ketoconazole has been researched along with aminoglutethimide in 54 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (18.52) | 18.7374 |
| 1990's | 18 (33.33) | 18.2507 |
| 2000's | 18 (33.33) | 29.6817 |
| 2010's | 7 (12.96) | 24.3611 |
| 2020's | 1 (1.85) | 2.80 |
| Authors | Studies |
|---|---|
| Cole, PA; Robinson, CH | 1 |
| Belluti, F; Bisi, A; Cavalli, A; Gobbi, S; Hartmann, RW; Palusczak, A; Palzer, M; Rampa, A; Recanatini, M; Valenti, P | 1 |
| Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL | 1 |
| Bilter, GK; Dias, J; Huang, Z; Keon, BH; Lamerdin, J; MacDonald, ML; Michnick, SW; Minami, T; Owens, S; Shang, Z; Westwick, JK; Yu, H | 1 |
| Berger, ML; Hahner, S; Hammerschmidt, F; Peric-Simov, B; Schirbel, A; Zolle, IM | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Choi, SS; Contrera, JF; Hastings, KL; Kruhlak, NL; Sancilio, LF; Weaver, JL; Willard, JM | 1 |
| García-Mera, X; González-Díaz, H; Prado-Prado, FJ | 1 |
| Muftuoglu, Y; Mustata, G | 1 |
| Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ | 1 |
| Ekins, S; Williams, AJ; Xu, JJ | 1 |
| Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ | 1 |
| Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ | 1 |
| Denis, L; Mahler, C | 1 |
| Cheah, JS; Kong, HL; Lee, KO | 1 |
| Rothschild, AJ; Schatzberg, AF | 1 |
| Chouinard, G; Dhar, V; Ghadirian, AM; Keller, R; Murphy, BE | 1 |
| Brun, HP; Caillaud, JM; Cordier, A; Leonard, JF; Melcion, C; Moronvalle, V | 1 |
| McConnell, JD | 1 |
| Bélanger, A; Caron, S; Labrie, F; Lacoste, D | 1 |
| Janssen, PA; Van Wauwe, JP | 1 |
| Armstrong, DT; Glasier, MA; Khalil, MW; Lang, T; Morley, P | 1 |
| Fair, WR; Sogani, PC | 1 |
| Nicholls, PJ; Shaw, MA; Smith, HJ | 1 |
| Belanger, A; Caron, S; Labrie, F; Lacoste, D; St-Arnaud, R | 1 |
| Beerens, D; De Coster, R; Goeminne, N; van Dun, J; Wouters, W | 1 |
| Ayub, M; Levell, MJ | 1 |
| Ikeda, M; Katagiri, M; Koshida, H; Miyamori, I; Nagai, K; Suhara, K; Takeda, R | 1 |
| Dubost, JJ; Rampon, S; Ristori, JM; Sauvezie, B; Thevenet, JP | 1 |
| Crapo, L; Miller, JW | 1 |
| Dluhy, RG; Solomon, CG | 1 |
| Chouinard, G; Dhar, V; Engelsmann, F; Filipini, D; Ghadirian, AM; Keller, R; Murphy, BE | 1 |
| Engelhardt, D | 1 |
| Engelhardt, D; Weber, MM | 1 |
| Bhatnagar, AS; King, EJ; Purba, HS; Richert, P | 1 |
| Nishikawa, T; Saito, J | 1 |
| Khalil, MW; Killinger, DW; Strutt, B; Vachon, D | 1 |
| Dhar, V; Ghadirian, AM; Murphy, BE | 1 |
| Bare, RL; Torti, FM | 1 |
| Chen, Y; Cidlowski, JA; French, FS; Hall, SH; Hamil, K; Mohler, JL; Sar, M; Wilson, EM | 1 |
| Evans, RM; Reyland, ME; White, EK | 1 |
| Bastida, CM; Cremades, A; Peñafiel, R; Tejada, F | 1 |
| Ito, N; Morishita, K; Okumura, H; Takahashi, N | 1 |
| Johansson, MK; Lund, BO; Sanderson, JT | 1 |
| Hobdy, EM; Kummar, S; Shafi, NQ | 1 |
| Giesy, JP; Gracia, T; Hecker, M; Higley, EB; Hilscherova, K; Jones, PD; Newsted, JL; Sanderson, JT; Wu, RS; Yu, RM; Zhang, X | 1 |
| Giesy, JP; Hecker, M; Higley, EB; Jones, PD; Murphy, MB; Newsted, JL; Wu, R | 1 |
| Gross, A; Tsafriri, A; Yacobi, K | 1 |
| Jordan, RM; Kosseifi, SG; Nassour, DN; Peiris, AN; Sarubbi, FA; Shaikh, MA | 1 |
| Nishikawa, T; Omura, M; Saito, J | 1 |
| Coleman, VH; Kling, MA; Schulkin, J | 1 |
| Lenie, S; Smitz, J | 1 |
| Forest, M; Nicolino, M; Vong, CH | 1 |
| Cheung, G; Lin, YC; Papadopoulos, V; Porter, E | 1 |
15 review(s) available for ketoconazole and aminoglutethimide
| Article | Year |
|---|---|
Mechanism and inhibition of cytochrome P-450 aromatase.
