jorunnamycin-a and 1-2-3-4-tetrahydroquinoline

The field of organic chemistry has recently witnessed a rapid rise in the use of chemoenzymatic strategies for the synthesis of complex molecules. Under this paradigm, biocatalytic methods and contemporary synthetic methods are used synergistically in a multistep approach toward a target molecule. In light of the unparalleled regioselectivity and stereoselectivity of enzymatic transformations and the reaction diversity of contemporary organic chemistry, chemoenzymatic strategies hold enormous potential for streamlining access to important bioactive molecules. This review covers recent demonstrations of chemoenzymatic approaches in chemical synthesis, with special emphasis on the preparation of medicinally relevant natural products.

Topics: Aspartic Acid; Biocatalysis; Biological Products; Enzymes; Isoquinolines; Kainic Acid; Molecular Conformation; Podophyllotoxin; Quinolines; Quinolones; Stereoisomerism