Page last updated: 2024-09-02

kahweol and cafestol

kahweol has been researched along with cafestol in 76 studies

Compound Research Comparison

Studies (kahweol)	Trials (kahweol)	Recent Studies (post-2010) (kahweol)	Studies (cafestol)	Trials (cafestol)	Recent Studies (post-2010) (cafestol)
118	9	55	119	9	52

Research

Studies (76)

Timeframe	Studies, this research(%)	All Research%
pre-1990	2 (2.63)	18.7374
1990's	23 (30.26)	18.2507
2000's	23 (30.26)	29.6817
2010's	22 (28.95)	24.3611
2020's	6 (7.89)	2.80

Authors

Authors	Studies
Hirsbrunner, P; McWhorter, K; Miller, EG; Rivera-Hidalgo, F; Sunahara, GI; Wright, JM	1
Formby, WA; Miller, EG; Rivera-Hidalgo, F; Wright, JM	1
Lam, LK; Sparnins, VL; Wattenberg, LW	1
Beynen, AC; Katan, MB; Nicolosi, RJ; Terpstra, AH; Weusten-van der Wouw, MP	1
Burggraaf, J; Cohen, AF; Hollaar, L; Kroon, C; Schoemaker, RC; Smelt, AH; van der Stegen, GH; van Rooij, J; Vroon, TF	1
Katan, MB; Schulz, AG; Urgert, R	1
Ahola, I; Aro, A; Huggett, AC; Katan, MB; Liardon, R; Lund-Larsen, PG; Thelle, DS; Viani, R; Weusten-Van der Wouw, MP	1
Göbel, U; Heckers, H; Kleppel, U	1
Katan, MB; Kosmeijer-Schuil, TG; Urgert, R	1
Cavin, C; Huggett, AC; Perrin, I; Schilter, B	1
Essed, N; Katan, MB; Kosmeijer-Schuil, TG; Urgert, R; van der Weg, G	1
Katan, MB; Urgert, R	2
Gross, G; Huggett, AC; Jaccaud, E	1
Beynen, AC; Hovenier, R; Katan, MB; Meyboom, S; Urgert, R; Weusten-van der Wouw, MP	1
de Jong-Caesar, R; de Roos, B; Katan, MB; Scheek, LM; Urgert, R; van Gent, T; van Tol, A	1
Drevon, CA; Halvorsen, B; Huggett, AC; Ranheim, T; Rustan, AC	1
de Wit, EC; Post, SM; Princen, HM	1
Biagi, GL; Cantelli-Forti, G; Paolini, M	1
Drevon, CA; Halvorsen, B; Huggett, AC; Nenseter, MS; Ranheim, T	1
Cavin, C; Constable, A; Holzhäuser, D; Huggett, AC; Schilter, B	1
De Roos, B; Katan, MB; Kosmeijer-Schuil, TG; Meyboom, S	1
Benowitz, NL; Everhart, JE; Sharp, DS	1
Blanch, GP; Herraiz, M; Ruiz del Castillo, ML	1
de Roos, B; Katan, MB; Rudel, LL; Sawyer, JK	1
Augustín, J	1
Buytenhek, R; De Roos, B; Katan, MB; Princen, HM; Scheek, LM; Urgert, R; Van Gent, T; Van Tol, A	1
Cavin, C; Mace, K; Offord, EA; Schilter, B	1
Huber, WW; Prustomersky, S; Scharf, G	1
Grasl-Kraupp, B; Huber, WW; Peter, B; Prustomersky, S; Rossmanith, W; Scharf, G; Schulte-Hermann, R; Turesky, RJ	1
Delbanco, E; Huber, WW; Prustomersky, S; Scharf, G; Schulte-Hermann, R; Thier, R; Turesky, RJ; Uhl, M	1
Cavin, C; Constable, A; Holzhaeuser, D; Huber, WW; Scharf, G; Schilter, B	1
Huber, WW; Kaina, B; Nagel, G; Prustomersky, S; Scharf, G; Schulte-Hermann, R	1
Huber, WW; Knasmuller, S; Prustomersky, S; Scharf, G; Schulte-Hermann, R	1
Bezencon, C; Cavin, C; Guignard, G; Schilter, B	1
Jeong, HG; Jung, KS; Kim, JY	1
Cavin, C; Glatt, HR; Hofer, E; Knasmüller, S; Lhoste, E; Majer, BJ; Meinl, W; Uhl, M	1
Halvorsen, B; Ranheim, T	1
Huber, WW; Parzefall, W	1
Frei, B; Higdon, JV	1
Boekschoten, MV; Katan, MB; Kosmeijer-Schuil, TG; van Cruchten, ST	1
