Page last updated: 2024-09-05

jtp 4819 and substance p

jtp 4819 has been researched along with substance p in 5 studies

Compound Research Comparison

Studies
(jtp 4819)
Trials
(jtp 4819)
Recent Studies (post-2010)
(jtp 4819)
Studies
(substance p)
Trials
(substance p)
Recent Studies (post-2010) (substance p)
251517,2892772,010

Protein Interaction Comparison

ProteinTaxonomyjtp 4819 (IC50)substance p (IC50)
Substance-P receptorRattus norvegicus (Norway rat)0.0005
Substance-K receptorRattus norvegicus (Norway rat)0.2
Substance-K receptorHomo sapiens (human)0.2455
Substance-P receptorHomo sapiens (human)0.0011
Neuromedin-K receptorHomo sapiens (human)0.125
Substance-K receptorMesocricetus auratus (golden hamster)0.148

Research

Studies (5)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's4 (80.00)18.2507
2000's1 (20.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Iwamoto, Y; Kato, T; Okamiya, K; Toide, K1
Fujiwara, T; Iwamoto, Y; Kato, T; Okamiya, K; Shinoda, M; Toide, K1
Matsuo, A; Shinoda, M; Toide, K1
Miyazaki, A; Shinoda, M; Toide, K1
Jalkanen, AJ; Jarho, EM; Mannila, A; Männistö, PT; Puttonen, KA; Ruotsalainen, S; Sinervä, V; Venäläinen, JI; Wallén, EA1

Other Studies

5 other study(ies) available for jtp 4819 and substance p

ArticleYear
Effect of a novel prolyl endopeptidase inhibitor, JTP-4819, on prolyl endopeptidase activity and substance P- and arginine-vasopressin-like immunoreactivity in the brains of aged rats.
    Journal of neurochemistry, 1995, Volume: 65, Issue:1

    Topics: Aging; Animals; Arginine Vasopressin; Cerebral Cortex; Diterpenes; Hippocampus; Immunoenzyme Techniques; Male; Phorbol Esters; Prolyl Oligopeptidases; Pyrrolidines; Rats; Rats, Inbred F344; Rats, Wistar; Serine Endopeptidases; Serine Proteinase Inhibitors; Substance P

1995
Effect of a novel prolyl endopeptidase inhibitor, JTP-4819, on neuropeptide metabolism in the rat brain.
    Naunyn-Schmiedeberg's archives of pharmacology, 1996, Volume: 353, Issue:3

    Topics: Administration, Oral; Alzheimer Disease; Animals; Arginine Vasopressin; Cerebral Cortex; Dose-Response Relationship, Drug; Hippocampus; Neuropeptides; Prolyl Oligopeptidases; Pyrrolidines; Rats; Rats, Wistar; Serine Endopeptidases; Serine Proteinase Inhibitors; Substance P; Thyrotropin-Releasing Hormone

1996
Pharmacological studies of a novel prolyl endopeptidase inhibitor, JTP-4819, in rats with middle cerebral artery occlusion.
    European journal of pharmacology, 1996, Jun-03, Volume: 305, Issue:1-3

    Topics: Animals; Arginine Vasopressin; Arterial Occlusive Diseases; Avoidance Learning; Brain Ischemia; Cerebral Arteries; Cerebral Cortex; Hippocampus; Learning; Male; Maze Learning; Motor Activity; Protease Inhibitors; Pyrrolidines; Rats; Rats, Sprague-Dawley; Substance P; Thyrotropin-Releasing Hormone

1996
Effect of a novel prolyl endopeptidase inhibitor, JTP-4819, on spatial memory and on cholinergic and peptidergic neurons in rats with ibotenate-induced lesions of the nucleus basalis magnocellularis.
    Behavioural brain research, 1999, Feb-15, Volume: 99, Issue:1

    Topics: Animals; Arginine Vasopressin; Basal Ganglia; Choline O-Acetyltransferase; Excitatory Amino Acid Agonists; Ibotenic Acid; Male; Maze Learning; Memory; Neurons; Neuropeptides; Parasympathetic Nervous System; Prolyl Oligopeptidases; Pyrrolidines; Rats; Rats, Wistar; Receptor, Muscarinic M1; Receptors, Muscarinic; Serine Endopeptidases; Serine Proteinase Inhibitors; Substance P; Thyrotropin-Releasing Hormone

1999
Beneficial effect of prolyl oligopeptidase inhibition on spatial memory in young but not in old scopolamine-treated rats.
    Basic & clinical pharmacology & toxicology, 2007, Volume: 100, Issue:2

    Topics: Aging; Amnesia; Animals; Frontal Lobe; Hippocampus; Hypothalamus; Inositol 1,4,5-Trisphosphate; Male; Maze Learning; Memory; Motor Activity; Muscarinic Antagonists; Neurotensin; Prolyl Oligopeptidases; Pyrrolidines; Rats; Rats, Wistar; Scopolamine; Serine Endopeptidases; Serine Proteinase Inhibitors; Substance P

2007