k 76 carboxylic acid has been researched along with sesquiterpenes in 39 studies
| Studies (k 76 carboxylic acid) | Trials (k 76 carboxylic acid) | Recent Studies (post-2010) (k 76 carboxylic acid) | Studies (sesquiterpenes) | Trials (sesquiterpenes) | Recent Studies (post-2010) (sesquiterpenes) |
|---|---|---|---|---|---|
| 39 | 0 | 1 | 17,489 | 536 | 7,668 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 13 (33.33) | 18.7374 |
| 1990's | 17 (43.59) | 18.2507 |
| 2000's | 8 (20.51) | 29.6817 |
| 2010's | 1 (2.56) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Fukuba, Y; Good, RA; Ikehara, S; Inaba, M; Miyazaki, W; Nishino, T; Saigo, S; Toki, J | 1 |
| Pachter, JA | 1 |
| Andoh, A; Bamba, T; Fujiyama, Y; Hodohara, K; Hosoda, S; Kitoh, K | 1 |
| Andoh, A; Bamba, T; Fujiyama, Y; Hirotani, S; Hodohara, K; Hosoda, S | 1 |
| Konno, S; Tsurufuji, S | 2 |
| Redelman, D; Wormsley, S | 1 |
| Inoue, M; Kato, H; Kondo, M; Sano, H; Sugino, S; Tanigawa, M; Yamamura, Y | 1 |
| Murakami, K; Muto, N; Suga, S; Yamamoto, I | 1 |
| Amiraian, K; Evans, BD | 1 |
| Asaka, M; Iida, H; Izumino, K; Mizumura, Y; Sasayama, S; Takata, M | 1 |
| Ishibashi, Y; Nagaoka, I; Yamashita, T | 1 |
| Hudig, D; Redelman, D | 1 |
| Katayama, Y; Kawai, K; Sakai, T; Yamaguchi, N; Yoshida, S | 1 |
| Hing, K; Inoue, K; Izawa, T; Kinoshita, T; Miyazaki, W; Nakano, Y; Shinohara, M | 1 |
| Carine, K; Hudig, D; Minning, L; Redelman, D | 1 |
| Baum, J; Bumpers, HL | 1 |
| Demetris, AJ; Manez, R; Miyazaki, W; Miyazawa, H; Murase, N; Nomoto, M; Starzl, TE; Tanaka, M; Todo, S; Ye, Q | 1 |
| Kaufman, TS; Marsh, HC; Scesney, SM; Sindelar, RD; Srivastava, RP | 1 |
| Inoue, Y; Kitano, A; Kobayashi, K; Matsumoto, T; Nakamura, S; Nakura, H; Obata, A; Okawa, K; Oshitani, N | 1 |
| Fukushima, N; Kitamura, H; Matsuda, H; Matsumiya, G; Matsumoto, M; Miyagawa, S; Nakata, S; Seya, T; Shirakura, R | 1 |
| Cooper, DK; Hancock, WW; Kobayashi, T; Koren, E; Neethling, FA; Niekrasz, M; Takagi, H; Taniguchi, S; Ye, Y | 1 |
| Demetris, AJ; Manez, R; Miyazaki, W; Miyazawa, H; Murase, N; Nomoto, M; Starzl, TE; Tanaka, M; Todo, S; Toyama, Y; Ye, Q | 1 |
| Imamura, M; Inoue, K; Kaji, H; Mori, C; Platt, JL; Shiota, K; Sutherland, DE | 1 |
| Imamura, M; Inoue, K; Kaji, H; Platt, JL; Setoyama, H | 1 |
| Blum, MG; Chang, AC; Collins, BJ; Knaus, SA; Pierson, RN; Zhang, JP | 1 |
| Andoh, A; Bamba, T; Fujiyama, Y; Kimura, T; Saotome, T | 1 |
| Endo, M; Fujita, T; Kanmatsuse, K; Komatsu, K; Ohi, H; Ohsawa, I | 1 |
| Brouckaert, P; Libert, C; Van Molle, W; Vanden Berghe, J | 1 |
| Awwad, M; Blair, KS; Blum, MG; Chang, AC; Pierson, RN; Shyr, Y; Zhang, JP | 1 |
| Endo, TY; Fujita, T; Kawabata, Y; Matsushita, M; Noikura, T; Shibazaki, M; Takada, H; Yang, TS; Yokochi, TT | 1 |
| Zang, YM; Zhou, SS | 1 |
