ketoconazole has been researched along with alprazolam in 15 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (26.67) | 18.2507 |
| 2000's | 6 (40.00) | 29.6817 |
| 2010's | 5 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL | 1 |
| Artursson, P; Bergström, CA; Draheim, R; Holmén, AG; Wassvik, CM | 1 |
| García-Mera, X; González-Díaz, H; Prado-Prado, FJ | 1 |
| Artursson, P; Mateus, A; Matsson, P | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Cotreau-Bibbo, MM; Greenblatt, DJ; Harmatz, JS; Shader, RI; von Moltke, LL | 1 |
| Corbett, K; Counihan, M; Ehrenberg, BL; Greenblatt, DJ; Harmatz, JS; Harrel, LM; Shader, RI; Tobias, S; von Moltke, LL; Wright, CE | 1 |
| Balian, JD; Flockhart, DA; Yuan, R | 1 |
| Arold, G; Bauer, S; Brockmöller, J; Roots, I; Schmider, J | 1 |
| Greenblatt, DJ; Harmatz, JS; Poku, JW; Shader, RI; von Moltke, LL; Warrington, JS | 1 |
| Daily, JP; Durol, AL; Graf, JA; Greenblatt, DJ; Harmatz, JS; Hoffman, JL; Mertzanis, P; Shader, RI; von Moltke, LL | 1 |
| Green, CE; Hirota, N; Ito, K; Iwatsubo, T; Shimada, N; Sugiyama, Y; Suzuki, H; Tyson, CA | 1 |
| Allqvist, A; Bertilsson, L; Mirghani, RA; Miura, J | 1 |
| Boulenc, X; Donazzolo, Y; Hermabessière, S; Martin, V; Nicolas, O; Ollier, C; Zobouyan, I | 1 |
| Boinpally, R; Chen, L; Gad, N; Ghahramani, P; Greenberg, WM; Periclou, A; Wangsa, J | 1 |
2 review(s) available for ketoconazole and alprazolam
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
Pharmacokinetic and pharmacodynamic consequences of metabolism-based drug interactions with alprazolam, midazolam, and triazolam.
Topics: Alprazolam; Anti-Anxiety Agents; Data Collection; Drug Interactions; Enzyme Induction; Enzyme Inhibitors; Humans; Itraconazole; Ketoconazole; Midazolam; Triazolam | 1999 |
5 trial(s) available for ketoconazole and alprazolam
| Article | Year |
|---|---|
Ketoconazole inhibition of triazolam and alprazolam clearance: differential kinetic and dynamic consequences.
Topics: Administration, Oral; Adult; Alprazolam; Antifungal Agents; Area Under Curve; Cross-Over Studies; Double-Blind Method; Electroencephalography; Humans; Hypnotics and Sedatives; Ketoconazole; Male; Reference Values; Time Factors; Triazolam | 1998 |
Simultaneous assessment of CYP3A4 and CYP1A2 activity in vivo with alprazolam and caffeine.
Topics: Adult; Alprazolam; Area Under Curve; Caffeine; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Induction; Enzyme Inhibitors; Female; Humans; Ketoconazole; Male; Middle Aged; Mixed Function Oxygenases; Reference Values; Rifampin | 1999 |
Alprazolam-ritonavir interaction: implications for product labeling.
Topics: Adult; Alprazolam; Anti-Anxiety Agents; Antifungal Agents; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Double-Blind Method; Drug Interactions; Drug Labeling; Female; HIV Protease Inhibitors; Humans; Hydroxylation; Ketoconazole; Male; Metabolic Clearance Rate; Microsomes, Liver; Oxidoreductases, N-Demethylating; Protein Isoforms; Ritonavir | 2000 |
CYP3A4-based drug-drug interaction: CYP3A4 substrates' pharmacokinetic properties and ketoconazole dose regimen effect.
Topics: Adolescent; Adult; Alprazolam; Cross-Over Studies; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Dose-Response Relationship, Drug; Drug Interactions; Humans; Ketoconazole; Male; Midazolam; Substrate Specificity; Young Adult | 2016 |
Evaluation of Cytochrome P450 (CYP) 3A4-Based Interactions of Levomilnacipran with Ketoconazole, Carbamazepine or Alprazolam in Healthy Subjects.
Topics: Adolescent; Adult; Alprazolam; Area Under Curve; Carbamazepine; Cyclopropanes; Cytochrome P-450 CYP3A Inducers; Cytochrome P-450 CYP3A Inhibitors; Delayed-Action Preparations; Drug Interactions; Female; Healthy Volunteers; Humans; Ketoconazole; Male; Middle Aged; Milnacipran; Young Adult | 2015 |
8 other study(ies) available for ketoconazole and alprazolam
| Article | Year |
|---|---|
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration | 2004 |
Molecular characteristics for solid-state limited solubility.
Topics: Chemical Phenomena; Chemistry, Physical; Molecular Structure; Multivariate Analysis; Pharmaceutical Preparations; Regression Analysis; Solubility | 2008 |
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species.
Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics | 2010 |
A high-throughput cell-based method to predict the unbound drug fraction in the brain.
Topics: Animals; Brain; Dialysis; HEK293 Cells; High-Throughput Screening Assays; Humans; Pharmaceutical Preparations; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | 2014 |
Inhibitors of alprazolam metabolism in vitro: effect of serotonin-reuptake-inhibitor antidepressants, ketoconazole and quinidine.
Topics: Adult; Aged; Alprazolam; Animals; Antidepressive Agents; Biotransformation; Female; Humans; Hydroxylation; Ketoconazole; Macaca fascicularis; Male; Mice; Microsomes, Liver; Middle Aged; Quinidine; Rats; Rats, Sprague-Dawley; Selective Serotonin Reuptake Inhibitors; Species Specificity | 1994 |
Effects of age on in vitro midazolam biotransformation in male CD-1 mouse liver microsomes.
Topics: Age Factors; Alprazolam; Animals; Anti-Anxiety Agents; Aryl Hydrocarbon Hydroxylases; Biotransformation; Blotting, Western; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; In Vitro Techniques; Ketoconazole; Male; Mice; Microsomes, Liver; Midazolam; Oxidoreductases, N-Demethylating | 2000 |
In vitro/in vivo scaling of alprazolam metabolism by CYP3A4 and CYP3A5 in humans.
Topics: Adult; Alprazolam; Anti-Anxiety Agents; Area Under Curve; Cimetidine; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Cytochromes b5; Female; Humans; Intestinal Mucosa; Ketoconazole; Male; Microsomes, Liver; Middle Aged; Mixed Function Oxygenases; Recombinant Proteins | 2001 |
Inhibition of CYP3A4 and CYP3A5 catalyzed metabolism of alprazolam and quinine by ketoconazole as racemate and four different enantiomers.
Topics: Alprazolam; Anti-Anxiety Agents; Antifungal Agents; Antimalarials; Chromatography, High Pressure Liquid; Chromatography, Liquid; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Drug Interactions; Humans; Inhibitory Concentration 50; Ketoconazole; Mass Spectrometry; Microsomes, Liver; Quinidine; Stereoisomerism | 2007 |