jte 522 has been researched along with oxazoles in 43 studies
| Studies (jte 522) | Trials (jte 522) | Recent Studies (post-2010) (jte 522) | Studies (oxazoles) | Trials (oxazoles) | Recent Studies (post-2010) (oxazoles) |
|---|---|---|---|---|---|
| 61 | 1 | 7 | 9,281 | 366 | 2,561 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 8 (18.60) | 18.2507 |
| 2000's | 33 (76.74) | 29.6817 |
| 2010's | 2 (4.65) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Masaki, M; Matsushita, M; Tanaka, T; Wakitani, K; Yagi, Y | 1 |
| Mue, S; Niki, H; Ohuchi, K; Yamada, M; Yamaki, K | 1 |
| Masaki, M; Matsushita, M; Wakitani, K | 1 |
| Masaki, M; Matsushita, M; Nanayama, T; Wakitani, K | 1 |
| Sakashita, Y; Yamamoto, T | 1 |
| Kawakami, K; Mizuno, H; Nishimura, G; Tsukuda, M; Yanoma, S | 1 |
| Hatano, K; Ishihara, S; Kitayama, J; Muto, T; Nagawa, H; Nita, ME; Osada, T; Shibata, Y; Sunami, E; Tomozawa, S; Tsuno, N; Tsuruo, T; Yano, H | 1 |
| Nozaki-Taguchi, N; Sakashita, Y; Yamamoto, T | 1 |
| Masaki, M; Sasai, H; Wakitani, K | 1 |
| Ogawa, S | 1 |
| Iwamura, H; Matsushita, M; Tazaki, H; Wakitani, K | 1 |
| Aizawa, H; Fukuyama, S; Hara, N; Inoue, H; Matsumoto, K; Nakano, H | 1 |
| Higashida, H; Kadoyama, K; Takahashi, Y; Tanabe, T; Yoshimoto, T | 1 |
| Ding, Y; Hong, T; Imamura, M; Kaganoi, J; Kawabe, A; Komoto, I; Li, Z; Maeda, M; Sato, F; Shimada, Y | 1 |
| Dubois, RN; Kobayashi, O; Miwa, H; Sato, N; Tsujii, M; Watanabe, S | 1 |
| Harada, M; Hayakawa, T; Ito, T; Matsui, H; Naruse, K; Numaguchi, Y; Okumura, K; Yamada, M | 1 |
| Haruta, J; Hashimoto, H; Imamura, K; Wakitani, K | 1 |
| Chen, DD; Li, HL; Li, XH; Lü, JH; Ren, XD; Wang, CC; Zhang, HW | 1 |
| Hirose, M; Kobayashi, O; Kurosawa, A; Misawa, H; Miwa, H; Oshida, K; Sato, N; Watanabe, S | 1 |
| Chen, DD; Li, HL; Li, XH; Lu, YQ; Ren, XD; Ye, CL; Zhang, HW | 1 |
| Chen, DD; Li, HL; Ren, XD; St-Tu, R; Zhang, HW; Zhong, L | 1 |
| Hida, T; Ito, H; Kozaki, K; Matsuo, K; Miyaishi, O; Ogawa, M; Sugiura, T; Suzuki, T; Takahashi, T; Tatematsu, Y | 1 |
| Hirakawa, K; Nagatsuka, I; Nishino, H; Ohira, M; Seki, S; Shimizu, S; Yamada, N | 1 |
| Kamoi, K; Kawauchi, A; Miki, T; Mizutani, Y; Ukimura, O | 1 |
| Ikeda, Y; Kobayashi, T; Kondo, K; Nakashima, M; Takahashi, M; Umemura, K | 1 |
| Chang-De, J; Damdinsuren, B; Dono, K; Kobayashi, S; Kondo, M; Matsuura, N; Monden, M; Nagano, H; Nakamori, S; Sakon, M; Sekimoto, M; Sugita, Y; Umeshita, K; Wakasa, K; Yamamoto, H | 1 |
| Amano, H; Hayashi, I; Inukai, M; Kamata, M; Kitasato, H; Majima, M; Yoshida, S; Yoshimura, H | 1 |
| Doi, K; Fukushima, S; Mitsuhashi, M; Moku, M; Morimura, K; Salim, EI; Shen, J; Wanibuchi, H; Wei, M | 1 |
| Dono, K; Fujiwara, Y; Hayashi, N; Hiraoka, N; Monden, M; Nagano, H; Nakamori, S; Okami, J; Sakon, M; Tsujie, M; Umeshita, K; Yamamoto, H | 1 |
| Imamura, M; Itami, A; Kaganoi, J; Kawabe, A; Kiyono, T; Maeda, M; Shimada, Y; Soma, T | 1 |
| Kawauchi, A; Li, YN; Miki, T; Mizutani, Y; Nakanishi, H; Sato, N | 1 |
| Enomoto, M; Gonda, T; Higuchi, T; Kobayashi, H; Sugihara, K; Uetake, H | 1 |
| Fukushima, S; Hakoi, K; Moku, M; Morimura, K; Salim, EI; Shen, J; Wanibuchi, H; Wei, M | 1 |