| Endo, Y; Fujita, T; Matsushita, M; Takada, H; Yokochi, T | 1 |
| Ikai, M; Itoh, M; Joh, T; Kurokawa, T; Okada, N; Oshima, T; Seno, K; Yokoyama, Y | 1 |
| Endo, Y; Fujita, T; Matsushita, M; Ohtaki, Y; Takada, H; Yamaguchi, K; Yokochi, T; Zhao, L | 1 |
| LaPatra, S; Overturf, K | 1 |
| Castellano, PM; Kaufman, TS; Operto, MA; Torres, R; Useglio, M | 1 |
| Kaufman, TS; Larghi, EL; Operto, MA; Torres, R | 2 |
39 other study(ies) available for k 76 carboxylic acid and sesquiterpenes
| Article | Year |
|---|---|
Effects of K-76COOH (MX-1) on immune response: induction of suppressor T-cells by MX-1.
Topics: Animals; Complement Inactivator Proteins; Female; Lymphocyte Activation; Mice; Mice, Inbred Strains; Sesquiterpenes; T-Lymphocytes; T-Lymphocytes, Regulatory | 1992 |
Noncompetitive inhibition of inositol monophosphatase by K-76 monocarboxylic acid.
Topics: Animals; Binding, Competitive; Cattle; Hydrolysis; Inositol Phosphates; Kinetics; Lithium; Magnesium; Phosphoric Monoester Hydrolases; Sesquiterpenes; Substrate Specificity | 1991 |
Flow cytometric assay for phagocytosis of human monocytes mediated via Fc gamma-receptors and complement receptor CR1 (CD35).
Topics: Antigens, Differentiation; Complement C3b; Complement C4b; Complement C5; Cytochalasin D; Flow Cytometry; Fluorescent Dyes; Humans; Monocytes; Phagocytosis; Receptors, Complement; Receptors, Complement 3b; Receptors, Fc; Receptors, IgG; Rubber; Serum Albumin, Bovine; Sesquiterpenes | 1991 |
[Flow cytometric analysis of immunophagocytosis using sensitized fluorescent microspheres bearing C3b].
Topics: Complement C3b; Depression, Chemical; Flow Cytometry; Fluorescence; Humans; Macrophages; Microspheres; Monocytes; Phagocytosis; Receptors, Complement; Receptors, Fc; Sesquiterpenes | 1990 |
Inhibitory effect of a novel anticomplementary agent, K-76COONa, on the release of histamine induced by zymosan and compound 48/80.
Topics: Animals; Capillary Permeability; Cells, Cultured; Complement Inactivator Proteins; Histamine Release; Inflammation; Male; Mast Cells; p-Methoxy-N-methylphenethylamine; Peritoneum; Rats; Rats, Inbred Strains; Sesquiterpenes; Zymosan | 1985 |
The induction of the human T-cell growth factor receptor precedes the production of RNA and occurs in the presence of inhibitors of RNA synthesis.
Topics: Antibodies, Monoclonal; Antigens, Surface; Cells, Cultured; Dactinomycin; DNA; Flow Cytometry; Fluorescent Antibody Technique; Humans; Phytohemagglutinins; Receptors, Immunologic; Receptors, Interleukin-2; RNA; Sesquiterpenes; T-Lymphocytes; Time Factors; Transcription, Genetic; Tumor Necrosis Factor Receptor Superfamily, Member 7 | 1986 |
Mechanism of polymorphonuclear leukocytes accumulation examined using inhibitors of complement and arachidonic acid cascade in rats treated with OK-432.