Angelis, K; Bichler, J; Cavin, C; Chakraborty, A; Ferk, F; Haidinger, G; Hoelzl, C; Knasmüller, S; Kundi, M; Schulte-Hermann, R; Simic, T	1
Choi, JH; Jeong, HG; Lee, KJ	1
Jeong, HG; Lee, KJ	1
Grusch, M; Haslinger, E; Huber, WW; Parzefall, W; Peter-Vörösmarty, B; Prustomersky, S; Rossmanith, W; Scharf, G; Schulte-Hermann, R	1
Cavin, C; Hayes, JD; Higgins, LG; Itoh, K; Yamamoto, M	1
Cao, DY; Dou, KF; Li, YQ; Tao, KS; Wang, L; Wang, W; Wu, SX	1
Aarts, JM; Boekschoten, MV; de Haan, LH; Katan, MB; Kunne, C; Mulder, PP; van Cruchten, ST; Witkamp, RF	1
d'Ischia, M; De Lucia, M; Giudicianni, I; Melck, D; Motta, A; Napolitano, A; Panzella, L	1
Campanha, FG; De Toledo Benassi, M; Dias, RC; Ferreira, LP; Marraccini, P; Pot, D; Vieira, LG	1
Buchmann, S; Chen, C; Koelling-Speer, I; Lee, J; Naidoo, N; Rebello, SA; Speer, K; Tai, ES; van Dam, RM	1
Chae, JI; Lee, KA; Shim, JH	1
Balzano, M; Boselli, E; Frega, NG; Pacetti, D	1
de Souza, RO; Dos Santos Júnior, HM; Hamerski, L; Hovell, AM; Oigman, SS; Rezende, CM	1
Beaumesnil, M; Bostyn, S; Chartier, A; de Oliveira, AL; Elfakir, C	1
Hayes, PC; Masterton, GS; Walton, HB	1
Ashihara, H; Clifford, MN; Crozier, A; Lean, ME; Ludwig, IA	1
de Aquino Neto, FR; de Souza, RO; Novaes, FJ; Oigman, SS; Rezende, CM	1
Castor, MG; Duarte, ID; Guzzo, LS; Perez, Ade C; Romero, TR	1
Lai, YC; Schwartz, RA; Yew, YW	1
Lima, DR; Santos, RM	1
Domingues, DS; Ferreira, LP; Ivamoto, ST; Kitzberger, CSG; Leroy, T; Pereira, LFP; Pot, D; Sakuray, LM; Scholz, MBS; Vieira, LGE	1
Charmetant, P; da Silva, BSR; de Oliveira, FF; Domingues, DS; Ferreira, RV; Guyot, R; Ivamoto, ST; Kitzberger, CSG; Labouisse, JP; Leroy, T; Nogueira, LM; Padilha, L; Pagiatto, NF; Pereira, LFP; Pot, D; Sant'Ana, GC; Scholz, MBS; Sera, GH	1
Aquino Neto, FR; Bizzo, HR; Itabaiana Junior, I; Marriott, PJ; Novaes, FJM; Rezende, CM; Souza, ROMA; Sutili, FK	1
Bragagnolo, N; Dos Santos Scholz, MB; Rendón, MY	1
Bizzo, HR; de Aguiar, PF; Godoy, RLO; Leite, SGF; Pacheco, S; Rezende, CM; Tinoco, NAB	1
Barbosa, MSG; Benassi, MT; Kitzberger, CSG; Scholz, MBDS	1
Abalo, R; Alonso, SG; Andres, MIS; Cornejo, FS; Del Castillo, MD; Fernandez-Gomez, B; Guisantes-Batan, E; Iriondo-DeHond, A; Lopez-Gomez, L; Sanchez-Fortun, S; Uranga, JA; Vera, G	1
Ren, Y; Wang, C; Wang, S; Xu, J	1
Cornelio-Santiago, HP; Fukumasu, H; Martinelli, ECL; Momo, C; Oliveira, AL; Oliveira, NA; Raspantini, LER; Raspantini, PC; Sandini, TM	1
Bruns, RE; de Almeida, AG; Marcheafave, GG; Ortiz, MCV; Pauli, ED; Rakocevic, M; Scarminio, IS; Tormena, CD	1
Araújo, AWO; Bastos, MDSR; Comunian, TA; Figueiredo, RW; Magalhães, HCR; Oliveira, AL; Oliveira, WQ; Ribeiro, HL; Sousa, PHM; Wurlitzer, NJ	1
Arunachalam, T; Berrué, F; Burton, IW; Martinez Farina, CF; Newmaster, S; Ragupathy, S	1
Abu Helwa, R; Abu-Gharbieh, E; Barqawi, H; Bustanji, Y; El-Huneidi, W; Eldesouki, S; Qadri, R	1
Bohlmann, J; Celedón, JM; Ivamoto-Suzuki, ST; Kitzberger, CSG; Protasio Pereira, LF; Silva Domingues, D; Yuen, MMS	1

