kaempferol has been researched along with galangin* in 3 studies
3 other study(ies) available for kaempferol and galangin
| Article | Year |
|---|---|
Relationships between structures of hydroxyflavones and their antioxidative effects.
Even hydroxyflavones show diverse biological functions, they have two common features such as showing antioxidative effects and containing hydroxyl groups. The authors tested the antioxidative effects of thirty hydroxyflavones using 1,1-diphenyl-2-picrylhydrazyl radical scavenging assay. While the scavenging activity of galangin, 3,5,7-trihydroxyflavone was 52.5%, fisetin, 3,7,3',4'-tetrahydroxyflavone showed 85.2%. To investigate the relationships between the structures of hydroxyflavones and their antioxidative effects, the three-dimensional quantitative structure-activity relationships were examined. Topics: Antioxidants; Flavones; Flavonoids; Flavonols; Free Radical Scavengers; Models, Molecular; Quantitative Structure-Activity Relationship | 2010 |
Melanogenesis inhibitors from the rhizomes of Alpinia officinarum in B16 melanoma cells.
The 80% aqueous acetone extract from the rhizomes of Alpinia officinarum, a Chinese medicinal herb, were found to inhibit melanogenesis in theophylline-stimulated murine B16 melanoma 4A5 cells. Among the constituents isolated, four diarylheptanoids [5-hydroxy-1,7-diphenyl-3-heptanone, 7-(4('')-hydroxy-3('')-methoxyphenyl)-1-phenylhept-4-en-3-one, 5-hydroxy-7-(4('')-hydroxy-3('')-methoxyphenyl)-1-phenyl-3-heptanone, and 3,5-dihydroxy-1,7-diphenylheptane] and two flavonol constituents (kaempferide and galangin) inhibited melanogenesis with IC(50) values of 10-48microM, and several structural requirements of the active constituents for the inhibition were clarified. In addition, 7-(4('')-hydroxy-3('')-methoxyphenyl)-1-phenylhept-4-en-3-one, kaempferide, and galangin inhibited mRNA expression of tyrosinase and tyrosinase-related proteins-1 and -2, and the protein level of a microphthalmia-associated transcription factor. Topics: Alpinia; Animals; Antineoplastic Agents; Enzyme Inhibitors; Flavonoids; Kaempferols; Melanoma, Experimental; Mice; Monophenol Monooxygenase; Oxidoreductases; Rhizome | 2009 |
B-ring substituted 5,7-dihydroxyflavonols with high-affinity binding to P-glycoprotein responsible for cell multidrug resistance.
Starting from the interaction of galangin (3,5,7-trihydroxyflavone) with a cytosolic nucleotide-binding domain of P-glycoprotein, a series of flavonol derivatives was synthesized and tested for their binding affinity towards the same target. The 5,7-dihydroxy-4'-iodoflavonol and 5,7-dihydroxy-4'-n-octylflavonol derivatives displayed much higher binding affinities, with respective increases of 6- and 93-fold as compared to galangin. Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Binding Sites; Chalcone; Drug Resistance, Multiple; Flavonoids; Flavonols; Fluorescence; Kaempferols; Molecular Structure; Protein Binding; Protein Structure, Tertiary; Quercetin; Recombinant Proteins; Thermodynamics; Tryptophan | 2001 |