ketanserin has been researched along with prazosin in 150 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 58 (38.67) | 18.7374 |
| 1990's | 51 (34.00) | 18.2507 |
| 2000's | 18 (12.00) | 29.6817 |
| 2010's | 22 (14.67) | 24.3611 |
| 2020's | 1 (0.67) | 2.80 |
| Authors | Studies |
|---|---|
| Dannals, RF; Frost, JJ; Ravert, HT; Wagner, HN; Wilson, AA | 1 |
| Arnt, J; Boeck, V; Bøgesø, KP; Christensen, AV; Hyttel, J; Jensen, KG | 1 |
| Janssen, CG; Laduron, PM; Thijssen, JB; Van Dun, J; Wouters, W | 1 |
| Andrews, PR; Craik, DJ; Martin, JL | 1 |
| Berardi, F; Colabufo, NA; Fiorentini, F; Ghiglieri, A; Govoni, S; Leopoldo, M; Olgiati, V; Perrone, R; Tortorella, V | 1 |
| Chan, CH; Chern, JW; Chien, SL; Lai, YJ; Lu, GY; Shiau, CY; Tao, PL; Yen, MH | 1 |
| Berardi, F; Caccia, C; Fornaretto, MG; Leopoldo, M; McArthur, RA; Perrone, R; Tortorella, V | 1 |
| Berardi, F; Caccia, C; Colabufo, NA; Fornaretto, MG; Leopoldo, M; McArthur, RA; Perrone, R; Tortorella, V | 1 |
| Bartoccini, F; Carminati, P; Castorina, M; Di Cesare, MA; Di Serio, S; Gallo, G; Ghirardi, O; Giorgi, F; Giorgi, L; Minetti, P; Piersanti, G; Tarzia, G; Tinti, MO | 1 |
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| Axe, FU; Bembenek, SD; Butler, CR; Coles, F; Dunford, PJ; Edwards, JP; Fourie, AM; Grice, CA; Karlsson, L; Lundeen, K; Riley, JP; Savall, BM; Tays, KL; Wei, J; Williams, KN; Xue, X | 1 |
| Altenbach, RJ; Brioni, JD; Carr, TL; Chandran, P; Cowart, MD; Esbenshade, TA; Honore, P; Hsieh, GC; Lewis, LG; Liu, H; Manelli, AM; Marsh, KC; Milicic, I; Miller, TR; Strakhova, MI; Vortherms, TA; Wakefield, BD; Wetter, JM; Witte, DG | 1 |
| Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV | 1 |
| Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ | 1 |
| Hayashi, S; Kato, A; Mizuno, K; Morita, A; Nakata, E; Ohashi, K; Yamamura, K | 1 |
| Colau, D; Dolusić, E; Frédérick, R; Larrieu, P; Masereel, B; Moineaux, L; Pilotte, L; Pochet, L; Stroobant, V; Van den Eynde, B; Wouters, J | 1 |
| Carmody, LC; Dandapani, S; Donckele, E; Feng, Y; Fernandez, C; Germain, AR; Gupta, PB; Lander, ES; Morgan, B; Munoz, B; Nag, PP; Palmer, M; Perez, JR; Schreiber, SL; Verplank, L | 1 |
| Anzini, M; Brogi, S; Butini, S; Campiani, G; Cappelli, A; Caselli, G; Castriconi, F; Gemma, S; Giordani, A; Giorgi, G; Giuliani, G; Lanza, M; Letari, O; Makovec, F; Manini, M; Mennuni, L; Valenti, S | 1 |
| Belyakov, S; Dambrova, M; Kazoka, H; Kuznecovs, J; Lebedev, A; Liepinsh, E; Mishnev, A; Orlova, N; Ponomaryov, Y; Vavers, E; Veinberg, G; Vikainis, S; Vilskersts, R; Vorona, M; Zvejniece, L | 1 |
| Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ | 1 |
| Bienkowski, P; Bucki, A; Jaśkowska, J; Kazek, G; Kowalski, P; Kołaczkowski, M; Marcinkowska, M; Mierzejewski, P; Mitka, K; Pawłowski, M; Siwek, A; Wasik, A; Wesołowska, A | 1 |
| Bienkowski, P; Bucki, A; Jastrzębska-Więsek, M; Kazek, G; Kołaczkowski, M; Marcinkowska, M; Mierzejewski, P; Partyka, A; Pawłowski, M; Siwek, A; Śniecikowska, J; Wasik, A; Wesołowska, A | 1 |
| Alberts, IL; Harding, WW; Kapadia, N; Madapa, S; Ponnala, S | 1 |
| Bednarski, M; Gunia-Krzyżak, A; Marona, H; Nitek, W; Pękala, E; Powroźnik, B; Słoczyńska, K; Walczak, M; Waszkielewicz, AM; Żesławska, E | 1 |
| Filipek, B; Gunia-Krzyżak, A; Marona, H; Nitek, W; Pańczyk, K; Pękala, E; Rapacz, A; Słoczyńska, K; Waszkielewicz, AM; Żelaszczyk, D; Żesławska, E | 1 |
| Abd Rahman, N; Buckle, MJC; Chee, CF; Chin, SP; Chung, LY; Doughty, SW; Heng, HL; Herr, DR; Ouyang, Y; Paterson, IC; Wang, H | 1 |
| Bansal, R; Malhotra, A | 1 |
| Hyttel, J; Nielsen, JB; Nowak, G | 1 |
| Gürdal, H; Onaran, HO; Tulunay, FC | 1 |
| Hansson, E; Nilsson, M; Rönnbäck, L | 1 |
| Deschênes, M; Pinault, D | 1 |
| Borges, Y; Cassels, BK; Gonzalez, E; Lobos, M | 1 |
| Pinardi, G; Vásquez, JV | 1 |
| Mori, K; Tani, A; Yoshihara, Y | 1 |
| Egashira, K; Hayashi, Y; Nakamura, M; Takeshita, A; Tomoike, H; Yamada, A | 1 |
| Barker, EL; Burris, KD; Sanders-Bush, E | 1 |
| Borowsky, B; Kuhn, CM | 1 |
| Ewing, FE; Furman, JS; Heym, JH; Howard, HR; Lowe, JA; Nagel, AA; Newman, ME; Schmidt, AW; Seeger, TF; Seymour, PA | 1 |
| Kinami, J; Maruyama, K; Nagatomo, T; Sugita, Y; Sugiyama, E; Takada, Y; Tsuchihashi, H | 1 |
| Pappius, HM | 1 |
| Brouwer, RM; Schalekamp, MA; Wenting, GJ | 1 |
| Adelstein, RS; Corson, MA; Schoenberg, M; Sellers, JR | 1 |
| Fernandez-Alfonso, MS; Guerra, P; Marín, J; Reviriego, J | 1 |
| Gaw, AJ; Humphrey, PP; Wadsworth, RM | 1 |
| Nakamura, H; Suzukawa, M | 1 |
| Biggio, G; Giorgi, O | 1 |
| Hagen, PO; McCann, RL; Mikat, EM; O'Donohoe, MK; Radic, ZS; Schwartz, LB; Stein, AD | 1 |
| Backus, LI; Grahame-Smith, DG; Sharp, T | 1 |
| Jackson, DA; White, SR | 1 |
| Akita, H; Fukuzaki, H; Goshima, K; Hamamori, Y; Yamada, M; Yokoyama, M | 1 |
| Andersson, KE; Forman, A; Funch-Jensen, P; Raundahl, U; Tøttrup, A | 1 |
| Kirsten, R; Ochs, JG; Storck, J | 1 |
| Gradin, K; Hedner, T; Persson, B; Pettersson, A | 4 |
| Coghlan, JP; Denton, DA; Mills, EH; Nelson, MA; Scoggins, BA; Spence, CD; Whitworth, JA | 1 |
| Arnold, G; Breuer, J; Meschig, R | 1 |
| Marwood, JF; Stokes, GS | 1 |
| Ball, SG; Robertson, JI; Stott, DJ | 1 |
| Iida, H; Ikeda, K; Mikawa, M; Sasayama, S; Takata, M; Tomoda, F | 1 |
| Lüscher, TF; Vanhoutte, PM | 1 |
| Ramage, AG | 1 |
| Coffman, JD; Cohen, RA | 2 |
| Brunello, N; Galimberti, R; Racagni, G; Riva, M; Rovescalli, AC | 1 |
| Basso, N; Kurnjek, M; Mikulic, L; Taquini, AC | 1 |
| Docherty, JR | 1 |
| Barkai, AI; Butler, PD; Edwards, E | 1 |
| Frenken, M | 1 |
| Leysen, JE; Schotte, A | 1 |
| Barrett, JE; Hoffmann, SM; Nader, MA | 1 |
| Nagatomo, T; Tsuchihashi, H | 1 |
| Abe, Y; Fukui, K; Iwao, H; Shoji, T; Tamaki, T | 1 |
| Andries, LJ; Brutsaert, DL; Meulemans, AL; Shah, AM | 1 |
| Cain, CR; Nicholson, CD | 1 |
| Brouwer, RM; Man in't Veld, AJ; Schalekamp, MA; vd Meiracker, AJ; Wenting, GJ | 1 |
| Gala, RR; Pan, JT | 1 |
| Gallager, D; Goldman-Rakic, PS; Rakic, P | 1 |
| Aono, J; Ishizuka, N; Nabata, H; Sakai, K | 1 |
| Greiner, HE; Haase, A; Klockow, M; Schmitges, CJ; Seyfried, C | 1 |
| Fisher, R; Gruebel, B; Koehle, W; Rosenthal, J | 1 |
| Fukuda, H; Ishida, Y; Kanaya, J; Moritoki, H | 1 |
| Arnt, J; Bach-Lauritsen, T; Hyttel, J | 1 |
| Baldwin, JJ; Clineschmidt, BV; Huff, JR; Lotti, VJ; Pettibone, DJ; Randall, WC; Vacca, J; Young, SD | 1 |
| Krootila, K; Palkama, A; Uusitalo, H | 1 |
| Merrell, WJ; Nadeau, JH; Naslund, TC; Wood, AJ | 1 |
| Forler, C; Fozard, JR; Middlemiss, DN; Tricklebank, MD | 1 |
| Marwood, JF; Mennie, BA; Stokes, GS | 1 |
| Hoekman, TB; Howlett, SE; Triggle, CR | 1 |
| Kawasaki, H; Takasaki, K | 1 |
| Smits, J; Struyker Boudier, H; van Dorsten, F | 1 |
| Karasawa, A; Kubo, K; Nakamizo, N; Shuto, K | 1 |
| Donnelly, R; Elliott, HL; Meredith, PA; Reid, JL | 1 |
| Hewson, G; Hill, RG; Hughes, J; Leighton, GE | 1 |
| Davie, M; Roberts, MH; Wilkinson, LS | 1 |
| Key, BJ; Loudon, RF | 1 |
| Harris, LT; McCall, RB | 1 |
| Kayaalp, SO; Tuncer, M; Uma, S | 1 |
| Battaglia, G; Borgundvaag, B; Shannon, M; Titeler, M | 1 |
| Edwards, CR; Shaikh, S; Williams, BC | 1 |
