kaempferol-3-o-rutinoside and acacetin

Brickellia cavanillesii (Asteraceae) (Cass.) A. Gray is one of the popular plants consumed in Central America and Mexico for the treatment of several diseases such as hypertension, diabetes and anxiety, among others.. To determine the anxiolytic-like effect of B. Cavanillesii and the safety of its use through toxicological studies.. Anxiolytic-like effects of soluble-methanol extract of B. cavanillesii (MEBc) were evaluated in ambulatory activity (open-field test), hole-board test, cylinder of exploration, the elevated plus-maze and the potentiation of the sodium pentobarbital-induced hypnosis mice models. On the other hand, in vivo toxicological studies were conducted on acute and sub-acute mice models recommended by OECD. Active MEBc was subjected to phytochemical studies through conventional chromatographic techniques to isolate bioactive compounds.. In current investigation, we have shown that MEBc has a wide range of pharmacology-toxicology patterns. The results support further investigation of MEBc as a potential anxiolytic phytomedicinal agent.

Topics: Animals; Anti-Anxiety Agents; Anxiety; Asteraceae; Behavior, Animal; Consciousness; Disease Models, Animal; Dose-Response Relationship, Drug; Exploratory Behavior; Flavones; Flavonoids; Lethal Dose 50; Male; Maze Learning; Mice; Motor Activity; Pentobarbital; Phenols; Phytotherapy; Plant Components, Aerial; Plant Extracts; Plants, Medicinal; Risk Assessment; Sleep; Time Factors; Toxicity Tests, Acute; Toxicity Tests, Subchronic