jasplakinolide has been researched along with chaetoglobosins* in 2 studies
1 review(s) available for jasplakinolide and chaetoglobosins
| Article | Year |
|---|---|
Exploiting the cytoskeletal filaments of neoplastic cells to potentiate a novel therapeutic approach.
Although cytoskeletal-directed agents have been a mainstay in chemotherapeutic protocols due to their ability to readily interfere with the rapid mitotic progression of neoplastic cells, they are all microtubule-based drugs, and there has yet to be any microfilament- or intermediate filament-directed agents approved for clinical use. There are many inherent differences between the cytoskeletal networks of malignant and normal cells, providing an ideal target to attain preferential damage. Further, numerous microfilament-directed agents, and an intermediate filament-directed agent of particular interest (withaferin A) have demonstrated in vitro and in vivo efficacy, suggesting that cytoskeletal filaments may be exploited to supplement chemotherapeutic approaches currently used in the clinical setting. Therefore, this review is intended to expose academics and clinicians to the tremendous variety of cytoskeletal filament-directed agents that are currently available for further chemotherapeutic evaluation. The mechanisms by which microfilament directed- and intermediate filament-directed agents damage malignant cells are discussed in detail in order to establish how the drugs can be used in combination with each other, or with currently approved chemotherapeutic agents to generate a substantial synergistic attack, potentially establishing a new paradigm of chemotherapeutic agents. Topics: Cytochalasins; Cytoskeleton; Depsipeptides; Humans; Indole Alkaloids; Neoplasms; Staurosporine | 2014 |
1 other study(ies) available for jasplakinolide and chaetoglobosins
| Article | Year |
|---|---|
Using jasplakinolide to turn on pathways that enable the isolation of new chaetoglobosins from Phomospis asparagi.
The isolation and structure elucidation of three new secondary metabolites, chaetoglobosin-510 (1), -540 (2), and -542 (3), are described. These compounds were produced by cultures of the marine-derived fungus Phomopsis asparagi, challenged with the known F-actin inhibitor jasplakinolide. Chaetoglobosin-542 (3) displayed antimicrofilament activity and was cytotoxic toward murine colon and leukemia cancer cell lines. Topics: Animals; Ascomycota; Depsipeptides; Indole Alkaloids; Indoles; Molecular Structure; Porifera | 2005 |