jtt 501 has been researched along with isoxazoles in 17 studies
| Studies (jtt 501) | Trials (jtt 501) | Recent Studies (post-2010) (jtt 501) | Studies (isoxazoles) | Trials (isoxazoles) | Recent Studies (post-2010) (isoxazoles) |
|---|---|---|---|---|---|
| 21 | 0 | 1 | 8,633 | 900 | 3,337 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 7 (41.18) | 18.2507 |
| 2000's | 10 (58.82) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Anai, M; Asano, T; Fukushima, Y; Funaki, M; Inukai, K; Ishihara, H; Katagiri, H; Kikuchi, M; Ogihara, T; Oka, Y; Onishi, Y; Sakoda, H; Shibata, T; Terasaki, J; Yazaki, Y | 1 |
| Iwao, M; Onogi, S; Shibata, T; Shinkai, H; Tanaka, M; Uchida, I; Wakitani, K | 1 |
| Matsui, K; Shibata, T; Wakitani, K; Yonemori, F | 2 |
| Matsui, K; Nagao, K; Shibata, T; Shinkai, H; Wakitani, K; Yonemori, F | 1 |
| Fujita, T; Haneda, M; Hidaka, H; Kashiwagi, A; Kikkawa, R; Kojima, H; Maegawa, H; Morino, K; Nishio, Y; Obata, T; Shibata, T; Ugi, S; Yasuda, H | 1 |
| Kadowaki, T | 1 |
| Kakimoto, K; Shibata, T; Takeuchi, S; Wakitani, K; Yokota, S; Yonemori, F | 1 |
| Inoue, S; Murakami, T; Osaka, T; Yamazaki, Y | 1 |
| Chan, O; Giacca, A; Kawamori, R; Mathoo, JM; Niwa, M; Rashid, S; Shum, K; Tchipashvili, V; Vranic, M | 1 |
| Hisatome, I; Ogino, K; Shigemasa, C; Shimoyama, M; Uchida, K | 1 |
| Hasegawa, M; Makino, H; Nishimiya, T; Ochi, M; Onuma, H; Osawa, H; Tang, Y | 1 |
| Abe, I; Eto, K; Fujishima, M; Nakamura, Y; Ohya, Y | 1 |
| Shinkai, H | 1 |
| Yamanouchi, T | 1 |
| Basileo, G; Breda, M; James, CA | 1 |
| Gao, XP; Liu, ZR; Wang, XC; Zhong, CB; Zhu, XJ | 1 |
3 review(s) available for jtt 501 and isoxazoles
| Article | Year |
|---|---|
[Insulin-sensitizing agents].
Topics: Animals; Diabetes Mellitus; Diabetes Mellitus, Experimental; Humans; Hypoglycemic Agents; Isoxazoles; Pioglitazone; Rosiglitazone; Thiazoles; Thiazolidinediones | 1999 |
[The chemical structure and pharmacological properties of a novel isoxazolidinedione insulin sensitizer, JTT-501].
Topics: Animals; Diabetes Mellitus; Diabetic Angiopathies; Diabetic Neuropathies; Glucose Transporter Type 4; Humans; Hypoglycemic Agents; Insulin; Insulin Resistance; Isoxazoles; Monosaccharide Transport Proteins; Muscle Proteins; Rats; Receptors, Cytoplasmic and Nuclear; Signal Transduction; Transcription Factors | 2001 |
[Chemical structures and pharmacological characteristics of novel non-thiazolidinedione insulin sensitizer (JTT-501, FK614)].
Topics: Animals; Blood Glucose; Drug Design; Humans; Hypoglycemic Agents; Insulin Resistance; Isoxazoles; Lipid Metabolism; Oxadiazoles; Receptor, Insulin; Receptors, Cytoplasmic and Nuclear; Thiazoles; Thiazolidinediones; Transcription Factors | 2002 |
14 other study(ies) available for jtt 501 and isoxazoles
| Article | Year |
|---|---|
Role of JTT-501, a new insulin sensitiser, in restoring impaired GLUT4 translocation in adipocytes of rats fed a high fat diet.
Topics: Adipocytes; Animals; Blood Glucose; Body Weight; Cell Membrane; Cells, Cultured; Dietary Fats; Glucose Clamp Technique; Glucose Transporter Type 4; Humans; Hypoglycemic Agents; Infusions, Intravenous; Insulin; Isoxazoles; Kinetics; Male; Monosaccharide Transport Proteins; Muscle Proteins; Rats; Rats, Sprague-Dawley; Recombinant Proteins | 1998 |
Isoxazolidine-3,5-dione and noncyclic 1,3-dicarbonyl compounds as hypoglycemic agents.
Topics: 3T3 Cells; Animals; Blood Glucose; Cell Differentiation; Drug Evaluation, Preclinical; Hypoglycemic Agents; Insulin; Isoxazoles; L Cells; Male; Malonates; Mice; Oxazoles; Triglycerides | 1998 |
JTT-501, a novel oral antidiabetic agent, improves insulin resistance in genetic and non-genetic insulin-resistant models.
Topics: Animals; Blood Glucose; Disease Models, Animal; Glucose; Glucose Clamp Technique; Glucose Tolerance Test; Hyperglycemia; Hypoglycemic Agents; Infusions, Intravenous; Insulin; Insulin Resistance; Isoxazoles; Leptin; Lipids; Male; Obesity; Oxidation-Reduction; Phosphorylation; Proteins; Rats; Rats, Sprague-Dawley; Rats, Zucker; Receptor, Insulin; Triglycerides | 1998 |
Pharmacological profiles of a novel oral antidiabetic agent, JTT-501, an isoxazolidinedione derivative.
