kelatorphan has been researched along with thiorphan in 15 studies
| Studies (kelatorphan) | Trials (kelatorphan) | Recent Studies (post-2010) (kelatorphan) | Studies (thiorphan) | Trials (thiorphan) | Recent Studies (post-2010) (thiorphan) |
|---|---|---|---|---|---|
| 58 | 0 | 1 | 665 | 50 | 82 |
| Protein | Taxonomy | kelatorphan (IC50) | thiorphan (IC50) |
|---|---|---|---|
| Thermolysin | Bacillus thermoproteolyticus | 9.5 | |
| Neprilysin | Rattus norvegicus (Norway rat) | 0.0058 | |
| Neprilysin | Oryctolagus cuniculus (rabbit) | 0.0085 | |
| Neprilysin | Homo sapiens (human) | 0.0024 | |
| Angiotensin-converting enzyme | Homo sapiens (human) | 0.2281 | |
| Angiotensin-converting enzyme | Oryctolagus cuniculus (rabbit) | 0.42 | |
| Neprilysin | Sus scrofa (pig) | 0.0062 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (66.67) | 18.7374 |
| 1990's | 4 (26.67) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (6.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bouboutou, R; Chaillet, P; Costentin, J; Coulaud, A; Devin, J; Fournié-Zaluski, MC; Roques, BP; Waksman, G | 1 |
| Bihovsky, R; Erhardt, PW; Levinson, BL; Loewi, RC; Polokoff, MA | 1 |
| Devi, LA; Fournié-Zaluski, MC; Gagnidze, K; Orng, SV; Ouimet, T; Poras, H; Roques, BP | 1 |
| Fournié-Zaluski, MC; Maldonado, R; Roques, BP | 1 |
| Costentin, J; Dourmap, N; Michael-Titus, A; Schwartz, JC | 1 |
| Benoliel, JJ; Berthier, JL; Bourgoin, S; Cesselin, F; Hamon, M; Hirsch, M; Mauborgne, A | 1 |
| Bovy, PR; Krieter, PA; Olins, GM; Spear, KL; Trapani, AJ | 1 |
| Arock, M; Devillier, P; Gros, C; Guillosson, JJ; Schwartz, JC | 1 |
| Callebert, J; Daugé, V; Feger, J; Fournié-Zaluski, MC; Maldonado, R; Roques, BP; Villette, JM | 1 |
| Bourgoin, S; Cesselin, F; Dickenson, AH; Fournié-Zaluski, MC; Hamon, M; Le Bars, D; Roques, BP | 1 |
| Artaud, F; Bouboutou, R; Bourgoin, S; Cesselin, F; Clot, AM; Fournie-Zaluski, MC; Hamon, M; Le Bars, D; Roques, BP | 1 |
| Dickenson, AH; Fournie-Zaluski, MC; Roques, BP; Sullivan, AF | 1 |
| Bouboutou, R; Bourgoin, S; Cesselin, F; Devin, J; Fournie-Zaluski, MC; Hamon, M; Roques, B; Waksman, G | 1 |
| Bouboutou, R; Chaillet, P; Cherot, P; Costentin, J; Coulaud, A; Fournie-Zaluski, MC; Roques, BP; Waksman, G | 1 |
| Beslot, F; Claperon, N; Fournie-Zaluski, MC; Peyroux, J; Roques, BP | 1 |
15 other study(ies) available for kelatorphan and thiorphan
| Article | Year |
|---|---|
New bidentates as full inhibitors of enkephalin-degrading enzymes: synthesis and analgesic properties.
Topics: Aminopeptidases; Analgesia; Animals; Dipeptidyl-Peptidases and Tripeptidyl-Peptidases; Hydroxylamines; Leucine; Male; Mice; Neprilysin; Protease Inhibitors; Rabbits; Rats; Stereoisomerism; Thiorphan; Tiopronin | 1985 |
Hydroxamic acids as potent inhibitors of endothelin-converting enzyme from human bronchiolar smooth muscle.
Topics: Aspartic Acid Endopeptidases; Bronchi; Cells, Cultured; Endothelin-Converting Enzymes; Humans; Hydroxamic Acids; Metalloendopeptidases; Muscle, Smooth | 1995 |
Identification of an endothelin-converting enzyme-2-specific fluorigenic substrate and development of an in vitro and ex vivo enzymatic assay.
Topics: Animals; Aspartic Acid Endopeptidases; Endothelin-Converting Enzymes; Endothelins; Enzyme Assays; Enzyme Inhibitors; Fluorescent Dyes; Gene Expression Regulation, Enzymologic; Humans; Metalloendopeptidases; Mice; Organ Specificity; Peptide Library; Peptides; Substrate Specificity | 2010 |
Attenuation of the morphine withdrawal syndrome by inhibition of catabolism of endogenous enkephalins in the periaqueductal gray matter.
Topics: Analgesics; Animals; Behavior, Animal; Body Temperature; Body Weight; Corticosterone; Dipeptides; Enkephalins; Hydroxamic Acids; Male; Morphine; Morphine Dependence; Naloxone; Neprilysin; Periaqueductal Gray; Phenylalanine; Rats; Rats, Inbred Strains; Substance Withdrawal Syndrome; Thiorphan | 1992 |
Role of delta opioid receptors in the effects of inhibitors of enkephalin-degrading peptidases on the horizontal and vertical components of locomotion in mice.
