kampirone has been researched along with buspirone in 76 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 21 (27.63) | 18.7374 |
| 1990's | 39 (51.32) | 18.2507 |
| 2000's | 11 (14.47) | 29.6817 |
| 2010's | 5 (6.58) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Glennon, RA; Lyon, RA; Naiman, NA; Titeler, M | 1 |
| Carrupt, PA; Gaillard, P; Schambel, P; Testa, B | 1 |
| Bellman, K; Knegtel, RM; Settimo, L | 1 |
| Betto, P; Meneguz, A; Pichini, S; Ricciarello, G | 1 |
| Byrnes, JJ; Greenblatt, DJ; Miller, LG; Shemer, A; Thompson, ML | 1 |
| Martin, P | 1 |
| Blier, P; Chaput, Y; Curet, O; de Montigny, C | 1 |
| Filippov, IT; Komissarov, IV; Mamonov, AV | 1 |
| Baudrie, V; Bluet-Pajot, MT; Broqua, P; Chaouloff, F | 1 |
| De Luigi, A; Fodritto, F; Garattini, S; Grazia De Simoni, M; Imeri, L | 1 |
| Lancaster, SP; Montague-Clouse, J; Tollefson, GD | 1 |
| Fuller, RW | 1 |
| Cervo, L; Grignaschi, G; Samanin, R | 1 |
| Kawasaki, H; Nakamura, S; Takasaki, K | 1 |
| Frittoli, E; Gobbi, M; Mennini, T | 1 |
| Balster, RL | 1 |
| Dolzhenko, AT; Komissarov, IV; Obraztsova, OG; Zin'kovskaia, LIa | 1 |
| Coke, JA; McMillen, BA; Sanghera, MK; Williams, HL | 1 |
| Fuller, RW; Perry, KW | 1 |
| Moser, PC | 1 |
| Engel, JA; Hjorth, S; Söderpalm, B | 1 |
| Dixon, V; Gage-White, D; Guthrie, D; Matheson, GK; Rhoades, J; White, G | 1 |
| Hughes, D; Smith, SM | 1 |
| Comellas, L; Diaz-Marot, A; Gassiot, M; Puigdellivol, E; Salvatella, C | 1 |
| Eison, MS; Matheson, GK | 1 |
| Caccia, S; Fong, MH; Guiso, G | 1 |
| Le Moal, M; Louilot, A; Simon, H | 1 |
| Caccia, S; Conti, I; Garattini, S; Viganò, G | 1 |
| Faulkner, HC; Gammans, RE; Goodson, PJ; Pfeffer, M; Rehm, KD; Westrick, ML | 1 |
| Bianchi, G; Garattini, S | 1 |
| Bianchi, G; Caccia, S; Della Vedova, F; Garattini, S | 1 |
| Bianchi, G; Caccia, S | 1 |
| Skolnick, P; Weissman, BA; Youdim, MB | 1 |
| Duncan, GF; Farmen, RH; Faulkner, HC; Pittman, KA; Sciacca, MA; Shea, JP | 1 |
| Caccia, S; Gammans, RE; Garattini, S; Mayol, RF; Mingardi, G; Pfeffer, M; Placchi, M; Vigano, GL | 1 |
| Bullen, WW; Gammans, RE; Kerns, EH | 1 |
| Caccia, S; Garattini, S; Mancinelli, A; Muglia, M | 2 |
| Berlin, I; Cesselin, F; Chalon, S; Payan, C; Puech, AJ; Schöllnhammer, G; Varoquaux, O | 1 |
| Cao, BJ; Li, WP | 2 |
| Abramets, II; Kharin, NA; Komissarov, IV; Samoĭlovich, IM | 1 |
| Barbhaiya, RH; Gammans, RE; Laroudie, C; Pfeffer, M; Pittman, KA; Shrotriya, R; Shukla, UA | 1 |
| Cullen, WK; Rowan, MJ | 1 |
| Evans, SM; Griffiths, RR; Troisi, JR | 1 |
| Grahame-Smith, D; Grasby, P; Moorman, J; Sharp, T | 1 |
| Achiha, M; Amano, M; Goto, A; Hara, C; Ogawa, N; Sakai, A; Takahashi, N | 1 |
| Farmen, RH; Pittman, KA; Sciacca, MA; Sostrin, MB; Tay, LK | 1 |
| Dursun, SM; Handley, SL | 1 |
| Kellar, KJ; Lumpkin, MD; Mulroney, SE; Shemer, A; Skudlarek, C | 1 |
| Anwyl, R; Manahan-Vaughan, D; Rowan, MJ | 1 |
| Franklin, M; Odontiadis, J | 1 |
| Cao, BJ; Rodgers, RJ | 1 |
| Jagannathan, V; Venitz, J | 1 |