Topics: Animals; Arachidonic Acids; Benzamidines; Benzoquinones; Biological Products; Cell Count; Chemotactic Factors; Complement C5a; Complement Inactivator Proteins; Edetic Acid; Egtazic Acid; Guanidines; Humans; Male; Methacrylates; Neutrophils; Peritoneal Cavity; Picibanil; Quinones; Rats; Rats, Inbred Strains; Sesquiterpenes | 1989 |
An enzyme immunoassay for K-76 monocarboxylic acid, a novel anticomplementary compound.
Topics: Animals; Antibody Formation; Antibody Specificity; Cross Reactions; Dogs; Enzyme-Linked Immunosorbent Assay; Immunoenzyme Techniques; Molecular Structure; Rats; Schiff Bases; Serum Albumin, Bovine; Sesquiterpenes; Time Factors | 1989 |
Effect of zinc on lysis of sheep erythrocytes by guinea pig C4-deficient serum.
Topics: Animals; Calcium; Complement C4; Complement Pathway, Alternative; Elapid Venoms; Guinea Pigs; Hemolysis; Hot Temperature; Magnesium; Sesquiterpenes; Sheep; Zinc; Zymosan | 1987 |
Effect of the anticomplementary agent, K-76 monocarboxylic acid, on experimental immune complex glomerulonephritis in rats.
Topics: Animals; Antibodies, Anti-Idiotypic; Antigen-Antibody Complex; Complement C5; Complement Inactivator Proteins; Glomerulonephritis; Kidney Glomerulus; Male; Proteinuria; Rats; Rats, Inbred SHR; Sesquiterpenes; Time Factors | 1987 |
Studies on phytohemagglutinin-induced peritonitis of mice: dynamics of inflammatory responses and influence of anticomplementary agents and anti-inflammatory drugs.
Topics: Animals; Anti-Inflammatory Agents; Benzamidines; Blood Proteins; Complement Inactivator Proteins; Dexamethasone; Exudates and Transudates; Guanidines; Indomethacin; Male; Mice; Mice, Inbred Strains; Peritonitis; Phytohemagglutinins; Sesquiterpenes | 1987 |
The mechanism of cell-mediated cytotoxicity. IV. K-76 COONa, which inhibits the activity of Factor I and of C5, inhibits early events in cytotoxic T-lymphocyte-mediated cytolysis and in T-lymphocyte activation.
Topics: Cells, Cultured; Complement C3b Inactivator Proteins; Complement C5; Cytotoxicity, Immunologic; Humans; Kinetics; Lymphocyte Activation; Lymphocyte Culture Test, Mixed; Receptors, Immunologic; Receptors, Interleukin-2; Sesquiterpenes; T-Lymphocytes, Cytotoxic | 1984 |
Anti-tumor activity of endotoxin depends on activation of serum complement fragments.
Topics: Animals; Complement Activation; Complement C5; Endotoxins; Escherichia coli; Lipopolysaccharides; Liver Neoplasms, Experimental; Mice; Mice, Inbred C3H; Sesquiterpenes | 1983 |
Effects of K-76 monocarboxylic acid, an anticomplementary agent, on various in vivo immunological reactions and on experimental glomerulonephritis.
Topics: Anaphylaxis; Animals; Complement Inactivator Proteins; Complement System Proteins; Glomerulonephritis; Guinea Pigs; Hemolysis; Immune System; Lupus Erythematosus, Systemic; Mice; Mice, Inbred ICR; Passive Cutaneous Anaphylaxis; Rabbits; Rats; Rats, Inbred Strains; Sesquiterpenes | 1984 |
Induction of zymosan-air-pouch inflammation in rats and its characterization with reference to the effects of anticomplementary and anti-inflammatory agents.