Topics: Affinity Labels; Aromatase; Aromatase Inhibitors; Binding, Competitive; Humans; Molecular Structure; Photochemistry | 1990 |
Management of relapsing disease in prostate cancer.
Topics: Aminoglutethimide; Androgen Antagonists; Antineoplastic Agents; Combined Modality Therapy; Estrogens; Humans; Imidazoles; Ketoconazole; Male; Neoplasm Metastasis; Orchiectomy; Palliative Care; Prostatic Neoplasms; Recurrence | 1992 |
Physiologic basis of endocrine therapy for prostatic cancer.
Topics: Aminoglutethimide; Androgen Antagonists; Androgens; Estrogens; Gonadotropin-Releasing Hormone; Humans; Ketoconazole; Leuprolide; Male; Orchiectomy; Progestins; Prostatic Neoplasms | 1991 |
Is there a case for P-450 inhibitors in cancer treatment?
Topics: Aminoglutethimide; Aromatase Inhibitors; Breast Neoplasms; Cytochrome P-450 Enzyme Inhibitors; Enzyme Inhibitors; Female; Humans; Ketoconazole; Male; Neoplasms; Prostatic Neoplasms | 1989 |
Treatment of advanced prostatic cancer.
Topics: Adrenalectomy; Aminoglutethimide; Androgen Antagonists; Antineoplastic Combined Chemotherapy Protocols; Clinical Trials as Topic; Combined Modality Therapy; Cyproterone; Cyproterone Acetate; Estrogens; Flutamide; Glucocorticoids; Humans; Ketoconazole; Male; Megestrol; Megestrol Acetate; Orchiectomy; Pituitary Hormone-Releasing Hormones; Prostatic Neoplasms; Spironolactone; Time Factors | 1987 |
Aminoglutethimide and ketoconazole: historical perspectives and future prospects.
Topics: Adrenal Gland Neoplasms; Aminoglutethimide; Aromatase Inhibitors; Breast Neoplasms; Fadrozole; Female; Humans; Imidazoles; Ketoconazole; Male; Nitriles; Prostatic Neoplasms | 1988 |
[New hormonal treatments of metastatic prostatic cancer. Review of the literature].
Topics: Aminoglutethimide; Androgen Antagonists; Animals; Antineoplastic Agents; Combined Modality Therapy; Drug Resistance; Gonadotropin-Releasing Hormone; Hormones; Humans; Ketoconazole; Male; Neoplasm Metastasis; Prostatic Neoplasms; Time Factors | 1985 |
The medical treatment of Cushing's syndrome.
Topics: Adrenal Cortex Neoplasms; Adrenal Glands; Aminoglutethimide; Animals; Bromocriptine; Cushing Syndrome; Cyproheptadine; Dogs; Horses; Humans; Ketoconazole; Metyrapone; Mifepristone; Mitotane; Octreotide; Palliative Care; Pituitary Gland; Radiography; Valproic Acid | 1993 |
Steroid biosynthesis inhibitors in Cushing's syndrome.
Topics: Adrenal Cortex Hormones; Aminoglutethimide; Cushing Syndrome; Dihydrotestosterone; Etomidate; Humans; Ketoconazole; Metyrapone; Mitotane | 1994 |
Therapy of Cushing's syndrome with steroid biosynthesis inhibitors.
Topics: 3-Hydroxysteroid Dehydrogenases; Aminoglutethimide; Cushing Syndrome; Dihydrotestosterone; Etomidate; Humans; Ketoconazole; Metyrapone; Steroids | 1994 |
[Clinical usefulness of pharmacological treatment of Cushing's syndrome].