| Timmermans, PB; van Zwieten, PA | 1 |
| Timmermans, PB; Van Brummelen, P; Van Zwieten, PA | 1 |
| Buczko, W; De Gaetano, G; Gambino, MC | 1 |
| Apprill, P; Ashton, J; Buja, LM; Bush, LR; Campbell, WB; Kern, K; Schmitz, J; Tilton, GD; Willerson, JT | 1 |
| Angus, JA; Wright, CE | 1 |
| Hu, XQ; Zhang, L | 1 |
| Baubichon, D; Blanchet, G; Bodjarian, N; Carpentier, P; Lallement, G | 1 |
| Marwood, JF | 1 |
| Morris, JL | 1 |
| Lidow, MS; Rakic, P | 1 |
| Hong, E; López-Muñoz, FJ; Terrón, JA; Villalón, CM | 1 |
| Bennie, J; Carroll, S; Dow, RC; Fink, G; Williams, BC | 1 |
| Ageel, AM; Alhaider, AA; Ginawi, OT | 1 |
| Bobadilla, RA; Castillo, C; Castillo, EF; Hong, E; Ibarra, M | 1 |
| Endoh, M; Morinobu, S; Okuyama, N; Totsuka, S | 1 |
| Clarke, DE; Ford, AP; Lachnit, WG | 1 |
| Buñag, RD; Davidow, LW | 1 |
| Bertolino, F; Fauré, P; John, GW; Valentin, JP; Vieu, S | 1 |
| Marwood, JF; Okoro, EO | 1 |
| Duman, RS; Morinobu, S; Strausbaugh, H; Terwilliger, R | 1 |
| Bigl, V; Heider, M; Rossner, S; Schliebs, R | 1 |
| Bobadilla, RA; Hong, E; Pérez-Alvarez, V | 1 |
| Aloyo, VJ; Harvey, JA; Hoffman, ME; Salt, GL | 1 |
| Borda, E; Busch, L; Wald, M | 1 |
| Hart-Favaloro, JL; Woodman, OL | 1 |
| Del Bel, EA; Guimarães, FS; Nucci-da-Silva, LP | 1 |
| Deis, RP; Hole, D; Jahn, GA; Kalia, V; Wilson, CA | 1 |
| Piguet, P; Schlichter, R; Stoeckel, ME | 1 |
| Filip, M; Nowak, E; Papla, I | 1 |
| Israilova, M; Muramatsu, I; Nagatomo, T; Suzuki, F; Tanaka, T; Taniguchi, T | 1 |
| Matsushima, K; Tozawa, Y | 1 |
| Fink, GD; Li, MW; Ni, W; Thakali, K; Watts, SW | 1 |
| Fu, YJ; Miao, CY; Shu, H; Su, DF; Wang, MW | 1 |
| Caparrotta, L; Froldi, G; Nicoletti, P; Ragazzi, E | 1 |
| Angers, P; Dalbó, S; Jürgensen, S; Ribeiro-do-Valle, RM; Santos, AR | 1 |
| Bourin, M; Dailly, E; Hascoët, M; Masse, F | 1 |
| Centurión, D; Gupta, S; MaassenVanDenBrink, A; Mehotra, S; Sánchez-López, A; Villalón, CM | 1 |
| Balsamo, A; Betti, L; Giannaccini, G; Nencetti, S; Orlandini, E; Rapposelli, S | 1 |
| Anisuzzaman, AS; Morishima, S; Muramatsu, I; Sathi, ZS; Suzuki, F; Tanaka, T; Yoshiki, H | 1 |
| Chen, IJ; Hsieh, SL; Kwan, AL; Lin, HL; Shen, KP; Wu, BN | 1 |
| Binfaré, RW; Budni, J; Freitas, AE; Jacinto, J; Lobato, KR; Machado, DG; Pizzolatti, MG; Rodrigues, AL; Veronezi, PO | 1 |
| Duffin, J; Peever, J; Tadjalli, A | 1 |
| Baker, PM; Ragozzino, ME; Sweeney, JA; Thompson, JL | 1 |
| Climent, L; Horga, A; Horga, JF; Peiró, AM; Zapater, P | 1 |
| Çaylak, B; Erdem, ŞR; Köse, MG; Peșkircioğlu, ÇL | 1 |
| Bexis, S; Docherty, JR | 1 |
| Gencer, A; Gunduz, O; Ulugol, A | 1 |
5 review(s) available for ketanserin and prazosin
| Article | Year |
|---|---|
Therapeutic progression of quinazolines as targeted chemotherapeutic agents.
Topics: Animals; Antineoplastic Agents; Cell Proliferation; Enzyme Inhibitors; Humans; Molecular Structure; Neoplasms; Quinazolines | 2021 |
Neurochemical approaches to the amelioration of brain injury.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Brain Injuries; Deoxyglucose; Dibenzocycloheptenes; Dizocilpine Maleate; Hydroxyindoleacetic Acid; Indomethacin; Ketanserin; Male; Prazosin; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Serotonin | 1990 |
Antihypertensive mode of action of ketanserin.
Topics: Adrenergic alpha-Antagonists; Aldosterone; Animals; Antihypertensive Agents; Blood Pressure; Carcinoid Heart Disease; Humans; Ketanserin; Piperidines; Prazosin; Ritanserin | 1987 |
Cardiovascular alpha 2-receptors.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Affinity Labels; Animals; Blood Pressure; Brain; Calcium Channel Blockers; Cardiovascular Physiological Phenomena; Guanosine Triphosphate; Heart Rate; Humans; Ketanserin; Kidney; Muscle, Smooth, Vascular; Piperazines; Piperidines; Prazosin; Receptors, Adrenergic, alpha; Synaptic Membranes; Tritium; Vasoconstriction | 1983 |
Role of alpha adrenoceptors in hypertension and in antihypertensive drug treatment.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Antihypertensive Agents; Azepines; Blood Pressure; Calcium Channel Blockers; Clonidine; Guanfacine; Guanidines; Humans; Hypertension; Ketanserin; Methyldopa; Muscle, Smooth, Vascular; Phenylacetates; Piperazines; Piperidines; Prazosin; Radioligand Assay; Receptors, Adrenergic, alpha; Vascular Resistance | 1984 |
4 trial(s) available for ketanserin and prazosin
| Article | Year |
|---|---|
Moderate essential hypertension control: a double-blind crossover study between a serotonin antagonist and a post-synaptic alpha-blocker.
Topics: Adrenergic beta-Antagonists; Adult; Aged; Clinical Trials as Topic; Double-Blind Method; Female; Heart Rate; Humans; Hypertension; Ketanserin; Male; Middle Aged; Piperidines; Prazosin; Serotonin Antagonists | 1986 |
Alpha-adrenergic blockade makes minimal contribution to ketanserin's hypotensive effect.
Topics: Adrenergic alpha-Antagonists; Antihypertensive Agents; Blood Pressure; Dose-Response Relationship, Drug; Heart Rate; Humans; Ketanserin; Male; Middle Aged; Phenylephrine; Posture; Prazosin | 1988 |
Ketanserin and prazosin: a comparison of antihypertensive and biochemical effects.
Topics: Adult; Aldosterone; Blood Pressure; Cholesterol; Drug Evaluation; Female; Heart Rate; Humans; Hypertension; Ketanserin; Male; Middle Aged; Physical Exertion; Piperidines; Prazosin; Random Allocation; Renin | 1986 |
Acute and chronic ketanserin in essential hypertension: antihypertensive mechanisms and pharmacokinetics.
Topics: Adult; Aldosterone; Angiotensin II; Blood Pressure; Electrocardiography; Female; Heart Rate; Humans; Hypertension; Ketanserin; Male; Middle Aged; Norepinephrine; Phenylephrine; Prazosin; Renin | 1987 |
141 other study(ies) available for ketanserin and prazosin
| Article | Year |
|---|---|
Synthesis and biological evaluation of [125I]- and [123I]-4-iododexetimide, a potent muscarinic cholinergic receptor antagonist.
Topics: Animals; Dexetimide; Iodine Radioisotopes; Isotope Labeling; Male; Mice; Parasympatholytics; Piperidines; Receptors, Muscarinic; Tomography, Emission-Computed | 1989 |
Antihypertensive activity in a series of 1-piperazino-3-phenylindans with potent 5-HT2-antagonistic activity.
Topics: Animals; Antihypertensive Agents; Antipsychotic Agents; Blood Pressure; Chemical Phenomena; Chemistry; Dopamine; Imidazoles; Ketanserin; Norepinephrine; Phenylephrine; Piperazines; Rats; Rats, Inbred SHR; Serotonin Antagonists; Structure-Activity Relationship | 1988 |
In vitro labeling of serotonin-S2 receptors: synthesis and binding characteristics of [3H]-7-aminoketanserin.
Topics: Animals; Binding, Competitive; Brain; Chemical Phenomena; Chemistry; Frontal Lobe; Guinea Pigs; Ketanserin; Kinetics; Piperidines; Rats; Rats, Inbred Strains; Receptors, Serotonin | 1986 |
Functional group contributions to drug-receptor interactions.
Topics: Animals; Calorimetry; Kinetics; Models, Biological; Protein Binding; Receptors, Cell Surface; Receptors, Drug; Structure-Activity Relationship | 1984 |
High affinity and selectivity on 5-HT1A receptor of 1-aryl-4-[1-tetralin)alkyl]piperazines. 2.