Reviews

14 review(s) available for kahweol and cafestol

Article	Year
Intake levels, sites of action and excretion routes of the cholesterol-elevating diterpenes from coffee beans in humans. Biochemical Society transactions, 1996, Volume: 24, Issue:3 Topics: Coffee; Colon; Diterpenes; Feces; Humans; Hypercholesterolemia; Kidney; Lipid Metabolism; Liver; Thyroid Gland; Urine	1996
The cholesterol-raising factor from coffee beans. Journal of the Royal Society of Medicine, 1996, Volume: 89, Issue:11 Topics: Cholesterol; Coffee; Diterpenes; Drinking Behavior; Female; Humans; Male; Risk Factors	1996
The cholesterol-raising factor from coffee beans. Annual review of nutrition, 1997, Volume: 17 Topics: Animals; Chemical and Drug Induced Liver Injury; Coffee; Coronary Disease; Diterpenes; Humans; Hypercholesterolemia; Infant	1997
Validity of animal models for the cholesterol-raising effects of coffee diterpenes in human subjects. The Proceedings of the Nutrition Society, 1999, Volume: 58, Issue:3 Topics: Animals; Chlorocebus aethiops; Cholesterol; Coffee; Diterpenes; Humans; Lipids; Models, Biological	1999
[Coffea arabica--production, botanical classification, new components and active agents and their pharmacological effects]. Ceska a Slovenska farmacie : casopis Ceske farmaceuticke spolecnosti a Slovenske farmaceuticke spolecnosti, 2000, Volume: 49, Issue:3 Topics: Coffee; Diterpenes; Humans; Seeds	2000
Cafestol and kahweol, two coffee specific diterpenes with anticarcinogenic activity. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2002, Volume: 40, Issue:8 Topics: 9,10-Dimethyl-1,2-benzanthracene; Aflatoxin B1; Animals; Anticarcinogenic Agents; Benzo(a)pyrene; Cells, Cultured; Coffee; Colorectal Neoplasms; Disease Models, Animal; Diterpenes; Enzyme Induction; Humans; Imidazoles	2002
Coffee consumption and human health--beneficial or detrimental?--Mechanisms for effects of coffee consumption on different risk factors for cardiovascular disease and type 2 diabetes mellitus. Molecular nutrition & food research, 2005, Volume: 49, Issue:3 Topics: Animals; Antioxidants; Cardiovascular Diseases; Cholesterol; Coffee; Diabetes Mellitus, Type 2; Diterpenes; Health Promotion; Homocysteine; Humans; Risk Factors	2005
Modification of N-acetyltransferases and glutathione S-transferases by coffee components: possible relevance for cancer risk. Methods in enzymology, 2005, Volume: 401 Topics: Acetyltransferases; Animals; Chemoprevention; Coffee; Diterpenes; Flavonoids; Glucuronosyltransferase; Glutamate-Cysteine Ligase; Glutathione; Glutathione Transferase; Humans; Molecular Structure; Neoplasms; Phenols; Plant Extracts; Polymers; Polyphenols; Pyridinium Compounds; Risk Factors; UDP-Glucuronosyltransferase 1A9	2005
Coffee and health: a review of recent human research. Critical reviews in food science and nutrition, 2006, Volume: 46, Issue:2 Topics: Adult; Caffeine; Carcinoma, Hepatocellular; Cardiovascular Diseases; Child; Chlorogenic Acid; Coffee; Colorectal Neoplasms; Diabetes Mellitus, Type 2; Diterpenes; Female; Glucose Intolerance; Health; Health Promotion; Hip Fractures; Humans; Insulin Resistance; Liver Cirrhosis; Liver Neoplasms; Osteoporosis; Parkinson Disease; Pregnancy; Suicide Prevention	2006
Coffee: biochemistry and potential impact on health. Food & function, 2014, Volume: 5, Issue:8 Topics: Alkaloids; Animals; Antioxidants; Caffeine; Cardiovascular Diseases; Chlorogenic Acid; Coffee; Diabetes Mellitus, Type 2; Disease Models, Animal; Diterpenes; Humans; Maillard Reaction; Meta-Analysis as Topic; Neoplasms; Parkinson Disease; Polymers	2014
Coffee Consumption and Melanoma: A Systematic Review and Meta-Analysis of Observational Studies. American journal of clinical dermatology, 2016, Volume: 17, Issue:2 Topics: Caffeine; Chemoprevention; Chlorogenic Acid; Coffee; Diterpenes; Humans; Male; Melanoma; Observational Studies as Topic; Publication Bias; Quinic Acid; Risk Factors; Skin; Skin Neoplasms; Ultraviolet Rays	2016
Coffee consumption, obesity and type 2 diabetes: a mini-review. European journal of nutrition, 2016, Volume: 55, Issue:4 Topics: Animals; Blood Glucose; Caffeine; Chlorogenic Acid; Coffee; Diabetes Mellitus, Type 2; Disease Models, Animal; Diterpenes; Gastrointestinal Microbiome; Humans; Lipid Metabolism; Metabolomics; Obesity; Polymers; Risk Factors	2016
Cafestol and Kahweol: A Review on Their Bioactivities and Pharmacological Properties. International journal of molecular sciences, 2019, Aug-30, Volume: 20, Issue:17 Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Agents; Apoptosis; Diterpenes; Humans; Hypoglycemic Agents	2019
Recent Updates on the Functional Impact of Kahweol and Cafestol on Cancer. Molecules (Basel, Switzerland), 2022, Oct-28, Volume: 27, Issue:21 Topics: Apoptosis; Coffea; Coffee; Diterpenes; Humans; Neoplasms	2022

