ketanserinol has been researched along with ketanserin in 17 studies
*Ketanserin: A selective serotonin receptor antagonist with weak adrenergic receptor blocking properties. The drug is effective in lowering blood pressure in essential hypertension. It also inhibits platelet aggregation. It is well tolerated and is particularly effective in older patients. [MeSH]
*Ketanserin: A selective serotonin receptor antagonist with weak adrenergic receptor blocking properties. The drug is effective in lowering blood pressure in essential hypertension. It also inhibits platelet aggregation. It is well tolerated and is particularly effective in older patients. [MeSH]
| Studies (ketanserinol) | Trials (ketanserinol) | Recent Studies (post-2010) (ketanserinol) | Studies (ketanserin) | Trials (ketanserin) | Recent Studies (post-2010) (ketanserin) |
|---|---|---|---|---|---|
| 17 | 3 | 0 | 3,094 | 335 | 283 |
| Protein | Taxonomy | ketanserinol (IC50) | ketanserin (IC50) |
|---|---|---|---|
| 5-hydroxytryptamine receptor 2C | Rattus norvegicus (Norway rat) | 0.0016 | |
| 5-hydroxytryptamine receptor 2A | Rattus norvegicus (Norway rat) | 0.0021 | |
| Alpha-1B adrenergic receptor | Rattus norvegicus (Norway rat) | 0.015 | |
| Alpha-1D adrenergic receptor | Rattus norvegicus (Norway rat) | 0.015 | |
| 5-hydroxytryptamine receptor 1D | Homo sapiens (human) | 0.265 | |
| 5-hydroxytryptamine receptor 1B | Homo sapiens (human) | 6.5 | |
| 5-hydroxytryptamine receptor 2A | Homo sapiens (human) | 0.0184 | |
| 5-hydroxytryptamine receptor 2C | Homo sapiens (human) | 0.0027 | |
| 5-hydroxytryptamine receptor 2B | Rattus norvegicus (Norway rat) | 0.0016 | |
| 5-hydroxytryptamine receptor 2B | Homo sapiens (human) | 0.29 | |
| Alpha-1A adrenergic receptor | Rattus norvegicus (Norway rat) | 0.015 | |
| D(2) dopamine receptor | Rattus norvegicus (Norway rat) | 1.8 | |
| Synaptic vesicular amine transporter | Homo sapiens (human) | 0.18 | |
| Sigma non-opioid intracellular receptor 1 | Homo sapiens (human) | 0.001 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 11 (64.71) | 18.7374 |
| 1990's | 2 (11.76) | 18.2507 |
| 2000's | 4 (23.53) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Barendregt, JN; Tjandra, YI; Van Der Hoeven, JG; Van Oene, JC; Van Peer, A | 1 |
| Benhamou, JP; Berthelot, P; Fraitag, B; Gaudin, C; Hadengue, A; Lebrec, D; Levron, JC | 1 |
| Gould, S; Gush, R; Jayson, MI; Kay, EA; Klimiuk, PS; Mitchell, WS; Taylor, L | 1 |
| Kurowski, M | 1 |
| Awouters, F; Heykants, J; Leysen, JE; Michiels, M; Schuurkes, J; Van Nueten, JM; Woestenborghs, R | 1 |
| De Cree, J; Hendrickx, J; Heykants, J; Lauwers, W; Meuldermans, W; Van Peer, A; Woestenborghs, R | 1 |
| Heykants, J; Knaeps, F; Meuldermans, W; Mostmans, E; Van Houdt, J; Verluyten, W | 1 |
| Hedner, T; Persson, B; Pettersson, A | 1 |
| Leeser, JE; Rawlins, MD; Williams, FM | 1 |
| Embrechts, L; Heykants, J; Van Peer, A; Woestenborghs, R | 1 |
| Gould, S; Heykants, J; Mills, J; Van Peer, A; Woestenborghs, R | 1 |
| Frenken, M; Kaumann, AJ | 1 |
| Lindelauf, F | 1 |
| Schoenwald, RD; Zhu, J | 1 |
| Hanff, LM; Vulto, AG; Yassen, A | 1 |
| Sinclair-Worley, L; Uphouse, L | 1 |
| Drozdov, I; Gustafsson, BI; Joseph, R; Kidd, M; Modlin, IM; Pfragner, R; Svejda, B | 1 |
3 trial(s) available for ketanserinol and ketanserin
| Article | Year |
|---|---|
Pharmacokinetics of ketanserin in patients with cirrhosis.
Topics: Administration, Oral; Chromatography, High Pressure Liquid; Female; Humans; Injections, Intravenous; Ketanserin; Liver Cirrhosis; Male; Middle Aged; Models, Biological | 1990 |
Pharmacodynamics and pharmacokinetics of single doses of ketanserin and propranolol alone and in combination in healthy volunteers.
Topics: Adult; Blood Pressure; Drug Administration Schedule; Female; Half-Life; Heart Rate; Humans; Ketanserin; Kinetics; Male; Middle Aged; Physical Exertion; Propranolol; Time Factors | 1986 |
Pharmacokinetics of ketanserin and its metabolite ketanserin-ol in man after intravenous, intramuscular and oral administration.
