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jadomycin b and jadomycin a

jadomycin b has been researched along with jadomycin a in 16 studies

Compound Research Comparison

Studies
(jadomycin b)
Trials
(jadomycin b)
Recent Studies (post-2010)
(jadomycin b)
Studies
(jadomycin a)
Trials
(jadomycin a)
Recent Studies (post-2010) (jadomycin a)
4701922015

Research

Studies (16)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's4 (25.00)29.6817
2010's10 (62.50)24.3611
2020's2 (12.50)2.80

Authors

AuthorsStudies
Chen, Y; Greenwell, LM; Lipata, FM; Remsing Rix, LL; Rix, U; Rohr, J; Vining, LC; Wang, C; Yang, K1
Borissow, CN; Graham, CL; Jakeman, DL; Syvitski, RT1
Graham, CL; Jakeman, DL; Vining, LC; Young, W1
Blay, J; Borissow, CN; Graham, CL; Jakeman, DL; Reid, TR; Syvitski, RT1
Borissow, CN; Cottreau, KM; Graham, CL; Jakeman, DL; McFarland, SA; Spencer, C; Wentzell, JR1
Chen, Y; Fan, K; He, Y; Jia, C; Peng, Y; Xu, X; Yang, K; Yu, T1
O'Doherty, GA; Shan, M; Sharif, EU1
Kharel, MK; Nybo, SE; Pahari, P; Rohr, J; Shaaban, KA; Shepherd, MD; Tibrewal, N1
Ji, J; Peng, X; Yang, K; Zhang, H; Zhang, Y; Zhu, H1
Fan, K; Gao, W; Li, Y; Pan, G; Peng, X; Wang, J; Wang, W; Yang, K; Zheng, J1
Fan, K; Ji, J; Jin, L; Peng, X; Yang, K; Zhang, X; Zhang, Y1
Yang, X; Yu, B1
Fan, K; Pan, G; Tan, H; Yang, K; Zhang, Y; Zou, Z1
Jakeman, DL; Martinez-Farina, CF1
de Koning, CB; Ngwira, KJ; Rousseau, AL1
Bonitto, EP; Goralski, KB; McKeown, BT1

Reviews

4 review(s) available for jadomycin b and jadomycin a

ArticleYear
Angucyclines: Biosynthesis, mode-of-action, new natural products, and synthesis.
    Natural product reports, 2012, Volume: 29, Issue:2

    Topics: Aminoglycosides; Anthraquinones; Anti-Bacterial Agents; Biological Products; Biosynthetic Pathways; Carbohydrate Sequence; Cell Line, Tumor; Coumarins; Glycosides; Glycosylation; Humans; Isoquinolines; Molecular Structure; Naphthoquinones; Neoplasms; Polyketides; Quinones; Streptomyces; Structure-Activity Relationship

2012
[Progress in the understanding of the function of atypical response regulators: a review].
    Sheng wu gong cheng xue bao = Chinese journal of biotechnology, 2012, Volume: 28, Issue:5

    Topics: Bacterial Proteins; Gene Expression Regulation, Bacterial; Gene Expression Regulation, Developmental; Genes, Regulator; Histidine Kinase; Isoquinolines; Naphthoquinones; Phosphorylation; Protein Kinases; RNA-Binding Proteins; Signal Transduction; Streptomyces; Transcription Factors

2012
Biosynthesis, synthetic studies, and biological activities of the jadomycin alkaloids and related analogues.
    The Alkaloids. Chemistry and biology, 2020, Volume: 84

    Topics: Alkaloids; Anti-Bacterial Agents; Antifungal Agents; Antineoplastic Agents; Bacteria; Candida albicans; Humans; Isoquinolines; Naphthoquinones; Neoplasms; Phenanthridines

2020
Jadomycins: A potential chemotherapy for multi-drug resistant metastatic breast cancer.
    Pharmacology research & perspectives, 2021, Volume: 9, Issue:6

    Topics: Animals; Antineoplastic Agents; Breast Neoplasms; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Female; Humans; Isoquinolines; Naphthoquinones; Streptomyces

2021

Other Studies

12 other study(ies) available for jadomycin b and jadomycin a

ArticleYear
The oxidative ring cleavage in jadomycin biosynthesis: a multistep oxygenation cascade in a biosynthetic black box.
    Chembiochem : a European journal of chemical biology, 2005, Volume: 6, Issue:5

    Topics: Amino Acid Sequence; Flavin-Adenine Dinucleotide; Isoquinolines; Magnetic Resonance Spectroscopy; Molecular Sequence Data; Molecular Structure; Multigene Family; NADP; Naphthoquinones; Oxidation-Reduction; Oxygenases; Protein Binding; Sequence Alignment; Streptomyces