Topics: Administration, Oral; Aminoglutethimide; Cushing Syndrome; Dihydrotestosterone; Humans; Ketoconazole; Metyrapone; Mitotane | 1994 |
Endocrine therapy of prostate cancer.
Topics: 5-alpha Reductase Inhibitors; Adenocarcinoma; Aminoglutethimide; Androgen Antagonists; Antineoplastic Agents, Hormonal; Chemotherapy, Adjuvant; Clinical Trials as Topic; Combined Modality Therapy; Drug Therapy, Combination; Enzyme Inhibitors; Estrogens; Gonadotropin-Releasing Hormone; Humans; Ketoconazole; Male; Neoplasm Metastasis; Neoplasms, Hormone-Dependent; Orchiectomy; Prognosis; Prostatic Neoplasms; Receptors, LHRH; Spironolactone; Survival Analysis; Testosterone | 1998 |
Nodular pulmonary histoplasmosis in Cushing's disease: a case report and literature review.
Topics: Adenoma; Aminoglutethimide; Dexamethasone; Histoplasmosis; Humans; Itraconazole; Ketoconazole; Lung Diseases; Male; Middle Aged; Pituitary ACTH Hypersecretion; Pituitary Neoplasms | 2007 |
[Medical treatment for Cushing's syndrome].
Topics: Aminoglutethimide; Aromatase Inhibitors; Cushing Syndrome; Humans; Ketoconazole; Metyrapone; Steroid 11-beta-Hydroxylase | 2008 |
Glucocorticoid inhibition in the treatment of depression: can we think outside the endocrine hypothalamus?
Topics: Adrenal Glands; Aminoglutethimide; Anti-Inflammatory Agents; Corticotropin-Releasing Hormone; Depressive Disorder, Major; Double-Blind Method; Glucocorticoids; Humans; Hydrocortisone; Hypothalamus; Ketoconazole; Metyrapone; Mifepristone; Severity of Illness Index | 2009 |
3 trial(s) available for ketoconazole and aminoglutethimide
| Article | Year |
|---|---|
Response to steroid suppression in major depression resistant to antidepressant therapy.
Topics: Adult; Aminoglutethimide; Antidepressive Agents; Dehydroepiandrosterone; Depressive Disorder; Dexamethasone; Dose-Response Relationship, Drug; Female; Hospitalization; Humans; Hydrocortisone; Ketoconazole; Male; Metyrapone; Middle Aged; Psychiatric Status Rating Scales | 1991 |
Treatment of advanced prostatic cancer.
Topics: Adrenalectomy; Aminoglutethimide; Androgen Antagonists; Antineoplastic Combined Chemotherapy Protocols; Clinical Trials as Topic; Combined Modality Therapy; Cyproterone; Cyproterone Acetate; Estrogens; Flutamide; Glucocorticoids; Humans; Ketoconazole; Male; Megestrol; Megestrol Acetate; Orchiectomy; Pituitary Hormone-Releasing Hormones; Prostatic Neoplasms; Spironolactone; Time Factors | 1987 |
Neuroendocrine responses to inhibitors of steroid biosynthesis in patients with major depression resistant to antidepressant therapy.
Topics: Adult; Aminoglutethimide; Analysis of Variance; Androgen Antagonists; Antidepressive Agents; Dehydroepiandrosterone Sulfate; Depressive Disorder; Dexamethasone; Drug Resistance; Enzyme Inhibitors; Female; Hormone Antagonists; Humans; Hydrocortisone; Ketoconazole; Male; Metyrapone; Middle Aged; Steroids; Treatment Outcome | 1998 |
37 other study(ies) available for ketoconazole and aminoglutethimide
| Article | Year |
|---|---|
A new class of nonsteroidal aromatase inhibitors: design and synthesis of chromone and xanthone derivatives and inhibition of the P450 enzymes aromatase and 17 alpha-hydroxylase/C17,20-lyase.
Topics: Aromatase Inhibitors; Chromones; Drug Design; Enzyme Inhibitors; Humans; In Vitro Techniques; Male; Microsomes; Models, Molecular; Placenta; Steroid 17-alpha-Hydroxylase; Structure-Activity Relationship; Testis; Xanthenes; Xanthones | 2001 |
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration | 2004 |
Identifying off-target effects and hidden phenotypes of drugs in human cells.