Topics: 3T3 Cells; Administration, Oral; Animals; Blood Glucose; Cell Differentiation; Chromans; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Dose-Response Relationship, Drug; Glucose; Hyperinsulinism; Hypertriglyceridemia; Hypoglycemic Agents; Insulin; Isoxazoles; Male; Mice; Mice, Inbred Strains; Oxidation-Reduction; Pioglitazone; Rats; Rats, Sprague-Dawley; Rats, Zucker; Receptors, Cytoplasmic and Nuclear; Thiazoles; Thiazolidinediones; Transcription Factors; Triglycerides; Troglitazone | 1999 |
A new antidiabetic agent (JTT-501) rapidly stimulates glucose disposal rates by enhancing insulin signal transduction in skeletal muscle.
Topics: Animals; Blood Glucose; Drug Synergism; Glucose; Glucose Clamp Technique; Hyperinsulinism; Hypertriglyceridemia; Hypoglycemic Agents; Immunosorbent Techniques; Insulin; Isoxazoles; Male; Muscle, Skeletal; Phosphatidylinositol 3-Kinases; Phosphotyrosine; Rats; Rats, Sprague-Dawley; Rats, Zucker; Receptor, Insulin; Signal Transduction | 1999 |
Triglyceride-lowering effect of a novel insulin-sensitizing agent, JTT-501.
Topics: Animals; Blood Glucose; Body Weight; Dietary Fats; Hypoglycemic Agents; Hypolipidemic Agents; Insulin; Insulin Resistance; Isoxazoles; Male; Pioglitazone; Rats; Rats, Sprague-Dawley; Thiazoles; Thiazolidinediones; Triglycerides | 1999 |
Effects of peroxisome proliferator-activated receptor-alpha and -gamma agonist, JTT-501, on diabetic complications in Zucker diabetic fatty rats.
Topics: Absorptiometry, Photon; Animals; Body Weight; Bone Density; Bone Diseases, Metabolic; Cataract; Chromans; Diabetes Complications; Diabetes Mellitus; Diabetic Nephropathies; Diabetic Neuropathies; Eating; Hypoglycemic Agents; Isoxazoles; Male; Neural Conduction; Obesity; Pancreas; Rats; Rats, Zucker; Receptors, Cytoplasmic and Nuclear; Thiazoles; Thiazolidinediones; Time Factors; Transcription Factors; Troglitazone | 2000 |
JTT-501, a new oral hypoglycemic agent, reverses hypertriglyceridemia in Zucker fatty and ventromedial hypothalamus-lesioned obese rats.
Topics: Animals; Blood Glucose; Female; Hypertriglyceridemia; Hypoglycemic Agents; Hypothalamus, Middle; Insulin; Isoxazoles; Lipoprotein Lipase; Obesity; Rats; Rats, Wistar; Triglycerides | 2000 |
Effect of JTT-501 on net hepatic glucose balance and peripheral glucose uptake in alloxan-induced diabetic dogs.
Topics: Alloxan; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Dogs; Glucagon; Glucose; Hypoglycemic Agents; Insulin; Isoxazoles; Liver; Male | 2000 |
Acute hemodynamic effects of insulin-sensitizing agents in isolated perfused rat hearts.
Topics: Animals; Chromans; Dose-Response Relationship, Drug; Hemodynamics; Hypoglycemic Agents; Indomethacin; Isoxazoles; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Perfusion; Pioglitazone; Prostaglandins; Rats; Rats, Wistar; Rosiglitazone; Thiazoles; Thiazolidinediones; Troglitazone; Vitamin E | 2000 |
Adipocyte-specific reduction of phosphodiesterase 3B gene expression and its restoration by JTT-501 in the obese, diabetic KKAy mouse.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adipocytes; Adipose Tissue; Animals; Blood Glucose; Blotting, Western; Cyclic Nucleotide Phosphodiesterases, Type 3; Diabetes Mellitus; Diabetes Mellitus, Experimental; Epididymis; Fatty Acids; Female; Gene Expression Regulation, Enzymologic; Hypoglycemic Agents; Insulin; Insulin Resistance; Isoxazoles; Liver; Male; Mice; Mice, Inbred C57BL; Obesity; RNA, Messenger; Triglycerides | 2001 |
Comparative actions of insulin sensitizers on ion channels in vascular smooth muscle.
Topics: Analysis of Variance; Animals; Barium; Calcium; Chromans; Dose-Response Relationship, Drug; Electric Stimulation; Female; Guinea Pigs; Humans; Insulin Resistance; Ion Channels; Isoxazoles; Membrane Potentials; Muscle, Smooth, Vascular; Pioglitazone; Potassium Channels; Prostaglandin D2; Rosiglitazone; Thiazoles; Thiazolidinediones; Troglitazone | 2001 |
Simultaneous determination of JTT-501 and its main metabolite in human plasma by liquid chromatography-ionspray mass spectrometry.
Topics: Chromatography, High Pressure Liquid; Humans; Hypoglycemic Agents; Isoxazoles; Reproducibility of Results; Spectrometry, Mass, Electrospray Ionization | 2003 |
[Design, synthesis and insulin-sensitizing activity of some peroxisome proliferator-activated gamma agonists].
Topics: 3T3-L1 Cells; Animals; Glucose; Hypoglycemic Agents; Insulin; Isoxazoles; Mice; PPAR gamma | 2005 |