| Fabre, LF; Fogelman, SM; Granda, BW; Grassi, JM; Greenblatt, DJ; Harmatz, JS; Kramer, SJ; Shader, RI; von Moltke, LL | 1 |
| Kivistö, KT; Lamberg, TS; Neuvonen, PJ | 1 |
| Mahmood, I; Sahajwalla, C | 1 |
| Kivistö, KT; Laitila, J; Mårtensson, K; Neuvonen, PJ | 1 |
| Greene, DS; Marathe, PH; Markham, P; Shen, F | 1 |
| Cistarelli, L; Gobert, A; Melon, C; Millan, MJ; Rivet, JM | 1 |
| Olivares, E; Tripathi, B; Turek, FW; Van Reeth, O; Zhang, Y | 1 |
| Bourin, M; Hascoët, M; Nic Dhonnchadha, BA | 1 |
| Danhof, M; Maas, HJ; Peletier, LA; Rusiç-Pavletiç, J; Van der Graaf, PH; Zuideveld, KP | 1 |
| Garteiz, DA; Giancarlo, GM; Greenblatt, DJ; Von Moltke, LL | 1 |
| Sitsen, JM; Timmer, CJ | 1 |
| Ahokoski, O; Anttila, M; Björklund, H; Hänninen, J; Huupponen, R; Laine, K; Palovaara, S; Rouru, J; Ruuskanen, J | 1 |
| Noma, T; Sugimoto, Y; Takashima, N; Yamada, J | 2 |
| Lodge, NJ; Myers, RA; Plym, MJ; Signor, LJ | 1 |
| Benjamin, D; Crooke, JJ; Ilyin, SE; Lang, W; Reitz, AB; Rosenthal, DI; Vaidya, AH | 1 |
| Aranda, JV; Chehab, J; Chugani, DC; Chugani, HT; Edwards, DJ; Malian, M | 1 |
| Lu, H; Xu, Y; Yang, P; Zhang, L | 1 |
| Apfel, CC; Chassard, D; Diemunsch, P; Eberhart, L; Fox, GM; Gan, TJ; Kranke, P; Lebuffe, G; Minkowitz, HS; Röhm, KD; Tramèr, MR; Wallenborn, J | 1 |
| Hu, M; Liu, Z; Tang, L; Xia, B; Yang, X; Zhou, F; Zhou, J; Zhu, L | 1 |
| Guo, E; Hu, M; Liu, Z; Lu, L; Wang, Y; Wu, J; Zhu, L | 1 |
| He, S; Hu, W; Jia, M; Jiang, X; Wang, L; Xie, H | 1 |
2 review(s) available for kampirone and buspirone
| Article | Year |
|---|---|
Abuse potential of buspirone and related drugs.
Topics: Animals; Anti-Anxiety Agents; Buspirone; Clinical Trials as Topic; Double-Blind Method; Drug Evaluation, Preclinical; Euphoria; Humans; Product Surveillance, Postmarketing; Pyrimidines; Rats; Substance-Related Disorders | 1990 |
Clinical pharmacokinetics and pharmacodynamics of buspirone, an anxiolytic drug.
Topics: Aged; Anti-Anxiety Agents; Area Under Curve; Buspirone; Clinical Trials as Topic; Cross-Over Studies; Drug Interactions; Female; Humans; Liver Cirrhosis; Male; Renal Insufficiency | 1999 |
13 trial(s) available for kampirone and buspirone
| Article | Year |
|---|---|
The association of buspirone and its metabolite 1-pyrimidinylpiperazine in the remission of comorbid anxiety with depressive features and alcohol dependency.
Topics: Alcoholism; Anxiety Disorders; Buspirone; Depressive Disorder; Double-Blind Method; Humans | 1991 |
Abuse potential of buspirone and related drugs.
Topics: Animals; Anti-Anxiety Agents; Buspirone; Clinical Trials as Topic; Double-Blind Method; Drug Evaluation, Preclinical; Euphoria; Humans; Product Surveillance, Postmarketing; Pyrimidines; Rats; Substance-Related Disorders | 1990 |
Evaluation of the alpha 2-adrenoceptor blocking properties of buspirone and ipsapirone in healthy subjects. Relationship with the plasma concentration of the common metabolite 1-(2-pyrimidinyl)-piperazine.