Trials

9 trial(s) available for kahweol and cafestol

Article	Year
A placebo-controlled parallel study of the effect of two types of coffee oil on serum lipids and transaminases: identification of chemical substances involved in the cholesterol-raising effect of coffee. The American journal of clinical nutrition, 1995, Volume: 61, Issue:6 Topics: Administration, Oral; Adult; Alanine Transaminase; Body Weight; Cholesterol; Coffee; Diterpenes; Double-Blind Method; Female; gamma-Glutamyltransferase; Humans; Lipids; Male; Middle Aged; Transaminases; Triglycerides	1995
Effects of cafestol and kahweol from coffee grounds on serum lipids and serum liver enzymes in humans. The American journal of clinical nutrition, 1995, Volume: 61, Issue:1 Topics: Adult; Alanine Transaminase; Cholesterol; Coffee; Creatinine; Diterpenes; Female; gamma-Glutamyltransferase; Humans; Lipids; Liver; Male; Particle Size; Patient Compliance; Triglycerides	1995
Identity of the cholesterol-raising factor from boiled coffee and its effects on liver function enzymes. Journal of lipid research, 1994, Volume: 35 Topics: Adult; Alanine Transaminase; Cholesterol; Coffee; Cooking; Cross-Sectional Studies; Diterpenes; Double-Blind Method; Female; gamma-Glutamyltransferase; Humans; Lipids; Male; Norway; Palmitates; Triglycerides	1994
End of the coffee mystery: diterpene alcohols raise serum low-density lipoprotein cholesterol and triglyceride levels. Journal of internal medicine, 1994, Volume: 235, Issue:2 Topics: Adult; Cholesterol, LDL; Coffee; Diterpenes; Female; Humans; Male; Triglycerides	1994
Separate effects of the coffee diterpenes cafestol and kahweol on serum lipids and liver aminotransferases. The American journal of clinical nutrition, 1997, Volume: 65, Issue:2 Topics: Administration, Oral; Adult; Coffee; Cross-Over Studies; Diterpenes; Double-Blind Method; Drug Combinations; Humans; Lipids; Liver; Male; Random Allocation; Transaminases	1997
Diterpenes from coffee beans decrease serum levels of lipoprotein(a) in humans: results from four randomised controlled trials. European journal of clinical nutrition, 1997, Volume: 51, Issue:7 Topics: Adult; Coffee; Diterpenes; Female; Humans; Lipid Metabolism; Lipoprotein(a); Male	1997
The cholesterol-raising diterpenes from coffee beans increase serum lipid transfer protein activity levels in humans. Atherosclerosis, 1997, Jul-25, Volume: 132, Issue:2 Topics: Adult; Carrier Proteins; Coffee; Diterpenes; Humans; Lipoproteins, HDL; Lipoproteins, LDL; Lipoproteins, VLDL; Male	1997
Absorption and urinary excretion of the coffee diterpenes cafestol and kahweol in healthy ileostomy volunteers. Journal of internal medicine, 1998, Volume: 244, Issue:6 Topics: Adult; Aged; Coffee; Diterpenes; Drug Stability; Duodenum; Female; Humans; Ileostomy; Intestinal Absorption; Male; Middle Aged; Random Allocation	1998
Consumption of French-press coffee raises cholesteryl ester transfer protein activity levels before LDL cholesterol in normolipidaemic subjects. Journal of internal medicine, 2000, Volume: 248, Issue:3 Topics: Adult; Aged; Carrier Proteins; Cholesterol Ester Transfer Proteins; Cholesterol, LDL; Coffee; Diterpenes; Female; Glycoproteins; Humans; Male; Membrane Proteins; Middle Aged; Phosphatidylcholine-Sterol O-Acyltransferase; Phospholipid Transfer Proteins	2000

