ketoconazole and amg 487

ketoconazole has been researched along with amg 487 in 1 studies

Research

Studies (1)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	1 (100.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Aidasani, DK; Chen, X; Henne, KR; Johnson, MG; Mason, AK; Rock, DA; Stresser, DM; Subramanian, R; Teffera, Y; Tonn, GR; Tran, TB; VandenBrink, BM; Wong, BK; Wong, SG	1

Other Studies

1 other study(ies) available for ketoconazole and amg 487

Article	Year
Sequential metabolism of AMG 487, a novel CXCR3 antagonist, results in formation of quinone reactive metabolites that covalently modify CYP3A4 Cys239 and cause time-dependent inhibition of the enzyme. Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:7 Topics: Acetamides; Biotransformation; Cytochrome P-450 CYP3A; Humans; Metabolic Networks and Pathways; Microsomes, Liver; Midazolam; Oxygen; Proteolysis; Pyrimidinones; Quinones; Receptors, CXCR3; Testosterone	2012

Article

Year

Sequential metabolism of AMG 487, a novel CXCR3 antagonist, results in formation of quinone reactive metabolites that covalently modify CYP3A4 Cys239 and cause time-dependent inhibition of the enzyme.

Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:7

Topics: Acetamides; Biotransformation; Cytochrome P-450 CYP3A; Humans; Metabolic Networks and Pathways; Microsomes, Liver; Midazolam; Oxygen; Proteolysis; Pyrimidinones; Quinones; Receptors, CXCR3; Testosterone

2012