kaempferol-7-o-glucoside and kaempferol

kaempferol-7-o-glucoside has been researched along with kaempferol* in 2 studies

Other Studies

2 other study(ies) available for kaempferol-7-o-glucoside and kaempferol

Article	Year
Antitumor, antioxidant and anti-inflammatory activities of kaempferol and its corresponding glycosides and the enzymatic preparation of kaempferol. PloS one, 2018, Volume: 13, Issue:5 Kaempferol (kae) and its glycosides are widely distributed in nature and show multiple bioactivities, yet few reports have compared them. In this paper, we report the antitumor, antioxidant and anti-inflammatory activity differences of kae, kae-7-O-glucoside (kae-7-O-glu), kae-3-O-rhamnoside (kae-3-O-rha) and kae-3-O-rutinoside (kae-3-O-rut). Kae showed the highest antiproliferation effect on the human hepatoma cell line HepG2, mouse colon cancer cell line CT26 and mouse melanoma cell line B16F1. Kae also significantly inhibited AKT phosphorylation and cleaved caspase-9, caspase-7, caspase-3 and PARP in HepG2 cells. A kae-induced increase in DPPH and ABTS radical scavenging activity, inhibition of concanavalin A (Con A)-induced activation of T cell proliferation and NO or ROS production in LPS-induced RAW 264.7 macrophage cells were also seen. Kae glycosides were used to produce kae via environment-friendly enzymatic hydrolysis. Kae-7-O-glu and kae-3-O-rut were hydrolyzed to kae by β-glucosidase and/or α-L-rhamnosidase. This paper demonstrates the application of enzymatic catalysis to obtain highly biologically active kae. This work provides a novel and efficient preparation of high-value flavone-related products. Topics: Animals; Anti-Inflammatory Agents; Antineoplastic Agents, Phytogenic; Antioxidants; Apoptosis; beta-Glucosidase; Cell Division; Cell Line, Tumor; Drug Evaluation, Preclinical; Free Radicals; Glucosides; Glycoside Hydrolases; Glycosides; Humans; Hydrolysis; Kaempferols; Lymphocyte Activation; Mice; Nitric Oxide; Reactive Oxygen Species; Recombinant Proteins	2018
Antityrosinase principles and constituents of the petals of Crocus sativus. Journal of natural products, 2004, Volume: 67, Issue:3 Three new monoterpenoids, crocusatin-J (1), -K (2), and -L (3), and a new naturally occurring acid, (3S),4-dihydroxybutyric acid (4), together with 31 known compounds were isolated and identified from the methanol extract of the petals of saffron (Crocus sativus). Their structures were established by spectroscopic methods. Among them, crocusatin-K (2), crocusatin-L (3), and 4-hydroxy-3,5,5-trimethylcyclohex-2-enone (8) showed significant antityrosinase activity, and protocatechuic acid (18), kaempferol (24), and kaempferol 7-O-beta-d-glucopyranoside (27) were more effective in scavenging alpha,alpha-diphenyl-beta-picrylhydrazyl (DPPH) radicals than alpha-tocopherol. In addition, the mechanism of tyrosinase inhibition by crocusatin-K (2) is also discussed. Topics: China; Crocus; Enzyme Inhibitors; Flowers; Free Radical Scavengers; Hydroxybutyrates; Kaempferols; Molecular Structure; Monophenol Monooxygenase; Monoterpenes; Nuclear Magnetic Resonance, Biomolecular; Plants, Medicinal	2004

Article

Year

Antitumor, antioxidant and anti-inflammatory activities of kaempferol and its corresponding glycosides and the enzymatic preparation of kaempferol.

PloS one, 2018, Volume: 13, Issue:5

Kaempferol (kae) and its glycosides are widely distributed in nature and show multiple bioactivities, yet few reports have compared them. In this paper, we report the antitumor, antioxidant and anti-inflammatory activity differences of kae, kae-7-O-glucoside (kae-7-O-glu), kae-3-O-rhamnoside (kae-3-O-rha) and kae-3-O-rutinoside (kae-3-O-rut). Kae showed the highest antiproliferation effect on the human hepatoma cell line HepG2, mouse colon cancer cell line CT26 and mouse melanoma cell line B16F1. Kae also significantly inhibited AKT phosphorylation and cleaved caspase-9, caspase-7, caspase-3 and PARP in HepG2 cells. A kae-induced increase in DPPH and ABTS radical scavenging activity, inhibition of concanavalin A (Con A)-induced activation of T cell proliferation and NO or ROS production in LPS-induced RAW 264.7 macrophage cells were also seen. Kae glycosides were used to produce kae via environment-friendly enzymatic hydrolysis. Kae-7-O-glu and kae-3-O-rut were hydrolyzed to kae by β-glucosidase and/or α-L-rhamnosidase. This paper demonstrates the application of enzymatic catalysis to obtain highly biologically active kae. This work provides a novel and efficient preparation of high-value flavone-related products.

Topics: Animals; Anti-Inflammatory Agents; Antineoplastic Agents, Phytogenic; Antioxidants; Apoptosis; beta-Glucosidase; Cell Division; Cell Line, Tumor; Drug Evaluation, Preclinical; Free Radicals; Glucosides; Glycoside Hydrolases; Glycosides; Humans; Hydrolysis; Kaempferols; Lymphocyte Activation; Mice; Nitric Oxide; Reactive Oxygen Species; Recombinant Proteins

2018

Antityrosinase principles and constituents of the petals of Crocus sativus.

Journal of natural products, 2004, Volume: 67, Issue:3

Three new monoterpenoids, crocusatin-J (1), -K (2), and -L (3), and a new naturally occurring acid, (3S),4-dihydroxybutyric acid (4), together with 31 known compounds were isolated and identified from the methanol extract of the petals of saffron (Crocus sativus). Their structures were established by spectroscopic methods. Among them, crocusatin-K (2), crocusatin-L (3), and 4-hydroxy-3,5,5-trimethylcyclohex-2-enone (8) showed significant antityrosinase activity, and protocatechuic acid (18), kaempferol (24), and kaempferol 7-O-beta-d-glucopyranoside (27) were more effective in scavenging alpha,alpha-diphenyl-beta-picrylhydrazyl (DPPH) radicals than alpha-tocopherol. In addition, the mechanism of tyrosinase inhibition by crocusatin-K (2) is also discussed.

Topics: China; Crocus; Enzyme Inhibitors; Flowers; Free Radical Scavengers; Hydroxybutyrates; Kaempferols; Molecular Structure; Monophenol Monooxygenase; Monoterpenes; Nuclear Magnetic Resonance, Biomolecular; Plants, Medicinal

2004