Topics: Adrenergic alpha-Antagonists; Adult; Analysis of Variance; Anti-Anxiety Agents; Blood Pressure; Body Temperature; Buspirone; C-Peptide; Clonidine; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Growth Hormone; Heart Rate; Humans; Insulin; Male; Methoxyhydroxyphenylglycol; Norepinephrine; Pyrimidines; Serotonin Antagonists | 1995 |
Disposition kinetics of buspirone in patients with renal or hepatic impairment after administration of single and multiple doses.
Topics: Adult; Anti-Anxiety Agents; Buspirone; Female; Humans; Kidney Diseases; Liver Cirrhosis; Liver Diseases; Male; Middle Aged | 1994 |
Tandospirone and alprazolam: comparison of behavioral effects and abuse liability in humans.
Topics: Adult; Alprazolam; Anti-Anxiety Agents; Buspirone; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Humans; Isoindoles; Male; Piperazines; Psychomotor Performance; Pyrimidines; Serotonin Receptor Agonists; Substance-Related Disorders | 1994 |
Effect of food on the bioavailability of gepirone in humans.
Topics: Administration, Oral; Adolescent; Adult; Anti-Anxiety Agents; Antidepressive Agents; Biological Availability; Buspirone; Fasting; Food; Humans; Male; Pyrimidines | 1993 |
Simultaneous quantitation of buspirone and its major metabolite 1-(2-pyrimidinyl)piperazine in human plasma by high-performance liquid chromatography with coulometric detection.
Topics: Adult; Biotransformation; Buspirone; Calibration; Chromatography, High Pressure Liquid; Electrochemistry; Humans; Indicators and Reagents; Male; Reference Standards; Serotonin Receptor Agonists | 1996 |
Pharmacokinetics and CNS pharmacodynamics of the 5-HT1A agonist buspirone in humans following acute L-tryptophan depletion challenge.
Topics: Administration, Oral; Adolescent; Adult; Anti-Anxiety Agents; Area Under Curve; Buspirone; Central Nervous System; Cognition; Cross-Over Studies; Diet; Double-Blind Method; Electroencephalography; Humans; Hydrocortisone; Male; Prolactin; Serotonin Receptor Agonists; Single-Blind Method; Tryptophan | 1997 |
Interactions of buspirone with itraconazole and rifampicin: effects on the pharmacokinetics of the active 1-(2-pyrimidinyl)-piperazine metabolite of buspirone.
Topics: Adolescent; Adult; Anti-Anxiety Agents; Buspirone; Cross-Over Studies; Double-Blind Method; Drug Interactions; Female; Humans; Itraconazole; Male; Piperazine; Piperazines; Placebos; Rifampin | 1999 |
Pharmacokinetic evaluation of gepirone immediate-release capsules and gepirone extended-release tablets in healthy volunteers.
Topics: Adult; Area Under Curve; Biological Availability; Buspirone; Capsules; Cross-Over Studies; Delayed-Action Preparations; Half-Life; Humans; Intestinal Absorption; Male; Pyrimidines; Serotonin Receptor Agonists; Tablets; Time Factors | 2003 |
Effect of the novel anxiolytic drug deramciclane on the pharmacokinetics and pharmacodynamics of the CYP3A4 probe drug buspirone.
Topics: Administration, Oral; Adult; Anti-Anxiety Agents; Area Under Curve; Buspirone; Camphanes; Cross-Over Studies; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Double-Blind Method; Drug Interactions; Female; Half-Life; Humans; Male; Time Factors | 2003 |
Pharmacokinetics of buspirone in autistic children.
Topics: Anti-Anxiety Agents; Autistic Disorder; Buspirone; Child; Child, Preschool; Female; Humans; Male; Serotonin Receptor Agonists | 2006 |
Intravenous buspirone for the prevention of postoperative nausea and vomiting.
Topics: Adult; Aged; Aged, 80 and over; Anti-Anxiety Agents; Antiemetics; Buspirone; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Incidence; Injections, Intravenous; Male; Middle Aged; Postoperative Nausea and Vomiting; Receptor, Serotonin, 5-HT1A; Receptors, Dopamine D2; Receptors, Dopamine D3; Serotonin 5-HT1 Receptor Agonists; Young Adult | 2012 |
62 other study(ies) available for kampirone and buspirone
| Article | Year |
|---|---|
Arylpiperazine derivatives as high-affinity 5-HT1A serotonin ligands.
Topics: Animals; Chemical Phenomena; Chemistry; Male; Piperazines; Rats; Rats, Inbred Strains; Receptors, Serotonin; Serotonin; Structure-Activity Relationship | 1988 |
Binding of arylpiperazines, (aryloxy)propanolamines, and tetrahydropyridylindoles to the 5-HT1A receptor: contribution of the molecular lipophilicity potential to three-dimensional quantitative structure-affinity relationship models.
