kb-r7943 and 3--4--dichlorobenzamil

kb-r7943 has been researched along with 3--4--dichlorobenzamil* in 2 studies

Other Studies

2 other study(ies) available for kb-r7943 and 3--4--dichlorobenzamil

Article	Year
Na+/Ca2+ exchanger inhibitors inhibit neurite outgrowth in PC12 cells. Journal of pharmacological sciences, 2011, Volume: 116, Issue:1 To elucidate the role of Na(+)/Ca(2+) exchanger (NCX) in neurite outgrowth, we investigated the effects of NCX inhibitors on neurite outgrowth in PC12 cells. KB-R7943 and 3',4'-dichlorobenzamil, NCX inhibitors, inhibited the neurite outgrowth caused by nerve growth factor (NGF). NCX inhibitors inhibited the neurite outgrowth caused by dibutylyl cAMP, which rapidly reorganizes the cytoskeleton. KB-R7943 inhibited the neurite outgrowth caused by Y-27632, an inhibitor of Rho kinase (ROCK) that regulates actin. However, NCX inhibitors did not inhibit NGF-induced phosphorylation of extracellular signal-regulated kinase. These results suggest that NCX inhibitor affects downstream of the Rho-ROCK signal transduction pathways in neurite outgrowth. Topics: Amides; Amiloride; Animals; Bucladesine; Cytoskeleton; Microscopy, Phase-Contrast; Nerve Growth Factor; Nerve Tissue Proteins; Neurites; Neurons; Osmolar Concentration; PC12 Cells; Protein Kinase Inhibitors; Pyridines; Rats; rho-Associated Kinases; Sodium-Calcium Exchanger; Thiourea	2011
Physiological role of the sodium-calcium exchanger in tracheal smooth muscle of guinea pig. Journal of muscle research and cell motility, 2004, Volume: 25, Issue:8 Topics: Amiloride; Animals; Guinea Pigs; Histamine; Muscle, Smooth; Nifedipine; Sodium-Calcium Exchanger; Thiourea; Trachea	2004

Article

Year

Na+/Ca2+ exchanger inhibitors inhibit neurite outgrowth in PC12 cells.

Journal of pharmacological sciences, 2011, Volume: 116, Issue:1

To elucidate the role of Na(+)/Ca(2+) exchanger (NCX) in neurite outgrowth, we investigated the effects of NCX inhibitors on neurite outgrowth in PC12 cells. KB-R7943 and 3',4'-dichlorobenzamil, NCX inhibitors, inhibited the neurite outgrowth caused by nerve growth factor (NGF). NCX inhibitors inhibited the neurite outgrowth caused by dibutylyl cAMP, which rapidly reorganizes the cytoskeleton. KB-R7943 inhibited the neurite outgrowth caused by Y-27632, an inhibitor of Rho kinase (ROCK) that regulates actin. However, NCX inhibitors did not inhibit NGF-induced phosphorylation of extracellular signal-regulated kinase. These results suggest that NCX inhibitor affects downstream of the Rho-ROCK signal transduction pathways in neurite outgrowth.

Topics: Amides; Amiloride; Animals; Bucladesine; Cytoskeleton; Microscopy, Phase-Contrast; Nerve Growth Factor; Nerve Tissue Proteins; Neurites; Neurons; Osmolar Concentration; PC12 Cells; Protein Kinase Inhibitors; Pyridines; Rats; rho-Associated Kinases; Sodium-Calcium Exchanger; Thiourea

2011

Physiological role of the sodium-calcium exchanger in tracheal smooth muscle of guinea pig.

Journal of muscle research and cell motility, 2004, Volume: 25, Issue:8

Topics: Amiloride; Animals; Guinea Pigs; Histamine; Muscle, Smooth; Nifedipine; Sodium-Calcium Exchanger; Thiourea; Trachea

2004