ketoconazole and bosutinib

ketoconazole has been researched along with bosutinib in 6 studies

Research

Studies (6)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	5 (83.33)	24.3611
2020's	1 (16.67)	2.80

Authors

Authors	Studies
Delabio, LC; Dutra, JP; Hembecker, M; Kita, DH; Moure, VR; Pereira, GDS; Scheiffer, G; Valdameri, G; Zattoni, IF	1
Abbas, R; Burns, J; Hug, BA; Leister, C; Sonnichsen, D	1
Abbas, R; Hug, BA; Leister, C; Sonnichsen, D	1
Abbas, R; Chalon, S; El Gaaloul, M; Leister, C; Sonnichsen, D	1
Abbas, R; Hsyu, PH; Loi, CM; Ono, C; Yamazaki, S	1
Costales, C; Kimoto, E; Loi, CM; Varma, MV; Yamazaki, S	1

Reviews

1 review(s) available for ketoconazole and bosutinib

Article	Year
Targeting breast cancer resistance protein (BCRP/ABCG2): Functional inhibitors and expression modulators. European journal of medicinal chemistry, 2022, Jul-05, Volume: 237 Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily G, Member 2; Breast Neoplasms; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Female; Humans; Neoplasm Proteins; Neoplastic Stem Cells	2022

Trials

3 trial(s) available for ketoconazole and bosutinib

Article	Year
Effect of ketoconazole on the pharmacokinetics of oral bosutinib in healthy subjects. Journal of clinical pharmacology, 2011, Volume: 51, Issue:12 Topics: Administration, Oral; Adult; Aniline Compounds; Antifungal Agents; Area Under Curve; Cross-Over Studies; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Drug Interactions; Humans; Ketoconazole; Male; Middle Aged; Nitriles; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Quinolines; Young Adult	2011
A randomized, crossover, placebo- and moxifloxacin-controlled study to evaluate the effects of bosutinib (SKI-606), a dual Src/Abl tyrosine kinase inhibitor, on cardiac repolarization in healthy adult subjects. International journal of cancer, 2012, Aug-01, Volume: 131, Issue:3 Topics: Adolescent; Adult; Aniline Compounds; Aza Compounds; Cross-Over Studies; Double-Blind Method; Electrocardiography; Female; Fluoroquinolones; Heart; Humans; Ketoconazole; Male; Middle Aged; Moxifloxacin; Nitriles; Quinolines; Young Adult	2012
Ascending single-dose study of the safety profile, tolerability, and pharmacokinetics of bosutinib coadministered with ketoconazole to healthy adult subjects. Clinical therapeutics, 2012, Volume: 34, Issue:9 Topics: Administration, Oral; Adolescent; Adult; Aniline Compounds; Antifungal Agents; Area Under Curve; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Dose-Response Relationship, Drug; Double-Blind Method; Drug Interactions; Humans; Ketoconazole; Male; Middle Aged; Nitriles; Protein Kinase Inhibitors; Quinolines; Young Adult	2012

Other Studies

2 other study(ies) available for ketoconazole and bosutinib

Article	Year
Application of Physiologically Based Pharmacokinetic Modeling to the Understanding of Bosutinib Pharmacokinetics: Prediction of Drug-Drug and Drug-Disease Interactions. Drug metabolism and disposition: the biological fate of chemicals, 2017, Volume: 45, Issue:4 Topics: Administration, Oral; Aniline Compounds; Area Under Curve; Computer Simulation; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inducers; Cytochrome P-450 CYP3A Inhibitors; Drug Interactions; Humans; Ketoconazole; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Models, Biological; Nitriles; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-abl; Quinolines; Rifampin; src-Family Kinases; Treatment Outcome	2017
Application of Physiologically Based Pharmacokinetic Modeling in Understanding Bosutinib Drug-Drug Interactions: Importance of Intestinal P-Glycoprotein. Drug metabolism and disposition: the biological fate of chemicals, 2018, Volume: 46, Issue:8 Topics: Administration, Oral; Aniline Compounds; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Availability; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Drug Interactions; Female; Humans; Intestinal Mucosa; Ketoconazole; Male; Nitriles; Quinolines; Rifampin	2018

Article

Year

Application of Physiologically Based Pharmacokinetic Modeling to the Understanding of Bosutinib Pharmacokinetics: Prediction of Drug-Drug and Drug-Disease Interactions.

Drug metabolism and disposition: the biological fate of chemicals, 2017, Volume: 45, Issue:4

Topics: Administration, Oral; Aniline Compounds; Area Under Curve; Computer Simulation; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inducers; Cytochrome P-450 CYP3A Inhibitors; Drug Interactions; Humans; Ketoconazole; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Models, Biological; Nitriles; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-abl; Quinolines; Rifampin; src-Family Kinases; Treatment Outcome

2017

Application of Physiologically Based Pharmacokinetic Modeling in Understanding Bosutinib Drug-Drug Interactions: Importance of Intestinal P-Glycoprotein.

Drug metabolism and disposition: the biological fate of chemicals, 2018, Volume: 46, Issue:8

Topics: Administration, Oral; Aniline Compounds; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Availability; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Drug Interactions; Female; Humans; Intestinal Mucosa; Ketoconazole; Male; Nitriles; Quinolines; Rifampin

2018