ketoconazole has been researched along with abiraterone acetate in 9 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (33.33) | 18.2507 |
| 2000's | 2 (22.22) | 29.6817 |
| 2010's | 4 (44.44) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Barrie, SE; Jarman, M; Potter, GA; Rowlands, MG | 1 |
| Bartels, M; Cavalli, A; Hartmann, RW; Hille, UE; Hu, Q; Jagusch, C; Jahn-Hoffmann, K; Lauterbach, T; Müller-Vieira, U; Negri, M; Pinto-Bazurco Mendieta, MA; Recanatini, M; Rodenwaldt, B; Schmidt, D | 1 |
| Bartels, M; Hartmann, RW; Hu, Q; Jahn-Hoffmann, K; Lauterbach, T; Müller-Vieira, U; Negri, M; Olgen, S; Zhuang, Y | 1 |
| Barrie, SE; Dowsett, M; Goddard, PM; Haynes, BP; Jarman, M; Potter, GA | 1 |
| Akaza, H; Fujikura, T; Ideyama, Y; Ishikawa, H; Kudoh, M; Nakahara, T; Nanya, T; Okada, M; Shikama, H; Susaki, Y; Tanimoto, K; Yoden, T | 1 |
| Berger, R; Carducci, MA; Eisenberger, MA; Gottfried, M; Keizman, D; Leibowitz-Amit, R; Peer, A; Sella, A; Sinibaldi, V | 1 |
| Mailankody, S; Prasad, V | 1 |
| Fetterly, G; Fong, L; Friedlander, TW; Harzstark, AL; Kim, W; Lin, AM; Mohler, JL; Molina, A; Morse, A; Ryan, CJ; Small, EJ; Szmulewitz, RZ; Weinberg, V; Wilton, JH; Zhang, L | 1 |
| Acharya, M; Bernard, A; Chien, C; De Vries, R; Jiao, J; Monbaliu, J; Stieltjes, H; Tran, N; Vaccaro, N; Yu, M | 1 |
1 trial(s) available for ketoconazole and abiraterone acetate
| Article | Year |
|---|---|
Sequential use of the androgen synthesis inhibitors ketoconazole and abiraterone acetate in castration-resistant prostate cancer and the predictive value of circulating androgens.
Topics: Abiraterone Acetate; Aged; Aged, 80 and over; Androgens; Androstenes; Humans; Ketoconazole; Male; Middle Aged; Neoplasm Metastasis; Prognosis; Prostatic Neoplasms, Castration-Resistant; Retreatment; Steroid Synthesis Inhibitors; Treatment Outcome | 2014 |
8 other study(ies) available for ketoconazole and abiraterone acetate
| Article | Year |
|---|---|
Novel steroidal inhibitors of human cytochrome P45017 alpha (17 alpha-hydroxylase-C17,20-lyase): potential agents for the treatment of prostatic cancer.
Topics: Cytochrome P-450 Enzyme Inhibitors; Humans; Magnetic Resonance Spectroscopy; Male; Prostatic Neoplasms; Steroid 17-alpha-Hydroxylase; Steroids; Structure-Activity Relationship; Testis | 1995 |
Synthesis, biological evaluation and molecular modelling studies of methyleneimidazole substituted biaryls as inhibitors of human 17alpha-hydroxylase-17,20-lyase (CYP17). Part I: Heterocyclic modifications of the core structure.
Topics: Binding Sites; Biological Availability; Enzyme Inhibitors; Heterocyclic Compounds; Humans; Imidazoles; Inhibitory Concentration 50; Liver; Models, Molecular; Polycyclic Aromatic Hydrocarbons; Steroid 17-alpha-Hydroxylase; Testosterone | 2008 |
Synthesis, biological evaluation, and molecular modeling studies of methylene imidazole substituted biaryls as inhibitors of human 17alpha-hydroxylase-17,20-lyase (CYP17)--part II: Core rigidification and influence of substituents at the methylene bridge.
Topics: Animals; Binding Sites; Biphenyl Compounds; Enzyme Inhibitors; Humans; Imidazoles; Inhibitory Concentration 50; Magnetic Resonance Spectroscopy; Male; Models, Molecular; Protein Structure, Secondary; Rats; Spectrometry, Mass, Electrospray Ionization; Spectrophotometry, Infrared; Steroid 17-alpha-Hydroxylase; Testosterone | 2008 |
Pharmacology of novel steroidal inhibitors of cytochrome P450(17) alpha (17 alpha-hydroxylase/C17-20 lyase).
Topics: Abiraterone Acetate; Adrenal Glands; Aldehyde-Lyases; Androgens; Androstadienes; Androstenes; Androstenols; Animals; Cytochrome P-450 Enzyme Inhibitors; Flutamide; Guinea Pigs; Ketoconazole; Kidney; Luteinizing Hormone; Male; Mice; Orchiectomy; Organ Size; Prostate; Seminal Vesicles; Steroid 17-alpha-Hydroxylase; Testis; Testosterone | 1994 |
Novel nonsteroidal inhibitor of cytochrome P450(17alpha) (17alpha-hydroxylase/C17-20 lyase), YM116, decreased prostatic weights by reducing serum concentrations of testosterone and adrenal androgens in rats.
Topics: Abiraterone Acetate; Adrenal Glands; Adrenocorticotropic Hormone; Androgens; Androstadienes; Animals; Carbazoles; Enzyme Inhibitors; Gonadotropin-Releasing Hormone; Guinea Pigs; Imidazoles; Ketoconazole; Male; Orchiectomy; Organ Size; Prostate; Rats; Seminal Vesicles; Steroid 17-alpha-Hydroxylase; Testosterone | 1998 |
Comparison of abiraterone acetate versus ketoconazole in patients with metastatic castration resistant prostate cancer refractory to docetaxel.
Topics: Abiraterone Acetate; Aged; Aged, 80 and over; Androstadienes; Antineoplastic Agents; Combined Modality Therapy; Databases, Factual; Disease Progression; Disease-Free Survival; Docetaxel; Humans; Ketoconazole; Male; Middle Aged; Orchiectomy; Prostatic Neoplasms; Retreatment; Retrospective Studies; Taxoids; Treatment Outcome | 2014 |
Comparative effectiveness questions in oncology.
Topics: Abiraterone Acetate; Androstadienes; Antineoplastic Agents; Comparative Effectiveness Research; Drug Costs; Humans; Ketoconazole; Medical Oncology; Randomized Controlled Trials as Topic; Steroid 17-alpha-Hydroxylase | 2014 |
Impact on abiraterone pharmacokinetics and safety: Open-label drug-drug interaction studies with ketoconazole and rifampicin.
Topics: Abiraterone Acetate; Adolescent; Adult; Area Under Curve; Belgium; Biotransformation; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inducers; Cytochrome P-450 CYP3A Inhibitors; Drug Interactions; Half-Life; Healthy Volunteers; Humans; Ketoconazole; Male; Metabolic Clearance Rate; Middle Aged; Models, Biological; Oxides; Rifampin; Sulfates; Young Adult | 2015 |