Topics: Animals; Chemical Phenomena; Chemistry, Physical; Guinea Pigs; Isomerism; Kinetics; Male; Piperazines; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Structure-Activity Relationship; Tetrahydronaphthalenes | 1995 |
Studies on quinazolines. 5. 2,3-dihydroimidazo[1,2-c]quinazoline derivatives: a novel class of potent and selective alpha 1-adrenoceptor antagonists and antihypertensive agents.
Topics: Adrenergic alpha-Antagonists; Animals; Antihypertensive Agents; Binding, Competitive; Blood Pressure; Quinazolines; Rats; Rats, Inbred SHR; Structure-Activity Relationship | 1993 |
1-aryl-4-[(1-tetralinyl)alkyl]piperazines: alkylamido and alkylamino derivatives. Synthesis, 5-HT1A receptor affinity, and selectivity. 3.
Topics: Animals; Buspirone; Mass Spectrometry; Molecular Structure; Piperazines; Protein Binding; Rats; Receptors, Adrenergic; Receptors, Dopamine; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin; Serotonin Receptor Agonists | 1996 |
Structure-activity relationship studies on the 5-HT(1A) receptor affinity of 1-phenyl-4-[omega-(alpha- or beta-tetralinyl)alkyl]piperazines. 4.
Topics: Magnetic Resonance Spectroscopy; Piperazines; Radioligand Assay; Receptors, Serotonin; Structure-Activity Relationship | 1996 |
2-n-Butyl-9-methyl-8-[1,2,3]triazol-2-yl-9H-purin-6-ylamine and analogues as A2A adenosine receptor antagonists. Design, synthesis, and pharmacological characterization.
Topics: Adenine; Adenosine A2 Receptor Antagonists; Animals; Cell Line; Cricetinae; Cricetulus; Drug Design; Humans; Imidazoles; Male; Models, Molecular; Motor Activity; Purines; Radioligand Assay; Rats; Rats, Inbred F344; Structure-Activity Relationship; Triazoles | 2005 |
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
Identification of a potent, selective, and orally active leukotriene a4 hydrolase inhibitor with anti-inflammatory activity.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents; Catalysis; Dogs; Drug Evaluation, Preclinical; Enzyme Inhibitors; Epoxide Hydrolases; Humans; Magnetic Resonance Spectroscopy; Mice; Structure-Activity Relationship | 2008 |
cis-4-(Piperazin-1-yl)-5,6,7a,8,9,10,11,11a-octahydrobenzofuro[2,3-h]quinazolin-2-amine (A-987306), a new histamine H4R antagonist that blocks pain responses against carrageenan-induced hyperalgesia.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzofurans; Carrageenan; Disease Models, Animal; Drug Design; Drug Evaluation, Preclinical; Humans; Hyperalgesia; Ligands; Mice; Molecular Structure; Pain; Peritonitis; Quinazolines; Rats; Receptors, G-Protein-Coupled; Receptors, Histamine; Receptors, Histamine H4; Stereoisomerism; Structure-Activity Relationship | 2008 |
Physicochemical determinants of human renal clearance.
Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight | 2009 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations | 2010 |
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics | 2010 |
Discovery of {1-[4-(2-{hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl}-1H-benzimidazol-1-yl)piperidin-1-yl]cyclooctyl}methanol, systemically potent novel non-peptide agonist of nociceptin/orphanin FQ receptor as analgesic for the treatment of neuropathic pain: de
Topics: Analgesics; Animals; Benzimidazoles; Drug Design; Drug Evaluation, Preclinical; Humans; Microsomes, Liver; Neuralgia; Nociceptin Receptor; Pyrroles; Rats; Receptors, Opioid; Structure-Activity Relationship | 2010 |
Tryptophan 2,3-dioxygenase (TDO) inhibitors. 3-(2-(pyridyl)ethenyl)indoles as potential anticancer immunomodulators.
Topics: Animals; Antineoplastic Agents; Biological Availability; Cell Line; Drug Design; Enzyme Inhibitors; Humans; Immunologic Factors; Indoles; Kinetics; Mice; Neoplasms; Structure-Activity Relationship; Tryptophan Oxygenase | 2011 |
Cinnamides as selective small-molecule inhibitors of a cellular model of breast cancer stem cells.
Topics: Amides; Breast Neoplasms; Cell Line, Tumor; Drug Screening Assays, Antitumor; Female; Humans; Neoplastic Stem Cells; Small Molecule Libraries; Structure-Activity Relationship | 2013 |
Synthesis and structure-activity relationship studies in serotonin 5-HT(1A) receptor agonists based on fused pyrrolidone scaffolds.
Topics: Animals; Area Under Curve; Humans; Intestinal Absorption; Ligands; Male; Metabolic Clearance Rate; Models, Chemical; Models, Molecular; Molecular Structure; Protein Binding; Protein Structure, Tertiary; Pyrrolidinones; Radioligand Assay; Receptor, Serotonin, 5-HT1A; Receptors, Serotonin, 5-HT3; Serotonin 5-HT1 Receptor Agonists; Structure-Activity Relationship | 2013 |
Synthesis and biological evaluation of 2-(5-methyl-4-phenyl-2-oxopyrrolidin-1-yl)-acetamide stereoisomers as novel positive allosteric modulators of sigma-1 receptor.
Topics: Acetamides; Allosteric Regulation; Animals; Rats; Rats, Wistar; Receptors, sigma; Sigma-1 Receptor; Stereoisomerism; Structure-Activity Relationship | 2013 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests | 2013 |
Novel arylsulfonamide derivatives with 5-HT₆/5-HT₇ receptor antagonism targeting behavioral and psychological symptoms of dementia.
Topics: Animals; Antidepressive Agents; Antipsychotic Agents; Avoidance Learning; Benzoxazoles; Catalepsy; CHO Cells; Cricetulus; Dementia; Dopamine D2 Receptor Antagonists; HEK293 Cells; Humans; Male; Models, Molecular; Motor Activity; Radioligand Assay; Rats, Wistar; Receptors, Serotonin; Serotonin Antagonists; Structure-Activity Relationship; Sulfonamides | 2014 |
Novel 5-HT6 receptor antagonists/D2 receptor partial agonists targeting behavioral and psychological symptoms of dementia.
Topics: Animals; Benzamides; Dementia; Dose-Response Relationship, Drug; Drug Partial Agonism; Humans; Indoles; Ligands; Male; Models, Molecular; Molecular Structure; Piperazines; Quinolones; Rats; Rats, Wistar; Receptors, Dopamine D2; Receptors, Serotonin; Structure-Activity Relationship; Swimming | 2015 |
Synthesis and evaluation of aporphine analogs containing C1 allyl isosteres at the h5-HT(2A) receptor.
Topics: Adrenergic alpha-1 Receptor Antagonists; Aporphines; Heterocyclic Compounds, 4 or More Rings; Humans; Hydrophobic and Hydrophilic Interactions; Ligands; Molecular Docking Simulation; Receptor, Serotonin, 5-HT2A; Serotonin 5-HT2 Receptor Agonists; Structure-Activity Relationship | 2015 |
Design, physico-chemical properties and biological evaluation of some new N-[(phenoxy)alkyl]- and N-{2-[2-(phenoxy)ethoxy]ethyl}aminoalkanols as anticonvulsant agents.
Topics: Amino Alcohols; Animals; Anticonvulsants; Chemistry, Physical; Dose-Response Relationship, Drug; Drug Design; Epilepsy; Male; Mice; Microsomes, Liver; Molecular Structure; Pilocarpine | 2016 |
Structure-anticonvulsant activity studies in the group of (E)-N-cinnamoyl aminoalkanols derivatives monosubstituted in phenyl ring with 4-Cl, 4-CH
Topics: Amino Alcohols; Animals; Anticonvulsants; Crystallography, X-Ray; Disease Models, Animal; Dose-Response Relationship, Drug; Electroshock; Mice; Models, Molecular; Molecular Structure; Rats; Seizures; Structure-Activity Relationship | 2017 |
Synthesis and evaluation of nuciferine and roemerine enantiomers as 5-HT
Topics: | 2018 |
The acute effect of sertindole on brain 5-HT2, D2 and alpha 1 receptors (ex vivo radioreceptor binding studies).
Topics: Animals; Brain Chemistry; Dose-Response Relationship, Drug; Imidazoles; Indoles; Ketanserin; Male; Prazosin; Radioligand Assay; Rats; Rats, Wistar; Receptors, Adrenergic, alpha; Receptors, Dopamine D2; Receptors, Serotonin; Serotonin; Spiperone | 1992 |
Role of alpha-adrenoceptors in the effects of buspirone and 5-carboxamidotryptamine in rabbit isolated thoracic aorta.
Topics: Adrenergic alpha-Antagonists; Animals; Aorta, Thoracic; Buspirone; Cystamine; Dose-Response Relationship, Drug; Drug Interactions; Ketanserin; Methysergide; Phenylephrine; Prazosin; Rabbits; Receptors, Adrenergic, alpha; Receptors, Serotonin; Serotonin; Vasoconstriction | 1992 |
Receptor-coupled uptake of valproate in rat astroglial primary cultures.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Animals, Newborn; Astrocytes; Biological Transport; Cells, Cultured; Cerebral Cortex; Clonidine; Drug Interactions; Glutamates; Glutamic Acid; Isoproterenol; Kainic Acid; Ketanserin; Phenylephrine; Prazosin; Quinoxalines; Quisqualic Acid; Rats; Rats, Inbred Strains; Receptors, Neurotransmitter; Serotonin; Valproic Acid; Yohimbine | 1992 |
Control of 40-Hz firing of reticular thalamic cells by neurotransmitters.
Topics: 2-Amino-5-phosphonovalerate; Acetylcholine; Animals; Bicuculline; Electric Conductivity; Female; gamma-Aminobutyric Acid; Ketanserin; Kynurenic Acid; Male; Neurons; Neurotransmitter Agents; Prazosin; Quinoxalines; Rats; Rats, Sprague-Dawley; Reticular Formation; Scopolamine; Thalamic Nuclei | 1992 |
The action of the psychoactive drug 2C-B on isolated rat thoracic aorta.
Topics: Adrenergic alpha-Agonists; Animals; Aorta, Thoracic; Dimethoxyphenylethylamine; Endothelium, Vascular; In Vitro Techniques; Ketanserin; Male; Muscle Contraction; Muscle, Smooth, Vascular; Norepinephrine; Prazosin; Psychotropic Drugs; Rats; Rats, Sprague-Dawley; Serotonin | 1992 |
Vasomotor responses in the isolated perfused external and internal carotid vascular beds of the rat.