Topics: Indoles; Ligands; Models, Molecular; Molecular Conformation; Molecular Structure; Piperazines; Propanolamines; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin; Structure-Activity Relationship; Tetrahydronaphthalenes | 1996 |
Comparison of the accuracy of experimental and predicted pKa values of basic and acidic compounds.
Topics: Chemistry, Pharmaceutical; Forecasting; Hydrogen-Ion Concentration; Pharmaceutical Preparations; Random Allocation | 2014 |
Simultaneous high-performance liquid chromatographic analysis of buspirone and its metabolite 1-(2-pyrimidinyl)-piperazine in plasma using electrochemical detection.
Topics: Administration, Oral; Animals; Anti-Anxiety Agents; Buspirone; Chromatography, High Pressure Liquid; Electrochemistry; Male; Mice | 1992 |
Kinetics, brain uptake, and receptor binding of tandospirone and its metabolite 1-(2-pyrimidinyl)-piperazine.
Topics: Animals; Anti-Anxiety Agents; Behavior, Animal; Brain; Brain Chemistry; Buspirone; Cerebral Cortex; Isoindoles; Male; Mice; Motor Activity; Piperazines; Pyrimidines; Receptors, GABA-A; Receptors, Serotonin | 1992 |
1-(2-pyrimidinyl)-piperazine may alter the effects of the 5-HT1A agonist in the learned helplessness paradigm in rats.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Anti-Anxiety Agents; Avoidance Learning; Buspirone; Electroshock; Helplessness, Learned; Male; Oxidation-Reduction; Proadifen; Rats; Rats, Inbred Strains; Receptors, Serotonin; Tetrahydronaphthalenes | 1991 |
Tandospirone and its metabolite, 1-(2-pyrimidinyl)-piperazine--II. Effects of acute administration of 1-PP and long-term administration of tandospirone on noradrenergic neurotransmission.
Topics: Animals; Anti-Anxiety Agents; Brain; Buspirone; Clonidine; Electric Stimulation; GABA Antagonists; Isoindoles; Male; Neurons; Norepinephrine; Piperazines; Pyrimidines; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha | 1991 |
[Effects of buspirone and buspirone-like 1-A-agonists of serotonin on the level of systemic blood pressure].
Topics: Animals; Anti-Anxiety Agents; Blood Pressure; Buspirone; Muscle, Smooth, Vascular; Rats; Receptors, Serotonin | 1991 |
Buspirone, ipsapirone and 1-(2-pyrimidinyl)-piperazine decrease cold-induced thyrotropin secretion in rats.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adrenergic alpha-Antagonists; Animals; Anti-Anxiety Agents; Buspirone; Cold Temperature; Hypothalamo-Hypophyseal System; Male; Pyrimidines; Rats; Rats, Inbred Strains; Receptors, Serotonin; Tetrahydronaphthalenes; Thyroid Gland; Thyrotropin | 1991 |
Effect of buspirone and its metabolite 1-(2-pyrimidinyl)-piperazine on hippocampal serotoninergic system, studied in freely moving rats.
Topics: Animals; Buspirone; Dose-Response Relationship, Drug; Hippocampus; Hydroxyindoleacetic Acid; Male; Motor Activity; Rats; Rats, Inbred Strains; Serotonin | 1990 |
Buspirone metabolite and panic attacks.
Topics: Anti-Anxiety Agents; Buspirone; Fear; Humans; Panic; Receptors, Adrenergic, alpha; Time Factors | 1990 |
Alpha 2-adrenoceptor blockade prevents the effect of desipramine in the forced swimming test.
Topics: Adrenergic alpha-Antagonists; Animals; Buspirone; Depression; Desipramine; Dioxanes; Hydroxydopamines; Idazoxan; Locus Coeruleus; Male; Motor Activity; Oxidopamine; Rats; Swimming | 1990 |
[Electroencephalographic study with buspirone, a novel nonbenzodiazepine anxiolytic, and its major metabolite, 1-(2-pyrimidinyl)piperazine (1-PP), in rabbits].
Topics: Animals; Anti-Anxiety Agents; Arousal; Brain; Buspirone; Diazepam; Electroencephalography; Evoked Potentials; Male; Photic Stimulation; Rabbits; Recruitment, Neurophysiological | 1990 |
Antagonist properties of 1-(2-pyrimidinyl)piperazine at presynaptic alpha 2-adrenoceptors in the rat brain.