Other Studies

53 other study(ies) available for kahweol and cafestol

Article	Year
Kahweol and cafestol: inhibitors of hamster buccal pouch carcinogenesis. Nutrition and cancer, 1991, Volume: 15, Issue:1 Topics: Animals; Cheek; Coffee; Cricetinae; Diterpenes; Fabaceae; Female; Mesocricetus; Mouth Neoplasms; Plants, Medicinal	1991
Inhibition of hamster buccal pouch carcinogenesis by green coffee beans. Oral surgery, oral medicine, and oral pathology, 1988, Volume: 65, Issue:6 Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Coffee; Cricetinae; Diterpenes; Female; Mesocricetus; Mouth Neoplasms	1988
Effects of derivatives of kahweol and cafestol on the activity of glutathione S-transferase in mice. Journal of medicinal chemistry, 1987, Volume: 30, Issue:8 Topics: Animals; Chemical Phenomena; Chemistry; Diterpenes; Enzyme Induction; Female; Glutathione Transferase; Intestinal Mucosa; Liver; Lung; Mice; Mice, Inbred ICR; Stomach; Structure-Activity Relationship; Sulfhydryl Compounds	1987
Coffee oil consumption does not affect serum cholesterol in rhesus and cebus monkeys. The Journal of nutrition, 1995, Volume: 125, Issue:9 Topics: Alanine Transaminase; Animals; Body Weight; Cebus; Cholesterol; Coffee; Cross-Over Studies; Diterpenes; Female; Macaca mulatta; Male; Random Allocation; Triglycerides	1995
Placental glutathione S-transferase (GST-P) induction as a potential mechanism for the anti-carcinogenic effect of the coffee-specific components cafestol and kahweol. Carcinogenesis, 1996, Volume: 17, Issue:11 Topics: Animals; Anticarcinogenic Agents; Behavior, Animal; Blotting, Northern; Diterpenes; Dose-Response Relationship, Drug; Enzyme Induction; Female; Glutathione Transferase; Immunohistochemistry; Isoenzymes; Liver; Male; Placenta; Rats; Rats, Sprague-Dawley; RNA, Messenger	1996
Analysis of the content of the diterpenes cafestol and kahweol in coffee brews. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 1997, Volume: 35, Issue:6 Topics: Cholesterol; Chromatography, High Pressure Liquid; Coffee; Diterpenes; Dose-Response Relationship, Drug; Food Analysis; Humans; Sensitivity and Specificity	1997
Effect of coffee lipids (cafestol and kahweol) on regulation of cholesterol metabolism in HepG2 cells. Arteriosclerosis, thrombosis, and vascular biology, 1997, Volume: 17, Issue:10 Topics: Bile Acids and Salts; Cell Line; Cholesterol; Cholesterol Esters; Diterpenes; Humans; Hydroxymethylglutaryl CoA Reductases; L-Lactate Dehydrogenase; Lipoproteins, LDL; Promoter Regions, Genetic; Receptors, LDL; RNA, Messenger	1997
Cafestol, the cholesterol-raising factor in boiled coffee, suppresses bile acid synthesis by downregulation of cholesterol 7 alpha-hydroxylase and sterol 27-hydroxylase in rat hepatocytes. Arteriosclerosis, thrombosis, and vascular biology, 1997, Volume: 17, Issue:11 Topics: Animals; Bile Acids and Salts; Cholestanetriol 26-Monooxygenase; Cholesterol; Cholesterol 7-alpha-Hydroxylase; Cholesterol Esters; Coffee; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Diterpenes; Enzyme Induction; Hot Temperature; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Synthase; Hypercholesterolemia; Liver; Male; Rats; Rats, Wistar; Receptors, LDL; RNA, Messenger; Steroid Hydroxylases; Terpenes; Transcription, Genetic; Triglycerides	1997
Cancer chemoprevention from the food-borne carcinogen 2-amino-1-methyl-6-phenylimidazol[4,5-b]pyridine: reconsideration of the evidence. Mutation research, 1997, Nov-28, Volume: 381, Issue:2 Topics: Animals; Anticarcinogenic Agents; Biotransformation; Carcinogens; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP1A2; Diterpenes; Enzyme Induction; Genotype; Hot Temperature; Humans; Hydroxylation; Imidazoles; Inactivation, Metabolic; Male; Meat; Microsomes, Liver; Oxidation-Reduction; Phytotherapy; Rats; Rats, Inbred F344; Tea	1997
Effect of a coffee lipid (cafestol) on cholesterol metabolism in human skin fibroblasts. Journal of lipid research, 1998, Volume: 39, Issue:4 Topics: Acetates; Cells, Cultured; Cholesterol; Cholesterol Esters; Coffee; Diterpenes; Dose-Response Relationship, Drug; Fibroblasts; Gene Expression; Humans; Hydroxycholesterols; Lipids; Lipoproteins, LDL; Oleic Acid; Promoter Regions, Genetic; Receptors, LDL; RNA, Messenger; Skin; Sterol O-Acyltransferase	1998
The coffee-specific diterpenes cafestol and kahweol protect against aflatoxin B1-induced genotoxicity through a dual mechanism. Carcinogenesis, 1998, Volume: 19, Issue:8 Topics: Aflatoxin B1; Animals; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Cytochrome P450 Family 2; Diterpenes; DNA Adducts; Dose-Response Relationship, Drug; Glutathione Transferase; Male; Membrane Proteins; Rats; Rats, Sprague-Dawley; Steroid 16-alpha-Hydroxylase; Steroid Hydroxylases	1998
Coffee, alcohol, and the liver. Annals of epidemiology, 1999, Volume: 9, Issue:7 Topics: Alanine Transaminase; Alcohol Drinking; Animals; Caffeine; Cebus; Clinical Trials as Topic; Coffee; Cricetinae; Diterpenes; Female; gamma-Glutamyltransferase; Gerbillinae; Humans; Liver; Liver Cirrhosis, Alcoholic; Liver Diseases; Macaca mulatta; Male; Rabbits; Randomized Controlled Trials as Topic; Rats; Research; Risk Factors	1999