Topics: Aminopeptidases; Animals; CD13 Antigens; Dipeptides; Drug Synergism; Enkephalin, Leucine; Enkephalins; Injections, Intravenous; Injections, Intraventricular; Leucine; Locomotion; Male; Mice; Naloxone; Neprilysin; Phenylcarbamates; Prodrugs; Receptors, Opioid; Receptors, Opioid, delta; Sulfhydryl Compounds; Thiorphan | 1990 |
Enkephalinase is involved in the degradation of endogenous substance P released from slices of rat substantia nigra.
Topics: Animals; Captopril; Dipeptides; In Vitro Techniques; Leucine; Male; Metalloendopeptidases; Naloxone; Neprilysin; Oligopeptides; Peptidyl-Dipeptidase A; Potassium; Protease Inhibitors; Rats; Rats, Inbred Strains; Substance P; Substantia Nigra; Thiorphan; Tiopronin | 1987 |
Specific inhibitors of endopeptidase 24.11 inhibit the metabolism of atrial natriuretic peptides in vitro and in vivo.
Topics: Animals; Atrial Natriuretic Factor; Dipeptides; Kidney; Male; Microvilli; Neprilysin; Protease Inhibitors; Rabbits; Rats; Thiorphan | 1989 |
Characterisation of enkephalinase (EC 3.4.24.11) activity on various leukemic cells expressing the common acute lymphocytic leukemia antigen (CALLA).
Topics: Antigens, Differentiation; Antigens, Neoplasm; Bone Marrow; Cell Division; Cell Line; Cell Membrane; Dipeptides; Glycopeptides; Humans; In Vitro Techniques; Neprilysin; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Thiorphan; Tumor Cells, Cultured | 1989 |
Comparison of selective and complete inhibitors of enkephalin-degrading enzymes on morphine withdrawal syndrome.
Topics: Animals; Behavior, Animal; Body Temperature; Body Weight; Corticosterone; Dipeptides; Hydroxamic Acids; Injections, Intraventricular; Male; Morphine Dependence; Naloxone; Neprilysin; Phenylalanine; Rats; Rats, Inbred Strains; Substance Withdrawal Syndrome; Thiorphan | 1989 |
Increase in met-enkephalin level and antinociceptive effects induced by kelatorphan in the rat spinal cord.
Topics: Analgesics; Animals; Dipeptides; Enkephalin, Methionine; In Vitro Techniques; Leucine; Neurons; Pain; Rats; Spinal Cord; Thiorphan; Tiopronin | 1986 |
Effects of kelatorphan and other peptidase inhibitors on the in vitro and in vivo release of methionine-enkephalin-like material from the rat spinal cord.
Topics: Animals; Dipeptides; Dose-Response Relationship, Drug; Enkephalin, Methionine; Leucine; Male; Potassium; Protease Inhibitors; Rats; Rats, Inbred Strains; Spinal Cord; Thiorphan; Tiopronin | 1986 |
Prevention of degradation of endogenous enkephalins produces inhibition of nociceptive neurones in rat spinal cord.
Topics: Action Potentials; Animals; Dipeptides; Enkephalins; Leucine; Male; Naloxone; Nerve Fibers; Neural Inhibition; Neurons, Afferent; Pain; Protease Inhibitors; Rats; Rats, Inbred Strains; Spinal Cord; Thiorphan; Tiopronin | 1987 |
In vitro and in vivo effects of kelatorphan on enkephalin metabolism in rodent brain.
Topics: Aminopeptidases; Animals; Brain; Brain Chemistry; Corpus Striatum; Dipeptides; Enkephalin, Methionine; Enkephalins; Hydrolysis; In Vitro Techniques; Leucine; Mice; Protease Inhibitors; Rats; Thiorphan; Tiopronin | 1985 |
Analgesic effects of kelatorphan, a new highly potent inhibitor of multiple enkephalin degrading enzymes.
Topics: Aminopeptidases; Analgesics; Animals; Brain; Dipeptides; Dipeptidyl-Peptidases and Tripeptidyl-Peptidases; Endopeptidases; Enkephalin, Methionine; Enkephalins; In Vitro Techniques; Kidney; Leucine; Neprilysin; Protease Inhibitors; Rabbits; Rats; Reaction Time; Thiorphan; Tiopronin | 1984 |
Effect of endopeptidase-24.11 inhibitors and C-ANP receptor ligand on responses evoked in arterioles of rat cremaster muscle by atrial natriuretic peptide.
Topics: Abdominal Muscles; Adenosine; Administration, Topical; Animals; Arterioles; Atrial Natriuretic Factor; Blood Pressure; Dipeptides; Injections, Intravenous; Male; Neprilysin; Nitroprusside; Peptide Fragments; Protease Inhibitors; Rats; Rats, Sprague-Dawley; Thiorphan; Vasodilator Agents | 1995 |