Topics: Adrenergic alpha-Antagonists; Animals; Brain Chemistry; Buspirone; In Vitro Techniques; Male; Nerve Endings; Norepinephrine; Potassium; Rats; Serotonin; Synapses; Synaptosomes | 1990 |
[An analysis of the hypothermic action of 8-hydroxy-2-(di-N-propylamino)tetralin, 1-(2-pyrimidinyl)piperazine and its derivatives].
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Body Temperature; Buspirone; Dose-Response Relationship, Drug; Drug Interactions; Fenclonine; Hypothermia; Mice; Naphthalenes; Rats; Serotonin Antagonists; Tetrahydronaphthalenes; Time Factors | 1990 |
Ipsapirone and 1-(2-pyrimidinyl)-piperazine increase rat locus coeruleus noradrenergic activity.
Topics: Action Potentials; Animals; Brain; Buspirone; Clonidine; Dose-Response Relationship, Drug; Locus Coeruleus; Male; Norepinephrine; Pyrimidines; Rats; Rats, Inbred Strains | 1990 |
Effects of buspirone and its metabolite, 1-(2-pyrimidinyl)piperazine, on brain monoamines and their metabolites in rats.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Brain; Buspirone; Dopamine; Male; Norepinephrine; Proadifen; Rats; Rats, Inbred Strains; Receptors, Serotonin; Serotonin; Tetrahydronaphthalenes | 1989 |
An evaluation of the elevated plus-maze test using the novel anxiolytic buspirone.
Topics: Animals; Anxiety; Behavior, Animal; Buspirone; Diazepam; Fenclonine; Male; Rats; Rats, Inbred Strains; Receptors, Serotonin | 1989 |
Effects of 5-HT1A receptor agonists and L-5-HTP in Montgomery's conflict test.
Topics: 5-Hydroxytryptophan; 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Anti-Anxiety Agents; Buspirone; Conflict, Psychological; Male; Motor Activity; Pyrimidines; Rats; Rats, Inbred Strains; Receptors, Serotonin; Tetrahydronaphthalenes | 1989 |
The effects of gepirone and 1-(2-pyrimidinyl)-piperazine on levels of corticosterone in rat plasma.
Topics: Animals; Buspirone; Circadian Rhythm; Corticosterone; Dose-Response Relationship, Drug; Hypothalamo-Hypophyseal System; Male; Pituitary-Adrenal System; Pyrimidines; Rats; Rats, Inbred Strains; Stress, Physiological | 1989 |
1-(2-Pyrimidinyl)piperazine antagonizes GABA-activated currents in cultured spinal neurones of the rat.
Topics: Animals; Buspirone; Cells, Cultured; gamma-Aminobutyric Acid; Membrane Potentials; Rats; Spinal Cord | 1989 |
Determination of buspirone and 1-(2-pyrimidinyl)piperazine in plasma samples by high-performance liquid chromatography.
Topics: Animals; Buspirone; Chemical Phenomena; Chemistry; Chromatography, High Pressure Liquid; Dogs; Humans; Rats; Spectrophotometry, Ultraviolet | 1989 |
The effects of buspirone, BMY-13805 and 1-(2-pyrimidinyl)-piperazine on cat spinal reflexes.
Topics: Animals; Anti-Anxiety Agents; Buspirone; Cats; Female; Ganglia, Spinal; Male; Piperazines; Pyrimidines; Reflex; Reflex, Monosynaptic; Spinal Cord | 1985 |
Disposition of the psychotropic drugs buspirone, MJ-13805 and piribedil, and of their common active metabolite 1-(2-pyrimidinyl)-piperazine in the rat.
Topics: Animals; Anti-Anxiety Agents; Blood Proteins; Brain; Buspirone; Kinetics; Male; Piperazines; Piribedil; Protein Binding; Pyrimidines; Rats; Rats, Inbred Strains | 1985 |
A study of the effects of buspirone, BMY 13805, and 1-PP on dopaminergic metabolism in the nucleus accumbens using in vivo voltammetry in freely moving rats.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Anti-Anxiety Agents; Buspirone; Dopamine; Electrochemistry; Injections, Intraperitoneal; Injections, Subcutaneous; Male; Nucleus Accumbens; Piperazines; Pyrimidines; Rats; Rats, Inbred Strains; Septal Nuclei | 1986 |
1-(2-Pyrimidinyl)-piperazine as active metabolite of buspirone in man and rat.
Topics: Adult; Animals; Anti-Anxiety Agents; Biotransformation; Brain; Buspirone; Humans; Kinetics; Male; Piperazines; Pyrimidines; Rabbits; Species Specificity; Time Factors | 1986 |
Lack of interaction between cimetidine and buspirone.