Topics: Animals; Blood Pressure; Carotid Arteries; Carotid Artery, External; Carotid Artery, Internal; Female; In Vitro Techniques; Ketanserin; Male; Muscle Contraction; Muscle, Smooth, Vascular; Norepinephrine; Prazosin; Rats; Serotonin; Sympathetic Nervous System; Yohimbine | 1992 |
Increase in cytoplasmic free Ca2+ elicited by noradrenalin and serotonin in cultured local interneurons of mouse olfactory bulb.
Topics: Animals; Animals, Newborn; Calcium; Cells, Cultured; Cytoplasm; Fura-2; Glutamate Decarboxylase; Immunohistochemistry; Interneurons; Ketanserin; Kinetics; Mice; Mice, Inbred Strains; Microscopy, Fluorescence; Neurofilament Proteins; Norepinephrine; Olfactory Bulb; Prazosin; Serotonin; Yohimbine | 1992 |
Mechanism of ergonovine-induced hyperconstriction of the large epicardial coronary artery in conscious dogs a month after arterial injury.
Topics: Animals; Blood Pressure; Coronary Circulation; Coronary Vasospasm; Coronary Vessels; Diltiazem; Dogs; Electrophysiology; Endothelium, Vascular; Ergonovine; Heart Rate; Indomethacin; Ketanserin; Methysergide; Phenylephrine; Prazosin; Receptors, Serotonin | 1992 |
Phosphoinositide hydrolysis linked 5-HT2 receptors in fibroblasts from choroid plexus.
Topics: Animals; Cells, Cultured; Choroid Plexus; DOM 2,5-Dimethoxy-4-Methylamphetamine; Fibroblasts; Haloperidol; Hydrolysis; Inositol Phosphates; Ketanserin; Lysergic Acid Diethylamide; Male; Mianserin; Phosphatidylinositols; Prazosin; Rabbits; Receptors, Serotonin; Serotonin; Spiperone | 1991 |
Monoamine mediation of cocaine-induced hypothalamo-pituitary-adrenal activation.
Topics: Adrenocorticotropic Hormone; Animals; Biogenic Monoamines; Cocaine; Corticosterone; Dopamine; Dopamine Antagonists; Haloperidol; Hypothalamo-Hypophyseal System; Injections, Intraperitoneal; Ketanserin; Male; Neurotransmitter Agents; Neurotransmitter Uptake Inhibitors; Piperazines; Pituitary-Adrenal System; Prazosin; Propranolol; Rats; Rats, Inbred Strains; Receptors, Dopamine; Stimulation, Chemical; Time Factors | 1991 |
1-Naphthylpiperazine derivatives as potential atypical antipsychotic agents.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Amphetamines; Animals; Antipsychotic Agents; Apomorphine; Autoradiography; Behavior, Animal; Dopamine Antagonists; Haloperidol; Ketanserin; Locomotion; Male; Piperazines; Prazosin; Rats; Rats, Inbred Strains; Structure-Activity Relationship; Tetrahydronaphthalenes | 1991 |
MCI-9042: high affinity for serotonergic receptors as assessed by radioligand binding assay.
Topics: Adrenergic alpha-Agonists; Adrenergic beta-Antagonists; Animals; Binding, Competitive; Brain Chemistry; Clonidine; Hippocampus; In Vitro Techniques; Ketanserin; Kinetics; Platelet Aggregation Inhibitors; Prazosin; Propanolamines; Radioligand Assay; Rats; Receptors, Adrenergic, alpha; Receptors, Adrenergic, beta; Receptors, Muscarinic; Receptors, Serotonin; Succinates | 1991 |
Acute effects and mechanism of action of ketanserin in patients with primary Raynaud's phenomenon.
Topics: Adult; Blood Gas Monitoring, Transcutaneous; Female; Fingers; Humans; Ketanserin; Lasers; Male; Oxygen; Phentolamine; Plethysmography; Prazosin; Raynaud Disease; Regional Blood Flow; Skin Temperature | 1990 |
Substance P contracts bovine tracheal smooth muscle via activation of myosin light chain kinase.
Topics: Animals; Atropine; Calcium; Cattle; Enzyme Activation; Glycopeptides; In Vitro Techniques; Indomethacin; Ketanserin; Kinetics; Masoprocol; Muscle Contraction; Muscle, Smooth; Myosin Subfragments; Myosin-Light-Chain Kinase; Peptide Mapping; Phosphorylation; Potassium Chloride; Prazosin; Propranolol; Pyrilamine; Substance P; Trachea | 1990 |
Effects of Ca2+ antagonists nifedipine and diltiazem on isolated human chorionic arteries and veins.
Topics: Arteries; Calcium; Calcium Radioisotopes; Diltiazem; Female; Humans; In Vitro Techniques; Ketanserin; Muscle Contraction; Muscle, Smooth, Vascular; Nifedipine; Placenta; Potassium; Prazosin; Pregnancy; Regional Blood Flow; Serotonin; Veins | 1990 |
Neurotransmission in the sheep middle cerebral artery: modulation of responses by 5-HT and haemolysate.
Topics: Animals; Atropine; Blood Physiological Phenomena; Cerebral Arteries; Erythrocytes; Hemoglobins; Hemolysis; Ketanserin; Neurotransmitter Agents; Prazosin; Serotonin; Sheep; Vasoconstriction | 1990 |
Effects of ketanserin tartrate on 3-hydroxy, 3-methylglutaryl coenzyme A reductase activity in cultured human skin fibroblasts.
Topics: Adrenergic alpha-Antagonists; Cells, Cultured; Fibroblasts; Humans; Hydroxymethylglutaryl CoA Reductases; Ketanserin; Piperidines; Prazosin; Ritanserin; Serotonin Antagonists | 1990 |
Selective unilateral inactivation of striatal D1 and D2 dopamine receptor subtypes by EEDQ: turning behavior elicited by D2 dopamine receptor agonists.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Corpus Striatum; Dopamine Agents; Dopamine Antagonists; Ergolines; Ketanserin; Male; Motor Activity; Prazosin; Quinolines; Quinpirole; Raclopride; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Dopamine D1; Receptors, Dopamine D2; Rotation; Salicylamides; Yohimbine | 1990 |
Alterations in serotonergic receptor expression in experimental vein grafts.
Topics: Animals; Carotid Arteries; Dose-Response Relationship, Drug; In Vitro Techniques; Jugular Veins; Ketanserin; Male; Methiothepin; Prazosin; Rabbits; Receptors, Serotonin; Serotonin; Vasoconstriction; Vasodilation; Veins | 1991 |
Behavioural evidence for a functional interaction between central 5-HT2 and 5-HT1A receptors.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Apomorphine; Behavior, Animal; Central Nervous System; Dose-Response Relationship, Drug; Haloperidol; Ketanserin; Male; Methoxydimethyltryptamines; Piperidines; Prazosin; Pyrimidines; Quinolines; Rats; Rats, Inbred Strains; Receptors, Serotonin; Ritanserin; Serotonin; Stereotyped Behavior; Tetrahydronaphthalenes | 1990 |
Receptor subtypes mediating facilitation by serotonin of excitability of spinal motoneurons.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Amphetamines; Animals; In Vitro Techniques; Injections, Intravenous; Iontophoresis; Ketanserin; Male; Methysergide; Microelectrodes; Motor Neurons; Piperidines; Prazosin; Quipazine; Rats; Rats, Inbred Strains; Receptors, Serotonin; Ritanserin; Serotonin; Serotonin Antagonists; Spinal Cord; Tetrahydronaphthalenes | 1990 |
5-Hydroxytryptamine induces phospholipase C-mediated hydrolysis of phosphoinositides through 5-hydroxytryptamine-2 receptors in cultured fetal mouse ventricular myocytes.
Topics: Aluminum; Aluminum Chloride; Aluminum Compounds; Animals; Cells, Cultured; Chlorides; Fetus; Hydrolysis; Inositol Phosphates; Ketanserin; Mice; Myocardium; Pertussis Toxin; Phorbol Esters; Phosphatidylinositols; Prazosin; Receptors, Serotonin; Serotonin; Sodium Fluoride; Type C Phospholipases; Virulence Factors, Bordetella | 1990 |
Effects of transmural field stimulation in isolated muscle strips from human esophagus.
Topics: Atropine; Carbachol; Electric Stimulation; Esophagus; Humans; In Vitro Techniques; Ketanserin; Muscle Contraction; Muscle, Smooth; Nicotine; Phentolamine; Prazosin; Propranolol; Stomach; Tetrodotoxin; Yohimbine | 1990 |
Effects of urapidil on 5-hydroxytryptamine induced platelet aggregation and on 14C-5-hydroxytryptamine uptake in platelets.
Topics: Administration, Oral; Adult; Blood Platelets; Carbon Radioisotopes; Epinephrine; Humans; Ketanserin; Nafronyl; Piperazines; Platelet Aggregation Inhibitors; Prazosin; Serotonin; Serotonin Antagonists | 1990 |
Antihypertensive effects of ketanserin in the spontaneously hypertensive rat: mode of action.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Heart Rate; Hypertension; Ketanserin; Male; Piperidines; Prazosin; Rats; Rats, Inbred SHR; Time Factors | 1985 |
Serotonergic mechanisms and blood pressure in sheep.
Topics: Adrenergic alpha-Antagonists; Adrenocorticotropic Hormone; Animals; Blood Pressure; Female; Heart Rate; Hypertension; Ketanserin; Phenylephrine; Piperidines; Prazosin; Serotonin; Serotonin Antagonists; Sheep | 1985 |
Serotonin-induced vasoconstriction in the perfused canine femoral artery can be blocked in vivo by ketanserin.
Topics: Animals; Blood Pressure; Dogs; Female; Femoral Artery; Hemodynamics; In Vitro Techniques; Isosorbide Dinitrate; Ketanserin; Male; Piperidines; Prazosin; Serotonin; Serotonin Antagonists; Vascular Resistance; Vasoconstriction | 1985 |
Bucindolol has serotonin and alpha-adrenoceptor blocking properties.