| Asakage, M; Hori, N; Kaisaki, S; Kawai, K; Kitayama, J; Nagawa, H; Okaji, Y; Sunami, E; Takahashi, K; Tsuno, NH; Watanabe, T; Yazawa, K | 2 |
| Enomoto, M; Higuchi, T; Kobayashi, H; Sugihara, K; Uetake, H | 1 |
| Inoue, H; Kuge, Y; Minematsu, K; Tamaki, N; Yokota, C | 1 |
| Hirakawa, K; Nakazawa, K; Tendo, M; Yamada, N; Yashiro, M | 1 |
| Hirakawa, K; Nakazawa, K; Ohira, M; Sawada, T; Tendo, M; Yamada, N; Yashiro, M | 1 |
| Hirakawa, K; Kosaka, K; Nakazawa, K; Shinto, O; Tendo, M; Yashiro, M | 1 |
| Murawaki, Y; Nagahara, T; Okano, J | 1 |
| Abe, K; Fujiwara, J; Hayashi, I; Ishida, H; Kawauchi, A; Li, YN; Miki, T; Mizutani, Y; Nakanishi, H; Sato, N; Toiyama, D | 1 |
| Abe, R; Fujise, Y; Murawaki, Y; Nagahara, T; Okano, J | 1 |
43 other study(ies) available for jte 522 and oxazoles
| Article | Year |
|---|---|
Pharmacological profile of JTE-522, a novel prostaglandin H synthase-2 inhibitor, in rats.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Benzenesulfonates; Carrageenan; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Disease Models, Animal; Dose-Response Relationship, Drug; Edema; Hyperalgesia; Indomethacin; Isoenzymes; Male; Membrane Proteins; Oxazoles; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Inbred Lew; Rats, Sprague-Dawley; Rats, Wistar | 1997 |
Effects of JTE-522, a specific inhibitor of cyclooxygenase-2, on the recurrence of allergic inflammation in rats.
Topics: Animals; Benzenesulfonates; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Hypersensitivity; Isoenzymes; Macrophages, Peritoneal; Male; Oxazoles; Peroxidases; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Sprague-Dawley | 1998 |
Inhibitory effects of JTE-522, a novel prostaglandin H synthase-2 inhibitor, on adjuvant-induced arthritis and bone changes in rats.
Topics: Administration, Oral; Amino Acids; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Benzenesulfonates; Bone Density; Cyclooxygenase Inhibitors; Hindlimb; Indomethacin; Male; Oxazoles; Pyridinium Compounds; Radiography; Rats; Rats, Inbred Lew; Stomach | 1998 |
Profile of JTE-522 as a human cyclooxygenase-2 inhibitor.
Topics: Benzenesulfonates; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Humans; Isoenzymes; Leukocytes, Mononuclear; Lipopolysaccharides; Membrane Proteins; Oxazoles; Prostaglandin-Endoperoxide Synthases; Time Factors | 1998 |
The role of the spinal opioid receptor like1 receptor, the NK-1 receptor, and cyclooxygenase-2 in maintaining postoperative pain in the rat.
Topics: Animals; Benzenesulfonates; Biphenyl Compounds; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dermatologic Surgical Procedures; Dipeptides; Hindlimb; Hyperalgesia; Indoles; Isoenzymes; Male; Neurokinin-1 Receptor Antagonists; Nitrobenzenes; Nociceptin; Nociceptin Receptor; Opioid Peptides; Oxazoles; Pain Threshold; Pain, Postoperative; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Receptors, Opioid; Spinal Cord; Sulfonamides | 1999 |
A selective cyclooxygenase-2 inhibitor suppresses tumor growth in nude mouse xenografted with human head and neck squamous carcinoma cells.