Topics: Animals; Anti-Inflammatory Agents; Carboxymethylcellulose Sodium; Complement Inactivator Proteins; Dexamethasone; Granulation Tissue; Inflammation; Male; Rats; Rats, Inbred Strains; Sesquiterpenes; Zymosan | 1983 |
Inhibition of human lymphocyte natural cytotoxicity and antibody-dependent cell-mediated cytotoxicity by K-76 COONa, a reagent that blocks complement activity.
Topics: Antibody-Dependent Cell Cytotoxicity; Binding, Competitive; Complement Inactivator Proteins; Cytotoxicity, Immunologic; Humans; Immunosuppressive Agents; Killer Cells, Natural; Kinetics; Sesquiterpenes; Stachybotrys | 1984 |
The effect of a novel C5 inhibitor (K-76 COONa) on tumor cell chemotaxis.
Topics: Animals; Carcinoma 256, Walker; Chemotaxis; Complement C5; Complement Inactivator Proteins; Rats; Sesquiterpenes | 1983 |
Effect of anticomplement agent K-76 COOH in hamster-to-rat and guinea pig-to-rat xenotransplantation.
Topics: Animals; Complement Inactivator Proteins; Cricetinae; Cyclophosphamide; Graft Rejection; Graft Survival; Guinea Pigs; Heart Transplantation; Male; Mesocricetus; Rats; Rats, Inbred Lew; Sesquiterpenes; Tacrolimus; Transplantation, Heterologous | 1995 |
Design, synthesis, and evaluation of A/C/D-ring analogs of the fungal metabolite K-76 as potential complement inhibitors.
Topics: Animals; Cell Division; Complement C3a; Complement C5a; Complement Inactivator Proteins; Drug Design; Guinea Pigs; Hemolysis; Humans; Lymphocytes; Mice; Sesquiterpenes; Stachybotrys | 1995 |
Multifunctional effects of anticomplementary agent K-76 on carrageenan-induced colitis in the rabbit.
Topics: Animals; Carrageenan; Colitis, Ulcerative; Complement C3; Complement Hemolytic Activity Assay; Complement Inactivator Proteins; Disease Models, Animal; Immunoglobulin G; Immunoglobulin M; Immunohistochemistry; Male; Mucoproteins; Rabbits; Sesquiterpenes | 1993 |
Prolonging discordant xenograft survival with anticomplement reagents K76COOH and FUT175.
Topics: Animals; Benzamidines; Complement C3; Complement Factor B; Complement Factor D; Complement Inactivator Proteins; Complement Pathway, Alternative; Complement System Proteins; Female; Graft Survival; Guanidines; Guinea Pigs; Heart Transplantation; Hemolysis; Male; Rats; Rats, Inbred Lew; Sesquiterpenes; Time Factors; Transplantation, Heterologous | 1993 |
In vitro and in vivo investigation of anticomplement agents FUT-175 and K76COOH, in the prevention of hyperacute rejection following discordant xenotransplantation in a nonhuman primate model.
Topics: Animals; Benzamidines; Cells, Cultured; Complement Inactivator Proteins; Cytotoxicity, Immunologic; Graft Rejection; Graft Survival; Guanidines; Hydroxamic Acids; Kidney; Kidney Transplantation; Papio; Sesquiterpenes; Swine | 1996 |
Effect of anticomplement agent K76 COOH on hamster-to-rat and guinea pig-to-rat heart xenotransplantation.
Topics: Animals; Complement Inactivator Proteins; Cricetinae; Cyclophosphamide; Graft Survival; Guinea Pigs; Heart Transplantation; Immunosuppressive Agents; Male; Mesocricetus; Rats; Rats, Inbred Lew; Sesquiterpenes; Tacrolimus; Transplantation, Heterologous | 1996 |
The effect of MX-1 on survival of discordant cardiac xenografts from guinea pig to rat.
Topics: Animals; Complement C5; Complement Inactivator Proteins; Elapid Venoms; Graft Rejection; Graft Survival; Guinea Pigs; Heart Transplantation; Immunohistochemistry; Rats; Rats, Inbred Lew; Receptors, Complement; Sesquiterpenes; Transplantation, Heterologous | 1997 |
The effect of MX-1 and FOY on survival of discordant cardiac xenograft.