Topics: Bacterial Proteins; Cell Line; Cell Proliferation; Cluster Analysis; Drug Design; Drug Evaluation, Preclinical; Genetics; Humans; Luminescent Proteins; Molecular Structure; Phenotype; Recombinant Fusion Proteins; Signal Transduction; Structure-Activity Relationship | 2006 |
New selective inhibitors of steroid 11beta-hydroxylation in the adrenal cortex. Synthesis and structure-activity relationship of potent etomidate analogues.
Topics: Adrenal Cortex; Animals; Binding Sites; Etomidate; Humans; Hydroxylation; Iodine Radioisotopes; Kinetics; Male; Molecular Structure; Rats; Rats, Wistar; Stereoisomerism; Steroid 11-beta-Hydroxylase; Structure-Activity Relationship | 2008 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models.
Topics: | 2008 |
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species.
Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics | 2010 |
Pharmacophore modeling strategies for the development of novel nonsteroidal inhibitors of human aromatase (CYP19).
Topics: Antineoplastic Agents; Aromatase; Aromatase Inhibitors; Binding Sites; Breast Neoplasms; Computer Simulation; Drug Design; Female; Humans; Models, Chemical; Models, Molecular; Structure-Activity Relationship | 2010 |
Developing structure-activity relationships for the prediction of hepatotoxicity.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes | 2010 |
A predictive ligand-based Bayesian model for human drug-induced liver injury.
Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands | 2010 |
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship | 2012 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests | 2013 |
Medical treatment of Cushing's syndrome with aminoglutethimide and ketoconazole.
Topics: Adenoma; Adrenal Gland Neoplasms; Aminoglutethimide; Cushing Syndrome; Humans; Hydrocortisone; Ketoconazole; Male; Middle Aged; Neoplasms, Multiple Primary | 1992 |
Theoretical basis for response to steroid suppression in major depression.
Topics: Aminoglutethimide; Depressive Disorder; Dopamine; Humans; Hydrocortisone; Ketoconazole; Metyrapone | 1992 |
Pig Leydig cell culture: a useful in vitro test for evaluating the testicular toxicity of compounds.
Topics: Aminoglutethimide; Animals; Cell Survival; Cells, Cultured; Chlorpromazine; Chorionic Gonadotropin; Cyclic AMP; Cycloheximide; Ketoconazole; Kinetics; Leydig Cells; Male; Progesterone; Spironolactone; Steroids; Swine; Testis; Testosterone; Time Factors; Toxicology | 1991 |
Effect of 3-week treatment with [D-Trp6, des-Gly-NH10(2)]LHRH ethylamide, aminoglutethimide, ketoconazole or flutamide alone or in combination on testicular, serum, adrenal and prostatic steroid levels in the dog.
Topics: Adrenal Glands; Aminoglutethimide; Androgens; Animals; Dogs; Flutamide; Gonadotropin-Releasing Hormone; Ketoconazole; Male; Prostate; Testis; Triptorelin Pamoate | 1989 |
Formation of 4-oestrene-3,17-dione (19-norandrostenedione) by porcine granulosa cells in vitro is inhibited by the aromatase inhibitor 4-hydroxyandrostenedione and the cytochrome P-450 inhibitors aminoglutethimide phosphate and ketoconazole.
Topics: Aminoglutethimide; Androstenedione; Animals; Cells, Cultured; Female; Granulosa Cells; Ketoconazole; Swine | 1989 |
The rise in testicular androgens during the first days of treatment with an LHRH agonist in the dog can be blocked by aminoglutethimide or ketoconazole.
Topics: Aldehyde-Lyases; Aminoglutethimide; Androgens; Animals; Cytochrome P-450 Enzyme Inhibitors; Dogs; Estradiol; Flutamide; Gonadotropin-Releasing Hormone; Ketoconazole; Luteinizing Hormone; Male; Pregnenolone; Progesterone; Steroid 17-alpha-Hydroxylase; Testis; Testosterone; Triptorelin Pamoate | 1988 |
Aromatase inhibition by the antifungal ketoconazole.
Topics: Adult; Aminoglutethimide; Animals; Aromatase Inhibitors; Cells, Cultured; Estradiol; Female; Follicular Phase; Granulosa Cells; Humans; Ketoconazole; Kinetics; Luteal Phase; Rats; Rats, Inbred Strains | 1988 |
Structure-activity relationships of the inhibition of human placental aromatase by imidazole drugs including ketoconazole.
