jaceosidin and wogonin

jaceosidin has been researched along with wogonin* in 1 studies

Other Studies

1 other study(ies) available for jaceosidin and wogonin

Article	Year
Oroxylin A analogs exhibited strong inhibitory activities against iNOS-mediated nitric oxide (NO) production. Bioorganic & medicinal chemistry letters, 2012, Apr-01, Volume: 22, Issue:7 A number of oroxylin A analogs were prepared and evaluated for their inhibitory activities against iNOS-mediated nitric oxide (NO) production from LPS-stimulated BV2 cells. The analogs were synthesized from purchased 2'-hydroxy-4,5,6-trimethoxyacetophenone and aldehydes in 3 steps. Among the tested compounds, several analogs (3b, 3c, 3d, 3f) exhibited strong inhibitory activities. Especially, the analog with 4-nitrophenyl group (3b) showed stronger inhibitory activity (IC(50)=4.73 μM) than that of wogonin (IC(50)=7.80 μM). Topics: Acetophenones; Aldehydes; Animals; Anti-Anxiety Agents; Cell Line, Transformed; Flavanones; Flavonoids; Lipopolysaccharides; Macrophages; Mice; Microglia; Nitric Oxide; Nitric Oxide Synthase Type II; Nitrophenols	2012

Article

Year

Oroxylin A analogs exhibited strong inhibitory activities against iNOS-mediated nitric oxide (NO) production.

Bioorganic & medicinal chemistry letters, 2012, Apr-01, Volume: 22, Issue:7

A number of oroxylin A analogs were prepared and evaluated for their inhibitory activities against iNOS-mediated nitric oxide (NO) production from LPS-stimulated BV2 cells. The analogs were synthesized from purchased 2'-hydroxy-4,5,6-trimethoxyacetophenone and aldehydes in 3 steps. Among the tested compounds, several analogs (3b, 3c, 3d, 3f) exhibited strong inhibitory activities. Especially, the analog with 4-nitrophenyl group (3b) showed stronger inhibitory activity (IC(50)=4.73 μM) than that of wogonin (IC(50)=7.80 μM).

Topics: Acetophenones; Aldehydes; Animals; Anti-Anxiety Agents; Cell Line, Transformed; Flavanones; Flavonoids; Lipopolysaccharides; Macrophages; Mice; Microglia; Nitric Oxide; Nitric Oxide Synthase Type II; Nitrophenols

2012