Page last updated: 2024-09-04

ivabradine and propranolol

ivabradine has been researched along with propranolol in 7 studies

Compound Research Comparison

Studies
(ivabradine)
Trials
(ivabradine)
Recent Studies (post-2010)
(ivabradine)
Studies
(propranolol)
Trials
(propranolol)
Recent Studies (post-2010) (propranolol)
1,14319783333,3103,4063,218

Protein Interaction Comparison

ProteinTaxonomyivabradine (IC50)propranolol (IC50)
Beta-1 adrenergic receptor Cavia porcellus (domestic guinea pig)0.0347
Gamma-aminobutyric acid receptor subunit piRattus norvegicus (Norway rat)0.0288
5-hydroxytryptamine receptor 4Cavia porcellus (domestic guinea pig)2.294
Cytochrome P450 1A2Homo sapiens (human)4
Beta-2 adrenergic receptorHomo sapiens (human)0.0114
Beta-1 adrenergic receptorHomo sapiens (human)0.0575
5-hydroxytryptamine receptor 1AHomo sapiens (human)3.9811
Beta-2 adrenergic receptorRattus norvegicus (Norway rat)0.012
Cytochrome P450 2D6Homo sapiens (human)2.9706
Beta-3 adrenergic receptorHomo sapiens (human)0.0493
Gamma-aminobutyric acid receptor subunit beta-1Rattus norvegicus (Norway rat)0.0288
Beta-1 adrenergic receptorRattus norvegicus (Norway rat)0.012
Gamma-aminobutyric acid receptor subunit deltaRattus norvegicus (Norway rat)0.0288
Gamma-aminobutyric acid receptor subunit gamma-2Rattus norvegicus (Norway rat)0.0288
5-hydroxytryptamine receptor 1ARattus norvegicus (Norway rat)0.0827
Gamma-aminobutyric acid receptor subunit alpha-5Rattus norvegicus (Norway rat)0.0288
Gamma-aminobutyric acid receptor subunit alpha-3Rattus norvegicus (Norway rat)0.0288
Gamma-aminobutyric acid receptor subunit gamma-1Rattus norvegicus (Norway rat)0.0288
Gamma-aminobutyric acid receptor subunit alpha-2Rattus norvegicus (Norway rat)0.0288
Beta-3 adrenergic receptorRattus norvegicus (Norway rat)0.012
5-hydroxytryptamine receptor 2AHomo sapiens (human)1.466
5-hydroxytryptamine receptor 2CHomo sapiens (human)2.294
Gamma-aminobutyric acid receptor subunit alpha-4Rattus norvegicus (Norway rat)0.0288
Gamma-aminobutyric acid receptor subunit gamma-3Rattus norvegicus (Norway rat)0.0288
5-hydroxytryptamine receptor 1BRattus norvegicus (Norway rat)0.243
Gamma-aminobutyric acid receptor subunit alpha-6Rattus norvegicus (Norway rat)0.0288
Sodium-dependent serotonin transporterHomo sapiens (human)0.38
5-hydroxytryptamine receptor 2BHomo sapiens (human)0.342
5-hydroxytryptamine receptor 6Homo sapiens (human)3.065
Beta-2 adrenergic receptorCanis lupus familiaris (dog)0.017
Gamma-aminobutyric acid receptor subunit alpha-1Rattus norvegicus (Norway rat)0.0288
Gamma-aminobutyric acid receptor subunit beta-3Rattus norvegicus (Norway rat)0.0288
Gamma-aminobutyric acid receptor subunit beta-2Rattus norvegicus (Norway rat)0.0288
Potassium voltage-gated channel subfamily H member 2Homo sapiens (human)2.828
Sodium channel protein type 5 subunit alphaHomo sapiens (human)2.1
Sodium/bile acid cotransporterHomo sapiens (human)5.5
Beta-2 adrenergic receptorCavia porcellus (domestic guinea pig)0.0288
GABA theta subunitRattus norvegicus (Norway rat)0.0288
Sigma non-opioid intracellular receptor 1Homo sapiens (human)2.87
Gamma-aminobutyric acid receptor subunit epsilonRattus norvegicus (Norway rat)0.0288

Research

Studies (7)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (14.29)18.2507
2000's2 (28.57)29.6817
2010's3 (42.86)24.3611
2020's1 (14.29)2.80