Topics: Administration, Oral; Adult; Analysis of Variance; Half-Life; Humans; Injections, Intramuscular; Injections, Intravenous; Ketanserin; Kinetics; Male; Random Allocation; Regression Analysis | 1986 |
14 other study(ies) available for ketanserinol and ketanserin
| Article | Year |
|---|---|
Ketanserin pharmacokinetics in patients with renal failure.
Topics: Adult; Aged; Blood Proteins; Female; Half-Life; Humans; Ketanserin; Kidney Failure, Chronic; Male; Middle Aged; Protein Binding; Renal Dialysis | 1990 |
Ketanserin: an effective treatment regimen for digital ischaemia in systemic sclerosis.
Topics: Administration, Oral; Adult; Aged; Female; Fingers; Humans; Infusions, Intravenous; Ischemia; Ketanserin; Middle Aged; Pain Measurement; Scleroderma, Systemic | 1989 |
Simultaneous determination of ketanserin and ketanserinol in biological fluids using ion-pair liquid chromatography and fluorometric detection.
Topics: Aged; Antihypertensive Agents; Body Fluids; Chromatography, High Pressure Liquid; Female; Humans; Hydrogen-Ion Concentration; Ketanserin; Kinetics; Piperidines; Spectrometry, Fluorescence; Spectrophotometry, Ultraviolet | 1985 |
Pharmacokinetic evaluation of the in vitro and in vivo pharmacological profile of the major metabolites of ketanserin in the rat.
Topics: Administration, Oral; Animals; Chromatography, High Pressure Liquid; Cricetinae; In Vitro Techniques; Injections, Subcutaneous; Ketanserin; Male; Muscle, Smooth, Vascular; Rats; Rats, Inbred Strains; Receptors, Drug; Stomach Ulcer | 1988 |
Absorption, metabolism and excretion of ketanserin in man after oral administration.
Topics: Administration, Oral; Adult; Biotransformation; Chromatography, High Pressure Liquid; Feces; Humans; Ketanserin; Male | 1988 |
Plasma protein binding of ketanserin and its distribution in blood.
Topics: Administration, Oral; Animals; Blood Proteins; Dogs; Drug Interactions; Humans; Hydrogen-Ion Concentration; Ketanserin; Male; Protein Binding; Rats; Rats, Inbred Strains; Tissue Distribution | 1988 |
Pharmacokinetics of ketanserin in patients with essential hypertension.
Topics: Administration, Oral; Aged; Biological Availability; Female; Half-Life; Hemodynamics; Humans; Hypertension; Injections, Intravenous; Ketanserin; Kinetics; Male; Metabolic Clearance Rate; Middle Aged | 1987 |
Pharmacokinetic approach to equilibrium between ketanserin and ketanserin-ol.
Topics: Administration, Oral; Adult; Half-Life; Humans; Ketanserin; Kinetics; Male; Oxidation-Reduction | 1986 |
Interaction of ketanserin and its metabolite ketanserinol with 5HT2 receptors in pulmonary and coronary arteries of calf.
Topics: Animals; Cattle; Coronary Vessels; In Vitro Techniques; Ketanserin; Muscle Contraction; Muscle, Smooth, Vascular; Piperidines; Pulmonary Artery; Receptors, Serotonin; Yohimbine | 1984 |
Determination of ketanserin and its major metabolite (reduced ketanserin) in human plasma by high-performance liquid chromatography.
Topics: Adult; Chromatography, High Pressure Liquid; Female; Humans; Ketanserin; Oxidation-Reduction; Piperidines; Spectrophotometry, Ultraviolet | 1983 |
The ocular pharmacokinetics of ketanserin and its metabolite, ketanserinol, in albino rabbits.
Topics: Administration, Topical; Animals; Eye; Female; Intraocular Pressure; Ketanserin; Male; Rabbits; Serotonin Antagonists | 2000 |
Simultaneous quantitative analysis of ketanserin and ketanserinol in plasma by RP-HPLC with fluorescence detection.
Topics: Calibration; Chromatography, High Pressure Liquid; Humans; Ketanserin; Reproducibility of Results; Sensitivity and Specificity; Spectrometry, Fluorescence | 2003 |
Effect of estrogen on the lordosis-inhibiting action of ketanserin and SB 206553.
Topics: Analysis of Variance; Animals; Dose-Response Relationship, Drug; Drug Interactions; Estradiol; Female; Hypothalamus, Middle; Indoles; Ketanserin; Posture; Progesterone; Pyridines; Rats; Rats, Inbred F344; Serotonin Antagonists; Sexual Behavior, Animal; Time Factors | 2004 |
Autoregulatory effects of serotonin on proliferation and signaling pathways in lung and small intestine neuroendocrine tumor cell lines.
Topics: Cell Line, Tumor; Cell Proliferation; Homeostasis; Humans; Intestinal Neoplasms; JNK Mitogen-Activated Protein Kinases; Ketanserin; Lung Neoplasms; Mitogen-Activated Protein Kinase 3; Neuroendocrine Tumors; Phosphorylation; Receptors, Serotonin; Serotonin; Signal Transduction; Tryptophan | 2009 |