Topics: Animals; Anticoagulants; Complement Inactivator Proteins; Creatine Kinase; Gabexate; Graft Survival; Guinea Pigs; Heart Transplantation; Immunosuppression Therapy; Isoenzymes; Rats; Rats, Inbred Lew; Sesquiterpenes; Transplantation, Heterologous | 1997 |
Complement inhibition by FUT-175 and K76-COOH in a pig-to-human lung xenotransplant model.
Topics: Animals; Benzamidines; Complement Inactivator Proteins; Complement Membrane Attack Complex; Complement System Proteins; Dose-Response Relationship, Drug; Fluorescent Antibody Technique; Graft Rejection; Guanidines; Humans; In Vitro Techniques; Lung Transplantation; Models, Biological; Perfusion; Pulmonary Circulation; Sesquiterpenes; Swine; Transplantation, Heterologous; Vascular Resistance | 1998 |
A blockade of complement activation prevents rapid intestinal ischaemia-reperfusion injury by modulating mucosal mast cell degranulation in rats.
Topics: Anaphylatoxins; Animals; Benzamidines; Cell Degranulation; Cell Membrane Permeability; Chelating Agents; Chromium Radioisotopes; Complement Activation; Complement Inactivator Proteins; Edetic Acid; Guanidines; Intestinal Mucosa; Ischemia; Jejunum; Male; Mast Cells; Rats; Rats, Wistar; Reperfusion Injury; Serine Proteinase Inhibitors; Sesquiterpenes | 1998 |
Complement activation accelerates glomerular injury in diabetic rats.
Topics: Animals; Blood Glucose; Complement Activation; Complement C3; Complement Inactivator Proteins; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Fluorescent Antibody Technique; Immunoglobulins; Kidney Glomerulus; Proteinuria; Rats; Rats, Inbred OLETF; Sesquiterpenes | 1999 |
Tumor necrosis factor-induced lethal hepatitis: pharmacological intervention with verapamil, tannic acid, picotamide and K76COOH.
Topics: Alanine Transaminase; Animals; Apoptosis; Astringents; Chemical and Drug Induced Liver Injury; Complement Inactivator Proteins; Dactinomycin; Disease Models, Animal; Galactosamine; Hydrolyzable Tannins; Liver; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Phthalic Acids; Platelet Aggregation Inhibitors; Sesquiterpenes; Tumor Necrosis Factor-alpha; Verapamil | 2000 |
Immunohistologic evaluation of mechanisms mediating hyperacute lung rejection, and the effect of treatment with K76-COOH, FUT-175, and anti-Gal column immunoadsorption.
Topics: Acute Disease; Animals; Benzamidines; Blood Transfusion; Complement Inactivator Proteins; Galactosides; Graft Rejection; Guanidines; Humans; Immunosorbent Techniques; Immunosuppression Therapy; Lung; Sesquiterpenes; Swine; Transplantation, Heterologous | 1999 |
Complement system is involved in anaphylactoid reaction induced by lipopolysaccharides in muramyldipeptide-treated mice.
Topics: Acetylmuramyl-Alanyl-Isoglutamine; Anaphylaxis; Animals; Blood Platelets; Carbohydrate Sequence; Complement Activation; Complement Inactivator Proteins; Escherichia coli; Female; Humans; Klebsiella; Lipopolysaccharides; Male; Mice; Mice, Inbred C3H; Molecular Sequence Data; Oligosaccharides; Prevotella intermedia; Recombinant Proteins; Salmonella typhimurium; Sesquiterpenes | 2000 |
[Effects of monocarboxylic acid derivatives on cardiac ventricular CFTR Cl- channels in guinea pig].
