Page last updated: 2024-09-04

jte 522 and dinoprostone

jte 522 has been researched along with dinoprostone in 14 studies

Compound Research Comparison

Studies
(jte 522)
Trials
(jte 522)
Recent Studies (post-2010)
(jte 522)
Studies
(dinoprostone)
Trials
(dinoprostone)
Recent Studies (post-2010) (dinoprostone)
611729,1051,3466,357

Protein Interaction Comparison

ProteinTaxonomyjte 522 (IC50)dinoprostone (IC50)
Prostaglandin E2 receptor EP1 subtypeHomo sapiens (human)0.0155
Prostaglandin E2 receptor EP4 subtypeHomo sapiens (human)0.0031
Prostaglandin E2 receptor EP4 subtypeRattus norvegicus (Norway rat)0.0021
Prostaglandin E2 receptor EP3 subtypeHomo sapiens (human)0.002
Prostaglandin E2 receptor EP2 subtypeHomo sapiens (human)0.0087
Prostacyclin receptorHomo sapiens (human)0.26
Prostaglandin E2 receptor EP2 subtypeRattus norvegicus (Norway rat)0.0052

Research

Studies (14)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (14.29)18.2507
2000's12 (85.71)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Mue, S; Niki, H; Ohuchi, K; Yamada, M; Yamaki, K1
Masaki, M; Matsushita, M; Nanayama, T; Wakitani, K1
Iwamura, H; Matsushita, M; Tazaki, H; Wakitani, K1
Aizawa, H; Fukuyama, S; Hara, N; Inoue, H; Matsumoto, K; Nakano, H1
Ding, Y; Hong, T; Imamura, M; Kaganoi, J; Kawabe, A; Komoto, I; Li, Z; Maeda, M; Sato, F; Shimada, Y1
Dubois, RN; Kobayashi, O; Miwa, H; Sato, N; Tsujii, M; Watanabe, S1
Harada, M; Hayakawa, T; Ito, T; Matsui, H; Naruse, K; Numaguchi, Y; Okumura, K; Yamada, M1
Hirose, M; Kobayashi, O; Kurosawa, A; Misawa, H; Miwa, H; Oshida, K; Sato, N; Watanabe, S1
Hirakawa, K; Nagatsuka, I; Nishino, H; Ohira, M; Seki, S; Shimizu, S; Yamada, N1
Imamura, M; Itami, A; Kaganoi, J; Kawabe, A; Kiyono, T; Maeda, M; Shimada, Y; Soma, T1
Asakage, M; Hori, N; Kaisaki, S; Kawai, K; Kitayama, J; Nagawa, H; Okaji, Y; Sunami, E; Takahashi, K; Tsuno, NH; Watanabe, T; Yazawa, K1
Inoue, H; Kuge, Y; Minematsu, K; Tamaki, N; Yokota, C1
Hirakawa, K; Kosaka, K; Nakazawa, K; Shinto, O; Tendo, M; Yashiro, M1
Murawaki, Y; Nagahara, T; Okano, J1

Other Studies

14 other study(ies) available for jte 522 and dinoprostone

ArticleYear
Effects of JTE-522, a specific inhibitor of cyclooxygenase-2, on the recurrence of allergic inflammation in rats.
    European journal of pharmacology, 1998, Mar-05, Volume: 344, Issue:2-3

    Topics: Animals; Benzenesulfonates; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Hypersensitivity; Isoenzymes; Macrophages, Peritoneal; Male; Oxazoles; Peroxidases; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Sprague-Dawley

1998
Profile of JTE-522 as a human cyclooxygenase-2 inhibitor.
    Japanese journal of pharmacology, 1998, Volume: 78, Issue:3

    Topics: Benzenesulfonates; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Humans; Isoenzymes; Leukocytes, Mononuclear; Lipopolysaccharides; Membrane Proteins; Oxazoles; Prostaglandin-Endoperoxide Synthases; Time Factors