Rapid analysis of cholesterol-elevating compounds in coffee brews by off-line high-performance liquid chromatography/high-resolution gas chromatography. Journal of agricultural and food chemistry, 1999, Volume: 47, Issue:4 Topics: Cholesterol; Chromatography, Gas; Chromatography, High Pressure Liquid; Coffee; Cooking; Diterpenes; Food Handling; Humans	1999
Protective effects of coffee diterpenes against aflatoxin B1-induced genotoxicity: mechanisms in rat and human cells. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2001, Volume: 39, Issue:6 Topics: Aflatoxin B1; Animals; Blotting, Western; Cells, Cultured; Chemoprevention; Coffee; Cytochrome P-450 Enzyme System; Diterpenes; DNA Adducts; Dose-Response Relationship, Drug; Gene Expression Regulation, Enzymologic; Hepatocytes; Humans; Liver; Rats; Rats, Sprague-Dawley	2001
Elevation of glutathione levels by coffee components and its potential mechanisms. Advances in experimental medicine and biology, 2001, Volume: 500 Topics: Animals; Coffee; Colon; Diterpenes; Glutathione; Glutathione Disulfide; Liver; Male; Oxidative Stress; Rats; Rats, Inbred F344; Thiobarbituric Acid Reactive Substances	2001
The coffee components kahweol and cafestol induce gamma-glutamylcysteine synthetase, the rate limiting enzyme of chemoprotective glutathione synthesis, in several organs of the rat. Archives of toxicology, 2002, Volume: 75, Issue:11-12 Topics: Aminoacyltransferases; Animals; Antimutagenic Agents; Colon; Diet; Diterpenes; Dose-Response Relationship, Drug; Enzyme Induction; Glutathione; Kidney; Liver; Lung; Male; Rats; Rats, Inbred F344; RNA, Messenger	2002
Enhancement of the chemoprotective enzymes glucuronosyl transferase and glutathione transferase in specific organs of the rat by the coffee components kahweol and cafestol. Archives of toxicology, 2002, Volume: 76, Issue:4 Topics: Animals; Coffee; Digestive System; Diterpenes; Exocrine Glands; Glucuronosyltransferase; Glutathione Transferase; Lung; Male; Myocardium; Organ Specificity; Rats; Rats, Inbred F344; Spleen; Testis; Urinary Tract	2002
Coffee and its chemopreventive components Kahweol and Cafestol increase the activity of O6-methylguanine-DNA methyltransferase in rat liver--comparison with phase II xenobiotic metabolism. Mutation research, 2003, Jan-28, Volume: 522, Issue:1-2 Topics: Animals; Coffee; Diterpenes; DNA Modification Methylases; Liver; Male; Rats; Xenobiotics	2003
Enhancement of glutathione and g-glutamylcysteine synthetase, the rate limiting enzyme of glutathione synthesis, by chemoprotective plant-derived food and beverage components in the human hepatoma cell line HepG2. Nutrition and cancer, 2003, Volume: 45, Issue:1 Topics: 4-Butyrolactone; Allyl Compounds; Animals; Anticarcinogenic Agents; Cell Line, Tumor; Diterpenes; Dose-Response Relationship, Drug; Glutamate-Cysteine Ligase; Glutathione; Glutathione Synthase; Hepatoblastoma; Humans; Isothiocyanates; Liver; Liver Neoplasms; Quercetin; Sulfides	2003
Coffee diterpenes prevent benzo[a]pyrene genotoxicity in rat and human culture systems. Biochemical and biophysical research communications, 2003, Jun-27, Volume: 306, Issue:2 Topics: Animals; Benzo(a)pyrene; Blotting, Western; Cell Survival; Cells, Cultured; Coffee; Cytochrome P-450 CYP1A1; Diterpenes; DNA; Dose-Response Relationship, Drug; Enzyme Inhibitors; Ethacrynic Acid; Glutathione Transferase; Humans; Rats; Rats, Sprague-Dawley; Time Factors; Tumor Cells, Cultured	2003
Suppressive effects of the kahweol and cafestol on cyclooxygenase-2 expression in macrophages. FEBS letters, 2004, Jul-02, Volume: 569, Issue:1-3 Topics: Animals; Cell Line; Coffee; Cyclooxygenase 2; Diterpenes; I-kappa B Proteins; Isoenzymes; Lipopolysaccharides; Macrophages; Mice; NF-kappa B; NF-KappaB Inhibitor alpha; Promoter Regions, Genetic; Prostaglandin-Endoperoxide Synthases; RNA, Messenger; Transcription, Genetic	2004
Coffee diterpenes prevent the genotoxic effects of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) and N-nitrosodimethylamine in a human derived liver cell line (HepG2). Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2005, Volume: 43, Issue:3 Topics: Analysis of Variance; Cell Line, Tumor; Coffee; Cytochrome P-450 Enzyme System; Dimethylnitrosamine; Diterpenes; Dose-Response Relationship, Drug; Glutathione Transferase; Humans; Imidazoles; Liver; Micronucleus Tests; Mutagens; Nitrosamines; Sulfotransferases	2005
[Negligible amounts of cholesterol-raising diterpenes in coffee made with coffee pads in comparison with unfiltered coffee]. Nederlands tijdschrift voor geneeskunde, 2006, Dec-30, Volume: 150, Issue:52 Topics: Cholesterol; Coffee; Diterpenes; Humans; Lipid Metabolism	2006
Coffee consumption protects human lymphocytes against oxidative and 3-amino-1-methyl-5H-pyrido[4,3-b]indole acetate (Trp-P-2) induced DNA-damage: results of an experimental study with human volunteers. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2007, Volume: 45, Issue:8 Topics: Adult; Carbolines; Cell Survival; Coffee; Comet Assay; Diterpenes; DNA; DNA Damage; Electrophoresis; Glutathione Peroxidase; Humans; Lymphocytes; Middle Aged; Oxidative Stress; Reactive Oxygen Species; Superoxide Dismutase	2007
