kaolinite has been researched along with nocistatin* in 1 studies
1 other study(ies) available for kaolinite and nocistatin
Article | Year |
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Intracerebroventricular administration of nocistatin reduces inflammatory hyperalgesia in rats.
Nocistatin is a biologically active peptide derived from prepronociceptin, and its intrathecal administration has been reported to reduce nociceptin- or prostaglandin E2-induced hyperalgesia and allodynia in mice. In this study, we investigated the effects of intracerebroventricular (i.c.v.) administration of nocistatin on the inflammatory hyperalgesia induced by hindlimb intraplantar injection of carrageenan/kaolin in the rat paw-pressure test. Intracerebroventricular administration of nocistatin (0.5-50 pmol/rat) dose-dependently reduced carrageenan/kaolin-induced hyperalgesia, which peaked at 15-30 m. However, i.c.v. administration of nocistatin (50 pmol/rat) had no effect on the nociceptive threshold of non-inflamed rats. These results indicate that nocistatin has anti-hyperalgesic effects on the inflammatory hyperalgesia induced by carrageenan/kaolin at the supraspinal level. Topics: Animals; Carrageenan; Drug Evaluation, Preclinical; Hindlimb; Hyperalgesia; Inflammation; Injections, Intraventricular; Kaolin; Male; Opioid Peptides; Rats; Rats, Sprague-Dawley | 1999 |