Topics: Adult; Anti-Anxiety Agents; Buspirone; Cimetidine; Drug Interactions; Half-Life; Humans; Kinetics; Male; Piperazines; Psychomotor Performance; Pyrimidines | 1987 |
Blockade of alpha 2-adrenoceptors by 1-(2-pyrimidinyl)-piperazine (PmP) in vivo and its relation to the activity of buspirone.
Topics: Adrenergic alpha-Antagonists; Animals; Buspirone; Cerebral Cortex; Clonidine; Gastrointestinal Transit; Hypnotics and Sedatives; Male; Methoxyhydroxyphenylglycol; Rats; Reflex; Yohimbine | 1988 |
The alpha 2-adrenoceptor antagonist activity of ipsapirone and gepirone is mediated by their common metabolite 1-(2-pyrimidinyl)-piperazine (PmP).
Topics: Administration, Oral; Adrenergic alpha-Antagonists; Animals; Anti-Anxiety Agents; Buspirone; Chromatography, High Pressure Liquid; Clonidine; Drug Interactions; Gastrointestinal Transit; Injections, Intravenous; Male; Pyrimidines; Rats | 1988 |
Simultaneous determination of buspirone, gepirone, ipsapirone and their common metabolite 1-(2-pyrimidinyl)piperazine in rat plasma and brain by high-performance liquid chromatography.
Topics: Animals; Anti-Anxiety Agents; Brain Chemistry; Buspirone; Male; Pyrimidines; Rats; Spectrophotometry, Ultraviolet | 1988 |
Monoaminergic involvement in the pharmacological actions of buspirone.
Topics: Animals; Apomorphine; Behavior, Animal; Brain; Buspirone; Dopamine; Ketanserin; Male; Methoxydimethyltryptamines; Monoamine Oxidase; p-Chloroamphetamine; Piperazines; Piperidines; Psychotropic Drugs; Pyrimidines; Rats; Serotonin | 1985 |
Simultaneous quantitation of buspirone and 1-(2-pyrimidinyl)piperazine in human plasma and urine by capillary gas chromatography-mass spectrometry.
Topics: Buspirone; Drug Residues; Gas Chromatography-Mass Spectrometry; Humans; Indicators and Reagents; Tablets | 1988 |
Clinical pharmacokinetics of oral buspirone in patients with impaired renal function.
Topics: Administration, Oral; Adult; Buspirone; Humans; Kidney; Kidney Diseases; Kidney Failure, Chronic; Kinetics; Male; Middle Aged | 1988 |
Quantitative analysis of 1-(2-pyrimidinyl)piperazine in plasma by capillary gas chromatography-mass spectrometry.
Topics: Buspirone; Gas Chromatography-Mass Spectrometry; Humans; Piperazines | 1986 |
Disposition and metabolism of buspirone and its metabolite 1-(2-pyrimidinyl)-piperazine in the rat.
Topics: Animals; Biotransformation; Brain; Buspirone; Half-Life; Kinetics; Male; Piperazines; Pyrimidines; Rats; Time Factors | 1983 |
Identification and quantitation of 1-(2-pyrimidinyl)piperazine, an active metabolite of the anxiolytic agent buspirone, in rat plasma and brain.
Topics: Administration, Oral; Animals; Brain Chemistry; Buspirone; Chromatography, Gas; Hydrolysis; Male; Piperazines; Pyrimidines; Rats | 1982 |
Buspirone and 1-(2-pyrimidinyl)-piperazine attenuate xylazine-induced antinociception in the mouse.
Topics: Analgesics; Animals; Anti-Anxiety Agents; Buspirone; Dose-Response Relationship, Drug; Injections, Subcutaneous; Male; Mice; Pain Measurement; Xylazine | 1994 |
[The different mechanism of the inhibition by buspirone and its camphorimide analogs of 5-HT3-serotoninergic effects].
Topics: Animals; Anti-Anxiety Agents; Buspirone; Camphor; Creatinine; Depression, Chemical; Drug Combinations; Ganglia, Spinal; In Vitro Techniques; Membrane Potentials; Neurons; Piperazines; Pyrimidines; Rats; Receptors, Serotonin; Serotonin; Serotonin Receptor Agonists | 1993 |
Gepirone and 1-(2-pyrimidinyl)-piperazine-induced reduction of aversively evoked ultrasonic vocalisation in the rat.
Topics: Animals; Anti-Anxiety Agents; Avoidance Learning; Buspirone; Darkness; Electroshock; Light; Male; Motor Activity; Proadifen; Pyrimidines; Rats; Rats, Wistar; Ultrasonics; Vocalization, Animal | 1994 |
Antagonism of clonidine antinociception by buspirone and 1-(2-pyrimidinyl)-piperazine.