Hepatoprotective and antioxidant effects of the coffee diterpenes kahweol and cafestol on carbon tetrachloride-induced liver damage in mice. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2007, Volume: 45, Issue:11 Topics: Animals; Antioxidants; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Cytochrome P-450 CYP2E1; Diterpenes; Free Radical Scavengers; Gene Expression Regulation, Enzymologic; Glutathione; Lipid Peroxidation; Liver; Liver Diseases; Male; Mice; Mice, Inbred ICR; Molecular Structure; Superoxides	2007
Protective effects of kahweol and cafestol against hydrogen peroxide-induced oxidative stress and DNA damage. Toxicology letters, 2007, Sep-10, Volume: 173, Issue:2 Topics: Animals; Cell Survival; Comet Assay; Diterpenes; DNA Damage; Dose-Response Relationship, Drug; Fibroblasts; Free Radical Scavengers; Guanine; Hydrogen Peroxide; Hydroxyl Radical; Lipid Peroxidation; Mice; NIH 3T3 Cells; Oxidants; Oxidative Stress; Reactive Oxygen Species; Superoxides; Time Factors	2007
Effects of coffee and its chemopreventive components kahweol and cafestol on cytochrome P450 and sulfotransferase in rat liver. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2008, Volume: 46, Issue:4 Topics: Animals; Anticarcinogenic Agents; Arylsulfotransferase; Coffee; Cytochrome P-450 Enzyme System; Diterpenes; Filtration; Isoenzymes; Liver; Male; Nuclease Protection Assays; Rats; Rats, Inbred F344; RNA	2008
Induction of cancer chemopreventive enzymes by coffee is mediated by transcription factor Nrf2. Evidence that the coffee-specific diterpenes cafestol and kahweol confer protection against acrolein. Toxicology and applied pharmacology, 2008, Feb-01, Volume: 226, Issue:3 Topics: Acrolein; Administration, Oral; Animals; Anticarcinogenic Agents; Coffee; Diet; Diterpenes; Dose-Response Relationship, Drug; Enzyme Induction; Gene Expression Regulation, Enzymologic; Gene Silencing; Glutathione Transferase; Intestine, Small; Isoenzymes; Liver; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; NAD(P)H Dehydrogenase (Quinone); NADPH Dehydrogenase; NF-E2-Related Factor 2; Response Elements; RNA, Messenger; Transcriptional Activation; Up-Regulation	2008
The multifaceted mechanisms for coffee's anti-tumorigenic effect on liver. Medical hypotheses, 2008, Volume: 71, Issue:5 Topics: Animals; Anticarcinogenic Agents; Antioxidants; Caffeine; Chlorogenic Acid; Coffee; Diterpenes; Humans; Intracellular Signaling Peptides and Proteins; Kelch-Like ECH-Associated Protein 1; Liver; Liver Neoplasms; Models, Biological; NF-E2-Related Factor 2; Response Elements	2008
The role of epoxidation and electrophile-responsive element-regulated gene transcription in the potentially beneficial and harmful effects of the coffee components cafestol and kahweol. The Journal of nutritional biochemistry, 2010, Volume: 21, Issue:8 Topics: Animals; Bile; Cell Line, Tumor; Chromatography, Liquid; Coffee; Diterpenes; Epoxy Compounds; Gene Expression Regulation; Humans; Male; Mass Spectrometry; Mice; Mice, Inbred C57BL; Transcription, Genetic	2010
Differential reactivity of purified bioactive coffee furans, cafestol and kahweol, with acidic nitrite: product characterization and factors controlling nitrosation versus ring-opening pathways. Chemical research in toxicology, 2009, Volume: 22, Issue:12 Topics: Cholesterol; Chromatography, High Pressure Liquid; Coffee; Diterpenes; Furans; Humans; Hydrogen-Ion Concentration; Nitrites; Triglycerides	2009
Evaluation of kahweol and cafestol in coffee tissues and roasted coffee by a new high-performance liquid chromatography methodology. Journal of agricultural and food chemistry, 2010, Jan-13, Volume: 58, Issue:1 Topics: Chromatography, High Pressure Liquid; Chromatography, Reverse-Phase; Coffea; Diterpenes; Food Handling; Fruit; Plant Extracts; Plant Leaves	2010
Cholesterol-raising diterpenes in types of coffee commonly consumed in Singapore, Indonesia and India and associations with blood lipids: a survey and cross sectional study. Nutrition journal, 2011, May-15, Volume: 10 Topics: Adult; Cholesterol; Coffee; Cross-Sectional Studies; Diterpenes; Female; Food Handling; Humans; India; Indonesia; Interviews as Topic; Male; Middle Aged; Plant Preparations; Prospective Studies; Singapore; Surveys and Questionnaires; Triglycerides	2011
What is it about coffee? Research is showing benefits for everything from depression to liver disease. Is it just the caffeine? Harvard health letter, 2012, Volume: 37, Issue:3 Topics: Antioxidants; Caffeine; Central Nervous System Stimulants; Chlorogenic Acid; Cholesterol; Coffee; Diterpenes; Filtration; Humans; Trace Elements; Vitamins	2012
Natural diterpenes from coffee, cafestol and kahweol induce apoptosis through regulation of specificity protein 1 expression in human malignant pleural mesothelioma. Journal of biomedical science, 2012, Jun-26, Volume: 19 Topics: Apoptosis; Biomarkers, Tumor; Cell Survival; Coffee; Diterpenes; Gene Expression Regulation, Neoplastic; Humans; Lung Neoplasms; Mesothelioma; Receptors, Immunologic	2012
Authentication of Italian Espresso coffee blends through the GC peak ratio between kahweol and 16-O-methylcafestol. Food chemistry, 2012, Dec-01, Volume: 135, Issue:3 Topics: Chromatography, Gas; Coffea; Coffee; Diterpenes; Quality Control	2012
Microwave-assisted methanolysis of green coffee oil. Food chemistry, 2012, Sep-15, Volume: 134, Issue:2 Topics: Chemical Fractionation; Chromatography, High Pressure Liquid; Coffea; Diterpenes; Methanol; Microwaves; Plant Oils; Temperature	2012
