ketoconazole and apixaban

ketoconazole has been researched along with apixaban in 3 studies

Research

Studies (3)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	3 (100.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Balimane, PV; Frost, CE; Gan, J; Han, YH; He, K; Herbst, JJ; Humphreys, WG; Kolb, J; Shou, W; Wang, L; Zhang, D	1
Boyd, RA; Byon, W; Dias, C; Frost, CE; LaCreta, F; Schuster, AE; Shenker, A; Song, Y; Wang, J; Yu, Z; Zhang, D	1
Burhenne, J; Foerster, KI; Haefeli, WE; Lehmann, ML; Mikus, G; Schaumaeker, M	1

Trials

2 trial(s) available for ketoconazole and apixaban

Article	Year
Effect of ketoconazole and diltiazem on the pharmacokinetics of apixaban, an oral direct factor Xa inhibitor. British journal of clinical pharmacology, 2015, Volume: 79, Issue:5 Topics: Adolescent; Adult; Cross-Over Studies; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Diltiazem; Dose-Response Relationship, Drug; Drug Interactions; Factor Xa Inhibitors; Female; Healthy Volunteers; Humans; Ketoconazole; Male; Middle Aged; Pyrazoles; Pyridones; Young Adult	2015
Microdosed Cocktail of Three Oral Factor Xa Inhibitors to Evaluate Drug-Drug Interactions with Potential Perpetrator Drugs. Clinical pharmacokinetics, 2019, Volume: 58, Issue:9 Topics: Administration, Oral; Adolescent; Adult; Atrial Fibrillation; Case-Control Studies; Chromatography, Liquid; Cross-Over Studies; Cytochrome P-450 CYP3A Inhibitors; Drug Interactions; Factor Xa Inhibitors; Female; Humans; Ketoconazole; Male; Middle Aged; Pyrazoles; Pyridines; Pyridones; Rivaroxaban; Tandem Mass Spectrometry; Thiazoles; Young Adult	2019

Article

Year

Effect of ketoconazole and diltiazem on the pharmacokinetics of apixaban, an oral direct factor Xa inhibitor.

British journal of clinical pharmacology, 2015, Volume: 79, Issue:5

Topics: Adolescent; Adult; Cross-Over Studies; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Diltiazem; Dose-Response Relationship, Drug; Drug Interactions; Factor Xa Inhibitors; Female; Healthy Volunteers; Humans; Ketoconazole; Male; Middle Aged; Pyrazoles; Pyridones; Young Adult

2015

Microdosed Cocktail of Three Oral Factor Xa Inhibitors to Evaluate Drug-Drug Interactions with Potential Perpetrator Drugs.

Clinical pharmacokinetics, 2019, Volume: 58, Issue:9

Topics: Administration, Oral; Adolescent; Adult; Atrial Fibrillation; Case-Control Studies; Chromatography, Liquid; Cross-Over Studies; Cytochrome P-450 CYP3A Inhibitors; Drug Interactions; Factor Xa Inhibitors; Female; Humans; Ketoconazole; Male; Middle Aged; Pyrazoles; Pyridines; Pyridones; Rivaroxaban; Tandem Mass Spectrometry; Thiazoles; Young Adult

2019

Other Studies

1 other study(ies) available for ketoconazole and apixaban

Article	Year
Characterization of efflux transporters involved in distribution and disposition of apixaban. Drug metabolism and disposition: the biological fate of chemicals, 2013, Volume: 41, Issue:4 Topics: Adenosine; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Caco-2 Cells; Cell Line, Transformed; Cell Membrane Permeability; Cyclosporine; Digoxin; Diketopiperazines; Dose-Response Relationship, Drug; Drug Interactions; Fibrinolytic Agents; Heterocyclic Compounds, 4 or More Rings; Humans; Ketoconazole; Male; Naproxen; Neoplasm Proteins; Pyrazoles; Pyridones; Rats	2013

Article

Year

Characterization of efflux transporters involved in distribution and disposition of apixaban.

Drug metabolism and disposition: the biological fate of chemicals, 2013, Volume: 41, Issue:4

Topics: Adenosine; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Caco-2 Cells; Cell Line, Transformed; Cell Membrane Permeability; Cyclosporine; Digoxin; Diketopiperazines; Dose-Response Relationship, Drug; Drug Interactions; Fibrinolytic Agents; Heterocyclic Compounds, 4 or More Rings; Humans; Ketoconazole; Male; Naproxen; Neoplasm Proteins; Pyrazoles; Pyridones; Rats

2013