2005
Ring-opening dynamics of jadomycin A and B and dalomycin T.
    Organic letters, 2006, Feb-16, Volume: 8, Issue:4

    Topics: Isoquinolines; Molecular Structure; Naphthoquinones; Stereoisomerism; Streptomyces

2006
Culture conditions improving the production of jadomycin B.
    Journal of industrial microbiology & biotechnology, 2006, Volume: 33, Issue:9

    Topics: Anti-Bacterial Agents; Bacteriological Techniques; Biotechnology; Chondroitin Sulfate Proteoglycans; Culture Media; Ethanol; Glucose; Isoquinolines; Molecular Structure; Morpholines; Naphthoquinones; Receptor-Like Protein Tyrosine Phosphatases, Class 5; Streptomyces

2006
Stereochemical integrity of oxazolone ring-containing jadomycins.
    Chembiochem : a European journal of chemical biology, 2007, Jul-09, Volume: 8, Issue:10

    Topics: Breast Neoplasms; Carbon; Catalysis; Cell Line, Tumor; Dose-Response Relationship, Drug; Drug Design; Ethanol; Humans; Isoleucine; Isoquinolines; Magnetic Resonance Spectroscopy; Naphthoquinones; Oxazolone; Stereoisomerism; Streptomyces

2007
Diverse DNA-cleaving capacities of the jadomycins through precursor-directed biosynthesis.
    Organic letters, 2010, Mar-19, Volume: 12, Issue:6

    Topics: DNA; DNA Cleavage; DNA Damage; Isoquinolines; Molecular Structure; Naphthoquinones; Stereoisomerism; Streptomyces; Structure-Activity Relationship

2010
Characterization of JadH as an FAD- and NAD(P)H-dependent bifunctional hydroxylase/dehydrase in jadomycin biosynthesis.
    Chembiochem : a European journal of chemical biology, 2010, May-17, Volume: 11, Issue:8

    Topics: Escherichia coli; Flavin-Adenine Dinucleotide; Gene Expression; Isoquinolines; Mixed Function Oxygenases; NADP; Naphthoquinones; Streptomyces

2010
Total synthesis of jadomycin A and a carbasugar analogue of jadomycin B.
    Angewandte Chemie (International ed. in English), 2010, Dec-03, Volume: 49, Issue:49

    Topics: Carbasugars; Isoquinolines; Molecular Conformation; Naphthoquinones; Stereoisomerism

2010
Identification of JadG as the B ring opening oxygenase catalyzing the oxidative C-C bond cleavage reaction in jadomycin biosynthesis.
    Chemistry & biology, 2012, Nov-21, Volume: 19, Issue:11

    Topics: Bacterial Proteins; Escherichia coli Proteins; Flavin Mononucleotide; Flavin-Adenine Dinucleotide; FMN Reductase; Hydroquinones; Isoquinolines; Mutation; Naphthoquinones; Streptomyces

2012
[Identification of key residues in the catalytic center JadH involved in binding substrates or catalysis of jadomycin biosynthesis].
    Sheng wu gong cheng xue bao = Chinese journal of biotechnology, 2012, Volume: 28, Issue:8

    Topics: Amino Acid Sequence; Catalysis; Hydro-Lyases; Isoquinolines; Mixed Function Oxygenases; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutant Proteins; Naphthoquinones; Streptomyces; Substrate Specificity

2012
Total synthesis of jadomycins B, S, T, and ILEVS1080.
    Chemistry (Weinheim an der Bergstrasse, Germany), 2013, Jun-24, Volume: 19, Issue:26

    Topics: Amino Acids; Anti-Bacterial Agents; Glycosylation; Isoleucine; Isoquinolines; Monosaccharides; Naphthoquinones; Oxidation-Reduction

2013
JadR*-mediated feed-forward regulation of cofactor supply in jadomycin biosynthesis.
    Molecular microbiology, 2013, Volume: 90, Issue:4

    Topics: Anthraquinones; Bacterial Proteins; DNA-Binding Proteins; Gene Expression Regulation, Bacterial; Genes, Bacterial; Genes, Regulator; Isoquinolines; Multigene Family; NADP; Naphthoquinones; Promoter Regions, Genetic; Protein Binding; Streptomyces; Surface Plasmon Resonance

2013
Jadomycins, put a bigger ring in it: isolation of seven- to ten-membered ring analogues.
    Chemical communications (Cambridge, England), 2015, Oct-07, Volume: 51, Issue:78

    Topics: Chromatography, High Pressure Liquid; Isoquinolines; Naphthoquinones; Proton Magnetic Resonance Spectroscopy; Tandem Mass Spectrometry

2015