal of molecular and cellular cardiology, 2013, Volume: 59 Topics: Cimetidine; Cytochrome P-450 Enzyme System; Ductus Arteriosus, Patent; Histamine H2 Antagonists; Humans; Immunohistochemistry; Infant, Newborn; Ketoconazole; Polymerase Chain Reaction; Randomized Controlled Trials as Topic; Ranitidine; Receptors, Histamine; Retrospective Studies	2013
Chloramphenicol significantly affects the pharmacokinetics of oral methadone in Greyhound dogs. Veterinary anaesthesia and analgesia, 2015, Volume: 42, Issue:6 Topics: Administration, Oral; Analgesics, Opioid; Animals; Chloramphenicol; Cimetidine; Cytochrome P-450 Enzyme Inhibitors; Dogs; Drug Interactions; Female; Fluoxetine; Ketoconazole; Male; Medetomidine; Methadone; Trimethoprim	2015
The effects of ketoconazole and cimetidine on the pharmacokinetics of oral tramadol in greyhound dogs. Journal of veterinary pharmacology and therapeutics, 2017, Volume: 40, Issue:6 Topics: Administration, Oral; Analgesics, Opioid; Animals; Antifungal Agents; Biological Availability; Cimetidine; Dogs; Drug Interactions; Female; Histamine H2 Antagonists; Ketoconazole; Male; Tramadol	2017