Topics: Animals; Anthracenes; Cell Separation; Chloride Channels; Cystic Fibrosis Transmembrane Conductance Regulator; Electrophysiology; Female; Guinea Pigs; Isoproterenol; Myocardium; Nitrobenzoates; ortho-Aminobenzoates; Sesquiterpenes; Ventricular Function | 1999 |
Complement-dependent platelet degradation and anaphylactoid shock in mice induced by lipopolysaccharide carrying the mannose homopolymer.
Topics: Anaphylaxis; Animals; Blood Platelets; Carbohydrate Sequence; Complement C5; Complement Inactivator Proteins; Complement System Proteins; Dose-Response Relationship, Drug; Escherichia coli; Humans; Injections, Intravenous; Klebsiella; Lipopolysaccharides; Male; Mannans; Mice; Mice, Inbred AKR; Mice, Inbred BALB C; Mice, Inbred DBA; Sesquiterpenes; Species Specificity | 2001 |
Complement plays an important role in gastric mucosal damage induced by ischemia-reperfusion in rats.
Topics: Animals; Chromium Radioisotopes; Complement Inactivator Proteins; Complement System Proteins; Dose-Response Relationship, Drug; Edetic Acid; Elapid Venoms; Fluorescent Antibody Technique; Gastric Mucosa; Injections, Intraperitoneal; Male; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Sesquiterpenes | 2001 |
LPS-induced platelet response and rapid shock in mice: contribution of O-antigen region of LPS and involvement of the lectin pathway of the complement system.
Topics: Anaphylaxis; Animals; Blood Platelets; Complement Activation; Complement C4; Complement C5; Endotoxins; Escherichia coli; Histamine; Humans; Injections, Intravenous; Lectins; Lipopolysaccharides; Liver; Lung; Male; Mannose; Mannose-Binding Lectin; Mannose-Binding Protein-Associated Serine Proteases; Mast Cells; Mice; Mice, Inbred AKR; Mice, Inbred BALB C; Mice, Inbred DBA; O Antigens; Ovalbumin; Pyrilamine; Serine Endopeptidases; Serotonin; Sesquiterpenes; Shock, Septic; Structure-Activity Relationship | 2002 |
Quantitative expression (Walbaum) of immunological factors in rainbow trout, Oncorhynchus mykiss (Walbaum), after infection with either Flavobacterium psychrophilum, Aeromonas salmonicida, or infectious haematopoietic necrosis virus.
Topics: Actins; Aeromonas salmonicida; Animals; CD8 Antigens; Complement C3; DNA Primers; Fish Diseases; Flavobacteriaceae Infections; Flavobacterium; Gene Expression Profiling; Gram-Negative Bacterial Infections; Infectious hematopoietic necrosis virus; Interleukin-8; Kidney; Liver; Oncorhynchus mykiss; Reverse Transcriptase Polymerase Chain Reaction; Rhabdoviridae Infections; Sesquiterpenes; Specific Pathogen-Free Organisms; Spleen | 2006 |
Synthesis of 3H-spiro[benzofuran-2,1'-cyclohexane] derivatives from naturally occurring filifolinol and their classical complement pathway inhibitory activity.
Topics: Animals; Benzofurans; Complement Pathway, Classical; Cyclohexanes; Hemolysis; Heterocyclic Compounds, 3-Ring; Humans; Inhibitory Concentration 50; Plant Extracts; Sesquiterpenes; Sheep; Spiro Compounds; Structure-Activity Relationship; Tritium | 2006 |
New inhibitors of the complement system inspired in K76-COOH. A SAR study of filifolinol derivatives through modifications of the C3' position.
Topics: Complement Inactivating Agents; Complement System Proteins; Sesquiterpenes; Structure-Activity Relationship | 2009 |
Synthesis and classical pathway Complement inhibitory activity of C7-functionalized filifolinol derivatives, inspired in K-76 COOH.
Topics: Benzofurans; Chemistry Techniques, Synthetic; Complement System Proteins; Humans; Sesquiterpenes; Spiro Compounds | 2012 |