Topics: Analgesics; Animals; Anti-Anxiety Agents; Buspirone; Clonidine; Male; Mice | 1994 |
Comparison of the effect of buspirone and 1-(2-pyrimidinyl)-piperazine on cerebral glucose utilization in the rat.
Topics: Animals; Anti-Anxiety Agents; Autoradiography; Behavior, Animal; Blood Pressure; Body Temperature; Brain Chemistry; Buspirone; Deoxyglucose; Dose-Response Relationship, Drug; Glucose; Male; Rats; Rats, Sprague-Dawley | 1993 |
Comparison of the anticonflict effect of buspirone and its major metabolite 1-(2-pyrimidinyl)-piperazine (1-PP) in rats.
Topics: Animals; Anti-Anxiety Agents; Buspirone; Conflict, Psychological; Diazepam; Dose-Response Relationship, Drug; Drinking Behavior; Male; Rats; Rats, Sprague-Dawley | 1993 |
The effects of alpha 2-adrenoceptor antagonists on the inhibition of 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI)-induced head shakes by 5-HT1A receptor agonists in the mouse.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Amphetamines; Animals; Brain Chemistry; Buspirone; Fenclonine; Male; Mice; Mice, Inbred Strains; Serotonin; Serotonin Receptor Agonists; Stereotyped Behavior | 1993 |
Tandospirone stimulates prolactin secretion in the rat by an action at serotonin-1A receptors.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Buspirone; Dose-Response Relationship, Drug; Isoindoles; Male; Metergoline; Piperazines; Prolactin; Pyrimidines; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Serotonin Receptor Agonists | 1994 |
The azapirone metabolite 1-(2-pyrimidinyl)piperazine depresses excitatory synaptic transmission in the hippocampus of the alert rat via 5-HT1A receptors.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Action Potentials; Animals; Buspirone; Dioxanes; Dose-Response Relationship, Drug; Hippocampus; Male; Rats; Rats, Wistar; Receptors, Serotonin; Spiro Compounds; Synaptic Transmission | 1995 |
Comparative behavioural profiles of buspirone and its metabolite 1-(2-pyrimidinyl)-piperazine (1-PP) in the murine elevated plus-maze.
Topics: Animals; Anti-Anxiety Agents; Biotransformation; Buspirone; Drug Antagonism; Male; Maze Learning; Mice; Proadifen; Serotonin Receptor Agonists | 1997 |
Gepirone and 1-(2-pyrimidinyl)-piperazine in vitro: human cytochromes mediating transformation and cytochrome inhibitory effects.
Topics: Antidepressive Agents; Biotransformation; Buspirone; Cytochrome P-450 Enzyme System; Drug Interactions; Humans; Ketoconazole; Microsomes, Liver; Pyrimidines | 1998 |
Determination of buspirone and 1-(2-pyrimidinyl)-piperazine (1-PP) in human plasma by capillary gas chromatography.
Topics: Anti-Anxiety Agents; Buspirone; Calibration; Chromatography, Gas; Humans; Reproducibility of Results; Serotonin Receptor Agonists | 1999 |
Pharmacokinetics of buspirone following oral administration to rhesus monkeys.
Topics: Administration, Oral; Animals; Anti-Anxiety Agents; Buspirone; Female; Macaca mulatta; Male | 1999 |
Buspirone modulates basal and fluoxetine-stimulated dialysate levels of dopamine, noradrenaline and serotonin in the frontal cortex of freely moving rats: activation of serotonin1A receptors and blockade of alpha2-adrenergic receptors underlie its actions
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Brain Chemistry; Buspirone; Chromatography, High Pressure Liquid; Dopamine; Dopamine Antagonists; Drug Interactions; Fluoxetine; Frontal Lobe; Locomotion; Male; Microdialysis; Neural Inhibition; Norepinephrine; Oxazoles; Piperazines; Pyridines; Raclopride; Rats; Rats, Wistar; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Selective Serotonin Reuptake Inhibitors; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists | 1999 |
Chronobiotic effects of gepirone, a potential antidepressant with 5HT1A receptor partial agonist properties.
Topics: Animals; Anti-Anxiety Agents; Antidepressive Agents, Second-Generation; Buspirone; Circadian Rhythm; Cricetinae; Darkness; Light; Male; Mesocricetus; Motor Activity; Pyrimidines; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin Receptor Agonists | 1999 |
The influence of buspirone, and its metabolite 1-PP, on the activity of paroxetine in the mouse light/dark paradigm and four plates test.