Optimization of the isolation and quantitation of kahweol and cafestol in green coffee oil. Talanta, 2013, Dec-15, Volume: 117 Topics: Chromatography, Gas; Coffea; Diterpenes; Esters; Factor Analysis, Statistical; Liquid-Liquid Extraction; Mass Spectrometry; Plant Oils; Temperature	2013
An epidemiological study of the association of coffee with chronic liver disease. Scottish medical journal, 2013, Volume: 58, Issue:4 Topics: Caffeine; Case-Control Studies; Coffee; Diterpenes; End Stage Liver Disease; Female; Humans; Liver Cirrhosis; Logistic Models; Male; Middle Aged; Prevalence; Protective Agents; Reproducibility of Results; Scotland; Surveys and Questionnaires	2013
New approaches on the analyses of thermolabile coffee diterpenes by gas chromatography and its relationship with cup quality. Talanta, 2015, Jul-01, Volume: 139 Topics: Chromatography, Gas; Chromatography, High Pressure Liquid; Coffee; Diterpenes; Microwaves; Plant Oils; Quality Control	2015
Natural Diterpenes from Coffee, Cafestol, and Kahweol Induce Peripheral Antinoceception by Adrenergic System Interaction. Planta medica, 2016, Volume: 82, Issue:1-2 Topics: Analgesics; Animals; Coffee; Diterpenes; Male; Molecular Structure; Rats; Rats, Wistar; Receptors, Adrenergic; Receptors, Adrenergic, alpha-2	2016
Diterpenes biochemical profile and transcriptional analysis of cytochrome P450s genes in leaves, roots, flowers, and during Coffea arabica L. fruit development. Plant physiology and biochemistry : PPB, 2017, Volume: 111 Topics: Chromatography, High Pressure Liquid; Coffea; Cytochrome P-450 Enzyme System; Diterpenes; Flowers; Fruit; Gene Expression Regulation, Plant; Genes, Plant; Genetic Association Studies; Plant Leaves; Plant Proteins; Plant Roots; Transcription, Genetic	2017
Genome-wide association study reveals candidate genes influencing lipids and diterpenes contents in Coffea arabica L. Scientific reports, 2018, 01-11, Volume: 8, Issue:1 Topics: Biosynthetic Pathways; Coffea; Diterpenes; Genome-Wide Association Study; Lipids; Plant Proteins; Polymorphism, Single Nucleotide; Quantitative Trait Loci; Sequence Analysis, DNA	2018
Lipase-catalysed esters synthesis of cafestol and kahweol. Food chemistry, 2018, Sep-01, Volume: 259 Topics: Biocatalysis; Chromatography, Gas; Chromatography, High Pressure Liquid; Coffee; Diterpenes; Esters; Lipase	2018
Physical characteristics of the paper filter and low cafestol content filter coffee brews. Food research international (Ottawa, Ont.), 2018, Volume: 108 Topics: Chromatography, High Pressure Liquid; Coffee; Cooking; Diterpenes; Equipment Design; Filtration; Food Analysis; Hot Temperature; Paper; Particle Size; Permeability; Porosity; Tandem Mass Spectrometry	2018
Reduction of Food research international (Ottawa, Ont.), 2019, Volume: 115 Topics: Beverages; Caffeine; Coffee; Diterpenes; Fermentation; Food Handling; Hydrogen-Ion Concentration; Quinic Acid; Saccharomyces cerevisiae; Temperature; Time Factors	2019
Correlation between the composition of green Arabica coffee beans and the sensory quality of coffee brews. Food chemistry, 2019, Sep-15, Volume: 292 Topics: Caffeine; Chlorogenic Acid; Cluster Analysis; Coffee; Diterpenes; Food Quality; Principal Component Analysis; Spectroscopy, Near-Infrared	2019
Bioaccesibility, Metabolism, and Excretion of Lipids Composing Spent Coffee Grounds. Nutrients, 2019, Jun-23, Volume: 11, Issue:6 Topics: Animals; Biological Availability; Biotransformation; Coffea; Diterpenes; Fatty Acids; Feces; Female; Gastrointestinal Motility; Intestinal Elimination; Liver; Male; Pilot Projects; Rats, Wistar; Seeds; Time Factors	2019
Acute and subacute (28 days) toxicity of green coffee oil enriched with diterpenes cafestol and kahweol in rats. Regulatory toxicology and pharmacology : RTP, 2020, Volume: 110 Topics: Administration, Oral; Animals; Coffea; Diterpenes; Female; Male; Plant Oils; Rats, Wistar; Toxicity Tests, Acute; Toxicity Tests, Subacute	2020
Factorial design fingerprint discrimination of Coffea arabica beans under elevated carbon dioxide and limited water conditions. Talanta, 2020, Mar-01, Volume: 209 Topics: Biosynthetic Pathways; Caffeine; Carbon Dioxide; Chlorogenic Acid; Coffea; Diterpenes; Droughts; Metabolome; Seeds; Water	2020
Complex coacervates of cashew gum and gelatin as carriers of green coffee oil: The effect of microcapsule application on the rheological and sensorial quality of a fruit juice. Food research international (Ottawa, Ont.), 2020, Volume: 131 Topics: Anacardium; Capsules; Chromatography, Gas; Coffee; Consumer Behavior; Diterpenes; Food Handling; Food Technology; Fruit and Vegetable Juices; Gelatin; Humans; Oxidation-Reduction; Plant Oils; Rheology; Smell; Tamarindus; Taste	2020
Quantitative NMR Methodology for the Authentication of Roasted Coffee and Prediction of Blends. Journal of agricultural and food chemistry, 2020, Dec-09, Volume: 68, Issue:49 Topics: Alkaloids; Caffeine; Coffea; Coffee; Cooking; Discriminant Analysis; Diterpenes; Food Contamination; Magnetic Resonance Spectroscopy; Seeds	2020
Functional Characterization of Journal of agricultural and food chemistry, 2023, Oct-25, Volume: 71, Issue:42 Topics: Alkyl and Aryl Transferases; Coffea; Diterpenes; Diterpenes, Kaurane; Humans; Plant Proteins	2023