kelatorphan has been researched along with naloxone in 14 studies
| Studies (kelatorphan) | Trials (kelatorphan) | Recent Studies (post-2010) (kelatorphan) | Studies (naloxone) | Trials (naloxone) | Recent Studies (post-2010) (naloxone) |
|---|---|---|---|---|---|
| 58 | 0 | 1 | 20,134 | 1,257 | 3,321 |
| Protein | Taxonomy | kelatorphan (IC50) | naloxone (IC50) |
|---|---|---|---|
| Cytochrome P450 2D6 | Homo sapiens (human) | 2 | |
| Delta-type opioid receptor | Mus musculus (house mouse) | 0.043 | |
| Delta-type opioid receptor | Rattus norvegicus (Norway rat) | 0.0219 | |
| Mu-type opioid receptor | Rattus norvegicus (Norway rat) | 0.0019 | |
| Kappa-type opioid receptor | Rattus norvegicus (Norway rat) | 0.0019 | |
| Mu-type opioid receptor | Homo sapiens (human) | 0.0397 | |
| Delta-type opioid receptor | Homo sapiens (human) | 0.1896 | |
| Kappa-type opioid receptor | Cavia porcellus (domestic guinea pig) | 0.05 | |
| Kappa-type opioid receptor | Homo sapiens (human) | 0.0795 | |
| Mu-type opioid receptor | Mus musculus (house mouse) | 0.0154 | |
| Mu-type opioid receptor | Cavia porcellus (domestic guinea pig) | 0.0089 | |
| Beta-2 adrenergic receptor | Cavia porcellus (domestic guinea pig) | 0.0055 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (42.86) | 18.7374 |
| 1990's | 6 (42.86) | 18.2507 |
| 2000's | 2 (14.29) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Boudinot, E; Champagnat, J; Denavit-Saubie, M; Fournie-Zaluski, MC; Morin-Surun, MP; Roques, BP | 1 |
| Fournié-Zaluski, MC; Maldonado, R; Roques, BP | 1 |
| Costentin, J; Dourmap, N; Michael-Titus, A; Schwartz, JC | 1 |
| Fournié-Zaluski, MC; Noble, F; Peyroux, J; Roques, BP; Schmidt, C | 1 |
| Sagen, J; Wang, H | 1 |
| Benoliel, JJ; Berthier, JL; Bourgoin, S; Cesselin, F; Hamon, M; Hirsch, M; Mauborgne, A | 1 |
| Callebert, J; Daugé, V; Feger, J; Fournié-Zaluski, MC; Maldonado, R; Roques, BP; Villette, JM | 1 |
| Fournie-Zaluski, MC; Guilbaud, G; Kayser, V; Roques, BP | 1 |
| Daugé, V; Roques, BP; Rossignol, P | 1 |
| Dickenson, AH; Fournie-Zaluski, MC; Roques, BP; Sullivan, AF | 1 |
| Duggan, AW; Morton, CR; Zhao, ZQ | 1 |
| Castro-Lopes, JM; Evan, G; Roques, BP; Schadrack, J; Tölle, TR; Zieglgänsberger, W | 1 |
| Boudinot, E; Denavit-Saubié, M; Fournié-Zaluski, M; Foutz, AS; Morin-Surun, M; Roques, BP | 1 |
| Crain, SM; Shen, KF | 1 |
14 other study(ies) available for kelatorphan and naloxone
| Article | Year |
|---|---|
Control of breathing by endogenous opioid peptides: possible involvement in sudden infant death syndrome.
Topics: Animals; Brain Stem; Cats; Dipeptides; Endorphins; Enkephalin, Methionine; Homeostasis; Humans; Infant; Inhalation; Iontophoresis; Models, Neurological; Naloxone; Neurons; Phrenic Nerve; Respiration; Sudden Infant Death | 1992 |
Attenuation of the morphine withdrawal syndrome by inhibition of catabolism of endogenous enkephalins in the periaqueductal gray matter.
Topics: Analgesics; Animals; Behavior, Animal; Body Temperature; Body Weight; Corticosterone; Dipeptides; Enkephalins; Hydroxamic Acids; Male; Morphine; Morphine Dependence; Naloxone; Neprilysin; Periaqueductal Gray; Phenylalanine; Rats; Rats, Inbred Strains; Substance Withdrawal Syndrome; Thiorphan | 1992 |
Role of delta opioid receptors in the effects of inhibitors of enkephalin-degrading peptidases on the horizontal and vertical components of locomotion in mice.
Topics: Aminopeptidases; Animals; CD13 Antigens; Dipeptides; Drug Synergism; Enkephalin, Leucine; Enkephalins; Injections, Intravenous; Injections, Intraventricular; Leucine; Locomotion; Male; Mice; Naloxone; Neprilysin; Phenylcarbamates; Prodrugs; Receptors, Opioid; Receptors, Opioid, delta; Sulfhydryl Compounds; Thiorphan | 1990 |
Analgesic responses elicited by endogenous enkephalins (protected by mixed peptidase inhibitors) in a variety of morphine-sensitive noxious tests.