Topics: Animals; Anti-Anxiety Agents; Buspirone; Dose-Response Relationship, Drug; Drug Interactions; Male; Mice; Paroxetine; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Selective Serotonin Reuptake Inhibitors | 2000 |
Pharmacokinetic-pharmacodynamic modeling of buspirone and its metabolite 1-(2-pyrimidinyl)-piperazine in rats.
Topics: Animals; Body Temperature; Buspirone; Male; Models, Biological; Models, Chemical; Rats; Rats, Wistar; Receptors, Serotonin; Receptors, Serotonin, 5-HT1 | 2002 |
Human cytochromes mediating gepirone biotransformation at low substrate concentrations.
Topics: Biotransformation; Buspirone; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Gas Chromatography-Mass Spectrometry; Humans; In Vitro Techniques; Microsomes, Liver; Piperidones; Pyrimidines; Serotonin Receptor Agonists | 2003 |
Effects of the serotonergic anxiolytic buspirone on plasma glucose and glucose-induced hyperglycemia in mice.
Topics: Animals; Anti-Anxiety Agents; Blood Glucose; Buspirone; Fasting; Glucose; Hyperglycemia; Hyperinsulinism; Injections, Subcutaneous; Insulin; Insulin Secretion; Male; Mice; Serotonin Receptor Agonists; Time Factors | 2003 |
1-(2-pyrimidinyl)-piperazine, a buspirone metabolite, modulates bladder function in the anesthetized rat.
Topics: Acetic Acid; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Antagonists; Anesthesia; Animals; ATP-Binding Cassette Transporters; Benzhydryl Compounds; Buspirone; Cresols; Cromakalim; Dose-Response Relationship, Drug; Female; Imidazoles; Indoles; Isoindoles; KATP Channels; Muscarinic Antagonists; Muscle Contraction; Muscle, Smooth; Phenylpropanolamine; Potassium Channels; Potassium Channels, Inwardly Rectifying; Rats; Rats, Wistar; Tolterodine Tartrate; Urinary Bladder; Urodynamics; Yohimbine | 2004 |
Inhibitory effects of the 5-HT(1A) receptor agonist buspirone on stress-induced hyperglycemia in mice: involvement of insulin and a buspirone metabolite, 1-(2-pyrimidinyl)piperazine (1-PP).
Topics: Animals; Buspirone; Hyperglycemia; Insulin; Male; Mice; Serotonin 5-HT1 Receptor Agonists; Serotonin Receptor Agonists; Stress, Physiological | 2005 |
Oral buspirone causes a shift in the dose-response curve between the elevated-plus maze and Vogel conflict tests in Long-Evans rats: relation of brain levels of buspirone and 1-PP to anxiolytic action.
Topics: Administration, Oral; Animals; Anti-Anxiety Agents; Behavior, Animal; Brain; Brain Chemistry; Buspirone; Conflict, Psychological; Dose-Response Relationship, Drug; Male; Maze Learning; Motor Activity; Rats; Rats, Long-Evans; Serotonin Receptor Agonists | 2005 |
Carboxy group derivatization for enhanced electron-transfer dissociation mass spectrometric analysis of phosphopeptides.
Topics: Buspirone; Mass Spectrometry; Phosphopeptides | 2009 |
The exposure of highly toxic aconitine does not significantly impact the activity and expression of cytochrome P450 3A in rats determined by a novel ultra performance liquid chromatography-tandem mass spectrometric method of a specific probe buspirone.
Topics: Aconitine; Aconitum; Administration, Oral; Animals; Buspirone; Chromatography, Liquid; Cytochrome P-450 CYP3A; Drug Interactions; Liver; Male; Medicine, Chinese Traditional; Microsomes, Liver; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Tandem Mass Spectrometry | 2013 |
The influences of aconitine, an active/toxic alkaloid from aconitum, on the oral pharmacokinetics of CYP3A probe drug buspirone in rats.
Topics: Aconitine; Aconitum; Administration, Oral; Animals; Area Under Curve; Buspirone; Cytochrome P-450 CYP3A; Dose-Response Relationship, Drug; Drug Interactions; Male; Rats; Rats, Sprague-Dawley | 2014 |
Simultaneous determination of tandospirone and its active metabolite, 1-[2-pyrimidyl]-piperazine in rat plasma by LC-MS/MS and its application to a pharmacokinetic study.
Topics: Animals; Buspirone; Chromatography, High Pressure Liquid; Drug Stability; Female; Isoindoles; Limit of Detection; Linear Models; Male; Piperazines; Pyrimidines; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Tandem Mass Spectrometry | 2019 |