jtp 4819 has been researched along with substance p in 5 studies
| Studies (jtp 4819) | Trials (jtp 4819) | Recent Studies (post-2010) (jtp 4819) | Studies (substance p) | Trials (substance p) | Recent Studies (post-2010) (substance p) |
|---|---|---|---|---|---|
| 25 | 1 | 5 | 17,289 | 277 | 2,010 |
| Protein | Taxonomy | jtp 4819 (IC50) | substance p (IC50) |
|---|---|---|---|
| Substance-P receptor | Rattus norvegicus (Norway rat) | 0.0005 | |
| Substance-K receptor | Rattus norvegicus (Norway rat) | 0.2 | |
| Substance-K receptor | Homo sapiens (human) | 0.2455 | |
| Substance-P receptor | Homo sapiens (human) | 0.0011 | |
| Neuromedin-K receptor | Homo sapiens (human) | 0.125 | |
| Substance-K receptor | Mesocricetus auratus (golden hamster) | 0.148 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (80.00) | 18.2507 |
| 2000's | 1 (20.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Iwamoto, Y; Kato, T; Okamiya, K; Toide, K | 1 |
| Fujiwara, T; Iwamoto, Y; Kato, T; Okamiya, K; Shinoda, M; Toide, K | 1 |
| Matsuo, A; Shinoda, M; Toide, K | 1 |
| Miyazaki, A; Shinoda, M; Toide, K | 1 |
| Jalkanen, AJ; Jarho, EM; Mannila, A; Männistö, PT; Puttonen, KA; Ruotsalainen, S; Sinervä, V; Venäläinen, JI; Wallén, EA | 1 |
5 other study(ies) available for jtp 4819 and substance p
| Article | Year |
|---|---|
Effect of a novel prolyl endopeptidase inhibitor, JTP-4819, on prolyl endopeptidase activity and substance P- and arginine-vasopressin-like immunoreactivity in the brains of aged rats.
Topics: Aging; Animals; Arginine Vasopressin; Cerebral Cortex; Diterpenes; Hippocampus; Immunoenzyme Techniques; Male; Phorbol Esters; Prolyl Oligopeptidases; Pyrrolidines; Rats; Rats, Inbred F344; Rats, Wistar; Serine Endopeptidases; Serine Proteinase Inhibitors; Substance P | 1995 |
Effect of a novel prolyl endopeptidase inhibitor, JTP-4819, on neuropeptide metabolism in the rat brain.
Topics: Administration, Oral; Alzheimer Disease; Animals; Arginine Vasopressin; Cerebral Cortex; Dose-Response Relationship, Drug; Hippocampus; Neuropeptides; Prolyl Oligopeptidases; Pyrrolidines; Rats; Rats, Wistar; Serine Endopeptidases; Serine Proteinase Inhibitors; Substance P; Thyrotropin-Releasing Hormone | 1996 |
Pharmacological studies of a novel prolyl endopeptidase inhibitor, JTP-4819, in rats with middle cerebral artery occlusion.
Topics: Animals; Arginine Vasopressin; Arterial Occlusive Diseases; Avoidance Learning; Brain Ischemia; Cerebral Arteries; Cerebral Cortex; Hippocampus; Learning; Male; Maze Learning; Motor Activity; Protease Inhibitors; Pyrrolidines; Rats; Rats, Sprague-Dawley; Substance P; Thyrotropin-Releasing Hormone | 1996 |
Effect of a novel prolyl endopeptidase inhibitor, JTP-4819, on spatial memory and on cholinergic and peptidergic neurons in rats with ibotenate-induced lesions of the nucleus basalis magnocellularis.
Topics: Animals; Arginine Vasopressin; Basal Ganglia; Choline O-Acetyltransferase; Excitatory Amino Acid Agonists; Ibotenic Acid; Male; Maze Learning; Memory; Neurons; Neuropeptides; Parasympathetic Nervous System; Prolyl Oligopeptidases; Pyrrolidines; Rats; Rats, Wistar; Receptor, Muscarinic M1; Receptors, Muscarinic; Serine Endopeptidases; Serine Proteinase Inhibitors; Substance P; Thyrotropin-Releasing Hormone | 1999 |
Beneficial effect of prolyl oligopeptidase inhibition on spatial memory in young but not in old scopolamine-treated rats.
Topics: Aging; Amnesia; Animals; Frontal Lobe; Hippocampus; Hypothalamus; Inositol 1,4,5-Trisphosphate; Male; Maze Learning; Memory; Motor Activity; Muscarinic Antagonists; Neurotensin; Prolyl Oligopeptidases; Pyrrolidines; Rats; Rats, Wistar; Scopolamine; Serine Endopeptidases; Serine Proteinase Inhibitors; Substance P | 2007 |