Topics: Animals; Benzenesulfonates; Carcinoma, Squamous Cell; Cell Cycle; Cell Division; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Cytotoxicity, Immunologic; Female; G1 Phase; Head and Neck Neoplasms; Humans; Isoenzymes; KB Cells; Killer Cells, Lymphokine-Activated; Killer Cells, Natural; Membrane Proteins; Mice; Mice, Nude; Oxazoles; Platelet-Derived Growth Factor; Prostaglandin-Endoperoxide Synthases; Telomerase; Transplantation, Heterologous | 1999 |
Inhibition of haematogenous metastasis of colon cancer in mice by a selective COX-2 inhibitor, JTE-522.
Topics: Animals; Benzenesulfonates; Cell Division; Colonic Neoplasms; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Disease Models, Animal; Isoenzymes; Lung Neoplasms; Matrix Metalloproteinase Inhibitors; Mice; Mice, Inbred BALB C; Neoplasm Transplantation; Oxazoles; Prostaglandin-Endoperoxide Synthases | 1999 |
Anti-allodynic effects of oral COX-2 selective inhibitor on postoperative pain in the rat.
Topics: Animals; Benzenesulfonates; Bradykinin Receptor Antagonists; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Drug Interactions; Indomethacin; Isoenzymes; Male; Oxazoles; Pain Measurement; Pain, Postoperative; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Sprague-Dawley | 2000 |
Suppression of polypogenesis in a new mouse strain with a truncated Apc(Delta474) by a novel COX-2 inhibitor, JTE-522.
Topics: Adenomatous Polyposis Coli; Amino Acid Sequence; Animals; Base Sequence; Benzenesulfonates; Colorectal Neoplasms; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Female; Genes, APC; Genotype; Isoenzymes; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Knockout; Molecular Sequence Data; Mutation; Oxazoles; Prostaglandin-Endoperoxide Synthases; Reverse Transcriptase Polymerase Chain Reaction | 2000 |
[Mechanism of postoperative pain and the analgesia].
Topics: Analgesia; Analgesics, Opioid; Anesthetics, Local; Animals; Benzenesulfonates; Central Nervous System; Cyclooxygenase Inhibitors; Humans; Lidocaine; Morphine; Oxazoles; Pain, Postoperative; Peripheral Nervous System | 1999 |
JTE-522 selectively inhibits cyclooxygenase-2-derived prostaglandin production in inflammatory tissues.
Topics: Animals; Benzenesulfonates; Carrageenan; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Edema; Foot; Gastric Mucosa; Inflammation; Isoenzymes; Macrophages, Peritoneal; Male; Oxazoles; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Rats; Rats, Sprague-Dawley; Thromboxane B2 | 2000 |
Cyclooxygenase-2 participates in the late phase of airway hyperresponsiveness after ozone exposure in guinea pigs.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Administration, Inhalation; Animals; Benzenesulfonates; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Cell Count; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Guinea Pigs; Histamine; Immunohistochemistry; Isoenzymes; Male; Oxazoles; Oxidants, Photochemical; Ozone; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Thromboxane A2 | 2000 |
Cyclooxygenase-2 stimulates production of amyloid beta-peptide in neuroblastoma x glioma hybrid NG108-15 cells.
Topics: Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Benzenesulfonates; Cell Division; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; DNA, Recombinant; Gene Expression Regulation, Enzymologic; Genetic Vectors; Glioma; Hybrid Cells; Indomethacin; Isoenzymes; Mice; Neurites; Neuroblastoma; Oxazoles; Prostaglandin-Endoperoxide Synthases; Rats; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Transfection; Tumor Cells, Cultured | 2001 |
Suppression of N-nitrosomethylbenzylamine (NMBA)-induced esophageal tumorigenesis in F344 rats by JTE-522, a selective COX-2 inhibitor.
Topics: Animals; Benzenesulfonates; Body Weight; Carcinogens; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dimethylnitrosamine; Dinoprostone; Enzyme-Linked Immunosorbent Assay; Esophageal Neoplasms; Esophagus; Isoenzymes; Male; Oxazoles; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Inbred F344; Reverse Transcriptase Polymerase Chain Reaction | 2001 |
Cyclooxygenase-2 downregulates inducible nitric oxide synthase in rat intestinal epithelial cells.