1998
JTE-522 selectively inhibits cyclooxygenase-2-derived prostaglandin production in inflammatory tissues.
    Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2000, Volume: 49, Issue:3

    Topics: Animals; Benzenesulfonates; Carrageenan; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Edema; Foot; Gastric Mucosa; Inflammation; Isoenzymes; Macrophages, Peritoneal; Male; Oxazoles; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Rats; Rats, Sprague-Dawley; Thromboxane B2

2000
Cyclooxygenase-2 participates in the late phase of airway hyperresponsiveness after ozone exposure in guinea pigs.
    European journal of pharmacology, 2000, Sep-08, Volume: 403, Issue:3

    Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Administration, Inhalation; Animals; Benzenesulfonates; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Cell Count; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Guinea Pigs; Histamine; Immunohistochemistry; Isoenzymes; Male; Oxazoles; Oxidants, Photochemical; Ozone; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Thromboxane A2

2000
Suppression of N-nitrosomethylbenzylamine (NMBA)-induced esophageal tumorigenesis in F344 rats by JTE-522, a selective COX-2 inhibitor.
    Carcinogenesis, 2001, Volume: 22, Issue:4

    Topics: Animals; Benzenesulfonates; Body Weight; Carcinogens; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dimethylnitrosamine; Dinoprostone; Enzyme-Linked Immunosorbent Assay; Esophageal Neoplasms; Esophagus; Isoenzymes; Male; Oxazoles; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Inbred F344; Reverse Transcriptase Polymerase Chain Reaction

2001
Cyclooxygenase-2 downregulates inducible nitric oxide synthase in rat intestinal epithelial cells.
    American journal of physiology. Gastrointestinal and liver physiology, 2001, Volume: 281, Issue:3

    Topics: Animals; Arachidonic Acid; Benzenesulfonates; Blotting, Western; Cells, Cultured; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; DNA-Binding Proteins; Down-Regulation; Enzyme Induction; Epithelial Cells; I-kappa B Proteins; Interferon Regulatory Factor-1; Interferon-gamma; Intestinal Mucosa; Isoenzymes; Lipopolysaccharides; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; NF-kappa B; NF-KappaB Inhibitor alpha; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Oxazoles; Phosphoproteins; Prostaglandin-Endoperoxide Synthases; Rats; RNA, Messenger; Transcription Factor AP-1; Transfection

2001
Prostacyclin synthase gene transfer modulates cyclooxygenase-2-derived prostanoid synthesis and inhibits neointimal formation in rat balloon-injured arteries.
    Arteriosclerosis, thrombosis, and vascular biology, 2002, Feb-01, Volume: 22, Issue:2

    Topics: Angioplasty, Balloon; Animals; Benzenesulfonates; Carotid Arteries; Cyclooxygenase 2; Cytochrome P-450 Enzyme System; Dinoprostone; Gene Transfer Techniques; Genetic Therapy; Immunohistochemistry; Indomethacin; Intramolecular Oxidoreductases; Isoenzymes; Male; Membrane Proteins; Oxazoles; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Rats; Rats, Sprague-Dawley; Saccharomyces cerevisiae Proteins; Tunica Intima

2002
Inhibition of proliferation of gastric epithelial cells by a cyclooxygenase 2 inhibitor, JTE522, is also mediated by a PGE2-independent pathway.
    Alimentary pharmacology & therapeutics, 2002, Volume: 16 Suppl 2

    Topics: Animals; Arachidonic Acid; Benzenesulfonates; Cell Division; Cell Line; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Epithelial Cells; Gastric Mucosa; Isoenzymes; Male; Oxazoles; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Wistar; Wound Healing

2002
Inhibitory effect of a selective cyclooxygenase-2 inhibitor on liver metastasis of colon cancer.
    International journal of cancer, 2002, Aug-10, Volume: 100, Issue:5