Topics: Aminoglutethimide; Androstenedione; Aromatase Inhibitors; Humans; Imidazoles; Ketoconazole; Microsomes; Placenta; Structure-Activity Relationship | 1988 |
Effect of ketoconazole (an imidazole antimycotic agent) and other inhibitors of steroidogenesis on cytochrome P450-catalyzed reactions.
Topics: 18-Hydroxycorticosterone; Adrenal Cortex; Aminoglutethimide; Animals; Cattle; Cholesterol; Corticosterone; Cytochrome P-450 Enzyme Inhibitors; Desoxycorticosterone; Electron Transport; In Vitro Techniques; Ketoconazole; Mitochondria; Pregnenolone; Steroids | 1986 |
Paraneoplastic endocrine syndromes.
Topics: Acromegaly; Adrenocorticotropic Hormone; Aminoglutethimide; Bromocriptine; Calcitonin; Cushing Syndrome; Diazoxide; Diphosphonates; Estrogens; Fluid Therapy; Hemangiopericytoma; Humans; Hypercalcemia; Hyperthyroidism; Hypoglycemia; Inappropriate ADH Syndrome; Ketoconazole; Mifepristone; Mineralocorticoids; Mitotane; Octreotide; Osteomalacia; Pamidronate; Paraneoplastic Endocrine Syndromes; Phosphorus; Plicamycin; Propylthiouracil; Saline Solution, Hypertonic; Somatostatin; Thyroid Neoplasms | 1994 |
The psychotropic effects of inhibitors of steroid biosynthesis in depressed patients refractory to treatment.
Topics: Adrenal Cortex Hormones; Adult; Aminoglutethimide; Bipolar Disorder; Depressive Disorder; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Female; Humans; Ketoconazole; Male; Metyrapone; Middle Aged; Personality Inventory; Psychotic Disorders | 1995 |
Effect of aromatase inhibitors on estrogen 2-hydroxylase in rat liver.
Topics: Aminoglutethimide; Androstenedione; Animals; Aromatase Inhibitors; Binding, Competitive; Cytochrome P-450 CYP1A1; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Estradiol; Estrone; Fadrozole; Female; Ketoconazole; Microsomes, Liver; Rats; Rats, Sprague-Dawley; Steroid Hydroxylases; Substrate Specificity | 1994 |
Effect of dexamethasone and cytochrome P450 inhibitors on the formation of 7 alpha-hydroxydehydroepiandrosterone by human adipose stromal cells.
Topics: Adipose Tissue; Aminoglutethimide; Cells, Cultured; Cytochrome P-450 Enzyme Inhibitors; Dehydroepiandrosterone; Dexamethasone; Humans; Ketoconazole; Metyrapone; Mifepristone; Stromal Cells | 1994 |
Androgen and glucocorticoid receptors in the stroma and epithelium of prostatic hyperplasia and carcinoma.
Topics: Aged; Aminoglutethimide; Epithelial Cells; Humans; Immunohistochemistry; Ketoconazole; Male; Middle Aged; Prostatic Hyperplasia; Prostatic Neoplasms; Receptors, Androgen; Receptors, Glucocorticoid; Stromal Cells | 1996 |
Lipoproteins regulate expression of the steroidogenic acute regulatory protein (StAR) in mouse adrenocortical cells.
Topics: Adrenal Cortex; Aminoglutethimide; Animals; Cells, Cultured; Cholesterol Side-Chain Cleavage Enzyme; Cyclic AMP-Dependent Protein Kinases; Electrophoresis, Polyacrylamide Gel; Gene Expression Regulation; Ketoconazole; Lipoproteins; Lipoproteins, HDL; Lipoproteins, LDL; Mice; Phosphoproteins; RNA, Messenger | 2000 |
Aminoglutethimide, a steroidogenesis inhibitor, abolishes hormonal induction of ornithine decarboxylase in steroidogenic tissues: evidence for its role as cAMP-dependent protein kinase inhibitor.
Topics: Adrenal Glands; Adrenocorticotropic Hormone; Aminoglutethimide; Animals; Aromatase; Chorionic Gonadotropin; Cyclic AMP-Dependent Protein Kinases; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Female; Gonads; Humans; Inhibitory Concentration 50; Ketoconazole; Male; Mice; Ornithine Decarboxylase; Ovary; Polyamines; Testis | 2001 |
Primary culture system of adrenocortical cells from dogs to evaluate direct effects of chemicals on steroidogenesis.