Topics: Animals; Arachidonic Acid; Benzenesulfonates; Blotting, Western; Cells, Cultured; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; DNA-Binding Proteins; Down-Regulation; Enzyme Induction; Epithelial Cells; I-kappa B Proteins; Interferon Regulatory Factor-1; Interferon-gamma; Intestinal Mucosa; Isoenzymes; Lipopolysaccharides; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; NF-kappa B; NF-KappaB Inhibitor alpha; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Oxazoles; Phosphoproteins; Prostaglandin-Endoperoxide Synthases; Rats; RNA, Messenger; Transcription Factor AP-1; Transfection | 2001 |
Prostacyclin synthase gene transfer modulates cyclooxygenase-2-derived prostanoid synthesis and inhibits neointimal formation in rat balloon-injured arteries.
Topics: Angioplasty, Balloon; Animals; Benzenesulfonates; Carotid Arteries; Cyclooxygenase 2; Cytochrome P-450 Enzyme System; Dinoprostone; Gene Transfer Techniques; Genetic Therapy; Immunohistochemistry; Indomethacin; Intramolecular Oxidoreductases; Isoenzymes; Male; Membrane Proteins; Oxazoles; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Rats; Rats, Sprague-Dawley; Saccharomyces cerevisiae Proteins; Tunica Intima | 2002 |
4-(4-cycloalkyl/aryl-oxazol-5-yl)benzenesulfonamides as selective cyclooxygenase-2 inhibitors: enhancement of the selectivity by introduction of a fluorine atom and identification of a potent, highly selective, and orally active COX-2 inhibitor JTE-522(1)
Topics: Anti-Inflammatory Agents; Arthritis, Rheumatoid; Benzenesulfonates; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Fluorine; Humans; Inhibitory Concentration 50; Isoenzymes; Membrane Proteins; Models, Chemical; Oxazoles; Prostaglandin-Endoperoxide Synthases; Sulfonamides; Temperature | 2002 |
JTE-522-induced apoptosis in human gastric adenocarcinoma [correction of adenocarcinoma] cell line AGS cells by caspase activation accompanying cytochrome C release, membrane translocation of Bax and loss of mitochondrial membrane potential.
Topics: Adenocarcinoma; Amino Acid Chloromethyl Ketones; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; bcl-2-Associated X Protein; Benzenesulfonates; Caspase Inhibitors; Caspases; Cyclooxygenase Inhibitors; Cysteine Proteinase Inhibitors; Cytochrome c Group; Enzyme Activation; Humans; In Situ Nick-End Labeling; Membrane Potentials; Mitochondria; Oxazoles; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Stomach Neoplasms; Tumor Cells, Cultured | 2002 |
Inhibition of proliferation of gastric epithelial cells by a cyclooxygenase 2 inhibitor, JTE522, is also mediated by a PGE2-independent pathway.
Topics: Animals; Arachidonic Acid; Benzenesulfonates; Cell Division; Cell Line; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Epithelial Cells; Gastric Mucosa; Isoenzymes; Male; Oxazoles; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Wistar; Wound Healing | 2002 |
Changes of NF-kB, p53, Bcl-2 and caspase in apoptosis induced by JTE-522 in human gastric adenocarcinoma cell line AGS cells: role of reactive oxygen species.
Topics: Adenocarcinoma; Apoptosis; Benzenesulfonates; Caspases; Cell Division; DNA-Binding Proteins; Humans; I-kappa B Proteins; NF-kappa B; NF-KappaB Inhibitor alpha; Oxazoles; Proto-Oncogene Proteins c-bcl-2; Reactive Oxygen Species; Stomach Neoplasms; Tumor Cells, Cultured; Tumor Suppressor Protein p53 | 2002 |
JTE-522, a selective COX-2 inhibitor, inhibits cell proliferation and induces apoptosis in RL95-2 cells.
