ketoconazole and acyclovir

ketoconazole has been researched along with acyclovir in 27 studies

Research

Studies (27)

TimeframeStudies, this research(%)All Research%
pre-19902 (7.41)18.7374
1990's6 (22.22)18.2507
2000's3 (11.11)29.6817
2010's14 (51.85)24.3611
2020's2 (7.41)2.80

Authors

AuthorsStudies
Jones, LH; Nadanaciva, S; Rana, P; Will, Y1
Brodsky, JL; Chiang, A; Chung, WJ; Denny, RA; Goeckeler-Fried, JL; Havasi, V; Hong, JS; Keeton, AB; Mazur, M; Piazza, GA; Plyler, ZE; Rasmussen, L; Rowe, SM; Sorscher, EJ; Weissman, AM; White, EL1
Balliano, TL; Barbosa, G; Carvalho, VF; da Silva, BA; de Souza, ET; Lima, LM; Martins, IRR; Martins, MA; Medeiros, MM; Moraes Junior, MO; Nunes, IKDC; Silva, PMR; Silva, SWD1
Ahmadi, R; Emami, S1
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL1
Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J1
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Aytemir, MD; Ozçelik, B1
Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ1
Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V1
Barber, J; Dawson, S; Kenna, JG; Paul, N; Stahl, S1
Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR1
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Bianchi Porro, G; Cernuschi, M; Lazzarin, A; Parente, F; Rizzardini, G; Valsecchi, L1
Bercy, P; De Beule, F; Ferrant, A1
Coker, DM; Kinghorn, GR; O'Mahony, C; Talbot, MD; Woolley, PD1
Barzilai, A; Hodes, DS; Hyatt, AC; Reidenberg, BE; Sperling, RS; Wedgwood, JF1
Benson, CA; Chase, R; Goodrich, JM; Kapell, K; Kessler, HA; Levin, S; Pottage, JC1
Enzensberger, W; Fischer, PA; Helm, EB; Hopp, G; Stille, W1
Grimfors, G; Järnmark, M; Lerner, R; Ljungman, P; Lönnqvist, B; Nyström-Rosander, C; Oberg, G; Palmblad, J1
Shumack, S; Wong, D1
Block, SL1
du Plessis, J; du Preez, JL; Fox, LT; Gerber, M; Jacobs, GA; Malan, MM1
Botes, D; Steenekamp, JH; Viljoen, JM1

Reviews

3 review(s) available for ketoconazole and acyclovir

ArticleYear
Recent applications of vinyl sulfone motif in drug design and discovery.
    European journal of medicinal chemistry, 2022, Apr-15, Volume: 234

    Topics: Chemistry, Pharmaceutical; Drug Design; Sulfones; Vinyl Compounds

2022
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016
Managing HIV. Part 5: Treating secondary outcomes. 5.1 HIV and skin disease.
    The Medical journal of Australia, 1996, Mar-18, Volume: 164, Issue:6

    Topics: Acyclovir; Antifungal Agents; Antiviral Agents; Dermatomycoses; Drug Eruptions; HIV Infections; Humans; Ketoconazole; Sarcoma, Kaposi; Skin Diseases; Skin Diseases, Papulosquamous; Skin Neoplasms

1996

Trials

1 trial(s) available for ketoconazole and acyclovir

ArticleYear
Oral acyclovir as prophylaxis for bacterial infections during induction therapy for acute leukaemia in adults. The Leukemia Group of Middle Sweden.
    Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 1993, Volume: 1, Issue:3

    Topics: Acyclovir; Administration, Oral; Adolescent; Adult; Aged; Bacteremia; Bacterial Infections; Double-Blind Method; Fever; Herpes Simplex; Humans; Incidence; Ketoconazole; Middle Aged; Mycoses; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prospective Studies

1993

Other Studies

23 other study(ies) available for ketoconazole and acyclovir

ArticleYear
Development of a cell viability assay to assess drug metabolite structure-toxicity relationships.
    Bioorganic & medicinal chemistry letters, 2016, 08-15, Volume: 26, Issue:16

    Topics: Adenosine Triphosphate; Benzbromarone; Cell Line; Cell Survival; Chromans; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Humans; Pharmaceutical Preparations; Thiazolidinediones; Troglitazone

2016
Increasing the Endoplasmic Reticulum Pool of the F508del Allele of the Cystic Fibrosis Transmembrane Conductance Regulator Leads to Greater Folding Correction by Small Molecule Therapeutics.
    PloS one, 2016, Volume: 11, Issue:10

    Topics: Alleles; Benzoates; Cells, Cultured; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Endoplasmic Reticulum; Furans; Gene Deletion; HEK293 Cells; HeLa Cells; High-Throughput Screening Assays; Humans; Hydroxamic Acids; Microscopy, Fluorescence; Protein Folding; Protein Structure, Tertiary; Pyrazoles; RNA, Messenger; Small Molecule Libraries; Ubiquitination; Vorinostat

2016
Discovery of sulfonyl hydrazone derivative as a new selective PDE4A and PDE4D inhibitor by lead-optimization approach on the prototype LASSBio-448: In vitro and in vivo preclinical studies.
    European journal of medicinal chemistry, 2020, Oct-15, Volume: 204

    Topics: Animals; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 4; Drug Design; Enzyme Inhibitors; Humans; Hydrazones; Hypersensitivity; Lung; Male; Mice

2020
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
    Current drug discovery technologies, 2004, Volume: 1, Issue:4

    Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration

2004
Chemical genetics reveals a complex functional ground state of neural stem cells.
    Nature chemical biology, 2007, Volume: 3, Issue:5

    Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells

2007
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.
    Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19

    Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship

2008
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
A study of cytotoxicity of novel chlorokojic acid derivatives with their antimicrobial and antiviral activities.
    European journal of medicinal chemistry, 2010, Volume: 45, Issue:9

    Topics: Animals; Anti-Infective Agents; Antiviral Agents; Bacteria; Cell Line; Chlorocebus aethiops; Drug Evaluation, Preclinical; Fungi; Herpesvirus 1, Human; Mannich Bases; Microbial Sensitivity Tests; Parainfluenza Virus 3, Human; Pyrones; Spectrum Analysis; Vero Cells

2010
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2010, Volume: 118, Issue:2

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics

2010
FDA-approved drug labeling for the study of drug-induced liver injury.
    Drug discovery today, 2011, Volume: 16, Issue:15-16

    Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Design; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmaceutical Preparations; Reproducibility of Results; United States; United States Food and Drug Administration

2011
In vitro inhibition of the bile salt export pump correlates with risk of cholestatic drug-induced liver injury in humans.
    Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:1

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Cholestasis; Drug-Related Side Effects and Adverse Reactions; Humans; Insecta; Rats; Risk Factors

2012
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.
    Journal of medicinal chemistry, 2012, May-24, Volume: 55, Issue:10

    Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection

2012
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
    Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship

2012
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests

2013
Opportunistic infections of the esophagus not responding to oral systemic antifungals in patients with AIDS: their frequency and treatment.
    The American journal of gastroenterology, 1991, Volume: 86, Issue:12

    Topics: Acquired Immunodeficiency Syndrome; Acyclovir; Administration, Oral; Adult; Amphotericin B; Antifungal Agents; Drug Resistance, Microbial; Esophagitis; Female; Fluconazole; Ganciclovir; Humans; Infusions, Intravenous; Ketoconazole; Male; Opportunistic Infections; Prospective Studies; Treatment Outcome

1991
The effectiveness of a preventive regimen on the periodontal health of patients undergoing chemotherapy for leukemia and lymphoma.
    Journal of clinical periodontology, 1991, Volume: 18, Issue:5

    Topics: Acyclovir; Amphotericin B; Ceftazidime; Chlorhexidine; Dental Plaque Index; Fluconazole; Humans; Immunosuppression Therapy; Ketoconazole; Leukemia; Lymphoma; Miconazole; Norfloxacin; Periodontal Diseases; Periodontal Index; Tooth Loss; Vancomycin

1991
Diabetic ketoacidosis precipitated by primary genital herpes.
    International journal of STD & AIDS, 1990, Volume: 1, Issue:5

    Topics: Acyclovir; Adolescent; Adult; Diabetic Ketoacidosis; Female; Fluconazole; Herpes Simplex; Humans; Ketoconazole

1990
Mother to child transmission of human immunodeficiency virus 1 infection despite zidovudine therapy from 18 weeks of gestation.
    The Pediatric infectious disease journal, 1990, Volume: 9, Issue:12

    Topics: Acyclovir; Adult; Diseases in Twins; Drug Therapy, Combination; Female; HIV Infections; HIV-1; Humans; Infant, Newborn; Infant, Premature, Diseases; Ketoconazole; Patient Compliance; Pregnancy; Pregnancy Complications, Infectious; Zidovudine

1990
In vitro activity of ketoconazole against herpes simplex virus.
    Antimicrobial agents and chemotherapy, 1986, Volume: 30, Issue:2

    Topics: Acyclovir; Animals; Cell Line; Drug Interactions; Humans; Ketoconazole; Simplexvirus; Vidarabine; Viral Proteins

1986
[Toxoplasmosis encephalitis in patients with AIDS].
    Deutsche medizinische Wochenschrift (1946), 1985, Jan-18, Volume: 110, Issue:3

    Topics: Acquired Immunodeficiency Syndrome; Acyclovir; Candidiasis, Oral; Electroencephalography; Encephalitis; Homosexuality; Humans; Ketoconazole; Male; Tomography, X-Ray Computed; Toxoplasmosis

1985
Tricky triggers of intertrigo.
    Pediatric annals, 2014, Volume: 43, Issue:5

    Topics: Acyclovir; Anti-Bacterial Agents; Antifungal Agents; Antimalarials; Antiviral Agents; Candidiasis; Child, Preschool; Clindamycin; Female; Herpes Simplex; Humans; Infant; Infant, Newborn; Intertrigo; Ketoconazole; Male; Staphylococcal Infections; Sulfamethoxazole; Trimethoprim

2014
Topical delivery of acyclovir and ketoconazole.
    Drug delivery, 2016, Volume: 23, Issue:2

    Topics: Acyclovir; Administration, Cutaneous; Antifungal Agents; Antiviral Agents; Diffusion; Drug Carriers; Drug Compounding; Drug Stability; Drug Storage; Fatty Acids; Female; Gels; Humans; Hydrogen-Ion Concentration; In Vitro Techniques; Ketoconazole; Nitrous Oxide; Ointments; Particle Size; Skin; Skin Absorption; Solubility; Technology, Pharmaceutical; Viscosity

2016
Formulation and evaluation of selected transmucosal dosage forms containing a double fixed-dose of acyclovir and ketoconazole.
    European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 2018, Jan-01, Volume: 111

    Topics: Acyclovir; Animals; Antifungal Agents; Antiviral Agents; Dosage Forms; Drug Stability; Female; Ketoconazole; Lip; Mucous Membrane; Swine; Vagina

2018