ketoconazole and cholest-5-ene-3,4-diol

ketoconazole has been researched along with cholest-5-ene-3,4-diol in 3 studies

Research

Studies (3)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	3 (100.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Cho, JY; Choi, MH; Jang, IJ; Lim, KS; Shin, KH; Yu, KS	1
Boulton, DW; Goodenough, A; Jemal, M; Kasichayanula, S; LaCreta, F; Lee, M; Luo, WL; Rodrigues, AD; Yang, Z	1
Chun, DY; Dutreix, C; Einolf, HJ; Gu, H; He, H; Ouatas, T; Rebello, S; Wang, L	1

Trials

2 trial(s) available for ketoconazole and cholest-5-ene-3,4-diol

Article	Year
Evaluation of endogenous metabolic markers of hepatic CYP3A activity using metabolic profiling and midazolam clearance. Clinical pharmacology and therapeutics, 2013, Volume: 94, Issue:5 Topics: Adult; Biomarkers; Cortisone; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Enzyme Induction; Gas Chromatography-Mass Spectrometry; Humans; Hydrocortisone; Hydroxycholesterols; Ketoconazole; Liver; Male; Metabolomics; Midazolam; Pharmacogenetics; Rifampin; Young Adult	2013
Validation of 4β-hydroxycholesterol and evaluation of other endogenous biomarkers for the assessment of CYP3A activity in healthy subjects. British journal of clinical pharmacology, 2014, Volume: 78, Issue:5 Topics: Adolescent; Adult; Biomarkers; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inducers; Cytochrome P-450 CYP3A Inhibitors; Dose-Response Relationship, Drug; Healthy Volunteers; Humans; Hydroxycholesterols; Injections, Intravenous; Ketoconazole; Limit of Detection; Midazolam; Middle Aged; Rifampin; Saliva; Substrate Specificity; Time Factors; Tissue Distribution; Young Adult	2014

Article

Year

Evaluation of endogenous metabolic markers of hepatic CYP3A activity using metabolic profiling and midazolam clearance.

Clinical pharmacology and therapeutics, 2013, Volume: 94, Issue:5

Topics: Adult; Biomarkers; Cortisone; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Enzyme Induction; Gas Chromatography-Mass Spectrometry; Humans; Hydrocortisone; Hydroxycholesterols; Ketoconazole; Liver; Male; Metabolomics; Midazolam; Pharmacogenetics; Rifampin; Young Adult

2013

Validation of 4β-hydroxycholesterol and evaluation of other endogenous biomarkers for the assessment of CYP3A activity in healthy subjects.

British journal of clinical pharmacology, 2014, Volume: 78, Issue:5

Topics: Adolescent; Adult; Biomarkers; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inducers; Cytochrome P-450 CYP3A Inhibitors; Dose-Response Relationship, Drug; Healthy Volunteers; Humans; Hydroxycholesterols; Injections, Intravenous; Ketoconazole; Limit of Detection; Midazolam; Middle Aged; Rifampin; Saliva; Substrate Specificity; Time Factors; Tissue Distribution; Young Adult

2014

Other Studies

1 other study(ies) available for ketoconazole and cholest-5-ene-3,4-diol

Article	Year
Simultaneous Physiologically Based Pharmacokinetic (PBPK) Modeling of Parent and Active Metabolites to Investigate Complex CYP3A4 Drug-Drug Interaction Potential: A Case Example of Midostaurin. Drug metabolism and disposition: the biological fate of chemicals, 2018, Volume: 46, Issue:2 Topics: Adult; Biomarkers; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inducers; Cytochrome P-450 CYP3A Inhibitors; Drug Interactions; Female; Humans; Hydroxycholesterols; Ketoconazole; Male; Midazolam; Middle Aged; Models, Biological; Rifampin; Staurosporine; Young Adult	2018

Article

Year

Simultaneous Physiologically Based Pharmacokinetic (PBPK) Modeling of Parent and Active Metabolites to Investigate Complex CYP3A4 Drug-Drug Interaction Potential: A Case Example of Midostaurin.

Drug metabolism and disposition: the biological fate of chemicals, 2018, Volume: 46, Issue:2

Topics: Adult; Biomarkers; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inducers; Cytochrome P-450 CYP3A Inhibitors; Drug Interactions; Female; Humans; Hydroxycholesterols; Ketoconazole; Male; Midazolam; Middle Aged; Models, Biological; Rifampin; Staurosporine; Young Adult

2018