Topics: Apoptosis; Benzenesulfonates; Caspase 3; Caspases; Cell Division; Cell Line, Tumor; Cyclooxygenase 2; Endometrial Neoplasms; Female; Humans; Isoenzymes; Membrane Proteins; Oxazoles; Prostaglandin-Endoperoxide Synthases; RNA, Messenger | 2002 |
Significant growth inhibition of human lung cancer cells both in vitro and in vivo by the combined use of a selective cyclooxygenase 2 inhibitor, JTE-522, and conventional anticancer agents.
Topics: Adenocarcinoma; Animals; Anthracyclines; Antibiotics, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Benzenesulfonates; Cell Division; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Docetaxel; Drug Resistance, Neoplasm; Female; Humans; In Vitro Techniques; Isoenzymes; Lung Neoplasms; Membrane Proteins; Mice; Mice, Nude; Neoplasm Transplantation; Oxazoles; Paclitaxel; Prostaglandin-Endoperoxide Synthases; Taxoids; Tumor Cells, Cultured; Vinblastine; Vinorelbine | 2002 |
Inhibitory effect of a selective cyclooxygenase-2 inhibitor on liver metastasis of colon cancer.
Topics: Animals; Benzenesulfonates; Cell Division; Colonic Neoplasms; Cyclooxygenase 2; Dinoprostone; Dose-Response Relationship, Drug; Endothelial Growth Factors; Enzyme-Linked Immunosorbent Assay; Humans; Isoenzymes; Liver Neoplasms; Lymphokines; Matrix Metalloproteinases; Membrane Proteins; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Invasiveness; Neoplasm Transplantation; Oxazoles; Platelet-Derived Growth Factor; Prostaglandin-Endoperoxide Synthases; Tumor Cells, Cultured; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors | 2002 |
Synergistic cytotoxicity and apoptosis of JTE-522, a selective cyclooxygenase-2 inhibitor, and 5-fluorouracil against bladder cancer.
Topics: Antimetabolites, Antineoplastic; Apoptosis; bcl-2-Associated X Protein; bcl-X Protein; Benzenesulfonates; Blotting, Western; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Drug Synergism; Fluorouracil; Humans; Isoenzymes; Male; Membrane Proteins; Oxazoles; Prostaglandin-Endoperoxide Synthases; Prostatic Neoplasms; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tumor Cells, Cultured; Urinary Bladder Neoplasms | 2002 |
Pharmacokinetics and safety of JTE-522, a novel selective cyclooxygenase-2 inhibitor, in healthy male volunteers.
Topics: Administration, Oral; Adult; Area Under Curve; Benzenesulfonates; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Half-Life; Humans; Isoenzymes; Male; Membrane Proteins; Oxazoles; Pilot Projects; Prostaglandin-Endoperoxide Synthases | 2002 |
JTE-522, a cyclooxygenase-2 inhibitor, is an effective chemopreventive agent against rat experimental liver fibrosis1.
Topics: Actins; Animals; Benzenesulfonates; Body Weight; Choline Deficiency; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; DNA Damage; Genes, myc; Isoenzymes; Liver; Liver Cirrhosis, Experimental; Liver Neoplasms, Experimental; Male; Oxazoles; Precancerous Conditions; Proliferating Cell Nuclear Antigen; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Wistar | 2003 |
COX-2/VEGF-dependent facilitation of tumor-associated angiogenesis and tumor growth in vivo.
Topics: Animals; Antibodies, Blocking; Aspirin; Benzenesulfonates; Carcinoma, Lewis Lung; Cyclooxygenase Inhibitors; Disease Models, Animal; Endothelial Growth Factors; Intercellular Signaling Peptides and Proteins; Isoxazoles; Lymphokines; Male; Mice; Mice, Inbred C57BL; Neoplasm Transplantation; Neovascularization, Pathologic; Nitrobenzenes; Oxazoles; Prostaglandin-Endoperoxide Synthases; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sarcoma 180; Sulfonamides; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors | 2003 |
Chemopreventive effect of JTE-522, a selective cyclooxygenase-2 inhibitor, on 1, 2-dimethylhydrazine-induced rat colon carcinogenesis.
Topics: 1,2-Dimethylhydrazine; Animals; Benzenesulfonates; Bromodeoxyuridine; Carcinogens; Cell Division; Colon; Colonic Neoplasms; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Disease Progression; Isoenzymes; Male; Oxazoles; Precancerous Conditions; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Inbred F344 | 2003 |
Suppression of pancreatic cancer cell invasion by a cyclooxygenase-2-specific inhibitor.
