Compounds > ketoconazole

ketoconazole and carbamates

ketoconazole has been researched along with carbamates in 12 studies

Research

Studies (12)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	1 (8.33)	18.2507
2000's	5 (41.67)	29.6817
2010's	6 (50.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Chittick, GE; Crouch, MA; Gouldin, W; Israel, DS; Lou, Y; Pastor, A; Polk, RE; Sadler, BM; Symonds, WT	1
Duan, SX; Durol, AL; Greenblatt, DJ; von Moltke, LL	1
Bernal, JL; del Nozal, MJ; Montequi, MI; Nieto, EM; Toribio, L	1
Hansen, KT; Hatorp, V; Thomsen, MS	1
Ballow, CH; Borland, J; Lewis, EW; Lin, J; Lou, Y; Shelton, MJ; Wire, MB; Yuen, G	1
Cheung, C; Gonzalez, FJ; Idle, JR; Krausz, KW; Ma, X; Shah, YM; Wang, T	1
Annaert, P; Augustijns, P; Brouwers, J; Mols, R	1
Choi, DH; Choi, JS; Li, C	1
Ahmed, Z; Bentz, J; Ellens, H; Hidalgo, IJ; Li, J; Li, L; Lumen, AA; Meng, Z; Owen, A	1
Aunes, M; Cullberg, M; Edvardsson, N; Frison, L; Johansson, S; Löfberg, B; Lunde, H	1
Goda, H; Ito, K; Komatsu, S; Kudo, T; Tanaka, R; Yokosuka, Y	1
Bhatt, S; Dogra, A; Gour, A; Kotwal, P; Magotra, A; Nandi, U; Sharma, A; Singh, G; Wazir, P	1

Trials

4 trial(s) available for ketoconazole and carbamates

Article	Year
Pharmacokinetic interaction between ketoconazole and amprenavir after single doses in healthy men. Pharmacotherapy, 1999, Volume: 19, Issue:12 Topics: Adult; Antifungal Agents; Breath Tests; Carbamates; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Drug Interactions; Erythromycin; Furans; HIV Protease Inhibitors; Humans; Ketoconazole; Male; Mixed Function Oxygenases; Sulfonamides; Time Factors	1999
Influence of drugs interacting with CYP3A4 on the pharmacokinetics, pharmacodynamics, and safety of the prandial glucose regulator repaglinide. Journal of clinical pharmacology, 2003, Volume: 43, Issue:6 Topics: Adult; Area Under Curve; Blood Glucose; Carbamates; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Drug Interactions; Female; Half-Life; Humans; Hypoglycemic Agents; Ketoconazole; Male; Piperidines; Rifampin; Simvastatin	2003
Fosamprenavir plus ritonavir increases plasma ketoconazole and ritonavir exposure, while amprenavir exposure remains unchanged. Antimicrobial agents and chemotherapy, 2007, Volume: 51, Issue:8 Topics: Adolescent; Adult; Antifungal Agents; Area Under Curve; Carbamates; Drug Interactions; Drug Therapy, Combination; Female; Furans; HIV Protease Inhibitors; Humans; Ketoconazole; Male; Middle Aged; Organophosphates; Ritonavir; Sulfonamides; Treatment Outcome	2007
In Silico Predictions and In Vivo Results of Drug-Drug Interactions by Ketoconazole and Verapamil on AZD1305, a Combined Ion Channel Blocker and a Sensitive CYP3A4 Substrate. Clinical pharmacology in drug development, 2016, Volume: 5, Issue:5 Topics: Adult; Anti-Arrhythmia Agents; Area Under Curve; Azabicyclo Compounds; Carbamates; Computer Simulation; Cross-Over Studies; Cytochrome P-450 CYP3A Inhibitors; Drug Interactions; Humans; Ketoconazole; Male; Middle Aged; Verapamil; Young Adult	2016