    Topics: Animals; Benzenesulfonates; Cell Division; Colonic Neoplasms; Cyclooxygenase 2; Dinoprostone; Dose-Response Relationship, Drug; Endothelial Growth Factors; Enzyme-Linked Immunosorbent Assay; Humans; Isoenzymes; Liver Neoplasms; Lymphokines; Matrix Metalloproteinases; Membrane Proteins; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Invasiveness; Neoplasm Transplantation; Oxazoles; Platelet-Derived Growth Factor; Prostaglandin-Endoperoxide Synthases; Tumor Cells, Cultured; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors

2002
Production of prostaglandinE2 via bile acid is enhanced by trypsin and acid in normal human esophageal epithelial cells.
    Life sciences, 2004, May-21, Volume: 75, Issue:1

    Topics: Benzenesulfonates; Cell Survival; Cells, Cultured; Chenodeoxycholic Acid; Culture Media; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Duodenogastric Reflux; Epithelial Cells; Esophagus; Humans; Hydrogen-Ion Concentration; Immunoblotting; Isoenzymes; Membrane Proteins; Oxazoles; Prostaglandin-Endoperoxide Synthases; Trypsin; Up-Regulation

2004
Selective inhibition of cyclooxygenase-2 inhibits colon cancer cell adhesion to extracellular matrix by decreased expression of beta1 integrin.
    Cancer science, 2005, Volume: 96, Issue:2

    Topics: Benzenesulfonates; Cell Adhesion; Cell Division; Cell Movement; Colonic Neoplasms; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Dose-Response Relationship, Drug; Down-Regulation; Extracellular Matrix; HT29 Cells; Humans; Integrin beta1; Membrane Proteins; Oxazoles; Prostaglandin-Endoperoxide Synthases; Tumor Cells, Cultured

2005
Bilateral induction of the S-100A9 gene in response to spreading depression is modulated by the cyclooxygenase-2 activity.
    Journal of the neurological sciences, 2005, Jul-15, Volume: 234, Issue:1-2

    Topics: Animals; Benzenesulfonates; Brain; Cortical Spreading Depression; Cyclooxygenase 2; Dinoprostone; Enzyme Inhibitors; Functional Laterality; Gene Expression; Male; Mitogen-Activated Protein Kinases; Oligonucleotide Array Sequence Analysis; Oxazoles; Potassium Chloride; Prostaglandin-Endoperoxide Synthases; Radioimmunoassay; Random Allocation; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; S100 Proteins

2005
Selective cyclooxygenase-2 inhibitor downregulates the paracrine epithelial-mesenchymal interactions of growth in scirrhous gastric carcinoma.
    International journal of cancer, 2007, Feb-01, Volume: 120, Issue:3

    Topics: Animals; Benzenesulfonates; Cell Line; Cell Line, Tumor; Cell Proliferation; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Dinoprostone; Dose-Response Relationship, Drug; Epithelial Cells; Female; Fibroblast Growth Factor 7; Fibroblasts; Humans; Immunoblotting; Immunohistochemistry; Mesoderm; Mice; Mice, Inbred BALB C; Mice, Nude; Oxazoles; Paracrine Communication; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Stomach Neoplasms; Xenograft Model Antitumor Assays

2007
Mechanisms of anti-proliferative effect of JTE-522, a selective cyclooxygenase-2 inhibitor, on human liver cancer cells.
    Oncology reports, 2007, Volume: 18, Issue:5

    Topics: Apoptosis; Benzenesulfonates; Carcinoma, Hepatocellular; Caspases; Cell Proliferation; Cyclin D; Cyclin E; Cyclin-Dependent Kinase Inhibitor p27; Cyclins; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Dinoprostone; Humans; Liver Neoplasms; Mitogen-Activated Protein Kinases; Oncogene Proteins; Oxazoles; PPAR gamma; Tumor Cells, Cultured

2007