Topics: Benzenesulfonates; Cell Adhesion; Cell Division; Cell Movement; Cell Survival; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Drug Evaluation; Humans; Isoenzymes; Matrix Metalloproteinases; Membrane Proteins; Neoplasm Invasiveness; Oxazoles; Pancreatic Neoplasms; Prostaglandin-Endoperoxide Synthases; Tumor Cells, Cultured | 2003 |
Production of prostaglandinE2 via bile acid is enhanced by trypsin and acid in normal human esophageal epithelial cells.
Topics: Benzenesulfonates; Cell Survival; Cells, Cultured; Chenodeoxycholic Acid; Culture Media; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Duodenogastric Reflux; Epithelial Cells; Esophagus; Humans; Hydrogen-Ion Concentration; Immunoblotting; Isoenzymes; Membrane Proteins; Oxazoles; Prostaglandin-Endoperoxide Synthases; Trypsin; Up-Regulation | 2004 |
Enhanced sensitivity of bladder cancer cells to cisplatin mediated cytotoxicity and apoptosis in vitro and in vivo by the selective cyclooxygenase-2 inhibitor JTE-522.
Topics: Animals; Antineoplastic Agents; Apoptosis; Benzenesulfonates; Carcinoma, Transitional Cell; Cell Division; Cell Line, Tumor; Cell Survival; Cisplatin; Cyclooxygenase Inhibitors; Drug Synergism; Female; Humans; Mice; Mice, SCID; Neoplasm Transplantation; Oxazoles; Proto-Oncogene Proteins c-bcl-2; Tumor Cells, Cultured; Tumor Stem Cell Assay; Urinary Bladder Neoplasms | 2004 |
JTE-522, a selective COX-2 inhibitor, interferes with the growth of lung metastases from colorectal cancer in rats due to inhibition of neovascularization: a vascular cast model study.
Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Agents; Benzenesulfonates; Cell Line, Tumor; Colorectal Neoplasms; Cyclooxygenase 2; Enzyme Inhibitors; Isoenzymes; Logistic Models; Lung Neoplasms; Male; Microcirculation; Microscopy, Electron, Scanning; Neovascularization, Pathologic; Oxazoles; Prostaglandin-Endoperoxide Synthases; Pulmonary Circulation; Rats; Rats, Inbred F344 | 2004 |
JTE-522, a selective cyclooxygenase-2 inhibitor, inhibits induction but not growth and invasion of 1,2-dimethylhydrazine-induced tubular adenocarcinomas of colon in rats.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Adenoma; Animals; Benzenesulfonates; Biomarkers, Tumor; Carcinogens; Colonic Neoplasms; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Disease Progression; Gene Expression Profiling; Isoenzymes; Male; Oligonucleotide Array Sequence Analysis; Oxazoles; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Inbred F344 | 2005 |
Selective inhibition of cyclooxygenase (COX)-2 inhibits endothelial cell proliferation by induction of cell cycle arrest.
Topics: Apoptosis; Benzenesulfonates; Cell Adhesion; Cell Proliferation; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Endothelium, Vascular; Extracellular Matrix; G1 Phase; Humans; Isoenzymes; Matrix Metalloproteinase 2; Membrane Proteins; Neovascularization, Pathologic; Oxazoles; Prostaglandin-Endoperoxide Synthases; Umbilical Veins | 2005 |
Selective inhibition of cyclooxygenase-2 inhibits colon cancer cell adhesion to extracellular matrix by decreased expression of beta1 integrin.
Topics: Benzenesulfonates; Cell Adhesion; Cell Division; Cell Movement; Colonic Neoplasms; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Dose-Response Relationship, Drug; Down-Regulation; Extracellular Matrix; HT29 Cells; Humans; Integrin beta1; Membrane Proteins; Oxazoles; Prostaglandin-Endoperoxide Synthases; Tumor Cells, Cultured | 2005 |
JTE-522, a selective COX-2 inhibitor, inhibits growth of pulmonary metastases of colorectal cancer in rats.
Topics: Animals; Benzenesulfonates; Colorectal Neoplasms; Cyclooxygenase 2 Inhibitors; Dose-Response Relationship, Drug; Lung; Lung Neoplasms; Organ Size; Oxazoles; Rats; Rats, Inbred F344; Vascular Endothelial Growth Factor A | 2005 |
Bilateral induction of the S-100A9 gene in response to spreading depression is modulated by the cyclooxygenase-2 activity.