Topics: Analgesics; Animals; Dipeptides; Dose-Response Relationship, Drug; Enkephalins; Hydroxamic Acids; Male; Mice; Morphine; Naloxone; Phenylalanine; Rats; Rats, Inbred Strains | 1991 |
Prolonged analgesia by enkephalinase inhibition in rats with spinal cord adrenal medullary transplants.
Topics: Adrenal Medulla; Analgesia; Animals; Chromaffin System; Dipeptides; Male; Naloxone; Neprilysin; Pain Measurement; Rats; Rats, Inbred Strains; Spinal Cord; Transplantation, Heterotopic | 1990 |
Enkephalinase is involved in the degradation of endogenous substance P released from slices of rat substantia nigra.
Topics: Animals; Captopril; Dipeptides; In Vitro Techniques; Leucine; Male; Metalloendopeptidases; Naloxone; Neprilysin; Oligopeptides; Peptidyl-Dipeptidase A; Potassium; Protease Inhibitors; Rats; Rats, Inbred Strains; Substance P; Substantia Nigra; Thiorphan; Tiopronin | 1987 |
Comparison of selective and complete inhibitors of enkephalin-degrading enzymes on morphine withdrawal syndrome.
Topics: Animals; Behavior, Animal; Body Temperature; Body Weight; Corticosterone; Dipeptides; Hydroxamic Acids; Injections, Intraventricular; Male; Morphine Dependence; Naloxone; Neprilysin; Phenylalanine; Rats; Rats, Inbred Strains; Substance Withdrawal Syndrome; Thiorphan | 1989 |
Potent antinociceptive effects of kelatorphan (a highly efficient inhibitor of multiple enkephalin-degrading enzymes) systemically administered in normal and arthritic rats.
Topics: Animals; Arthritis; Arthritis, Experimental; Dipeptides; Dose-Response Relationship, Drug; Enkephalins; Enzyme Inhibitors; Male; Naloxone; Pain; Rats; Rats, Inbred Strains | 1989 |
Comparison of the behavioural effects induced by administration in rat nucleus accumbens or nucleus caudatus of selective mu and delta opioid peptides or kelatorphan an inhibitor of enkephalin-degrading-enzymes.
Topics: Animals; Behavior, Animal; Caudate Nucleus; Dipeptides; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Male; Motor Activity; Naloxone; Neprilysin; Norepinephrine; Nucleus Accumbens; Oligopeptides; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu | 1988 |
Prevention of degradation of endogenous enkephalins produces inhibition of nociceptive neurones in rat spinal cord.
Topics: Action Potentials; Animals; Dipeptides; Enkephalins; Leucine; Male; Naloxone; Nerve Fibers; Neural Inhibition; Neurons, Afferent; Pain; Protease Inhibitors; Rats; Rats, Inbred Strains; Spinal Cord; Thiorphan; Tiopronin | 1987 |
Kelatorphan potentiates the effect of [Met5]enkephalin in the substantia gelatinosa of the cat spinal cord.
Topics: Analgesics; Animals; Cats; Dipeptides; Drug Synergism; Enkephalin, Methionine; Naloxone; Spinal Cord; Substantia Gelatinosa | 1987 |
Effects of Kelatorphan and morphine before and after noxious stimulation on immediate-early gene expression in rat spinal cord neurons.
Topics: Analgesics; Animals; Dipeptides; Dose-Response Relationship, Drug; Gene Expression; Genes, Immediate-Early; Hot Temperature; Immunohistochemistry; Male; Morphine; Naloxone; Neurons; Pain; Physical Stimulation; Rats; Rats, Sprague-Dawley; Spinal Cord | 1994 |
Effects of the potent analgesic enkephalin-catabolizing enzyme inhibitors RB101 and kelatorphan on respiration.
Topics: Analgesics; Animals; Cats; Dipeptides; Disulfides; Enkephalins; Enzyme Inhibitors; Mice; Naloxone; Narcotic Antagonists; Phenylalanine; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Respiration | 2001 |
Naloxone rapidly evokes endogenous kappa opioid receptor-mediated hyperalgesia in naïve mice pretreated briefly with GM1 ganglioside or in chronic morphine-dependent mice.
Topics: Analgesics, Opioid; Animals; Chronic Disease; Dipeptides; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Synergism; G(M1) Ganglioside; Hyperalgesia; Male; Mice; Morphine; Morphine Dependence; Naloxone; Naltrexone; Narcotic Antagonists; Nociceptors; Opioid Peptides; Receptors, Opioid, kappa; Substance Withdrawal Syndrome | 2007 |