Authors

AuthorsStudies
Benis, A; Carré, F; Lerebours, G; Mangin, L; Swynghedauw, B; Thibault, N1
Bidouard, JP; Lesage, L; Péglion, JL; Reure, H; Vilaine, JP1
Compagnon, P; Iacob, M; Joannides, R; Lerebours, G; Menard, JF; Moore, N; Thuillez, C1
Bui-Xuan, B; Chevalier, P; Dehina, L; Descotes, J; Dizerens, N; Lauzier, B; Tabib, A; Timour, Q; Vaillant, F1
Casas, G; Francisco-Pascual, J; García-Dorado, D; Moya-Mitjans, À; Rivas-Gándara, N1
Fadeeva, IS; Glushkova, OV; Khrenov, MO; Komelina, NP; Kovtun, AL; Kutyshenko, VP; Prokhorov, DA; Tarahovsky, YS; Zakharova, NM1
Fadeeva, IS; Komelina, NP; Kovtun, AL; Tarahovsky, YS; Zakharova, NM1

Trials

1 trial(s) available for ivabradine and propranolol

ArticleYear
Comparative effects of ivabradine, a selective heart rate-lowering agent, and propranolol on systemic and cardiac haemodynamics at rest and during exercise.
    British journal of clinical pharmacology, 2006, Volume: 61, Issue:2

    Topics: Adolescent; Adrenergic beta-Antagonists; Adult; Benzazepines; Cardiovascular Agents; Cross-Over Studies; Depression, Chemical; Double-Blind Method; Epinephrine; Exercise; Heart Rate; Hemodynamics; Humans; Ivabradine; Male; Norepinephrine; Propranolol; Rest; Tilt-Table Test

2006

Other Studies

6 other study(ies) available for ivabradine and propranolol

ArticleYear
Relationships between heart rate and heart rate variability: study in conscious rats.
    Journal of cardiovascular pharmacology, 1998, Volume: 32, Issue:4

    Topics: Animals; Anti-Arrhythmia Agents; Atropine; Benzazepines; Cardiotonic Agents; Drug Interactions; Heart Rate; Injections, Intraperitoneal; Ivabradine; Male; Propranolol; Rats; Rats, Wistar

1998
Anti-ischemic effects of ivabradine, a selective heart rate-reducing agent, in exercise-induced myocardial ischemia in pigs.
    Journal of cardiovascular pharmacology, 2003, Volume: 42, Issue:5

    Topics: Animals; Benzazepines; Blood Pressure; Female; Heart Rate; Ivabradine; Male; Myocardial Ischemia; Physical Exertion; Propranolol; Swine, Miniature

2003
Ivabradine but not propranolol delays the time to onset of ischaemia-induced ventricular fibrillation by preserving myocardial metabolic energy status.
    Resuscitation, 2013, Volume: 84, Issue:3

    Topics: Animals; Anti-Arrhythmia Agents; Benzazepines; Cyclic Nucleotide-Gated Cation Channels; Disease Models, Animal; Energy Metabolism; Ivabradine; Male; Myocardial Ischemia; Myocardium; Propranolol; Resuscitation; Swine; Ventricular Fibrillation

2013
Postural Orthostatic Tachycardia Syndrome and Vasospastic Angina: Therapeutic Approach to a Previously Unreported Association.
    Revista espanola de cardiologia (English ed.), 2019, Volume: 72, Issue:6

    Topics: Adrenergic beta-Antagonists; Angina Pectoris, Variant; Anti-Inflammatory Agents; Cardiovascular Agents; Coronary Angiography; Drug Therapy, Combination; Electrocardiography; Female; Fludrocortisone; Humans; Ivabradine; Middle Aged; Postural Orthostatic Tachycardia Syndrome; Propranolol; Tilt-Table Test

2019
A pharmacological composition for induction of a reversible torpor-like state and hypothermia in rats.
    Life sciences, 2019, Feb-15, Volume: 219

    Topics: Animals; Body Temperature; Brain; Diphenhydramine; Drug Combinations; Heart Rate; Hypothermia; Injections, Intravenous; Ivabradine; Magnesium Sulfate; Male; Oxygen Consumption; Phenothiazines; Phospholipids; Propranolol; Propylthiouracil; Rats; Rats, Wistar; Reserpine; Respiratory Rate; Serotonin; Sorbitol; Torpor; Xenon

2019
Long-term pharmacological torpor of rats with feedback-controlled drug administration.
    Life sciences in space research, 2021, Volume: 28

    Topics: Animals; Body Temperature; Diphenhydramine; Drug Combinations; Drug Delivery Systems; Feedback; Heart Rate; Hypothermia; Injections, Intravenous; Ivabradine; Magnesium Sulfate; Male; Phenothiazines; Propranolol; Propylthiouracil; Rats, Wistar; Reserpine; Serotonin; Telemetry; Torpor

2021