Topics: Animals; Benzenesulfonates; Brain; Cortical Spreading Depression; Cyclooxygenase 2; Dinoprostone; Enzyme Inhibitors; Functional Laterality; Gene Expression; Male; Mitogen-Activated Protein Kinases; Oligonucleotide Array Sequence Analysis; Oxazoles; Potassium Chloride; Prostaglandin-Endoperoxide Synthases; Radioimmunoassay; Random Allocation; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; S100 Proteins | 2005 |
Inhibitory effect of a selective cyclooxygenase inhibitor on the invasion-stimulating activity of orthotopic fibroblasts for scirrhous gastric cancer cells.
Topics: Adenocarcinoma, Scirrhous; Animals; Antineoplastic Agents; Benzenesulfonates; Cell Line, Tumor; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Down-Regulation; Drug Synergism; Fibroblasts; Fluorouracil; Hepatocyte Growth Factor; Humans; In Vitro Techniques; Mice; Mice, Nude; Oxazoles; Prostaglandins E; Stomach Neoplasms | 2005 |
A synergic inhibitory-effect of combination with selective cyclooxygenase-2 inhibitor and S-1 on the peritoneal metastasis for scirrhous gastric cancer cells.
Topics: Adenocarcinoma, Scirrhous; Animals; Antimetabolites, Antineoplastic; Benzenesulfonates; Cyclooxygenase 2 Inhibitors; Drug Combinations; Drug Synergism; Drug Therapy, Combination; Female; Humans; Mice; Mice, Inbred BALB C; Mice, Nude; Oxazoles; Oxonic Acid; Peritoneal Neoplasms; Stomach Neoplasms; Survival Rate; Tegafur; Tumor Cells, Cultured | 2006 |
Selective cyclooxygenase-2 inhibitor downregulates the paracrine epithelial-mesenchymal interactions of growth in scirrhous gastric carcinoma.
Topics: Animals; Benzenesulfonates; Cell Line; Cell Line, Tumor; Cell Proliferation; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Dinoprostone; Dose-Response Relationship, Drug; Epithelial Cells; Female; Fibroblast Growth Factor 7; Fibroblasts; Humans; Immunoblotting; Immunohistochemistry; Mesoderm; Mice; Mice, Inbred BALB C; Mice, Nude; Oxazoles; Paracrine Communication; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Stomach Neoplasms; Xenograft Model Antitumor Assays | 2007 |
Mechanisms of anti-proliferative effect of JTE-522, a selective cyclooxygenase-2 inhibitor, on human liver cancer cells.
Topics: Apoptosis; Benzenesulfonates; Carcinoma, Hepatocellular; Caspases; Cell Proliferation; Cyclin D; Cyclin E; Cyclin-Dependent Kinase Inhibitor p27; Cyclins; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Dinoprostone; Humans; Liver Neoplasms; Mitogen-Activated Protein Kinases; Oncogene Proteins; Oxazoles; PPAR gamma; Tumor Cells, Cultured | 2007 |
Enhancement of the sensitivity of renal cell carcinoma cells to fas-mediated cytotoxicity and apoptosis by the selective cyclooxygenase-2 inhibitor JTE-522.
Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Murine-Derived; Antineoplastic Agents; Apoptosis; Benzenesulfonates; Carcinoma, Renal Cell; Cyclooxygenase 2 Inhibitors; Drug Screening Assays, Antitumor; Humans; Kidney Neoplasms; Oxazoles; Tumor Cells, Cultured | 2010 |
Preventive effect of JTE-522, a selective cyclooxygenase-2 inhibitor, on DEN-induced hepatocarcinogenesis in rats.
Topics: Animals; Apoptosis; Benzenesulfonates; Blotting, Western; Carcinoma, Hepatocellular; Cell Proliferation; Chemoprevention; Cyclooxygenase 2 Inhibitors; Diethylnitrosamine; Gene Expression Regulation, Neoplastic; Glutathione Transferase; In Situ Nick-End Labeling; Liver Neoplasms, Experimental; Male; Oxazoles; Oxidative Stress; Proliferating Cell Nuclear Antigen; Rats; Rats, Wistar; Time Factors | 2010 |