Other Studies

8 other study(ies) available for ketoconazole and carbamates

Article	Year
Potent mechanism-based inhibition of human CYP3A in vitro by amprenavir and ritonavir: comparison with ketoconazole. European journal of clinical pharmacology, 2000, Volume: 56, Issue:3 Topics: Aryl Hydrocarbon Hydroxylases; Carbamates; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Enzyme Inhibitors; Furans; Humans; Hydroxylation; Ketoconazole; Oxidoreductases, N-Demethylating; Ritonavir; Sulfonamides; Triazolam	2000
Separation of antifungal chiral drugs by SFC and HPLC: a comparative study. Journal of biochemical and biophysical methods, 2002, Dec-31, Volume: 54, Issue:1-3 Topics: Amylose; Antifungal Agents; Benzoates; Carbamates; Cellulose; Chromatography, High Pressure Liquid; Chromatography, Supercritical Fluid; Dioxolanes; Ketoconazole; Phenylcarbamates; Reproducibility of Results; Sensitivity and Specificity; Stereoisomerism	2002
A double transgenic mouse model expressing human pregnane X receptor and cytochrome P450 3A4. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:12 Topics: Animals; Carbamates; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Interactions; Female; Furans; Gene Expression; Gene Expression Regulation; HIV Protease Inhibitors; Humans; Intestine, Small; Ketoconazole; Liver; Male; Mice; Mice, Knockout; Mice, Transgenic; Microsomes, Liver; Models, Animal; Nelfinavir; Pregnane X Receptor; Pregnenolone Carbonitrile; Receptors, Steroid; Rifampin; Saquinavir; Sex Characteristics; Sulfonamides	2008
Validation of a differential in situ perfusion method with mesenteric blood sampling in rats for intestinal drug interaction profiling. Biopharmaceutics & drug disposition, 2010, Volume: 31, Issue:5-6 Topics: Adrenergic beta-Antagonists; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Carbamates; Drug Interactions; Furans; Intestinal Absorption; Ketoconazole; Male; Perfusion; Polyethylene Glycols; Rats; Rats, Wistar; Splanchnic Circulation; Sulfonamides; Verapamil; Vitamin E	2010
Effects of efonidipine on the pharmacokinetics and pharmacodynamics of repaglinide: possible role of CYP3A4 and P-glycoprotein inhibition by efonidipine. Journal of pharmacokinetics and pharmacodynamics, 2012, Volume: 39, Issue:1 Topics: Animals; Antihypertensive Agents; Area Under Curve; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biocatalysis; Biological Availability; Blood Glucose; Carbamates; Cell Line, Tumor; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dihydropyridines; Drug Interactions; Humans; Hypoglycemic Agents; Ketoconazole; Male; Models, Biological; Nitrophenols; Organophosphorus Compounds; Pharmacological Phenomena; Piperidines; Rats; Rats, Sprague-Dawley; Rhodamine 123	2012
Transport inhibition of digoxin using several common P-gp expressing cell lines is not necessarily reporting only on inhibitor binding to P-gp. PloS one, 2013, Volume: 8, Issue:8 Topics: Acridines; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Caco-2 Cells; Carbamates; Cell Membrane Permeability; Cyclosporine; Digoxin; Dogs; Furans; Gene Expression; Humans; Ketoconazole; Kinetics; Loperamide; Madin Darby Canine Kidney Cells; Protein Binding; Quinidine; Sulfonamides; Tetrahydroisoquinolines; Vinblastine	2013
Estimation of the Contribution of CYP2C8 and CYP3A4 in Repaglinide Metabolism by Human Liver Microsomes Under Various Buffer Conditions. Journal of pharmaceutical sciences, 2017, Volume: 106, Issue:9 Topics: Acetates; Buffers; Carbamates; Cyclopropanes; Cytochrome P-450 CYP2C8; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inducers; Cytochrome P-450 Enzyme Inhibitors; Drug Interactions; Humans; Hypoglycemic Agents; Ketoconazole; Microsomes, Liver; Piperidines; Quinolines; Sulfides	2017
Intervention of curcumin on oral pharmacokinetics of daclatasvir in rat: A possible risk for long-term use. Phytotherapy research : PTR, 2018, Volume: 32, Issue:10 Topics: Administration, Oral; Animals; Antiviral Agents; Carbamates; Curcumin; Drug Interactions; Imidazoles; Ketoconazole; Male; Pyrrolidines; Quinidine; Rats; Rats, Wistar; Valine	2018