Topics: Adrenal Cortex; Adrenal Cortex Hormones; Aminoglutethimide; Animals; Cell Survival; Cells, Cultured; Chromatography, High Pressure Liquid; Dogs; Female; Ketoconazole; Metyrapone; Miconazole; Mitotane; Toxicity Tests | 2001 |
Effects of 3-MeSO2-DDE and some CYP inhibitors on glucocorticoid steroidogenesis in the H295R human adrenocortical carcinoma cell line.
Topics: Adrenal Cortex Neoplasms; Aminoglutethimide; Carcinoma; Chromatography, High Pressure Liquid; Colforsin; Cytochrome P-450 Enzyme Inhibitors; Dichlorodiphenyl Dichloroethylene; Dose-Response Relationship, Drug; Drug Combinations; Environmental Pollutants; Enzyme Inhibitors; Hydrocortisone; Ketoconazole; Metyrapone; Tumor Cells, Cultured | 2002 |
Prostate cancer metastasis to supraclavicular lymph node.
Topics: Acid Phosphatase; Adenocarcinoma; Aged; Aminoglutethimide; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Bone Neoplasms; Combined Modality Therapy; Fatal Outcome; Humans; Ketoconazole; Lymphatic Metastasis; Male; Neck; Neoplasm Proteins; Prednisone; Prostate-Specific Antigen; Prostatic Neoplasms | 2004 |
The H295R system for evaluation of endocrine-disrupting effects.
Topics: Aminoglutethimide; Biological Assay; Cell Line, Tumor; Colforsin; Drug Interactions; Endocrine Disruptors; Estradiol; Gene Expression Profiling; Gene Expression Regulation; Humans; Ketoconazole; Metyrapone; Progesterone; Testosterone | 2006 |
Human adrenocarcinoma (H295R) cells for rapid in vitro determination of effects on steroidogenesis: hormone production.
Topics: Adrenal Cortex; Adrenocortical Carcinoma; Aminoglutethimide; Antifungal Agents; Aromatase Inhibitors; Cell Line, Tumor; Cell Survival; Dose-Response Relationship, Drug; Endocrine Disruptors; Enzyme-Linked Immunosorbent Assay; Estradiol; Fadrozole; Fungicides, Industrial; Gonadal Steroid Hormones; Humans; Imidazoles; Ketoconazole; Oxazoles; Progesterone; Testosterone | 2006 |
Luteinizing hormone-induced caspase activation in rat preovulatory follicles is coupled to mitochondrial steroidogenesis.
Topics: Aminoglutethimide; Animals; Apoptosis; Aromatase Inhibitors; Caspases; Cholesterol Side-Chain Cleavage Enzyme; Enzyme Activation; Female; Follicular Phase; Ketoconazole; Luteinizing Hormone; Mitochondria; Models, Biological; Ovarian Follicle; Rats; Rats, Wistar; Steroids | 2007 |
Steroidogenesis-disrupting compounds can be effectively studied for major fertility-related endpoints using in vitro cultured mouse follicles.
Topics: Aminoglutethimide; Animals; Animals, Newborn; Diethylhexyl Phthalate; Dose-Response Relationship, Drug; Endocrine Disruptors; Female; In Vitro Techniques; Ketoconazole; Mice; Mice, Inbred Strains; Ovarian Follicle; Sensitivity and Specificity; Steroids; Toxicity Tests; Triazoles | 2009 |
Ketoconazole treatment for Cushing syndrome in McCune-Albright syndrome.
Topics: Adrenergic Agents; Adrenocorticotropic Hormone; Aminoglutethimide; Antifungal Agents; Chemical and Drug Induced Liver Injury; Cushing Syndrome; Enzyme Inhibitors; Female; Fibrous Dysplasia, Polyostotic; Humans; Hydrocortisone; Infant; Ketoconazole; Liver Function Tests; Metyrapone; Remission Induction | 2009 |
The neurosteroid pregnenolone is synthesized by a mitochondrial P450 enzyme other than CYP11A1 in human glial cells.
Topics: Aminoglutethimide; Cholesterol; Cholesterol Side-Chain Cleavage Enzyme; Humans; Ketoconazole; Neuroglia; Neurosteroids; Pregnenolone; Reactive Oxygen Species | 2022 |