ketoconazole and 3-hydroxyquinidine

ketoconazole has been researched along with 3-hydroxyquinidine in 7 studies

Research

Studies (7)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (28.57)18.2507
2000's4 (57.14)29.6817
2010's1 (14.29)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Ishizaki, T; Kawashiro, T; Zhao, XJ1
Bertilsson, L; Ericsson, O; Gustafsson, LL; Hellgren, U; Mirghani, RA; Westerberg, PA1
Bhoopathy, S; Karnes, HT; Sarkar, MA1
Bertilsson, L; Ericsson, O; Gustafsson, LL; Mirghani, RA; Tybring, G1
Bertilsson, L; Ericsson, O; Gustafsson, LL; Hellgren, U; Mirghani, RA1
Allqvist, A; Bertilsson, L; Mirghani, RA; Miura, J1
de Graaf, IA; de Jager, MH; Groothuis, GM; Li, M; van de Steeg, E1

Trials

3 trial(s) available for ketoconazole and 3-hydroxyquinidine

ArticleYear
The roles of cytochrome P450 3A4 and 1A2 in the 3-hydroxylation of quinine in vivo.
    Clinical pharmacology and therapeutics, 1999, Volume: 66, Issue:5

    Topics: Adult; Antifungal Agents; Antimalarials; Area Under Curve; Cross-Over Studies; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Female; Fluvoxamine; Humans; Hydroxylation; Ketoconazole; Male; Mixed Function Oxygenases; Quinidine; Quinine; Selective Serotonin Reuptake Inhibitors

1999
Quinine 3-hydroxylation as a biomarker reaction for the activity of CYP3A4 in man.
    European journal of clinical pharmacology, 2003, Volume: 59, Issue:1

    Topics: Adult; Biomarkers; Cross-Over Studies; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Drug Interactions; Female; Fluvoxamine; Humans; Hydroxylation; Isoenzymes; Ketoconazole; Male; Middle Aged; Quinidine; Quinine

2003
Metabolism and elimination of quinine in healthy volunteers.
    European journal of clinical pharmacology, 2003, Volume: 59, Issue:5-6

    Topics: Antimalarials; Area Under Curve; Aryl Hydrocarbon Hydroxylases; Benzoquinones; Chromatography, High Pressure Liquid; Cross-Over Studies; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Interactions; Fluvoxamine; Humans; Ketoconazole; Mixed Function Oxygenases; Quinidine; Quinine; Quinones; Time Factors

2003

Other Studies

4 other study(ies) available for ketoconazole and 3-hydroxyquinidine

ArticleYear
Mutual inhibition between quinine and etoposide by human liver microsomes. Evidence for cytochrome P4503A4 involvement in their major metabolic pathways.
    Drug metabolism and disposition: the biological fate of chemicals, 1998, Volume: 26, Issue:2

    Topics: Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Etoposide; Humans; Ketoconazole; Microsomes, Liver; Mixed Function Oxygenases; Oxidoreductases, O-Demethylating; Quinidine; Quinine; Troleandomycin

1998
Characterization of quinidine 3-hydroxylation as a probe for the CYP 3A enzyme using a novel capillary electrophoresis technique.
    European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 2002, Volume: 16, Issue:4-5

    Topics: Animals; Aryl Hydrocarbon Hydroxylases; Biomarkers; Cytochrome P-450 CYP3A; Electrophoresis, Capillary; Enzyme Inhibitors; Erythromycin; Fluconazole; Hydroxylation; Ketoconazole; Microsomes, Liver; Oxidoreductases, N-Demethylating; Quinidine; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Sensitivity and Specificity; Stereoisomerism

2002
Inhibition of CYP3A4 and CYP3A5 catalyzed metabolism of alprazolam and quinine by ketoconazole as racemate and four different enantiomers.
    European journal of clinical pharmacology, 2007, Volume: 63, Issue:2

    Topics: Alprazolam; Anti-Anxiety Agents; Antifungal Agents; Antimalarials; Chromatography, High Pressure Liquid; Chromatography, Liquid; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Drug Interactions; Humans; Inhibitory Concentration 50; Ketoconazole; Mass Spectrometry; Microsomes, Liver; Quinidine; Stereoisomerism

2007
The consequence of regional gradients of P-gp and CYP3A4 for drug-drug interactions by P-gp inhibitors and the P-gp/CYP3A4 interplay in the human intestine ex vivo.
    Toxicology in vitro : an international journal published in association with BIBRA, 2017, Volume: 40

    Topics: Adult; Aged; Aged, 80 and over; ATP Binding Cassette Transporter, Subfamily B, Member 1; Colon; Cyclosporins; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Drug Interactions; Female; Humans; Ileum; In Vitro Techniques; Isoquinolines; Jejunum; Ketoconazole; Male; Middle Aged; Quinazolines; Quinidine; Verapamil

2017