Topics: Adrenergic alpha-Antagonists; Animals; Blood Pressure; In Vitro Techniques; Ketanserin; Male; Phenylephrine; Piperidines; Prazosin; Propanolamines; Rats; Rats, Inbred Strains; Regional Blood Flow; Serotonin Antagonists | 1985 |
Differences in vasodilating action between ketanserin, a 5-HT2-serotonergic receptor antagonist, and terazosin, an alpha 1-adrenoceptor antagonist, in anesthetized rabbits.
Topics: Animals; Blood Pressure; Heart Rate; Ketanserin; Male; Prazosin; Rabbits; Receptors, Adrenergic, alpha; Receptors, Serotonin; Renal Circulation; Vasodilation | 1987 |
Are there interactions between S2-serotonergic and alpha 1-adrenergic receptors in isolated canine arteries?
Topics: Animals; Coronary Vessels; Dogs; Female; Femoral Artery; In Vitro Techniques; Ketanserin; Male; Muscle Contraction; Muscle, Smooth, Vascular; Norepinephrine; Phenylephrine; Prazosin; Receptors, Adrenergic, alpha; Receptors, Serotonin; Serotonin | 1988 |
Antihypertensive effects of ketanserin and ritanserin in the spontaneously hypertensive rat.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Heart Rate; Hypertension; Ketanserin; Male; Phenylephrine; Piperidines; Prazosin; Rats; Rats, Inbred SHR; Receptors, Adrenergic, alpha; Receptors, Serotonin; Ritanserin; Serotonin; Sympathetic Nervous System | 1988 |
Are drugs that act both on serotonin receptors and alpha 1-adrenoceptors more potent hypotensive agents than those that act only on alpha 1-adrenoceptors?
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Blood Pressure; Cats; Cinanserin; Ergolines; Ketanserin; Male; Metergoline; Piperidines; Prazosin; Receptors, Adrenergic, alpha; Receptors, Serotonin; Ritanserin; Serotonin Antagonists; Sympathetic Nervous System; Tetrahydronaphthalenes | 1988 |
Alpha-adrenergic and serotonergic mechanisms in the human digit.
Topics: Adult; Blood Pressure; Clonidine; Dose-Response Relationship, Drug; Fingers; Humans; Ketanserin; Phenylephrine; Prazosin; Receptors, Adrenergic, alpha; Receptors, Serotonin; Reflex; Regional Blood Flow; Serotonin; Sympathetic Nervous System; Vascular Resistance; Vasoconstriction; Yohimbine | 1988 |
Age-related changes in rat serotonergic and adrenergic systems and in receptor responsiveness to subchronic desipramine treatment.
Topics: Aging; Animals; Brain; Clonidine; Desipramine; Dihydroalprenolol; Hydroxyindoleacetic Acid; Imipramine; Ketanserin; Kinetics; Male; Paroxetine; Piperidines; Prazosin; Proteins; Rats; Rats, Inbred Strains; Receptors, Adrenergic; Receptors, Serotonin; Serotonin; Time Factors | 1988 |
Effect of ketanserin and prazosin on blood pressure and cardiovascular reactivity to vasopressor agents during the development of two kidney-two clip renal hypertension in the conscious rat.
Topics: Adrenergic alpha-Antagonists; Angiotensin II; Animals; Blood Pressure; Heart Rate; Hypertension, Renovascular; Ketanserin; Male; Norepinephrine; Prazosin; Rats; Rats, Inbred Strains; Tyramine | 1989 |
An investigation of the effects of intravenous injection of the 5-hydroxytryptamine 2 receptor antagonists ketanserin and LY 53857 on blood pressure in anesthetized spontaneously hypertensive rats.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Anesthesia; Animals; Blood Pressure; Ergolines; Heart Rate; Hypertension; Ketanserin; Male; Prazosin; Rats; Rats, Inbred SHR; Receptors, Adrenergic, alpha; Receptors, Serotonin; Serotonin Antagonists; Tetrahydronaphthalenes; Xylazine | 1989 |
Imipramine and tetrabenazine: effects on monoamine receptor binding sites and phosphoinositide hydrolysis.
Topics: Animals; Dihydroalprenolol; Hydrolysis; Imipramine; Inositol Phosphates; Ketanserin; Kinetics; Male; Phosphatidylinositols; Prazosin; Rats; Rats, Inbred Strains; Receptors, Adrenergic; Receptors, Serotonin; Tetrabenazine | 1989 |
Evidence for two populations of 5-hydroxytryptamine receptors in dog basilar artery.
Topics: Animals; Basilar Artery; Cocaine; Dogs; In Vitro Techniques; Indomethacin; Ketanserin; Muscle Contraction; Muscle, Smooth, Vascular; Norepinephrine; Phentolamine; Potassium; Prazosin; Receptors, Adrenergic, alpha; Receptors, Serotonin; Serotonin; Spiperone; Vasoconstriction | 1989 |
Identification of 5-HT2 receptors, alpha 1-adrenoceptors and amine release sites in rat brain by autoradiography with [125I]7-amino-8-iodo-ketanserin.
Topics: Amidines; Amines; Animals; Autoradiography; Binding, Competitive; Brain; Brain Chemistry; Female; In Vitro Techniques; Iodine Radioisotopes; Ketanserin; Male; Prazosin; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Receptors, Serotonin; Serotonin Antagonists; Tetrabenazine | 1989 |
Behavioral effects of (+-) 3,4-methylenedioxyamphetamine (MDA) and (+-) 3,4-methylenedioxymethamphetamine (MDMA) in the pigeon: interactions with noradrenergic and serotonergic systems.
Topics: 3,4-Methylenedioxyamphetamine; Amphetamines; Animals; Behavior, Animal; Columbidae; Conditioning, Operant; Dose-Response Relationship, Drug; Female; Ketanserin; Male; Metergoline; N-Methyl-3,4-methylenedioxyamphetamine; Norepinephrine; Prazosin; Reinforcement Schedule; Serotonin; Sympathetic Nervous System | 1989 |
Alpha-blocking potencies of antihypertensive agents (prazosin, terazosin, bunazosin, SGB-1534 and ketanserin) having with quinazoline or quinazolinedione as assessed by radioligand binding assay methods in rat brain.
Topics: Adrenergic alpha-Antagonists; Animals; Antihypertensive Agents; Brain; Cell Membrane; Clonidine; Dihydroalprenolol; Ketanserin; Male; Prazosin; Quinazolines; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Receptors, Adrenergic, beta | 1989 |
Renal hemodynamic responses to 5-hydroxytryptamine (5-HT): involvement of the 5-HT receptor subtypes in the canine kidney.
Topics: Adrenergic alpha-Antagonists; Animals; Dogs; Female; Ketanserin; Kidney; Male; Methysergide; Prazosin; Receptors, Serotonin; Renal Circulation; Renin; Serotonin | 1989 |
Endocardium modulates myocardial inotropic response to 5-hydroxytryptamine.
Topics: Animals; Cats; Endocardium; Endothelium, Vascular; In Vitro Techniques; Ketanserin; Kinetics; Metoclopramide; Microscopy, Electron, Scanning; Myocardial Contraction; Papillary Muscles; Prazosin; Propranolol; Serotonin; Ventricular Function | 1989 |
Comparison of the effects of cromakalim, a potassium conductance enhancer, and nimodipine, a calcium antagonist, on 5-hydroxytryptamine responses in a variety of vascular smooth muscle preparations.
Topics: Animals; Basilar Artery; Benzopyrans; Cromakalim; Female; In Vitro Techniques; Ketanserin; Male; Mesenteric Arteries; Muscle Relaxation; Muscle, Smooth, Vascular; Nimodipine; Potassium Channels; Prazosin; Pyrroles; Rabbits; Serotonin Antagonists; Swine | 1989 |
Mechanism of action of ketanserin in hypertension and vasospastic disease.
Topics: Blood Pressure; Drug Therapy, Combination; Fingers; Humans; Hypertension; Ketanserin; Muscle, Smooth, Vascular; Prazosin; Raynaud Disease; Receptors, Adrenergic, alpha; Receptors, Serotonin; Regional Blood Flow; Skin Temperature | 1987 |
The serotonin 5-HT2 receptor system, but not the alpha 1-adrenergic receptor system, is involved in the estrogen-induced afternoon prolactin surge in the rat.
Topics: Animals; Circadian Rhythm; Ergolines; Estradiol; Estrogens; Female; Ketanserin; Ovariectomy; Prazosin; Prolactin; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Receptors, Serotonin; Serotonin Antagonists | 1988 |
Quantitative autoradiography of major neurotransmitter receptors in the monkey striate and extrastriate cortex.
Topics: Animals; Autoradiography; Cerebral Cortex; Clonidine; Female; Flunitrazepam; Ketanserin; Macaca mulatta; Male; Muscimol; Pindolol; Prazosin; Quinuclidinyl Benzilate; Radioligand Assay; Receptors, Neurotransmitter; Serotonin; Spiperone; Visual Cortex | 1988 |
Mechanism of the hypotensive effect of a novel phenylpiperazine derivative, SGB-1534: antagonism at alpha 1-adrenergic and 5-HT2 receptors.
Topics: Adrenergic alpha-Antagonists; Anesthesia; Animals; Antihypertensive Agents; Decerebrate State; Gastric Fundus; Guinea Pigs; In Vitro Techniques; Ketanserin; Male; Muscle Contraction; Muscle, Smooth; Muscle, Smooth, Vascular; Piperidines; Prazosin; Quinazolines; Rats; Rats, Inbred Strains; Serotonin Antagonists | 1985 |
Studies on the receptor profile of bisoprolol.
Topics: Adrenergic beta-Antagonists; Animals; Binding, Competitive; Bisoprolol; Cattle; Dihydroalprenolol; Domperidone; Humans; In Vitro Techniques; Ketanserin; Male; Piperidines; Prazosin; Propanolamines; Quinuclidinyl Benzilate; Rats; Rats, Inbred Strains; Receptors, Adrenergic; Receptors, Adrenergic, alpha; Receptors, Adrenergic, beta; Receptors, Dopamine; Receptors, Histamine; Receptors, Muscarinic; Spiperone; Tetrahydronaphthalenes; Yohimbine | 1986 |
Ketanserin potentiates the prejunctional inhibitory effect of 5-hydroxytryptamine on rat vas deferens.
Topics: Animals; Drug Synergism; In Vitro Techniques; Ketanserin; Male; Muscle Contraction; Muscle, Smooth; Neuroeffector Junction; Prazosin; Rats; Rats, Inbred Strains; Serotonin; Serotonin Antagonists; Vas Deferens | 1986 |
Further studies of the mechanism behind scopolamine-induced reversal of antistereotypic and cataleptogenic effects of neuroleptics in rats.
Topics: Animals; Antipsychotic Agents; Behavior, Animal; Benzamides; Benzazepines; Catalepsy; Dopamine Antagonists; Droperidol; In Vitro Techniques; Ketanserin; Male; Prazosin; Rats; Rats, Inbred Strains; Receptors, Dopamine; Scopolamine; Stereotyped Behavior | 1986 |
Pharmacological profile of a new potent and specific alpha 2-adrenoceptor antagonist, L-657,743.
Topics: Adrenergic alpha-Antagonists; Animals; Benzazepines; Binding, Competitive; Blood Platelets; Cattle; Cerebral Cortex; Clonidine; Humans; In Vitro Techniques; Ketanserin; Male; Prazosin; Quinolizines; Radioligand Assay; Rats; Rats, Inbred Strains; Serotonin; Spiperone; Vas Deferens | 1987 |
Effect of alpha-adrenergic and serotonergic blockers on the acute irritative response in the rabbit eye.
Topics: Adrenergic alpha-Antagonists; Animals; Aqueous Humor; Blood Pressure; Eye Diseases; Eye Proteins; Female; Formaldehyde; Intraocular Pressure; Ketanserin; Male; Methysergide; Phentolamine; Prazosin; Pupil; Rabbits; Serotonin Antagonists; Yohimbine | 1987 |
Chronic 5-HT2 receptor blockade with ritanserin does not reduce blood pressure in the spontaneously hypertensive rat.
Topics: Animals; Blood Pressure; Decerebrate State; Dose-Response Relationship, Drug; Electric Stimulation; Heart Rate; Hypertension; Ketanserin; Male; Phenylephrine; Piperidines; Prazosin; Rats; Rats, Inbred SHR; Receptors, Serotonin; Ritanserin; Time Factors | 1985 |
Subtypes of the 5-HT receptor mediating the behavioural responses to 5-methoxy-N,N-dimethyltryptamine in the rat.
Topics: Animals; Apomorphine; Behavior, Animal; Betaxolol; Haloperidol; Ketanserin; Male; Pindolol; Piperidines; Prazosin; Propanolamines; Rats; Rats, Inbred Strains; Receptors, Serotonin; Reserpine; Spiperone | 1985 |
Effects of noradrenaline, serotonin, and selected antagonists on the vascular smooth muscle of normal and dystrophic chickens.
Topics: Animals; Chickens; Dose-Response Relationship, Drug; Ketanserin; Male; Muscle Contraction; Muscle, Smooth, Vascular; Muscular Dystrophy, Animal; Norepinephrine; Organ Size; Piperidines; Prazosin; Reference Values; Serotonin; Serotonin Antagonists; Tetrodotoxin | 1986 |
Antihypertensive mechanism of action of ketanserin and some ketanserin analogues in the spontaneously hypertensive rat.
Topics: Animals; Blood Pressure; Dose-Response Relationship, Drug; Electric Stimulation; Hypertension; Ketanserin; Phenylephrine; Piperidines; Prazosin; Pyrimidines; Rats; Rats, Inbred SHR; Receptors, Adrenergic, alpha; Ritanserin; Sympathetic Nervous System | 1985 |
Central alpha-2 adrenoceptor-mediated hypertensive response to clonidine in conscious, normotensive rats.
Topics: Animals; Azepines; Blood Pressure; Brain; Cimetidine; Clonidine; Hydroxydopamines; Injections, Intraventricular; Ketanserin; Male; Methoxamine; Oxidopamine; Piperidines; Prazosin; Procaine; Pyrilamine; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Yohimbine | 1986 |
Interference of ketanserin with baroreflex control of the circulation in the conscious spontaneously hypertensive rat.
Topics: Animals; Blood Pressure; Heart Rate; Hypertension; Ketanserin; Male; Piperidines; Prazosin; Pressoreceptors; Rats; Rats, Inbred SHR; Ritanserin; Serotonin Antagonists | 1988 |
Interaction of 5-hydroxytryptamine and ketanserin in rat vas deferens subjected to low frequency field stimulation.
Topics: Animals; Drug Interactions; Electric Stimulation; In Vitro Techniques; Ketanserin; Male; Methysergide; Muscle, Smooth; Piperidines; Prazosin; Rats; Rats, Inbred Strains; Serotonin; Serotonin Antagonists; Vas Deferens | 1985 |
Ketanserin antagonises the anorectic effect of DL-fenfluramine in the rat.
Topics: Animals; Anorexia; Fenfluramine; Ketanserin; Male; Prazosin; Rats; Receptors, Adrenergic; Receptors, Serotonin | 1988 |
Serotonergic vasoconstriction in human fingers during reflex sympathetic response to cooling.
Topics: Adult; Angiotensin II; Cold Temperature; Fingers; Humans; Ketanserin; Phenylephrine; Prazosin; Reflex; Serotonin; Sympathetic Nervous System; Vasoconstriction | 1988 |
Evidence for excitatory 5-HT2-receptors on rat brainstem neurones.
Topics: Action Potentials; Animals; Brain Stem; Ketanserin; Male; Neurons; Norepinephrine; Prazosin; Rats; Receptors, Serotonin; Serotonin | 1988 |
Involvement of 5-hydroxytryptamine in the blood pressure changes evoked by electrical stimulation of the median raphe nucleus.
Topics: 5-Hydroxytryptophan; Animals; Blood Pressure; Electric Stimulation; Ketanserin; Methiothepin; Prazosin; Raphe Nuclei; Rats; Rats, Inbred Strains | 1987 |
Characterization of the central sympathoinhibitory action of ketanserin.
Topics: Animals; Blood Pressure; Cats; Clonidine; Electrophysiology; Ergolines; Heart Rate; Ketanserin; Prazosin; Sympathetic Nervous System | 1987 |
The subtype of serotonin (5-HT) receptors in the rat pulmonary artery.
Topics: Animals; Female; In Vitro Techniques; Ketanserin; Male; Methysergide; Mianserin; Muscle Contraction; Muscle, Smooth, Vascular; Norepinephrine; Phenylephrine; Pizotyline; Prazosin; Pulmonary Artery; Rats; Receptors, Serotonin | 1987 |
Alpha 1 adrenergic receptors in the porcine pituitary neurointermediate lobe: detection with [3H]ketanserin.
Topics: Animals; Binding, Competitive; Brain; Cinanserin; In Vitro Techniques; Ketanserin; Kinetics; Piperidines; Pituitary Gland; Prazosin; Receptors, Adrenergic, alpha; Receptors, Serotonin; Swine | 1984 |
The specificity of ketanserin in the inhibition of serotonin-induced steroidogenesis in the rat adrenal zona glomerulosa.
Topics: Adrenal Cortex; Aldosterone; Animals; Corticosterone; Cyclic AMP; Dose-Response Relationship, Drug; Female; In Vitro Techniques; Ketanserin; Methysergide; Piperidines; Prazosin; Rats; Rats, Inbred Strains; Receptors, Serotonin; Serotonin; Serotonin Antagonists | 1984 |
Prolongation of rat tail bleeding time by ketanserin: mechanisms of action.
Topics: Animals; Bleeding Time; Blood Coagulation; Blood Platelets; Blood Pressure; Drug Interactions; Fenclonine; Ketanserin; Male; Metergoline; Piperidines; Platelet Aggregation; Prazosin; Rats; Serotonin; Serotonin Antagonists; Sympatholytics; Tail | 1984 |
The effects of alpha 2-adrenergic and serotonergic receptor antagonists on cyclic blood flow alterations in stenosed canine coronary arteries.
Topics: Adenosine Diphosphate; Animals; Blood Flow Velocity; Coronary Circulation; Coronary Disease; Dogs; Female; Heart Rate; Hemodynamics; Ketanserin; Male; Piperidines; Platelet Aggregation; Prazosin; Propranolol; Receptors, Serotonin; Serotonin; Serotonin Antagonists; Yohimbine | 1984 |
Haemodynamic response to ketanserin in rabbits with Page hypertension: comparison with prazosin.
Topics: Animals; Blood Pressure; Dose-Response Relationship, Drug; Heart Rate; Hemodynamics; Hypertension; Ketanserin; Male; Methoxamine; Piperidines; Prazosin; Quinazolines; Rabbits; Receptors, Serotonin; Serotonin Antagonists | 1983 |
Serotonin stimulates rapid increase of inositol 1,4,5-trisphosphate in ovine uterine artery: correlation with contractile state.
Topics: Adrenergic alpha-Antagonists; Animals; Arteries; Calcium; Female; Inositol 1,4,5-Trisphosphate; Ketanserin; Phenoxybenzamine; Prazosin; Pregnancy; Receptors, Serotonin; Serotonin; Serotonin Antagonists; Sheep; Time Factors; Uterine Contraction; Uterus | 1995 |
Involvement of non-muscarinic receptors in phosphoinositide signalling during soman-induced seizures.
Topics: Animals; Chlorpheniramine; Dimethyl Sulfoxide; Electroencephalography; Inositol 1,4,5-Trisphosphate; Ketanserin; Male; Prazosin; Rats; Rats, Wistar; Receptors, Muscarinic; Seizures; Signal Transduction; Soman | 1995 |
Influence of alpha 1-adrenoceptor antagonism of ketanserin on the nature of its 5-HT2 receptor antagonism.
Topics: Adrenergic alpha-1 Receptor Antagonists; Animals; In Vitro Techniques; Ketanserin; Male; Muscle, Smooth, Vascular; Prazosin; Rats; Rats, Sprague-Dawley; Regional Blood Flow; Reserpine; Serotonin; Serotonin Antagonists; Tail | 1994 |
Blockade of noradrenaline-induced constrictions by yohimbine and prazosin differs between consecutive segments of cutaneous arteries in guinea-pig ears.
Topics: Animals; Arteries; Dihydroergotamine; Ear, External; Female; Guinea Pigs; In Vitro Techniques; Ketanserin; Male; Muscle, Smooth, Vascular; Norepinephrine; Prazosin; Regional Blood Flow; Serotonin; Vasoconstriction; Yohimbine | 1994 |
Distribution and density of monoamine receptors in the primate visual cortex devoid of retinal input from early embryonic stages.
Topics: Animals; Anophthalmos; Benzazepines; Clonidine; Eye Enucleation; Gene Expression Regulation, Developmental; Gestational Age; Ketanserin; Macaca mulatta; Pindolol; Prazosin; Radioligand Assay; Receptors, Adrenergic; Receptors, Dopamine; Receptors, Serotonin; Serotonin; Spiperone; Visual Cortex; Visual Pathways | 1995 |
Inhibition of serotonin-induced increase in canine external carotid blood flow by drugs that decrease the sympathetic outflow.
Topics: Animals; Blood Pressure; Carotid Arteries; Dioxanes; Dogs; Dose-Response Relationship, Drug; Female; Heart Rate; Infusions, Intra-Arterial; Injections, Intravenous; Ketanserin; Male; Mecamylamine; Methiothepin; Prazosin; Receptors, Serotonin; Regional Blood Flow; Regression Analysis; Ritanserin; Serotonin; Spiro Compounds; Vascular Resistance | 1994 |
A central 5-HT2 receptor mechanism plays a key role in the proestrous surge of luteinizing hormone in the rat.
Topics: Animals; Female; Ketanserin; Luteinizing Hormone; Prazosin; Proestrus; Rats; Rats, Wistar; Receptors, Serotonin; Ritanserin | 1994 |
The quipazine- and TFMPP-increased conditioned avoidance response in rats: role of 5HT1C/5-HT2 receptors.
Topics: Animals; Avoidance Learning; Conditioning, Operant; Ketanserin; Male; Mianserin; Nadolol; Pindolol; Piperazines; Prazosin; Quipazine; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Reference Values; Serotonin Antagonists; Serotonin Receptor Agonists; Spiperone; Tropanes | 1993 |
A comparative study of the effects of some 5-HT1A receptor agonists on the blood pressure of pithed rats.
Topics: 5-Methoxytryptamine; Adrenergic alpha-1 Receptor Agonists; Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Blood Pressure; Buspirone; Decerebrate State; Ketanserin; Male; Methoxamine; Pindolol; Prazosin; Pyrimidines; Quipazine; Rats; Rats, Wistar; Serotonin Receptor Agonists | 1995 |
Enhancement of 5-hydroxytryptamine-stimulated phosphoinositide hydrolysis in the rat cerebral cortex by repeated immobilization stress.
Topics: Animals; Body Weight; Cerebral Cortex; Hydrolysis; Imipramine; Immobilization; Ketanserin; Male; Phosphatidylinositols; Prazosin; Rats; Rats, Wistar; Receptors, Serotonin; Serotonin; Stress, Physiological | 1995 |
SDZ NVI 085, an alpha 1A-adrenoceptor agonist with 5-HT2A receptor antagonist properties.
Topics: Adrenergic alpha-1 Receptor Agonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Bridged-Ring Compounds; Idazoxan; Ketanserin; Male; Muscle Contraction; Muscle, Smooth, Vascular; Oxazines; Prazosin; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Regional Blood Flow; Serotonin Antagonists; Tail | 1996 |
Hypotensive and reflex bradycardic effects of ketanserin, but not of prazosin, enhanced selectively in aging conscious rats.
Topics: Adrenergic alpha-1 Receptor Agonists; Adrenergic alpha-Agonists; Aging; Angiotensin II; Animals; Antihypertensive Agents; Blood Pressure; Heart Rate; Injections, Intravenous; Ketanserin; Male; Nitroprusside; Phenylephrine; Prazosin; Rats; Rats, Sprague-Dawley; Regional Blood Flow; Vasoconstrictor Agents | 1996 |
Differential involvement of serotonin 2A/C and thromboxane A2/prostanoid receptors in high- vs. low-shear rate arterial thrombosis in rabbits.
Topics: Animals; Arteriovenous Shunt, Surgical; Aspirin; Blood Pressure; Bridged Bicyclo Compounds, Heterocyclic; Carotid Arteries; Carotid Stenosis; Endothelium, Vascular; Fatty Acids, Unsaturated; Heart Rate; Hemodynamics; Hydrazines; Jugular Veins; Ketanserin; Male; Oxadiazoles; Piperazines; Platelet Aggregation; Prazosin; Rabbits; Receptor, Serotonin, 5-HT2A; Receptor, Serotonin, 5-HT2C; Receptors, Prostaglandin; Receptors, Serotonin; Receptors, Thromboxane; Ritanserin; Serotonin Antagonists; Stress, Mechanical | 1997 |
Effects of 5HT2 receptor antagonists on responses to potassium depolarization in rat isolated aorta.
Topics: Animals; Aorta, Thoracic; Cinnarizine; Cyproheptadine; Diltiazem; Drug Synergism; Felodipine; Female; In Vitro Techniques; Ketanserin; Male; Mianserin; Muscle Contraction; Nifedipine; Potassium; Prazosin; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Reproducibility of Results; Ritanserin; Serotonin Antagonists; Verapamil | 1997 |
Regulation of c-Fos and NGF1-A by antidepressant treatments.
Topics: Adrenergic Antagonists; Animals; Antidepressive Agents; Benzazepines; Blotting, Western; Dizocilpine Maleate; DNA-Binding Proteins; Dopamine Antagonists; Early Growth Response Protein 1; Electroshock; Excitatory Amino Acid Antagonists; Frontal Lobe; Genes, fos; Genes, Immediate-Early; Haloperidol; Imipramine; Immediate-Early Proteins; Ketanserin; Male; Prazosin; Propranolol; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Serotonin Antagonists; Transcription Factors; Transcription, Genetic; Tranylcypromine | 1997 |
Basal forebrain cholinergic immunolesion by 192IgG-saporin: evidence for a presynaptic location of subpopulations of alpha 2- and beta-adrenergic as well as 5-HT2A receptors on cortical cholinergic terminals.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Acetylcholinesterase; Animals; Antibodies, Monoclonal; Autoradiography; Cerebral Cortex; Cholinergic Fibers; Dihydroalprenolol; Immunotoxins; Isotope Labeling; Ketanserin; Male; N-Glycosyl Hydrolases; Prazosin; Presynaptic Terminals; Prosencephalon; Radioligand Assay; Rats; Rats, Wistar; Receptor, Serotonin, 5-HT2A; Receptors, Adrenergic, alpha; Receptors, Adrenergic, alpha-1; Receptors, Adrenergic, alpha-2; Receptors, Adrenergic, beta; Receptors, Presynaptic; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Ribosome Inactivating Proteins, Type 1; Saporins; Tritium; Yohimbine | 1997 |
Direct effects of new indorenate analogs on blood pressure of pithed rats.
Topics: 5-Methoxytryptamine; Animals; Antihypertensive Agents; Blood Pressure; Denervation; Dose-Response Relationship, Drug; Ketanserin; Male; Prazosin; Rats; Rats, Wistar; Serotonin Receptor Agonists; Time Factors | 1998 |
Agonist and antagonist binding to rabbit cortical 5-HT2A receptors: opposite effects of magnesium.
Topics: Amphetamines; Animals; Cerebral Cortex; Fluorobenzenes; Guanylyl Imidodiphosphate; Ketanserin; Magnesium; Methysergide; Piperidines; Prazosin; Rabbits; Receptor, Serotonin, 5-HT2A; Receptors, Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Spiperone | 1998 |
Long-term treatment with fluoxetine associates with peripheral effects on rat vas deferens contractility.
Topics: Adrenergic Agents; Animals; Antidepressive Agents, Second-Generation; Binding Sites; Calcium; Cyclooxygenase Inhibitors; Fluoxetine; Indomethacin; Isoproterenol; Ketanserin; Male; Muscle Contraction; Nitroprusside; Norepinephrine; Prazosin; Rats; Rats, Wistar; Serotonin; Serotonin Antagonists; Vas Deferens; Verapamil | 1999 |
Rabbit mononuclear leukocytes cause contraction of isolated aorta by the release of serotonin.
Topics: Adrenergic alpha-Antagonists; Animals; Aorta; Cells, Cultured; Chromatography, High Pressure Liquid; Culture Media, Conditioned; Female; In Vitro Techniques; Ketanserin; Leukocytes, Mononuclear; Male; Prazosin; Rabbits; Serotonin; Serotonin Antagonists; Vasoconstriction | 1999 |
Serotonin modulation of catalepsy induced by N(G)-nitro-L-arginine in mice.
Topics: Adrenergic alpha-Antagonists; Animals; Bridged Bicyclo Compounds, Heterocyclic; Catalepsy; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Inhibitors; Indoles; Ketanserin; Male; Mice; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; Piperazines; Prazosin; Ritanserin; Serotonin Antagonists; Time Factors | 1999 |
Receptors and neurotransmitters involved in the dual modulation of prolactin release by the serotoninergic system in pregnant and lactating rats.
Topics: 5-Hydroxytryptophan; 8-Hydroxy-2-(di-n-propylamino)tetralin; Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Amphetamines; Analysis of Variance; Animals; Brain Chemistry; Dopamine; Female; Fenclonine; Fenfluramine; Gestational Age; Ketanserin; Metoprolol; Norepinephrine; p-Chloroamphetamine; Prazosin; Pregnancy; Pregnancy, Animal; Prolactin; Rats; Rats, Wistar; Selective Serotonin Reuptake Inhibitors; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Signal Transduction | 1999 |
Synaptically released 5-HT modulates the activity of tonically discharging neuronal populations in the rostral ventral medulla (RVM).
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Bicuculline; Electric Stimulation; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Fenfluramine; GABA Antagonists; Glycine Agents; Ketanserin; Medulla Oblongata; Neural Inhibition; Neurons; Organ Culture Techniques; Piperazines; Prazosin; Propranolol; Rats; Rats, Wistar; Selective Serotonin Reuptake Inhibitors; Serotonin; Serotonin Antagonists; Strychnine; Synaptic Transmission | 2000 |
On the role of serotonin2A/2C receptors in the sensitization to cocaine.
Topics: Animals; Cocaine; Ketanserin; Male; Motor Activity; Prazosin; Rats; Rats, Wistar; Receptor, Serotonin, 5-HT1D; Receptor, Serotonin, 5-HT2A; Receptor, Serotonin, 5-HT2C; Receptors, Serotonin | 2001 |
Binding and functional affinity of sarpogrelate, its metabolite m-1 and ketanserin for human recombinant alpha-1-adrenoceptor subtypes.
Topics: Adrenergic alpha-Agonists; Animals; Binding, Competitive; CHO Cells; Cricetinae; Dose-Response Relationship, Drug; Gene Expression; Humans; Ketanserin; Phenylephrine; Prazosin; Propanolamines; Receptors, Adrenergic, alpha-1; Serotonin Antagonists; Succinates; Tritium | 2002 |
Peripheral 5-HT(2A)-receptor-mediated formation of an inhibitor of atrial natriuretic peptide binding involves inflammation.
Topics: Adrenergic alpha-Antagonists; alpha-Methyltyrosine; Animals; Atrial Natriuretic Factor; Catecholamines; Cyclooxygenase Inhibitors; Dexamethasone; Ditiocarb; Dopamine beta-Hydroxylase; Dose-Response Relationship, Drug; Endothelium, Vascular; Humans; Indomethacin; Inflammation; Isatin; Ketanserin; Muscle, Smooth; Prazosin; Propranolol; Protein Binding; Rats; Rats, Wistar; Reactive Oxygen Species; Receptor, Angiotensin, Type 1; Receptor, Serotonin, 5-HT2A; Receptors, Angiotensin; Receptors, Serotonin; Reserpine; Ritanserin; Serotonin; Serotonin Receptor Agonists; Tyrosine 3-Monooxygenase; Urination; Vascular Resistance; Yohimbine | 2002 |
The fenfluramine metabolite (+)-norfenfluramine is vasoactive.
Topics: Animals; Aorta; Blood Pressure; Ergolines; Fenfluramine; In Vitro Techniques; Ketanserin; Male; Norfenfluramine; Prazosin; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT2A; Receptor, Serotonin, 5-HT2C; Receptors, Adrenergic, alpha; Serotonin 5-HT2 Receptor Antagonists; Serotonin Antagonists; Sympathectomy; Sympathetic Nervous System; Vasoconstriction | 2004 |
Restoration of baroreflex function by ketanserin is not blood pressure dependent in conscious freely moving rats.
Topics: Animals; Antihypertensive Agents; Baroreflex; Blood Pressure; Female; Ketanserin; Male; Myocardial Infarction; Prazosin; Rats; Rats, Inbred SHR; Rats, Sprague-Dawley; Ritanserin; Time Factors | 2004 |
5-HT receptors mediating contraction in the rat-tail artery.
Topics: Animals; Arteries; Ketanserin; Male; Piperidones; Prazosin; Rats; Rats, Wistar; Receptor, Serotonin, 5-HT1B; Receptor, Serotonin, 5-HT2A; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Spiro Compounds; Vasoconstriction | 2003 |
Involvement of 5-HT2 receptors in the antinociceptive effect of Uncaria tomentosa.
Topics: Acetic Acid; Analgesics; Animals; Arginine; Atropine; Behavior, Animal; Capsaicin; Cat's Claw; Dose-Response Relationship, Drug; Formaldehyde; Ketanserin; Male; Mice; Motor Activity; Naltrexone; Pain; Pain Measurement; Phytotherapy; Plant Preparations; Prazosin; Receptors, Serotonin, 5-HT2; Reserpine; Serotonin 5-HT2 Receptor Antagonists; Serotonin Antagonists; Yohimbine | 2005 |
Anxiolytic-like effect of milnacipran in the four-plate test in mice: mechanism of action.
Topics: Alprazolam; Animals; Anti-Anxiety Agents; Behavior, Animal; Benzylamines; Brain; Cyclopropanes; Dopamine; Dose-Response Relationship, Drug; Fenclonine; Flumazenil; Fluorobenzenes; Idazoxan; Indoles; Ketanserin; Male; Mice; Milnacipran; Motor Activity; Neurotransmitter Uptake Inhibitors; Norepinephrine; Phenols; Prazosin; Punishment; Pyridines; Selective Serotonin Reuptake Inhibitors; Serotonin; Serotonin 5-HT2 Receptor Antagonists; Serotonin Antagonists | 2005 |
Potential vascular alpha1-adrenoceptor blocking properties of an array of 5-HT receptor ligands in the rat.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adrenergic alpha-1 Receptor Agonists; Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Blood Pressure; Buspirone; Clozapine; Decerebrate State; Dose-Response Relationship, Drug; Drug Interactions; Ergotamine; Heart Rate; Ketanserin; Lisuride; Male; Metergoline; Methiothepin; Methysergide; Phenylephrine; Piperazines; Pizotyline; Prazosin; Pyridines; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-1; Serotonin Antagonists; Serotonin Receptor Agonists; Yohimbine | 2006 |
Synthesis and 5-HT2A, 5-HT1A and alpha1-binding affinities of 2-[2-Hydroxy-3-(pyridin-3-yl-methyl)amino]-, 2-[2-hydroxy-3-(2-pyridin-2-yl-ethyl)amino]- and 2-[2-hydroxy-3-(4-N-methyl-piperazin-1-yl)-amino]propoxybenzaldehyde-O-(substituted) benzyl oximes.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adrenergic alpha-Antagonists; Animals; Binding, Competitive; Cerebral Cortex; In Vitro Techniques; Ketanserin; Ligands; Molecular Structure; Oximes; Piperazines; Prazosin; Protein Binding; Pyridines; Rats; Receptor, Serotonin, 5-HT1A; Receptor, Serotonin, 5-HT2A; Receptors, Adrenergic, alpha-1; Serotonin Antagonists; Serotonin Receptor Agonists; Structure-Activity Relationship; Succinates | 2007 |
Different affinities of native alpha1B-adrenoceptors for ketanserin between intact tissue segments and membrane preparations.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Antagonists; Animals; Aorta, Thoracic; Arteries; Binding, Competitive; Cell Line; Cell Membrane; Cerebral Cortex; Dose-Response Relationship, Drug; Humans; Indoles; Ketanserin; Male; Piperazines; Prazosin; Protein Binding; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-1; Recombinant Proteins; Subcellular Fractions; Tail; Transfection; Vasoconstriction | 2008 |
Eugenosedin-A prevents hyperglycaemia, hyperlipidaemia and lipid peroxidation in C57BL/6J mice fed a high-fat diet.
Topics: Adipose Tissue; Animals; Atorvastatin; Blood Glucose; Body Weight; Brain; Dietary Fats; Female; Glutathione Peroxidase; Heptanoic Acids; Hyperglycemia; Hyperlipidemias; Insulin; Ketanserin; Lipid Peroxidation; Lipogenesis; Liver; Malondialdehyde; Mice; Mice, Inbred C57BL; Piperazines; PPAR gamma; Prazosin; Propranolol; Pyrroles; Superoxide Dismutase; Weight Gain | 2009 |
Antidepressant-like action of the ethanolic extract from Tabebuia avellanedae in mice: evidence for the involvement of the monoaminergic system.
Topics: Adrenergic alpha-Antagonists; Analysis of Variance; Animals; Antidepressive Agents; Biogenic Monoamines; Depression; Disease Models, Animal; Dopamine Agents; Enzyme Inhibitors; Exploratory Behavior; Hindlimb Suspension; Immobility Response, Tonic; Ketanserin; Mice; Motor Activity; Phytotherapy; Plant Extracts; Prazosin; Serotonin Antagonists; Swimming; Tabebuia | 2010 |
Identification of a novel form of noradrenergic-dependent respiratory motor plasticity triggered by vagal feedback.
Topics: Adrenergic alpha-1 Receptor Antagonists; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Apnea; Diaphragm; Feedback, Sensory; Hypoglossal Nerve; Hypoxia; Ketanserin; Long-Term Potentiation; Male; Motor Neurons; Prazosin; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT2A; Receptors, Adrenergic, alpha-1; Receptors, AMPA; Respiratory System; Serotonin Antagonists; Vagus Nerve | 2010 |
Differential effects of 5-HT(2A) and 5-HT(2C) receptor blockade on strategy-switching.
Topics: Adrenergic alpha-Antagonists; Aminopyridines; Animals; Choice Behavior; Cues; Decision Making; Discrimination, Psychological; Indoles; Ketanserin; Learning; Male; Maze Learning; Photic Stimulation; Prazosin; Rats; Rats, Long-Evans; Receptor, Serotonin, 5-HT2A; Receptor, Serotonin, 5-HT2C; Serotonin Antagonists | 2011 |
Ketanserin potentiates morphine-induced antinociception mediated by kappa-receptor activation.
Topics: Adrenergic alpha-1 Receptor Antagonists; Analgesics; Animals; Dose-Response Relationship, Drug; Drug Synergism; Ketanserin; Male; Mice; Mice, Inbred Strains; Morphine; Naltrexone; Pain; Pain Measurement; Pain Threshold; Prazosin; Pyrrolidines; Receptors, Adrenergic, alpha-1; Receptors, Opioid, kappa; Receptors, Serotonin, 5-HT2; Serotonin Antagonists | 2011 |
Effects of angiogenesis inhibition by spironolactone on isolated vas deferens contractility in an experimental varicocele model in rats.
Topics: Adrenergic alpha-1 Receptor Agonists; Adrenergic alpha-1 Receptor Antagonists; Angiogenesis Inhibitors; Animals; In Vitro Techniques; Isometric Contraction; Ketanserin; Male; Microvessels; Muscle, Smooth; Neovascularization, Physiologic; Phenylephrine; Prazosin; Rats; Rats, Wistar; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Spermatogenesis; Spironolactone; Statistics, Nonparametric; Testis; Varicocele; Vas Deferens | 2012 |
Influence of ketanserin on the effects of methylenedioxymethamphetamine on body temperature in the mouse.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic Uptake Inhibitors; Animals; Aorta; Body Temperature; Fever; Ketanserin; Male; Mice; N-Methyl-3,4-methylenedioxyamphetamine; Prazosin; Rats; Serotonin Antagonists; Vas Deferens | 2013 |
Involvement of Descending Serotonergic and Noradrenergic Systems and their Spinal Receptor Subtypes in the Antinociceptive Effect of Dipyrone.
Topics: 5,7-Dihydroxytryptamine; Adrenergic Neurons; Analgesics; Animals; Dipyrone; Dose-Response Relationship, Drug; Injections, Spinal; Ketanserin; Mice; Ondansetron; Oxidopamine; Pain Measurement; Piperidines; Prazosin; Propranolol; Receptors, Adrenergic, beta; Receptors, Serotonin; Serotonergic Neurons; Spinal Cord; Sulfonamides; Yohimbine | 2015 |